3-Nitrotyrosine: a versatile oxidative stress biomarker for major neurodegenerative diseases

Advancements in the Analytical Quantification of Nitroxidative Stress Biomarker 3-Nitrotyrosine in Biological Matrices

(2019) Maria Bandookwala et al.   CRITICAL REVIEWS IN ANALYTICAL CHEMISTRY

Origin and pathophysiology of protein carbonylation, nitration and chlorination in age-related brain diseases and aging

(2018) Efstathios S. Gonos et al.   Aging-US

Neuroprotection in Oxidative Stress-Related Neurodegenerative Diseases: Role of Endocannabinoid System Modulation

(2018) Janos Paloczi et al.   ANTIOXIDANTS & REDOX SIGNALING

Age-dependent effects of dimethyl fumarate on cognitive and neuropathological features in the streptozotocin-induced rat model of Alzheimer’s disease

(2018) Irena Majkutewicz et al.   BRAIN RESEARCH

Alterations in neuronal metabolism contribute to the pathogenesis of prion disease

(2018) Julie-Myrtille Bourgognon et al.   CELL DEATH AND DIFFERENTIATION

2-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease

(2018) Marika Cordaro et al.   MOLECULAR NEUROBIOLOGY

Simvastatin Inhibits Activation of NADPH Oxidase/p38 MAPK Pathway and Enhances Expression of Antioxidant Protein in Parkinson Disease Models

(2018) Huichun Tong et al.   Frontiers in Molecular Neuroscience

Fucoidan Protects Dopaminergic Neurons by Enhancing the Mitochondrial Function in a Rotenone-induced Rat Model of Parkinson’s Disease

(2018) Li Zhang et al.   Aging and Disease

Clinical efficacy of edaravone for the treatment of amyotrophic lateral sclerosis

(2017) Hideyuki Sawada   EXPERT OPINION ON PHARMACOTHERAPY

Old Maids: Aging and Its Impact on Microglia Function

(2017) Edward Koellhoffer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Oxidative stress and mitochondrial damage in the pathogenesis of ALS: New perspectives

(2017) F. Bozzo et al.   NEUROSCIENCE LETTERS

The Isothiocyanate Isolated fromMoringa oleiferaShows Potent Anti-Inflammatory Activity in the Treatment of Murine Subacute Parkinson's Disease

(2017) Sabrina Giacoppo et al.   REJUVENATION RESEARCH

Pre-clinical therapeutic development of a series of metalloporphyrins for Parkinson's disease

(2017) Li-Ping Liang et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

The Role of Interleukin-18, Oxidative Stress and Metabolic Syndrome in Alzheimer’s Disease

(2017) et al.   Journal of Clinical Medicine

Mechanism of the Reaction of Human Manganese Superoxide Dismutase with Peroxynitrite: Nitration of Critical Tyrosine 34

(2016) Verónica Demicheli et al.   BIOCHEMISTRY

3-Nitrotyrosine quantification methods: Current concepts and future challenges

(2016) Dulce Teixeira et al.   BIOCHIMIE

Inflammatory Mechanisms and Oxidative Stress as Key Factors Responsible for Progression of Neurodegeneration: Role of Brain Innate Immune System

(2016) Jerzy Leszek et al.   CNS & Neurological Disorders-Drug Targets

Bioenergetics and redox adaptations of astrocytes to neuronal activity

(2016) Juan P. Bolaños   JOURNAL OF NEUROCHEMISTRY

Mitoapocynin Treatment Protects Against Neuroinflammation and Dopaminergic Neurodegeneration in a Preclinical Animal Model of Parkinson’s Disease

(2016) Anamitra Ghosh et al.   Journal of Neuroimmune Pharmacology

Molecular Alterations in the Cerebellum of Sporadic Creutzfeldt–Jakob Disease Subtypes with DJ-1 as a Key Regulator of Oxidative Stress

(2016) Waqas Tahir et al.   MOLECULAR NEUROBIOLOGY

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Quercetin, not caffeine, is a major neuroprotective component in coffee

(2016) Moonhee Lee et al.   NEUROBIOLOGY OF AGING

Oxidative stress and mitochondrial dysfunction-linked neurodegenerative disorders

(2016) Md. Torequl Islam   NEUROLOGICAL RESEARCH

Poly(GR) in C9ORF72 -Related ALS/FTD Compromises Mitochondrial Function and Increases Oxidative Stress and DNA Damage in iPSC-Derived Motor Neurons

(2016) Rodrigo Lopez-Gonzalez et al.   NEURON

Therapeutic targeting of oxygen-sensing prolyl hydroxylases abrogates ATF4-dependent neuronal death and improves outcomes after brain hemorrhage in several rodent models

(2016) Saravanan S. Karuppagounder et al.   Science Translational Medicine

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Epidemiological characteristics of human prion diseases

(2016) Cao Chen et al.   Infectious Diseases of Poverty

Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5–Nrf2 pathway

(2015) D Jimenez-Blasco et al.   CELL DEATH AND DIFFERENTIATION

Oxidative stress response and Nrf2 signaling in aging

(2015) Hongqiao Zhang et al.   FREE RADICAL BIOLOGY AND MEDICINE

Antioxidative effects of ethyl 2-(3-(benzo[d]thiazol-2-yl)ureido)acetate against amyloid β-induced oxidative cell death via NF-κB, GSK-3β and β-catenin signaling pathways in cultured cortical neurons

(2015) E.-A. Kim et al.   FREE RADICAL RESEARCH

Combined administration of levetiracetam and valproic acid attenuates age-related hyperactivity of CA3 place cells, reduces place field area, and increases spatial information content in aged rat hippocampus

(2015) Jonathan Robitsek et al.   HIPPOCAMPUS

Orientin alleviates cognitive deficits and oxidative stress in Aβ1–42-induced mouse model of Alzheimer's disease

(2015) Linjie Yu et al.   LIFE SCIENCES

Oxidative Stress in Neurodegenerative Diseases

(2015) Ewa Niedzielska et al.   MOLECULAR NEUROBIOLOGY

Treatment with Hydrogen-Rich Saline Delays Disease Progression in a Mouse Model of Amyotrophic Lateral Sclerosis

(2015) Yu Zhang et al.   NEUROCHEMICAL RESEARCH

Edaravone leads to proteome changes indicative of neuronal cell protection in response to oxidative stress

(2015) Mohammad-Saeid Jami et al.   NEUROCHEMISTRY INTERNATIONAL

The Roles of PINK1, Parkin, and Mitochondrial Fidelity in Parkinson’s Disease

(2015) Alicia M. Pickrell et al.   NEURON

Pyrroloquinoline quinone-conferred neuroprotection in rotenone models of Parkinson’s disease

(2015) Jiaojiao Qin et al.   TOXICOLOGY LETTERS

Oxidative stress and Parkinson’s disease

(2015) Javier Blesa et al.   Frontiers in Neuroanatomy

The Role of Oxidative Stress in Neurodegenerative Diseases

(2015) Geon Ha Kim et al.   Experimental Neurobiology

Cinnamon and Its Metabolite Sodium Benzoate Attenuate the Activation of p21rac and Protect Memory and Learning in an Animal Model of Alzheimer’s Disease

(2015) Khushbu K. Modi et al.   PLoS One

Pathways Disrupted in Human ALS Motor Neurons Identified through Genetic Correction of Mutant SOD1

(2014) Evangelos Kiskinis et al.   Cell Stem Cell

Opposing roles of p38 and JNK in a Drosophila model of TDP-43 proteinopathy reveal oxidative stress and innate immunity as pathogenic components of neurodegeneration

(2014) Lihong Zhan et al.   HUMAN MOLECULAR GENETICS

Evaluation of a Method for Nitrotyrosine Site Identification and Relative Quantitation Using a Stable Isotope-Labeled Nitrated Spike-In Standard and High Resolution Fourier Transform MS and MS/MS Analysis

(2014) Kent Seeley et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Protective and toxic roles of dopamine in Parkinson's disease

(2014) Juan Segura-Aguilar et al.   JOURNAL OF NEUROCHEMISTRY

Iron dysregulation in Huntington's disease

(2014) Michelle Muller et al.   JOURNAL OF NEUROCHEMISTRY

Slowing of neurodegeneration in Parkinson's disease and Huntington's disease: future therapeutic perspectives

(2014) Anthony H V Schapira et al.   LANCET

Motor cortex glutathione deficit in ALS measured in vivo with the J-editing technique

(2014) N. Weiduschat et al.   NEUROSCIENCE LETTERS

Multimarker Screening of Oxidative Stress in Aging

(2014) Kamila Syslová et al.   Oxidative Medicine and Cellular Longevity

The role of oxidative stress in degeneration of the neuromuscular junction in amyotrophic lateral sclerosis

(2014) Eveliina Pollari et al.   Frontiers in Cellular Neuroscience

The Potential for Transition Metal-Mediated Neurodegeneration in Amyotrophic Lateral Sclerosis

(2014) David B. Lovejoy et al.   Frontiers in Aging Neuroscience

May the Evaluation of Nitrosative Stress Through Selective Increase of 3-Nitrotyrosine Proteins Other Than Nitroalbumin and Dominant Tyrosine-125/136 Nitrosylation of Serum α-Synuclein Serve for Diagnosis of Sporadic Parkinson's Disease?

(2013) Emilio Fernández et al.   ANTIOXIDANTS & REDOX SIGNALING

Abeta, oxidative stress in Alzheimer disease: Evidence based on proteomics studies

(2013) Aaron M. Swomley et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Mitochondria Are Required for Antigen-Specific T Cell Activation through Reactive Oxygen Species Signaling

(2013) Laura A. Sena et al.   IMMUNITY

Oxidative Stress as an Underlying Contributor in the Development of Chronic Complications in Diabetes Mellitus

(2013) Suziy de M. Bandeira et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Aberrant Assembly of RNA Recognition Motif 1 Links to Pathogenic Conversion of TAR DNA-binding Protein of 43 kDa (TDP-43)

(2013) Akemi Shodai et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Peroxynitrite, a Stealthy Biological Oxidant

(2013) Rafael Radi   JOURNAL OF BIOLOGICAL CHEMISTRY

Mass spectrometry analysis of nitrotyrosine-containing proteins

(2013) Xianquan Zhan et al.   MASS SPECTROMETRY REVIEWS

Amyotrophic lateral sclerosis-linked FUS/TLS alters stress granule assembly and dynamics

(2013) Desiree M Baron et al.   Molecular Neurodegeneration

Neuroprotective Function of DJ-1 in Parkinson’s Disease

(2013) Hiroyoshi Ariga et al.   Oxidative Medicine and Cellular Longevity

Analyses of the Survival Time and the Influencing Factors of Chinese Patients with Prion Diseases Based on the Surveillance Data from 2008–2011

(2013) Cao Chen et al.   PLoS One

ALS-Associated TDP-43 Induces Endoplasmic Reticulum Stress, Which Drives Cytoplasmic TDP-43 Accumulation and Stress Granule Formation

(2013) Adam K. Walker et al.   PLoS One

Huntington disease arises from a combinatory toxicity of polyglutamine and copper binding

(2013) G. Xiao et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Neuronal activity regulates astrocytic Nrf2 signaling

(2013) A. Habas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Biological markers of oxidative stress: Applications to cardiovascular research and practice

(2013) Edwin Ho et al.   Redox Biology

Protein Tyrosine Nitration: Biochemical Mechanisms and Structural Basis of Functional Effects

(2012) Rafael Radi   ACCOUNTS OF CHEMICAL RESEARCH

Alterations in Brain Transition Metals in Huntington Disease

(2012) H. Diana Rosas et al.   ARCHIVES OF NEUROLOGY

Post-aggregation Oxidation of Mutant Huntingtin Controls the Interactions between Aggregates

(2012) Yasushi Mitomi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

NGF and nitrosative stress in patients with Huntington's disease

(2012) Inmaculada Tasset et al.   JOURNAL OF THE NEUROLOGICAL SCIENCES

Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase

(2012) Manal A. Farg et al.   NEUROBIOLOGY OF AGING

Neuroprotective effect of sinapic acid in a mouse model of amyloid β1–42 protein-induced Alzheimer's disease

(2012) Hyung Eun Lee et al.   PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR

An over-oxidized form of superoxide dismutase found in sporadic amyotrophic lateral sclerosis with bulbar onset shares a toxic mechanism with mutant SOD1

(2012) S. Guareschi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Nitrosative protein tyrosine modifications: biochemistry and functional significance

(2011) Woon-Seok Yeo et al.   BMB Reports

Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking

(2011) Todd J Cohen et al.   EMBO JOURNAL

Neurotoxic 43-kDa TAR DNA-binding Protein (TDP-43) Triggers Mitochondrion-dependent Programmed Cell Death in Yeast

(2011) Ralf J. Braun et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cysteine Oxidation within N-terminal Mutant Huntingtin Promotes Oligomerization and Delays Clearance of Soluble Protein

(2011) Jonathan H. Fox et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Etiology and pathogenesis of Parkinson's disease

(2011) Anthony H. Schapira et al.   MOVEMENT DISORDERS

Oxidative stress induced by glutathione depletion reproduces pathological modifications of TDP-43 linked to TDP-43 proteinopathies

(2011) Yohei Iguchi et al.   NEUROBIOLOGY OF DISEASE

Nitration of Tyrosine 10 Critically Enhances Amyloid β Aggregation and Plaque Formation

(2011) Markus P. Kummer et al.   NEURON

Edaravone Guards Dopamine Neurons in a Rotenone Model for Parkinson's Disease

(2011) Nian Xiong et al.   PLoS One

Analytical methods for 3-nitrotyrosine quantification in biological samples: the unique role of tandem mass spectrometry

(2010) Dimitrios Tsikas   AMINO ACIDS

Evidence of Oxidant Damage in Huntington's Disease: Translational Strategies Using Antioxidants

(2010) Edward C. Stack et al.   Annals of the New York Academy of Sciences

Mechanisms Underlying Inflammation in Neurodegeneration

(2010) Christopher K. Glass et al.   CELL

Mutant FUS proteins that cause amyotrophic lateral sclerosis incorporate into stress granules

(2010) Daryl A. Bosco et al.   HUMAN MOLECULAR GENETICS

Peroxynitrite Mediates Active Site Tyrosine Nitration in Manganese Superoxide Dismutase. Evidence of a Role for the Carbonate Radical Anion

(2010) N. Basak Surmeli et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Instant coffee with high chlorogenic acid levels protects humans against oxidative damage of macromolecules

(2010) Christine Hoelzl et al.   MOLECULAR NUTRITION & FOOD RESEARCH

Mutant TAR DNA-binding protein-43 induces oxidative injury in motor neuron-like cell

(2010) W. Duan et al.   NEUROSCIENCE

Preferentially Increased Nitration of α-Synuclein at Tyrosine-39 in a Cellular Oxidative Model of Parkinson’s Disease

(2009) Steven R. Danielson et al.   ANALYTICAL CHEMISTRY

Nitroproteomics of Peripheral Blood Mononuclear Cells from Patients and a Rat Model of ALS

(2009) Giovanni Nardo et al.   ANTIOXIDANTS & REDOX SIGNALING

Neuroprotective effect of epigallocatechin-3-gallate against β-amyloid-induced oxidative and nitrosative cell death via augmentation of antioxidant defense capacity

(2009) Chang-Yul Kim et al.   ARCHIVES OF PHARMACAL RESEARCH

Structure-Dependent DNA Damage and Repair in a Trinucleotide Repeat Sequence

(2009) Daniel A. Jarem et al.   BIOCHEMISTRY

TDP-43 is recruited to stress granules in conditions of oxidative insult

(2009) Claudia Colombrita et al.   JOURNAL OF NEUROCHEMISTRY

Genome-Wide Microarray Analysis of the Differential Neuroprotective Effects of Antioxidants in Neuroblastoma Cells Overexpressing the Familial Parkinson’s Disease α-Synuclein A53T Mutation

(2009) Lei Ma et al.   NEUROCHEMICAL RESEARCH

Prion Diseases: From Protein to Cell Pathology

(2008) Gabor G. Kovacs et al.   AMERICAN JOURNAL OF PATHOLOGY

Proteomic analysis of protein tyrosine nitration after ischemia reperfusion injury: Mitochondria as the major target

(2008) Bin Liu et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Treatment with edaravone, initiated at symptom onset, slows motor decline and decreases SOD1 deposition in ALS mice

(2008) Hidefumi Ito et al.   EXPERIMENTAL NEUROLOGY

Proteomic and oxidative stress analysis in human brain samples of Huntington disease

(2008) M Alba Sorolla et al.   FREE RADICAL BIOLOGY AND MEDICINE

Proteomic identification of nitrated brain proteins in early Alzheimer’s disease inferior parietal lobule

(2008) Tanea T. Reed et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis

(2008) Julie D. Atkin et al.   NEUROBIOLOGY OF DISEASE