Hedgehog signaling pathway inhibitors: an updated patent review (2015–present)
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Title
Hedgehog signaling pathway inhibitors: an updated patent review (2015–present)
Authors
Keywords
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Journal
EXPERT OPINION ON THERAPEUTIC PATENTS
Volume -, Issue -, Pages 1-16
Publisher
Informa UK Limited
Online
2020-02-19
DOI
10.1080/13543776.2020.1730327
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Note: Only part of the references are listed.- Natural products inspired modulators of cancer stem cells-specific signaling pathways Notch and Hedgehog
- (2019) Rocco Palermo et al. CURRENT PHARMACEUTICAL DESIGN
- Structure-Activity Relationships for Itraconazole-Based Triazolone Analogues as Hedgehog Pathway Inhibitors
- (2019) Jennifer Pace et al. JOURNAL OF MEDICINAL CHEMISTRY
- Next-Generation Hedgehog/GLI Pathway Inhibitors for Cancer Therapy
- (2019) Elisabeth Peer et al. Cancers
- ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP
- (2019) Francesca Bufalieri et al. Nature Communications
- Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened
- (2019) Silvia Pietrobono et al. Frontiers in Genetics
- 1H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma
- (2019) Giuseppina D’Alessandro et al. Cell Communication and Signaling
- Truncated Itraconazole Analogues Exhibiting Potent Anti-Hedgehog Activity and Improved Drug-like Properties
- (2019) Jiachen Wen et al. ACS Medicinal Chemistry Letters
- Inhibition of hedgehog signaling by stereochemically defined des-triazole itraconazole analogues
- (2019) Jiachen Wen et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth
- (2019) Lospinoso Severini et al. Cancers
- Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold
- (2018) Simone Berardozzi et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61
- (2018) Andrea Calcaterra et al. JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY
- Targeting GLI Transcription Factors in Cancer
- (2018) Miroslava Didiasova et al. MOLECULES
- Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis
- (2018) Paola Infante et al. Nature Communications
- Preclinical characterization of therapeutic antibodies targeted at the carboxy-terminus of Sonic hedgehog
- (2018) Bhairavi Tolani et al. Oncotarget
- Current trends in Hedgehog signaling pathway inhibition by small molecules
- (2018) Francesca Ghirga et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Overcoming the emerging drug resistance of smoothened: an overview of small-molecule SMO antagonists with antiresistance activity
- (2018) Heng Zhang et al. Future Medicinal Chemistry
- Development of posaconazole-based analogues as hedgehog signaling pathway inhibitors
- (2018) Kelly A. Teske et al. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- Design, Palladium-Catalyzed Synthesis, and Biological Investigation of 2-Substituted 3-Aroylquinolin-4(1H)-ones as Inhibitors of the Hedgehog Signaling Pathway
- (2017) Romina Alfonsi et al. JOURNAL OF MEDICINAL CHEMISTRY
- Design and Evolution of a Macrocyclic Peptide Inhibitor of the Sonic Hedgehog/Patched Interaction
- (2017) Andrew E. Owens et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Polymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapyin vitro
- (2017) Cinzia Ingallina et al. Nanomedicine
- Characterization of Hedgehog Acyltransferase Inhibitors Identifies a Small Molecule Probe for Hedgehog Signaling by Cancer Cells
- (2016) Ursula R. Rodgers et al. ACS Chemical Biology
- Development of thieno- and benzopyrimidinone inhibitors of the Hedgehog signaling pathway reveals PDE4-dependent and PDE4-independent mechanisms of action
- (2016) Jonathan E. Hempel et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Repurposing the Clinically Efficacious Antifungal Agent Itraconazole as an Anticancer Chemotherapeutic
- (2016) Jennifer R. Pace et al. JOURNAL OF MEDICINAL CHEMISTRY
- Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype
- (2016) Paola Infante et al. Cell Death & Disease
- Signal Transduction Pathways of EMT Induced by TGF-β, SHH, and WNT and Their Crosstalks
- (2016) Jingyu Zhang et al. Journal of Clinical Medicine
- Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma
- (2015) Scott X. Atwood et al. CANCER CELL
- An Investigator-Initiated Open-Label Trial of Sonidegib in Advanced Basal Cell Carcinoma Patients Resistant to Vismodegib
- (2015) C. Danial et al. CLINICAL CANCER RESEARCH
- Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy
- (2015) Silvia Pandolfi et al. EXPERT REVIEWS IN MOLECULAR MEDICINE
- MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor
- (2015) Lucile Hoch et al. FASEB JOURNAL
- Endocannabinoids are conserved inhibitors of the Hedgehog pathway
- (2015) Helena Khaliullina et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Targeting GLI factors to inhibit the Hedgehog pathway
- (2015) Paola Infante et al. TRENDS IN PHARMACOLOGICAL SCIENCES
- An In Vivo Chemical Genetic Screen Identifies Phosphodiesterase 4 as a Pharmacological Target for Hedgehog Signaling Inhibition
- (2015) Charles H. Williams et al. Cell Reports
- Inhibition of Hedgehog signalling by NVP-LDE225 (Erismodegib) interferes with growth and invasion of human renal cell carcinoma cells
- (2014) C D’Amato et al. BRITISH JOURNAL OF CANCER
- Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors
- (2014) P. Infante et al. EMBO JOURNAL
- GLI activation by atypical protein kinase C ι/λ regulates the growth of basal cell carcinomas
- (2013) Scott X. Atwood et al. NATURE
- Structure of the human smoothened receptor bound to an antitumour agent
- (2013) Chong Wang et al. NATURE
- The mechanisms of Hedgehog signalling and its roles in development and disease
- (2013) James Briscoe et al. NATURE REVIEWS MOLECULAR CELL BIOLOGY
- Gli1 Mediates Lung Cancer Cell Proliferation and Sonic Hedgehog-Dependent Mesenchymal Cell Activation
- (2013) Olga Bermudez et al. PLoS One
- The Crosstalk of mTOR/S6K1 and Hedgehog Pathways
- (2012) Yan Wang et al. CANCER CELL
- Gli Proteins in Development and Disease
- (2011) Chi-chung Hui et al. Annual Review of Cell and Developmental Biology
- Hedgehog Signaling Inhibition Blocks Growth of Resistant Tumors through Effects on Tumor Microenvironment
- (2011) E. Heller et al. CANCER RESEARCH
- Hedgehog Signaling: Networking to Nurture a Promalignant Tumor Microenvironment
- (2011) L. G. Harris et al. MOLECULAR CANCER RESEARCH
- Mechanisms and functions of Hedgehog signalling across the metazoa
- (2011) Philip W. Ingham et al. NATURE REVIEWS GENETICS
- Canonical hedgehog signaling augments tumor angiogenesis by induction of VEGF-A in stromal perivascular cells
- (2011) W. Chen et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Hedgehog signaling pathway mediates the progression of non-invasive breast cancer to invasive breast cancer
- (2010) Masae Souzaki et al. CANCER SCIENCE
- Sonic Hedgehog/GLI1 signaling pathway inhibition restricts cell migration and invasion in human gliomas
- (2010) Ke Wang et al. NEUROLOGICAL RESEARCH
- Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma
- (2010) S. Buonamici et al. Science Translational Medicine
- A small molecule that binds Hedgehog and blocks its signaling in human cells
- (2009) Benjamin Z Stanton et al. Nature Chemical Biology
- Sonic hedgehog paracrine signaling regulates metastasis and lymphangiogenesis in pancreatic cancer
- (2009) J M Bailey et al. ONCOGENE
- Hedgehog signaling is restricted to the stromal compartment during pancreatic carcinogenesis
- (2009) H. Tian et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
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