ALS-Associated TDP-43 Induces Endoplasmic Reticulum Stress, Which Drives Cytoplasmic TDP-43 Accumulation and Stress Granule Formation
Published 2013 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
ALS-Associated TDP-43 Induces Endoplasmic Reticulum Stress, Which Drives Cytoplasmic TDP-43 Accumulation and Stress Granule Formation
Authors
Keywords
Cytoplasmic inclusions, Endoplasmic reticulum, Co-immunoprecipitation, Fluorescence imaging, Spinal cord, Golgi apparatus, Immunoblotting, Cytoplasm
Journal
PLoS One
Volume 8, Issue 11, Pages e81170
Publisher
Public Library of Science (PLoS)
Online
2013-11-30
DOI
10.1371/journal.pone.0081170
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Association studies indicate that protein disulfide isomerase is a risk factor in amyotrophic lateral sclerosis
- (2013) Chun Tak Kwok et al. FREE RADICAL BIOLOGY AND MEDICINE
- Pharmacological reduction of ER stress protects against TDP-43 neuronal toxicity in vivo
- (2013) Alexandra Vaccaro et al. NEUROBIOLOGY OF DISEASE
- Reticulon1-C modulates protein disulphide isomerase function
- (2013) P Bernardoni et al. Cell Death & Disease
- TDP-43 aggregation in neurodegeneration: Are stress granules the key?
- (2012) Colleen M. Dewey et al. BRAIN RESEARCH
- Ataxin-2 interacts with FUS and intermediate-length polyglutamine expansions enhance FUS-related pathology in amyotrophic lateral sclerosis
- (2012) Manal A. Farg et al. HUMAN MOLECULAR GENETICS
- XBP1 depletion precedes ubiquitin aggregation and Golgi fragmentation in TDP-43 transgenic rats
- (2012) Jianbin Tong et al. JOURNAL OF NEUROCHEMISTRY
- Mutant FUS induces endoplasmic reticulum stress in amyotrophic lateral sclerosis and interacts with protein disulfide-isomerase
- (2012) Manal A. Farg et al. NEUROBIOLOGY OF AGING
- Endogenous TDP-43 localized to stress granules can subsequently form protein aggregates
- (2012) Sarah J. Parker et al. NEUROCHEMISTRY INTERNATIONAL
- Bim Links ER Stress and Apoptosis in Cells Expressing Mutant SOD1 Associated with Amyotrophic Lateral Sclerosis
- (2012) Kai Y. Soo et al. PLoS One
- Cell stress induces TDP-43 pathological changes associated with ERK1/2 dysfunction: implications in ALS
- (2011) Victòria Ayala et al. ACTA NEUROPATHOLOGICA
- Protein disulfide isomerase-immunopositive inclusions in patients with amyotrophic lateral sclerosis
- (2011) Yasuyuki Honjo et al. Amyotrophic Lateral Sclerosis
- Redox signalling directly regulates TDP-43 via cysteine oxidation and disulphide cross-linking
- (2011) Todd J Cohen et al. EMBO JOURNAL
- TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1
- (2011) Karli K. McDonald et al. HUMAN MOLECULAR GENETICS
- Mutant HFE H63D Protein Is Associated with Prolonged Endoplasmic Reticulum Stress and Increased Neuronal Vulnerability
- (2011) Yiting Liu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TDP-43-induced Death Is Associated with Altered Regulation of BIM and Bcl-xL and Attenuated by Caspase-mediated TDP-43 Cleavage
- (2011) Hiroaki Suzuki et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- TDP-43 toxicity is mediated by the unfolded protein response-unrelated induction of C/EBP homologous protein expression
- (2011) Hiroaki Suzuki et al. JOURNAL OF NEUROSCIENCE RESEARCH
- C-Jun N-terminal kinase controls TDP-43 accumulation in stress granules induced by oxidative stress
- (2011) Jodi Meyerowitz et al. Molecular Neurodegeneration
- The unfolded protein response in familial amyotrophic lateral sclerosis
- (2010) L. Wang et al. HUMAN MOLECULAR GENETICS
- TDP-43 M337V Mutation in Familial Amyotrophic Lateral Sclerosis in Japan
- (2010) Akira Tamaoka et al. INTERNAL MEDICINE
- TDP-43 Is Directed to Stress Granules by Sorbitol, a Novel Physiological Osmotic and Oxidative Stressor
- (2010) C. M. Dewey et al. MOLECULAR AND CELLULAR BIOLOGY
- OGFOD1, a Novel Modulator of Eukaryotic Translation Initiation Factor 2 Phosphorylation and the Cellular Response to Stress
- (2010) K. A. Wehner et al. MOLECULAR AND CELLULAR BIOLOGY
- Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue
- (2010) Liqun Liu-Yesucevitz et al. PLoS One
- Activation of the Endoplasmic Reticulum Stress-Associated Transcription Factor X Box-Binding Protein-1 Occurs in a Subset of Normal Germinal-Center B Cells and in Aggressive B-Cell Lymphomas with Prognostic Implications
- (2009) Olga Balague et al. AMERICAN JOURNAL OF PATHOLOGY
- Protein disulphide isomerase protects against protein aggregation and is S-nitrosylated in amyotrophic lateral sclerosis
- (2009) Adam K. Walker et al. BRAIN
- Knockdown of transactive response DNA-binding protein (TDP-43) downregulates histone deacetylase 6
- (2009) Fabienne C Fiesel et al. EMBO JOURNAL
- XBP-1 deficiency in the nervous system protects against amyotrophic lateral sclerosis by increasing autophagy
- (2009) C. Hetz et al. GENES & DEVELOPMENT
- High frequency ofTARDBPgene mutations in Italian patients with amyotrophic lateral sclerosis
- (2009) Lucia Corrado et al. HUMAN MUTATION
- VCPMutations Causing Frontotemporal Lobar Degeneration Disrupt Localization of TDP-43 and Induce Cell Death
- (2009) Michael A. Gitcho et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Protein disulphide isomerase family members show distinct substrate specificity: P5 is targeted to BiP client proteins
- (2009) C. E. Jessop et al. JOURNAL OF CELL SCIENCE
- Reticulon-4A (Nogo-A) Redistributes Protein Disulfide Isomerase to Protect Mice from SOD1-Dependent Amyotrophic Lateral Sclerosis
- (2009) Y. S. Yang et al. JOURNAL OF NEUROSCIENCE
- A role for motoneuron subtype–selective ER stress in disease manifestations of FALS mice
- (2009) Smita Saxena et al. NATURE NEUROSCIENCE
- TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
- (2009) I. Wegorzewska et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Aberrant cleavage of TDP-43 enhances aggregation and cellular toxicity
- (2009) Y.-J. Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TDP-43A315T mutation in familial motor neuron disease
- (2008) Michael A. Gitcho et al. ANNALS OF NEUROLOGY
- The Amyotrophic Lateral Sclerosis 8 Protein VAPB Is Cleaved, Secreted, and Acts as a Ligand for Eph Receptors
- (2008) Hiroshi Tsuda et al. CELL
- Phosphorylated and ubiquitinated TDP-43 pathological inclusions in ALS and FTLD-U are recapitulated in SH-SY5Y cells
- (2008) Takashi Nonaka et al. FEBS LETTERS
- Disturbance of Nuclear and Cytoplasmic TAR DNA-binding Protein (TDP-43) Induces Disease-like Redistribution, Sequestration, and Aggregate Formation
- (2008) Matthew J. Winton et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Structural determinants of the cellular localization and shuttling of TDP-43
- (2008) Y. M. Ayala et al. JOURNAL OF CELL SCIENCE
- ALS-linked P56S-VAPB, an aggregated loss-of-function mutant of VAPB, predisposes motor neurons to ER stress-related death by inducing aggregation of co-expressed wild-type VAPB
- (2008) Hiroaki Suzuki et al. JOURNAL OF NEUROCHEMISTRY
- Formation of stress granules inhibits apoptosis by suppressing stress-responsive MAPK pathways
- (2008) Kyoko Arimoto et al. NATURE CELL BIOLOGY
- TARDBP mutations in individuals with sporadic and familial amyotrophic lateral sclerosis
- (2008) Edor Kabashi et al. NATURE GENETICS
- Endoplasmic reticulum stress and induction of the unfolded protein response in human sporadic amyotrophic lateral sclerosis
- (2008) Julie D. Atkin et al. NEUROBIOLOGY OF DISEASE
- TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
- (2008) J. Sreedharan et al. SCIENCE
- Novel Mutations in TARDBP (TDP-43) in Patients with Familial Amyotrophic Lateral Sclerosis
- (2008) Nicola J. Rutherford et al. PLoS Genetics
- Superoxide dismutase 1 mutants related to amyotrophic lateral sclerosis induce endoplasmic stress in neuro2a cells
- (2007) Yeo Kyoung Oh et al. JOURNAL OF NEUROCHEMISTRY
Find Funding. Review Successful Grants.
Explore over 25,000 new funding opportunities and over 6,000,000 successful grants.
ExploreAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now