The Role of Interleukin-18, Oxidative Stress and Metabolic Syndrome in Alzheimer’s Disease

Adaptive responses of neuronal mitochondria to bioenergetic challenges: Roles in neuroplasticity and disease resistance

(2017) Sophia M. Raefsky et al.   FREE RADICAL BIOLOGY AND MEDICINE

A 3-Month Aerobic Training Program Improves Brain Energy Metabolism in Mild Alzheimer’s Disease: Preliminary Results from a Neuroimaging Study

(2017) Christian-Alexandre Castellano et al.   JOURNAL OF ALZHEIMERS DISEASE

Nutrition and AGE-ing: Focusing on Alzheimer’s Disease

(2017) Giulia Abate et al.   Oxidative Medicine and Cellular Longevity

Aerobic exercise for Alzheimer's disease: A randomized controlled pilot trial

(2017) Jill K. Morris et al.   PLoS One

Interleukin-18 Binding Protein Pretreatment Attenuates Kidney Injury Induced by Hepatic Ischemia Reperfusion

(2016) Yucel Gonul et al.   AMERICAN JOURNAL OF THE MEDICAL SCIENCES

Alpha-tocopherol quinine ameliorates spatial memory deficits by reducing beta-amyloid oligomers, neuroinflammation and oxidative stress in transgenic mice with Alzheimer's disease

(2016) Shao-wei Wang et al.   BEHAVIOURAL BRAIN RESEARCH

Effects of a healthy Nordic diet on gene expression changes in peripheral blood mononuclear cells in response to an oral glucose tolerance test in subjects with metabolic syndrome: a SYSDIET sub-study

(2016) Lena Leder et al.   Genes and Nutrition

Stroke, Vascular Dementia, and Alzheimer’s Disease: Molecular Links

(2016) Murali Vijayan et al.   JOURNAL OF ALZHEIMERS DISEASE

Biliverdin Reductase A Attenuates Hepatic Steatosis by Inhibition of Glycogen Synthase Kinase (GSK) 3β Phosphorylation of Serine 73 of Peroxisome Proliferator-activated Receptor (PPAR) α

(2016) Terry D. Hinds et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Matrix metalloproteinases in the brain and blood–brain barrier: Versatile breakers and makers

(2016) Ralf G Rempe et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Differential subnetwork of chemokines/cytokines in human, mouse, and rat brain cells after oxygen–glucose deprivation

(2016) Yang Du et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Effects of a healthy Nordic diet on gene expression changes in peripheral blood mononuclear cells in response to an oral glucose tolerance test in subjects with metabolic syndrome: a SYSDIET sub-study

(2016) Lena Leder et al.   Genes and Nutrition

Marine omega-3 fatty acids and inflammatory processes: Effects, mechanisms and clinical relevance

(2015) Philip C. Calder   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

A high calorie diet causes memory loss, metabolic syndrome and oxidative stress into hippocampus and temporal cortex of rats

(2015) Samuel Treviño et al.   SYNAPSE

Targeting the Warburg effect in cancer cells through ENO1 knockdown rescues oxidative phosphorylation and induces growth arrest

(2015) Michela Capello et al.   Oncotarget

The effects of C-glycosylation of luteolin on its antioxidant, anti-Alzheimer’s disease, anti-diabetic, and anti-inflammatory activities

(2014) Jae Sue Choi et al.   ARCHIVES OF PHARMACAL RESEARCH

Membrane lipid modifications and therapeutic effects mediated by hydroxydocosahexaenoic acid on Alzheimer's disease

(2014) Manuel Torres et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Leptin attenuates BACE1 expression and amyloid-β genesis via the activation of SIRT1 signaling pathway

(2014) Gurdeep Marwarha et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Critical role of matrix metalloprotease-9 in chronic high fat diet-induced cerebral vascular remodelling and increase of ischaemic brain injury in mice

(2014) J. Deng et al.   CARDIOVASCULAR RESEARCH

Oxidized LDL lipids increase β-amyloid production by SH-SY5Y cells through glutathione depletion and lipid raft formation

(2014) Irundika H.K. Dias et al.   FREE RADICAL BIOLOGY AND MEDICINE

Hyperhomocysteinemia and Neurologic Disorders: a Review

(2014) Ramin Ansari et al.   Journal of Clinical Neurology

Higher Diet Quality Is Associated with Decreased Risk of All-Cause, Cardiovascular Disease, and Cancer Mortality among Older Adults

(2014) Jill Reedy et al.   JOURNAL OF NUTRITION

Neuroinflammation in the pathogenesis of Alzheimer’s disease. A rational framework for the search of novel therapeutic approaches

(2014) Inelia Morales et al.   Frontiers in Cellular Neuroscience

Interleukin-18 alters protein expressions of neurodegenerative diseases-linked proteins in human SH-SY5Y neuron-like cells

(2014) Elina M. Sutinen et al.   Frontiers in Cellular Neuroscience

Lifestyle and Advanced Glycation End Products (AGEs) Burden: Its Relevance to Healthy Aging

(2014) Chandan Prasad   Aging and Disease

Thioredoxins, Glutaredoxins, and Peroxiredoxins—Molecular Mechanisms and Health Significance: from Cofactors to Antioxidants to Redox Signaling

(2013) Eva-Maria Hanschmann et al.   ANTIOXIDANTS & REDOX SIGNALING

Interleukin-18 null mutation increases weight and food intake and reduces energy expenditure and lipid substrate utilization in high-fat diet fed mice

(2013) Eric P. Zorrilla et al.   BRAIN BEHAVIOR AND IMMUNITY

Late-life depression and risk of vascular dementia and Alzheimer's disease: systematic review and meta-analysis of community-based cohort studies

(2013) Breno S. Diniz et al.   BRITISH JOURNAL OF PSYCHIATRY

Lifestyle change and the prevention of cognitive decline and dementia

(2013) Martin Lövdén et al.   CURRENT OPINION IN PSYCHIATRY

Genomic responses in mouse models poorly mimic human inflammatory diseases

(2013) Junhee Seok et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Effect of lifestyle activities on alzheimer disease biomarkers and cognition

(2012) Prashanthi Vemuri et al.   ANNALS OF NEUROLOGY

γ-Enolase C-terminal peptide promotes cell survival and neurite outgrowth by activation of the PI3K/Akt and MAPK/ERK signalling pathways

(2012) Anja Hafner et al.   BIOCHEMICAL JOURNAL

Mitochondrial glutathione: Features, regulation and role in disease

(2012) Montserrat Marí et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Docosahexaenoic and Eicosapentaenoic Acids Segregate Differently between Raft and Nonraft Domains

(2012) Justin A. Williams et al.   BIOPHYSICAL JOURNAL

Mitochondrial dysfunction and oxidative stress activate inflammasomes: impact on the aging process and age-related diseases

(2012) Antero Salminen et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Physical Activity and Inflammatory Markers Over 10 Years

(2012) Mark Hamer et al.   CIRCULATION

Metabolic Alterations Induced by Sucrose Intake and Alzheimer’s Disease Promote Similar Brain Mitochondrial Abnormalities

(2012) Cristina Carvalho et al.   DIABETES

α-Enolase, a Multifunctional Protein: Its Role on Pathophysiological Situations

(2012) Àngels Díaz-Ramos et al.   JOURNAL OF BIOMEDICINE AND BIOTECHNOLOGY

Nitric oxide-mediated regulation of β-amyloid clearance via alterations of MMP-9/TIMP-1

(2012) Lisa A. Ridnour et al.   JOURNAL OF NEUROCHEMISTRY

Pro-inflammatory interleukin-18 increases Alzheimer’s disease-associated amyloid-β production in human neuron-like cells

(2012) Elina M Sutinen et al.   Journal of Neuroinflammation

Effect of Exercise Training on Inflammation Status Among People with Metabolic Syndrome

(2012) Dorthe Stensvold et al.   Metabolic Syndrome and Related Disorders

Estrogen activates matrix metalloproteinases-2 and -9 to increase beta amyloid degradation

(2012) Sara Merlo et al.   MOLECULAR AND CELLULAR NEUROSCIENCE

A role for the NLRP3 inflammasome in metabolic diseases—did Warburg miss inflammation?

(2012) Haitao Wen et al.   NATURE IMMUNOLOGY

Age- and diet-dependent requirement of DJ-1 for glucose homeostasis in mice with implications for human type 2 diabetes

(2012) Deepak Jain et al.   Journal of Molecular Cell Biology

Physiological Antioxidative Network of the Bilirubin System in Aging and Age-Related Diseases

(2012) Sung Young Kim et al.   Frontiers in Pharmacology

Biliverdin Reductase: More than a Namesake – The Reductase, Its Peptide Fragments, and Biliverdin Regulate Activity of the Three Classes of Protein Kinase C

(2012) Peter E. M. Gibbs et al.   Frontiers in Pharmacology

Go Green: The Anti-Inflammatory Effects of Biliverdin Reductase

(2012) Barbara Wegiel et al.   Frontiers in Pharmacology

Direct Antioxidant Properties of Bilirubin and Biliverdin. Is there a Role for Biliverdin Reductase?

(2012) Thomas Jansen et al.   Frontiers in Pharmacology

DJ-1 modulates the expression of Cu/Zn-superoxide dismutase-1 through the Erk1/2-Elk1 pathway in neuroprotection

(2011) Zhiquan Wang et al.   ANNALS OF NEUROLOGY

Alzheimer's Disease: Redox Dysregulation As a Common Denominator for Diverse Pathogenic Mechanisms

(2011) Rommy von Bernhardi et al.   ANTIOXIDANTS & REDOX SIGNALING

Biliverdin reductase-A protein levels and activity in the brains of subjects with Alzheimer disease and mild cognitive impairment

(2011) Eugenio Barone et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Changes in the arginine methylation of organ proteins during the development of diabetes mellitus

(2011) Jong Hoon Lee et al.   DIABETES RESEARCH AND CLINICAL PRACTICE

Promoter variants in IL18 are associated with onset of depression in patients previously exposed to stressful-life events

(2011) Eva Haastrup et al.   JOURNAL OF AFFECTIVE DISORDERS

Fatty acid–induced NLRP3-ASC inflammasome activation interferes with insulin signaling

(2011) Haitao Wen et al.   NATURE IMMUNOLOGY

Gamma-1-Syntrophin Mediates Trafficking of Gamma-Enolase towards the Plasma Membrane and Enhances Its Neurotrophic Activity

(2011) Anja Hafner et al.   NEUROSIGNALS

Correction: Matrix Metalloproteinase-2 and -9 Secreted by Leukemic Cells Increase the Permeability of Blood-Brain Barrier by Disrupting Tight Junction Proteins

(2011) Saran Feng et al.   PLoS One

14-3-3ε marks the amyloid-stimulated microglia long-term activation

(2011) Laura Di Francesco et al.   PROTEOMICS

14-3-3 proteins in neurodegeneration

(2011) Petra Steinacker et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Pathophysiologically Relevant Levels of Hydrogen Peroxide Induce Glutamate-Independent Neurodegeneration That Involves Activation of Transient Receptor Potential Melastatin 7 Channels

(2010) Emily Coombes et al.   ANTIOXIDANTS & REDOX SIGNALING

Peroxiredoxin 6: A Bifunctional Enzyme with Glutathione Peroxidase and Phospholipase A2 Activities

(2010) Aron B. Fisher   ANTIOXIDANTS & REDOX SIGNALING

Degradation of Soluble and Fibrillar Amyloid β-Protein by Matrix Metalloproteinase (MT1-MMP)in Vitro

(2010) Mei-Chen Liao et al.   BIOCHEMISTRY

Involvements of the lipid peroxidation product, HNE, in the pathogenesis and progression of Alzheimer's disease☆

(2010) D. Allan Butterfield et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Metalloproteinase mediated occludin cleavage in the cerebral microcapillary endothelium under pathological conditions

(2010) Mira Lischper et al.   BRAIN RESEARCH

Signaling by ROS drives inflammasome activation

(2010) Fabio Martinon   EUROPEAN JOURNAL OF IMMUNOLOGY

Survival responses to oxidative stress and aging

(2010) Yuri Miura et al.   Geriatrics & Gerontology International

Loss of the Parkinson's disease-linked gene DJ-1 perturbs mitochondrial dynamics

(2010) I. Irrcher et al.   HUMAN MOLECULAR GENETICS

Inflammation in neurodegenerative diseases

(2010) Sandra Amor et al.   IMMUNOLOGY

Conversion of biliverdin to bilirubin by biliverdin reductase contributes to endothelial cell protection by heme oxygenase-1—evidence for direct and indirect antioxidant actions of bilirubin

(2010) Thomas Jansen et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Interleukin 18 in the CNS

(2010) Silvia Alboni et al.   Journal of Neuroinflammation

Metals, oxidative stress and neurodegenerative disorders

(2010) Klaudia Jomova et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

A model of ischemia and reperfusion increases JNK activity, inhibits the association of BAD and 14-3-3, and induces apoptosis of rabbit spinal neurocytes

(2010) Jin Fan et al.   NEUROSCIENCE LETTERS

Oxidative Stress and Autophagy in Cardiac Disease, Neurological Disorders, Aging and Cancer

(2010) Eric E. Essick et al.   Oxidative Medicine and Cellular Longevity

Differential neuroprotective effects of 14-3-3 proteins in models of Parkinson's disease

(2010) T A Yacoubian et al.   Cell Death & Disease

The oxysterol 27-hydroxycholesterol increases β-amyloid and oxidative stress in retinal pigment epithelial cells

(2010) Bhanu Dasari et al.   BMC Ophthalmology

Lipid peroxidation in relation to ageing and the role of endogenous aldehydes in diabetes and other age-related diseases

(2009) L.F. Dmitriev et al.   AGEING RESEARCH REVIEWS

The ADMA/DDAH Pathway Regulates VEGF-Mediated Angiogenesis

(2009) Lorna R Fiedler et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Interleukin-18 regulates motor activity, anxiety and spatial learning without affecting synaptic plasticity

(2009) Takahiro Yaguchi et al.   BEHAVIOURAL BRAIN RESEARCH

Exposure of HL-60 human leukaemic cells to 4-hydroxynonenal promotes the formation of adduct(s) with α-enolase devoid of plasminogen binding activity

(2009) Fabrizio Gentile et al.   BIOCHEMICAL JOURNAL

Accumulation of overoxidized Peroxiredoxin III in aged rat liver mitochondria

(2009) Clara Musicco et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS

Matrix metalloproteinases: What do they not do? New substrates and biological roles identified by murine models and proteomics

(2009) David Rodríguez et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Reduced glutathione is highly expressed in white matter and neurons in the unperturbed mouse brain — Implications for oxidative stress associated with neurodegeneration

(2009) V.M. Miller et al.   BRAIN RESEARCH

Ligand-Activated Peroxisome Proliferator–Activated Receptor-γ Protects Against Ischemic Cerebral Infarction and Neuronal Apoptosis by 14-3-3ε Upregulation

(2009) Jui-Sheng Wu et al.   CIRCULATION

Matrix metalloproteinase proteomics: substrates, targets, and therapy

(2009) Charlotte J Morrison et al.   CURRENT OPINION IN CELL BIOLOGY

Involvement of ROS in BBB dysfunction

(2009) Pamela B. L. Pun et al.   FREE RADICAL RESEARCH

Cathepsin X cleaves the C-terminal dipeptide of alpha- and gamma-enolase and impairs survival and neuritogenesis of neuronal cells

(2009) Nataša Obermajer et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Characterization of the S-denitrosylating activity of bilirubin

(2009) Eugenio Barone et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Increased Brain Microvascular MMP-9 and Incidence of Haemorrhagic Transformation in Obese Mice after Experimental Stroke

(2009) Barry W McColl et al.   JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM

Multifunctional roles of enolase in Alzheimer’s disease brain: beyond altered glucose metabolism

(2009) D. Allan Butterfield et al.   JOURNAL OF NEUROCHEMISTRY

Oxidative stress up-regulates presenilin 1 in lipid rafts in neuronal cells

(2009) Akiko Oda et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Midlife predictors of Alzheimer's disease

(2009) B.B. Bendlin et al.   MATURITAS

Serum levels of interleukin-18 are reduced by diet and n-3 fatty acid intervention in elderly high-risk men

(2009) Marius Trøseid et al.   METABOLISM-CLINICAL AND EXPERIMENTAL

Increased DJ-1 expression under oxidative stress and in Alzheimer's disease brains

(2009) Stéphanie Baulac et al.   Molecular Neurodegeneration

Systemic inflammation and disease progression in Alzheimer disease

(2009) C. Holmes et al.   NEUROLOGY

Role of the PRMT–DDAH–ADMA axis in the regulation of endothelial nitric oxide production

(2009) Arthur J. Pope et al.   PHARMACOLOGICAL RESEARCH

Peroxiredoxin 6 in human brain: molecular forms, cellular distribution and association with Alzheimer’s disease pathology

(2008) John H. T. Power et al.   ACTA NEUROPATHOLOGICA

Proteomic identification of nitrated brain proteins in early Alzheimer’s disease inferior parietal lobule

(2008) Tanea T. Reed et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Interleukin-18 increases expression of kinases involved in tau phosphorylation in SH-SY5Y neuroblastoma cells

(2008) Johanna O. Ojala et al.   JOURNAL OF NEUROIMMUNOLOGY

Proteomics-Determined Differences in the Concanavalin-A-Fractionated Proteome of Hippocampus and Inferior Parietal Lobule in Subjects with Alzheimer’s Disease and Mild Cognitive Impairment: Implications for Progression of AD

(2008) Joshua B. Owen et al.   JOURNAL OF PROTEOME RESEARCH

Leucine-Rich Repeat Kinase 2 Colocalizes with α-Synuclein in Parkinson’s Disease, but Not Tau-Containing Deposits in Tauopathies

(2008) George Perry et al.   Neurodegenerative Diseases

Lipid rafts, cholesterol, and the brain

(2008) Zeljka Korade et al.   NEUROPHARMACOLOGY

Interleukin-18 and stress

(2007) Shuei Sugama et al.   BRAIN RESEARCH REVIEWS

Expression of interleukin-18 is increased in the brains of Alzheimer's disease patients

(2007) Johanna Ojala et al.   NEUROBIOLOGY OF AGING

Overexpression of Dimethylarginine Dimethylaminohydrolase Inhibits Asymmetric Dimethylarginine–Induced Endothelial Dysfunction in the Cerebral Circulation

(2007) Hayan Dayoub et al.   STROKE