Opposing roles of p38 and JNK in a Drosophila model of TDP-43 proteinopathy reveal oxidative stress and innate immunity as pathogenic components of neurodegeneration
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Title
Opposing roles of p38 and JNK in a Drosophila model of TDP-43 proteinopathy reveal oxidative stress and innate immunity as pathogenic components of neurodegeneration
Authors
Keywords
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Journal
HUMAN MOLECULAR GENETICS
Volume 24, Issue 3, Pages 757-772
Publisher
Oxford University Press (OUP)
Online
2014-10-04
DOI
10.1093/hmg/ddu493
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Note: Only part of the references are listed.- C9orf72 nucleotide repeat structures initiate molecular cascades of disease
- (2014) Aaron R. Haeusler et al. NATURE
- Microglia Induce Motor Neuron Death via the Classical NF-κB Pathway in Amyotrophic Lateral Sclerosis
- (2014) Ashley E. Frakes et al. NEURON
- C9orf72 repeat expansions cause neurodegeneration in Drosophila through arginine-rich proteins
- (2014) S. Mizielinska et al. SCIENCE
- The DLK signalling pathway—a double-edged sword in neural development and regeneration
- (2013) Andrea Tedeschi et al. EMBO REPORTS
- The Innate Immune Response Transcription Factor Relish Is Necessary for Neurodegeneration in aDrosophilaModel of Ataxia-Telangiectasia
- (2013) Andrew J. Petersen et al. GENETICS
- Loss and gain of Drosophila TDP-43 impair synaptic efficacy and motor control leading to age-related neurodegeneration by loss-of-function phenotypes
- (2013) Danielle C. Diaper et al. HUMAN MOLECULAR GENETICS
- RNA binding mediates neurotoxicity in the transgenic Drosophila model of TDP-43 proteinopathy
- (2013) Ryoko Ihara et al. HUMAN MOLECULAR GENETICS
- The ALS disease-associated mutant TDP-43 impairs mitochondrial dynamics and function in motor neurons
- (2013) Wenzhang Wang et al. HUMAN MOLECULAR GENETICS
- JNK-mediated phosphorylation of DLK suppresses its ubiquitination to promote neuronal apoptosis
- (2013) Sarah Huntwork-Rodriguez et al. JOURNAL OF CELL BIOLOGY
- Stress granules as crucibles of ALS pathogenesis
- (2013) Yun R. Li et al. JOURNAL OF CELL BIOLOGY
- Dual leucine zipper kinase is required for excitotoxicity-induced neuronal degeneration
- (2013) Christine D. Pozniak et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Independent Pathways Downstream of the Wnd/DLK MAPKKK Regulate Synaptic Structure, Axonal Transport, and Injury Signaling
- (2013) S. Klinedinst et al. JOURNAL OF NEUROSCIENCE
- Sustained, neuron-specific IKK/NF-κB activation generates a selective neuroinflammatory response promoting local neurodegeneration with aging
- (2013) Ayesha Maqbool et al. Molecular Neurodegeneration
- Unconventional Translation of C9ORF72 GGGGCC Expansion Generates Insoluble Polypeptides Specific to c9FTD/ALS
- (2013) Peter E.A. Ash et al. NEURON
- RNA Toxicity from the ALS/FTD C9ORF72 Expansion Is Mitigated by Antisense Intervention
- (2013) Christopher J. Donnelly et al. NEURON
- Identification of Genetic Modifiers of TDP-43 Neurotoxicity in Drosophila
- (2013) Lihong Zhan et al. PLoS One
- Inhibition of Fast Axonal Transport by Pathogenic SOD1 Involves Activation of p38 MAP Kinase
- (2013) Gerardo A. Morfini et al. PLoS One
- Dnr1 mutations cause neurodegeneration in Drosophila by activating the innate immune response in the brain
- (2013) Y. Cao et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- ALS-linked TDP-43 mutations produce aberrant RNA splicing and adult-onset motor neuron disease without aggregation or loss of nuclear TDP-43
- (2013) E. S. Arnold et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The C9orf72 GGGGCC Repeat Is Translated into Aggregating Dipeptide-Repeat Proteins in FTLD/ALS
- (2013) K. Mori et al. SCIENCE
- TDP-43 Loss-of-Function Causes Neuronal Loss Due to Defective Steroid Receptor-Mediated Gene Program Switching in Drosophila
- (2013) Lies Vanden Broeck et al. Cell Reports
- Hexanucleotide Repeats in ALS/FTD Form Length-Dependent RNA Foci, Sequester RNA Binding Proteins, and Are Neurotoxic
- (2013) Youn-Bok Lee et al. Cell Reports
- High-content RNAi screening identifies the Type 1 inositol triphosphate receptor as a modifier of TDP-43 localization and neurotoxicity
- (2012) Sang Hwa Kim et al. HUMAN MOLECULAR GENETICS
- A Conditioning Lesion Protects Axons from Degeneration via the Wallenda/DLK MAP Kinase Signaling Cascade
- (2012) X. Xiong et al. JOURNAL OF NEUROSCIENCE
- High-Resolution Protein Interaction Map of the Drosophila melanogaster p38 Mitogen-Activated Protein Kinases Reveals Limited Functional Redundancy
- (2012) V. E. Belozerov et al. MOLECULAR AND CELLULAR BIOLOGY
- ATM kinase inhibition in glial cells activates the innate immune response and causes neurodegeneration in Drosophila
- (2012) A. J. Petersen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TDP-43 promotes microRNA biogenesis as a component of the Drosha and Dicer complexes
- (2012) Y. Kawahara et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- The generation of chromosomal deletions to provide extensive coverage and subdivision of the Drosophila melanogaster genome
- (2012) R Kimberley Cook et al. GENOME BIOLOGY
- A Muscle-Specific p38 MAPK/Mef2/MnSOD Pathway Regulates Stress, Motor Function, and Life Span in Drosophila
- (2011) Alysia Vrailas-Mortimer et al. DEVELOPMENTAL CELL
- A Drosophila model of FUS-related neurodegeneration reveals genetic interaction between FUS and TDP-43
- (2011) N. A. Lanson et al. HUMAN MOLECULAR GENETICS
- TAR DNA-binding protein 43 (TDP-43) regulates stress granule dynamics via differential regulation of G3BP and TIA-1
- (2011) Karli K. McDonald et al. HUMAN MOLECULAR GENETICS
- TDP-43 Is a Transcriptional Repressor
- (2011) Avin S. Lalmansingh et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- DLK induces developmental neuronal degeneration via selective regulation of proapoptotic JNK activity
- (2011) Arundhati Sengupta Ghosh et al. JOURNAL OF CELL BIOLOGY
- Deregulation of TDP-43 in amyotrophic lateral sclerosis triggers nuclear factor κB–mediated pathogenic pathways
- (2011) Vivek Swarup et al. JOURNAL OF EXPERIMENTAL MEDICINE
- Evaluation of potential reference genes for reverse transcription-qPCR studies of physiological responses in Drosophila melanogaster
- (2011) Fleur Ponton et al. JOURNAL OF INSECT PHYSIOLOGY
- Expression of mutant TDP-43 induces neuronal dysfunction in transgenic mice
- (2011) Ya-Fei Xu et al. Molecular Neurodegeneration
- Long pre-mRNA depletion and RNA missplicing contribute to neuronal vulnerability from loss of TDP-43
- (2011) Magdalini Polymenidou et al. NATURE NEUROSCIENCE
- Characterizing the RNA targets and position-dependent splicing regulation by TDP-43
- (2011) James R Tollervey et al. NATURE NEUROSCIENCE
- An ALS-associated mutation affecting TDP-43 enhances protein aggregation, fibril formation and neurotoxicity
- (2011) Weirui Guo et al. NATURE STRUCTURAL & MOLECULAR BIOLOGY
- Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS
- (2011) Mariely DeJesus-Hernandez et al. NEURON
- A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD
- (2011) Alan E. Renton et al. NEURON
- TDP-43 Regulates Drosophila Neuromuscular Junctions Growth by Modulating Futsch/MAP1B Levels and Synaptic Microtubules Organization
- (2011) Vinay K. Godena et al. PLoS One
- Neuronal Function and Dysfunction of Drosophila dTDP
- (2011) Meng-Jau Lin et al. PLoS One
- Pathological roles of MAPK signaling pathways in human diseases
- (2010) Eun Kyung Kim et al. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE
- TDP-43 regulates its mRNA levels through a negative feedback loop
- (2010) Youhna M Ayala et al. EMBO JOURNAL
- Neurotoxic effects of TDP-43 overexpression in C. elegans
- (2010) Peter E.A. Ash et al. HUMAN MOLECULAR GENETICS
- Ubiquilin Modifies TDP-43 Toxicity in a Drosophila Model of Amyotrophic Lateral Sclerosis (ALS)
- (2010) Keith A. Hanson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Protein turnover of the Wallenda/DLK kinase regulates a retrograde response to axonal injury
- (2010) Xin Xiong et al. JOURNAL OF CELL BIOLOGY
- Ataxin-2 intermediate-length polyglutamine expansions are associated with increased risk for ALS
- (2010) Andrew C. Elden et al. NATURE
- From transcriptome analysis to therapeutic anti-CD40L treatment in the SOD1 model of amyotrophic lateral sclerosis
- (2010) John M Lincecum et al. NATURE GENETICS
- Both cytoplasmic and nuclear accumulations of the protein are neurotoxic in Drosophila models of TDP-43 proteinopathies
- (2010) Laetitia Miguel et al. NEUROBIOLOGY OF DISEASE
- TDP-43-Mediated Neuron Loss In Vivo Requires RNA-Binding Activity
- (2010) Aaron Voigt et al. PLoS One
- Tar DNA Binding Protein-43 (TDP-43) Associates with Stress Granules: Analysis of Cultured Cells and Pathological Brain Tissue
- (2010) Liqun Liu-Yesucevitz et al. PLoS One
- ALS-associated mutations in TDP-43 increase its stability and promote TDP-43 complexes with FUS/TLS
- (2010) S.-C. Ling et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- A Drosophila model for TDP-43 proteinopathy
- (2010) Y. Li et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mutant superoxide dismutase 1-induced IL-1 accelerates ALS pathogenesis
- (2010) F. Meissner et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Participation of the p38 pathway in Drosophila host defense against pathogenic bacteria and fungi
- (2010) J. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- TARDBP 3′-UTR variant in autopsy-confirmed frontotemporal lobar degeneration with TDP-43 proteinopathy
- (2009) Michael A. Gitcho et al. ACTA NEUROPATHOLOGICA
- Gain and loss of function of ALS-related mutations of TARDBP (TDP-43) cause motor deficits in vivo
- (2009) Edor Kabashi et al. HUMAN MOLECULAR GENETICS
- Toll-dependent antimicrobial responses in Drosophila larval fat body require Spätzle secreted by haemocytes
- (2009) Alice K. H. Shia et al. JOURNAL OF CELL SCIENCE
- A Role for p38 Stress-Activated Protein Kinase in Regulation of Cell Growth via TORC1
- (2009) M. Cully et al. MOLECULAR AND CELLULAR BIOLOGY
- A dual leucine kinase–dependent axon self-destruction program promotes Wallerian degeneration
- (2009) Bradley R Miller et al. NATURE NEUROSCIENCE
- Immune Activation in Brain Aging and Neurodegeneration: Too Much or Too Little?
- (2009) Kurt M. Lucin et al. NEURON
- TDP-43 mutant transgenic mice develop features of ALS and frontotemporal lobar degeneration
- (2009) I. Wegorzewska et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Mutations in FUS, an RNA Processing Protein, Cause Familial Amyotrophic Lateral Sclerosis Type 6
- (2009) C. Vance et al. SCIENCE
- Mutations in the FUS/TLS Gene on Chromosome 16 Cause Familial Amyotrophic Lateral Sclerosis
- (2009) T. J. Kwiatkowski et al. SCIENCE
- Keap1/Nrf2 Signaling Regulates Oxidative Stress Tolerance and Lifespan in Drosophila
- (2008) Gerasimos P. Sykiotis et al. DEVELOPMENTAL CELL
- TARDBP mutations in amyotrophic lateral sclerosis with TDP-43 neuropathology: a genetic and histopathological analysis
- (2008) Vivianna M Van Deerlin et al. LANCET NEUROLOGY
- TDP-43 Mutations in Familial and Sporadic Amyotrophic Lateral Sclerosis
- (2008) J. Sreedharan et al. SCIENCE
- Novel Mutations in TARDBP (TDP-43) in Patients with Familial Amyotrophic Lateral Sclerosis
- (2008) Nicola J. Rutherford et al. PLoS Genetics
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