Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

A Proposed Atomic Structure of the Self-Assembly of the Non-Amyloid-β Component of Human α-Synuclein As Derived by Computational Tools

(2015) Yoav Atsmon-Raz et al.   JOURNAL OF PHYSICAL CHEMISTRY B

Studies of lipopolysaccharide effects on the induction of α-synuclein pathology by exogenous fibrils in transgenic mice

(2015) Nicola J. Rutherford et al.   Molecular Neurodegeneration

α-Synuclein strains cause distinct synucleinopathies after local and systemic administration

(2015) W. Peelaerts et al.   NATURE

Structure of the toxic core of α-synuclein from invisible crystals

(2015) Jose A. Rodriguez et al.   NATURE

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Atomic-Resolution Three-Dimensional Structure of Amyloid β Fibrils Bearing the Osaka Mutation

(2014) Anne K. Schütz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Fiber Diffraction of the Prion-Forming Domain HET-s(218–289) Shows Dehydration-Induced Deformation of a Complex Amyloid Structure

(2014) William Wan et al.   BIOCHEMISTRY

Unlike Twins: An NMR Comparison of Two α-Synuclein Polymorphs Featuring Different Toxicity

(2014) Julia Gath et al.   PLoS One

Fungal prion HET-s as a model for structural complexity and self-propagation in prions

(2014) W. Wan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome

(2013) Suzanne Lesage et al.   ANNALS OF NEUROLOGY

Protein Structure Determination by Magic-Angle Spinning Solid-State NMR, and Insights into the Formation, Structure, and Stability of Amyloid Fibrils

(2013) Gemma Comellas et al.   Annual Review of Biophysics

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

(2013) Jun-Xia Lu et al.   CELL

Distinct α-Synuclein Strains Differentially Promote Tau Inclusions in Neurons

(2013) Jing L. Guo et al.   CELL

Protein backbone and sidechain torsion angles predicted from NMR chemical shifts using artificial neural networks

(2013) Yang Shen et al.   JOURNAL OF BIOMOLECULAR NMR

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease

(2013) Silke Appel-Cresswell et al.   MOVEMENT DISORDERS

Site-Specific Perturbations of Alpha-Synuclein Fibril Structure by the Parkinson's Disease Associated Mutations A53T and E46K

(2013) Luisel R. Lemkau et al.   PLoS One

Binding of the Radioligand SIL23 to α-Synuclein Fibrils in Parkinson Disease Brain Tissue Establishes Feasibility and Screening Approaches for Developing a Parkinson Disease Imaging Agent

(2013) Devika P. Bagchi et al.   PLoS One

Structural and functional characterization of two alpha-synuclein strains

(2013) Luc Bousset et al.   Nature Communications

Mutant Protein A30P α-Synuclein Adopts Wild-type Fibril Structure, Despite Slower Fibrillation Kinetics

(2012) Luisel R. Lemkau et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Structural Comparison of Mouse and Human α-Synuclein Amyloid Fibrils by Solid-State NMR

(2012) Guohua Lv et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural Intermediates during α-Synuclein Fibrillogenesis on Phospholipid Vesicles

(2012) Gemma Comellas et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Smooth statistical torsion angle potential derived from a large conformational database via adaptive kernel density estimation improves the quality of NMR protein structures

(2012) Guillermo A. Bermejo et al.   PROTEIN SCIENCE

Pathological  -Synuclein Transmission Initiates Parkinson-like Neurodegeneration in Nontransgenic Mice

(2012) K. C. Luk et al.   SCIENCE

Solid-state NMR sequential assignments of α-synuclein

(2011) Julia Gath et al.   Biomolecular NMR Assignments

α-Synuclein Populates Both Elongated and Broken Helix States on Small Unilamellar Vesicles

(2011) Sowmya Bekshe Lokappa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Straightforward, effective calibration of SPINAL-64 decoupling results in the enhancement of sensitivity and resolution of biomolecular solid-state NMR

(2011) Gemma Comellas et al.   JOURNAL OF MAGNETIC RESONANCE

Structured Regions of α-Synuclein Fibrils Include the Early-Onset Parkinson's Disease Mutation Sites

(2011) Gemma Comellas et al.   JOURNAL OF MOLECULAR BIOLOGY

Exogenous α-Synuclein Fibrils Induce Lewy Body Pathology Leading to Synaptic Dysfunction and Neuron Death

(2011) Laura A. Volpicelli-Daley et al.   NEURON

MolProbity: all-atom structure validation for macromolecular crystallography

(2009) Vincent B. Chen et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Atomic resolution protein structure determination by three-dimensional transferred echo double resonance solid-state nuclear magnetic resonance spectroscopy

(2009) Andrew J. Nieuwkoop et al.   JOURNAL OF CHEMICAL PHYSICS

Inclusion formation and neuronal cell death through neuron-to-neuron transmission of  -synuclein

(2009) P. Desplats et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Exogenous  -synuclein fibrils seed the formation of Lewy body-like intracellular inclusions in cultured cells

(2009) K. C. Luk et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Enclosed chambers for humidity control and sample containment in fiber diffraction

(2008) Michele McDonald et al.   JOURNAL OF APPLIED CRYSTALLOGRAPHY

Dipole tensor-based atomic-resolution structure determination of a nanocrystalline protein by solid-state NMR

(2008) W. T. Franks et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The fold of  -synuclein fibrils

(2008) M. Vilar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Amyloid Fibrils of the HET-s(218-289) Prion Form a   Solenoid with a Triangular Hydrophobic Core

(2008) C. Wasmer et al.   SCIENCE