Regulation of CDK9 Activity by Phosphorylation and Dephosphorylation

Viral–Host Interactions That Control HIV-1 Transcriptional Elongation

(2013) Huasong Lu et al.   CHEMICAL REVIEWS

Phosphorylation of CDK9 at Ser175 Enhances HIV Transcription and Is a Marker of Activated P-TEFb in CD4+ T Lymphocytes

(2013) Uri R. Mbonye et al.   PLoS Pathogens

The cyclin K/Cdk12 complex

(2012) Dalibor Blazek   CELL CYCLE

Cyclin T1 and CDK9 T-Loop Phosphorylation Are Downregulated during Establishment of HIV-1 Latency in Primary Resting Memory CD4+ T Cells

(2012) S. Budhiraja et al.   JOURNAL OF VIROLOGY

Cyclin-dependent kinase control of the initiation-to-elongation switch of RNA polymerase II

(2012) Stéphane Larochelle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Small Molecules Targeted to a Non-Catalytic “RVxF” Binding Site of Protein Phosphatase-1 Inhibit HIV-1

(2012) Tatiana Ammosova et al.   PLoS One

HIV-1 Tat recruits transcription elongation factors dispersed along a flexible AFF4 scaffold

(2012) S. Chou et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

CDK2 Regulates HIV-1 Transcription by Phosphorylation of CDK9 on Serine 90

(2012) Denitra Breuer et al.   Retrovirology

Cyclin K goes with Cdk12 and Cdk13

(2012) Jiri Kohoutek et al.   Cell Division

Serine-7 but not serine-5 phosphorylation primes RNA polymerase II CTD for P-TEFb recognition

(2012) Nadine Czudnochowski et al.   Nature Communications

Curing HIV: Pharmacologic Approaches to Target HIV-1 Latency

(2011) Shailesh K. Choudhary et al.   Annual Review of Pharmacology and Toxicology

Cdk9 T-loop phosphorylation is regulated by the calcium signaling pathway

(2011) Rajesh Ramakrishnan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Correction to "Iron Chelators of the Di-2-pyridylketone Thiosemicarbazone and 2-Benzoylpyridine Thiosemicarbazone Series Inhibit HIV-1 Transcription: Identification of Novel Cellular Targets--Iron, Cyclin-Dependent Kinase (CDK) 2, and CDK9"

(2011)   MOLECULAR PHARMACOLOGY

Protein Phosphatase-1 Activates CDK9 by Dephosphorylating Ser175

(2011) Tatiana Ammosova et al.   PLoS One

Conserved and divergent features of the structure and function of La and La-related proteins (LARPs)

(2010) Mark A. Bayfield et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

Expression of a Protein Phosphatase 1 Inhibitor, cdNIPP1, Increases CDK9 Threonine 186 Phosphorylation and Inhibits HIV-1 Transcription

(2010) Tatiana Ammosova et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

HIV-1 Tat and Host AFF4 Recruit Two Transcription Elongation Factors into a Bifunctional Complex for Coordinated Activation of HIV-1 Transcription

(2010) Nanhai He et al.   MOLECULAR CELL

HIV-1 Tat Assembles a Multifunctional Transcription Elongation Complex and Stably Associates with the 7SK snRNP

(2010) Bijan Sobhian et al.   MOLECULAR CELL

HIV-1 Tat: Its Dependence on Host Factors is Crystal Clear

(2010) Iván D’Orso et al.   Viruses-Basel

Controlling Cellular P-TEFb Activity by the HIV-1 Transcriptional Transactivator Tat

(2010) Lisa Muniz et al.   PLoS Pathogens

TFIIH Kinase Places Bivalent Marks on the Carboxy-Terminal Domain of RNA Polymerase II

(2009) Md. Sohail Akhtar et al.   MOLECULAR CELL

A capping-independent function of MePCE in stabilizing 7SK snRNA and facilitating the assembly of 7SK snRNP

(2009) Y. Xue et al.   NUCLEIC ACIDS RESEARCH

7SK snRNP/P-TEFb couples transcription elongation with alternative splicing and is essential for vertebrate development

(2009) M. Barboric et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

P-TEFb- the final frontier

(2009) Jiri Kohoutek   Cell Division

The multi-tasking P-TEFb complex

(2008) Vanessa Brès et al.   CURRENT OPINION IN CELL BIOLOGY

The structure of P-TEFb (CDK9/cyclin T1), its complex with flavopiridol and regulation by phosphorylation

(2008) Sonja Baumli et al.   EMBO JOURNAL

The La-related protein LARP7 is a component of the 7SK ribonucleoprotein and affects transcription of cellular and viral polymerase II genes

(2008) Andreas Markert et al.   EMBO REPORTS

PP2B and PP1  cooperatively disrupt 7SK snRNP to release P-TEFb for transcription in response to Ca2+ signaling

(2008) R. Chen et al.   GENES & DEVELOPMENT

Phosphatase PPM1A Regulates Phosphorylation of Thr-186 in the Cdk9 T-loop

(2008) Yan Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Bromodomain Protein Brd4 Regulates Human Immunodeficiency Virus Transcription through Phosphorylation of CDK9 at Threonine 29

(2008) M. Zhou et al.   JOURNAL OF VIROLOGY

A La-Related Protein Modulates 7SK snRNP Integrity to Suppress P-TEFb-Dependent Transcriptional Elongation and Tumorigenesis

(2008) Nanhai He et al.   MOLECULAR CELL

LARP7 is a stable component of the 7SK snRNP while P-TEFb, HEXIM1 and hnRNP A1 are reversibly associated

(2008) B. J. Krueger et al.   NUCLEIC ACIDS RESEARCH