2-Pentadecyl-2-Oxazoline Reduces Neuroinflammatory Environment in the MPTP Model of Parkinson Disease

N-Palmitoylethanolamine-Oxazoline as a New Therapeutic Strategy to Control Neuroinflammation: Neuroprotective Effects in Experimental Models of Spinal Cord and Brain Injury

(2017) Daniela Impellizzeri et al.   JOURNAL OF NEUROTRAUMA

Neuroprotective Effects of Temsirolimus in Animal Models of Parkinson’s Disease

(2017) Rosalba Siracusa et al.   MOLECULAR NEUROBIOLOGY

2-Pentadecyl-2-Oxazoline, the Oxazoline of Pea, Modulates Carrageenan-Induced Acute Inflammation

(2017) Stefania Petrosino et al.   Frontiers in Pharmacology

Nrf2: a modulator of Parkinson’s disease?

(2016) Michael Todorovic et al.   JOURNAL OF NEURAL TRANSMISSION

KU0063794, a Dual mTORC1 and mTORC2 Inhibitor, Reduces Neural Tissue Damage and Locomotor Impairment After Spinal Cord Injury in Mice

(2016) Marika Cordaro et al.   MOLECULAR NEUROBIOLOGY

2-pentadecyl-2-oxazoline: Identification in coffee, synthesis and activity in a rat model of carrageenan-induced hindpaw inflammation

(2016) Daniela Impellizzeri et al.   PHARMACOLOGICAL RESEARCH

Palmitoylethanolamide protects mice against 6-OHDA-induced neurotoxicity and endoplasmic reticulum stress: In vivo and in vitro evidence

(2016) Carmen Avagliano et al.   PHARMACOLOGICAL RESEARCH

Nrf2 mitigates LRRK2- and α-synuclein–induced neurodegeneration by modulating proteostasis

(2016) Gaia Skibinski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Potent Systemically Active N-Acylethanolamine Acid Amidase Inhibitor that Suppresses Inflammation and Human Macrophage Activation

(2015) Alison Ribeiro et al.   ACS Chemical Biology

The Association of Palmitoylethanolamide with Luteolin Decreases Neuroinflammation and Stimulates Autophagy in Parkinson’s Disease Model

(2015) Rosalba Siracusa et al.   CNS & Neurological Disorders-Drug Targets

Immunohistochemical Analysis of Paraoxonases and Chemokines in Arteries of Patients with Peripheral Artery Disease

(2015) Anna Hernández-Aguilera et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Promising cannabinoid-based therapies for Parkinson’s disease: motor symptoms to neuroprotection

(2015) Sandeep Vasant More et al.   Molecular Neurodegeneration

Pharmacological blockade of the fatty acid amide hydrolase (FAAH) alters neural proliferation, apoptosis and gliosis in the rat hippocampus, hypothalamus and striatum in a negative energy context

(2015) Patricia Rivera et al.   Frontiers in Cellular Neuroscience

Potential analgesic effects of a novel N-acylethanolamine acid amidase inhibitor F96 through PPAR-α

(2015) Longhe Yang et al.   Scientific Reports

Poly (ADP-ribose) in the pathogenesis of Parkinson's disease

(2014) Yunjong Lee et al.   BMB Reports

Fatty acid amide hydrolase but not monoacyl glycerol lipase controls cell death induced by the endocannabinoid 2-arachidonoyl glycerol in hepatic cell populations

(2013) Sören V. Siegmund et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Inhibition of fatty acid amide hydrolase activates Nrf2 signalling and induces heme oxygenase 1 transcription in breast cancer cells

(2013) H Li et al.   BRITISH JOURNAL OF PHARMACOLOGY

Mast cells, glia and neuroinflammation: partners in crime?

(2013) Stephen D. Skaper et al.   IMMUNOLOGY

Inhibition of endocannabinoid-degrading enzyme fatty acid amide hydrolase increases atherosclerotic plaque vulnerability in mice

(2013) Friedrich Felix Hoyer et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Proteostasis of polyglutamine varies among neurons and predicts neurodegeneration

(2013) Andrey S Tsvetkov et al.   Nature Chemical Biology

Interleukin-1β and tumor necrosis factor-α: reliable targets for protective therapies in Parkinson’s Disease?

(2013) María C. Leal et al.   Frontiers in Cellular Neuroscience

 -Synuclein in Parkinson's Disease

(2013) L. Stefanis   Cold Spring Harbor Perspectives in Medicine

Lipophilic amines as potent inhibitors of N-acylethanolamine-hydrolyzing acid amidase

(2012) Yumiko Yamano et al.   BIOORGANIC & MEDICINAL CHEMISTRY

β−Amyloid exacerbates inflammation in astrocytes lacking fatty acid amide hydrolase through a mechanism involving PPAR-α, PPAR-γ and TRPV1, but not CB1 or CB2 receptors

(2012) Cristina Benito et al.   BRITISH JOURNAL OF PHARMACOLOGY

The Endocannabinoid System and Pain

(2012) Josee Guindon et al.   CNS & Neurological Disorders-Drug Targets

Microglia and mast cells: two tracks on the road to neuroinflammation

(2012) Stephen D. Skaper et al.   FASEB JOURNAL

α-Synuclein expression and Nrf2 deficiency cooperate to aggravate protein aggregation, neuronal death and inflammation in early-stage Parkinson's disease

(2012) Isabel Lastres-Becker et al.   HUMAN MOLECULAR GENETICS

Mast cell-glia axis in neuroinflammation and therapeutic potential of the anandamide congener palmitoylethanolamide

(2012) S. D. Skaper et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Apoptosis Signal-Regulating Kinase 1 Mediates MPTP Toxicity and Regulates Glial Activation

(2012) Kang-Woo Lee et al.   PLoS One

Neuroprotective Activities of Palmitoylethanolamide in an Animal Model of Parkinson's Disease

(2012) Emanuela Esposito et al.   PLoS One

Dopamine Transporter Loss in 6-OHDA Parkinson’s Model Is Unmet by Parallel Reduction in Dopamine Uptake

(2012) Tanya Chotibut et al.   PLoS One

Genetic activation of Nrf2 signaling is sufficient to ameliorate neurodegenerative phenotypes in a Drosophila model of Parkinson's disease

(2011) M. C. Barone et al.   Disease Models & Mechanisms

Reduced calcium/calmodulin-dependent protein kinase II activity in the hippocampus is associated with impaired cognitive function in MPTP-treated mice

(2011) Shigeki Moriguchi et al.   JOURNAL OF NEUROCHEMISTRY

Effects of Hypericum Perforatum, in a rodent model of periodontitis

(2010) Irene Paterniti et al.   BMC Complementary and Alternative Medicine

Cyclooxygenase and Neuroinflammation in Parkinsons Disease Neurodegeneration

(2010) Anna Bartels et al.   Current Neuropharmacology

Tissue distribution and expression of paraoxonases and chemokines in mouse: the ubiquitous and joint localisation suggest a systemic and coordinated role

(2010) Fernando Rodríguez-Sanabria et al.   JOURNAL OF MOLECULAR HISTOLOGY

Role of Nrf2 in Suppressing LPS-Induced Inflammation in Mouse Peritoneal Macrophages by Polyunsaturated Fatty Acids Docosahexaenoic Acid and Eicosapentaenoic Acid

(2010) Hu Wang et al.   MOLECULAR PHARMACEUTICS

Microglial activation and chronic neurodegeneration

(2010) Melinda E. Lull et al.   Neurotherapeutics

N-acylethanolamine metabolism with special reference to N-acylethanolamine-hydrolyzing acid amidase (NAAA)

(2010) Natsuo Ueda et al.   PROGRESS IN LIPID RESEARCH

Hypochlorous acid-induced heme oxygenase-1 gene expression promotes human endothelial cell survival

(2009) Yong Wei et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

The Triterpenoid CDDO-Imidazolide Confers Potent Protection against Hyperoxic Acute Lung Injury in Mice

(2009) Narsa M. Reddy et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Microglial Physiology: Unique Stimuli, Specialized Responses

(2009) Richard M. Ransohoff et al.   Annual Review of Immunology

Parkinson's Disease: From Molecular Pathways in Disease to Therapeutic Approaches

(2009) Bobby Thomas   ANTIOXIDANTS & REDOX SIGNALING

Melatonin downregulates nuclear erythroid 2-related factor 2 and nuclear factor-kappaB during prevention of oxidative liver injury in a dimethylnitrosamine model

(2009) Kyung Hee Jung et al.   JOURNAL OF PINEAL RESEARCH

Behavioral Disinhibition and Reduced Anxiety-like Behaviors in Monoamine Oxidase B-Deficient Mice

(2009) Marco Bortolato et al.   NEUROPSYCHOPHARMACOLOGY

Selective N-acylethanolamine-hydrolyzing acid amidase inhibition reveals a key role for endogenous palmitoylethanolamide in inflammation

(2009) C. Solorzano et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targets for neuroprotection in Parkinson's disease

(2008) Talene A. Yacoubian et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE