1H-NMR metabolomics reveals the Glabrescione B exacerbation of glycolytic metabolism beside the cell growth inhibitory effect in glioma

High-throughput metabolomics by 1D NMR

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Current trends in Hedgehog signaling pathway inhibition by small molecules

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Increased Lactate Secretion by Cancer Cells Sustains Non-cell-autonomous Adaptive Resistance to MET and EGFR Targeted Therapies

(2018) Maria Apicella et al.   Cell Metabolism

Uniqueness of the NMR approach to metabolomics

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Lactate: A Metabolic Driver in the Tumour Landscape

(2018) Luigi Ippolito et al.   TRENDS IN BIOCHEMICAL SCIENCES

Evidence of a DHA Signature in the Lipidome and Metabolome of Human Hepatocytes

(2017) Veronica Ghini et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

NMR metabolomics highlights sphingosine kinase-1 as a new molecular switch in the orchestration of aberrant metabolic phenotype in cancer cells

(2017) Caterina Bernacchioni et al.   Molecular Oncology

Polymeric glabrescione B nanocapsules for passive targeting of Hedgehog-dependent tumor therapyin vitro

(2017) Cinzia Ingallina et al.   Nanomedicine

pH, Lactate, and Hypoxia: Reciprocity in Regulating High-Affinity Monocarboxylate Transporter Expression in Glioblastoma

(2017) James P. Caruso et al.   NEOPLASIA

Glutamate and α-ketoglutarate: key players in glioma metabolism

(2016) Andreas Maus et al.   AMINO ACIDS

The Emerging Hallmarks of Cancer Metabolism

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Metabolomics: beyond biomarkers and towards mechanisms

(2016) Caroline H. Johnson et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The energy sensor AMPK regulates Hedgehog signaling in human cells through a unique Gli1 metabolic checkpoint

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A metabolomics cell-based approach for anticipating and investigating drug-induced liver injury

(2016) Juan Carlos García- Cañaveras et al.   Scientific Reports

Targeting Notch, Hedgehog and Wnt pathways in cancer stem cells: clinical update

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Loss of succinate dehydrogenase activity results in dependency on pyruvate carboxylation for cellular anabolism

(2015) Charlotte Lussey-Lepoutre et al.   Nature Communications

Identification of a novel synthetic lethality of combined inhibition of hedgehog and PI3K signaling in rhabdomyosarcoma

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Metabolic Targeting of Lactate Efflux by Malignant Glioma Inhibits Invasiveness and Induces Necrosis: An In Vivo Study

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AMP-Activated Protein Kinase: Maintaining Energy Homeostasis at the Cellular and Whole-Body Levels

(2014) D. Grahame Hardie   Annual Review of Nutrition

Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors

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Endothelial cells promote stem-like phenotype of glioma cells through activating the Hedgehog pathway

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The epidemiology of glioma in adults: a "state of the science" review

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Unraveling the therapeutic potential of the Hedgehog pathway in cancer

(2013) Dereck Amakye et al.   NATURE MEDICINE

Arsenic Trioxide Prevents Osteosarcoma Growth by Inhibition of GLI Transcription via DNA Damage Accumulation

(2013) Shunsuke Nakamura et al.   PLoS One

Arsenic trioxide inhibits viability of pancreatic cancer stem cells in culture and in a xenograft model via binding to SHH-Gli

(2013) Jin-bin Han et al.   OncoTargets and Therapy

Delineating metabolic signatures of head and neck squamous cell carcinoma: Phospholipase A2, a potential therapeutic target

(2012) Pratima Tripathi et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Immune microenvironments in solid tumors: new targets for therapy

(2011) S. L. Shiao et al.   GENES & DEVELOPMENT

Role of sonic hedgehog signaling in migration of cell lines established from CD133-positive malignant glioma cells

(2011) Hiroyuki Uchida et al.   JOURNAL OF NEURO-ONCOLOGY

Rethinking the Warburg Effect with Myc Micromanaging Glutamine Metabolism

(2010) C. V. Dang   CANCER RESEARCH

Glutaminolysis: Supplying carbon or nitrogen or both for cancer cells?

(2010) Chi V. Dang   CELL CYCLE

Interactions between Hedgehog proteins and their binding partners come into view

(2010) P. A. Beachy et al.   GENES & DEVELOPMENT

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Intranasal delivery bypasses the blood-brain barrier to target therapeutic agents to the central nervous system and treat neurodegenerative disease

(2008) Leah R Hanson et al.   BMC NEUROSCIENCE

A Stochastic Model for Cancer Stem Cell Origin in Metastatic Colon Cancer

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