Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype

An analysis of FDA-approved drugs: natural products and their derivatives

(2016) Eric Patridge et al.   DRUG DISCOVERY TODAY

Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma

(2015) Scott X. Atwood et al.   CANCER CELL

Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma

(2015) Hayley J. Sharpe et al.   CANCER CELL

Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy

(2015) Silvia Pandolfi et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

MRT-92 inhibits Hedgehog signaling by blocking overlapping binding sites in the transmembrane domain of the Smoothened receptor

(2015) Lucile Hoch et al.   FASEB JOURNAL

The re-emergence of natural products for drug discovery in the genomics era

(2015) Alan L. Harvey et al.   NATURE REVIEWS DRUG DISCOVERY

Targeting GLI factors to inhibit the Hedgehog pathway

(2015) Paola Infante et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Click Reaction as a Tool to Combine Pharmacophores: The Case of Vismodegib

(2015) Michael S. Christodoulou et al.   ChemPlusChem

Genome Sequencing of SHH Medulloblastoma Predicts Genotype-Related Response to Smoothened Inhibition

(2014) Marcel Kool et al.   CANCER CELL

Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors

(2014) P. Infante et al.   EMBO JOURNAL

Targeted treatment for sonic hedgehog-dependent medulloblastoma

(2014) M. W. Kieran   NEURO-ONCOLOGY

Targeting of Smoothened for therapeutic gain

(2014) Martial Ruat et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography

(2014) Uwe Weierstall et al.   Nature Communications

Natural products: A continuing source of novel drug leads

(2013) Gordon M. Cragg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS

Phase I Study of the Hedgehog Pathway Inhibitor IPI-926 in Adult Patients with Solid Tumors

(2013) A. Jimeno et al.   CLINICAL CANCER RESEARCH

Structure of the human smoothened receptor bound to an antitumour agent

(2013) Chong Wang et al.   NATURE

Unraveling the therapeutic potential of the Hedgehog pathway in cancer

(2013) Dereck Amakye et al.   NATURE MEDICINE

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Discovery of Mycobacterium tuberculosis Protein Tyrosine Phosphatase B (PtpB) Inhibitors from Natural Products

(2013) Alessandra Mascarello et al.   PLoS One

Medulloblastoma stem cells: Modeling tumor heterogeneity

(2012) Branavan Manoranjan et al.   CANCER LETTERS

Hedgehog Partial Agonism Drives Warburg-like Metabolism in Muscle and Brown Fat

(2012) Raffaele Teperino et al.   CELL

Hedgehog-EGFR cooperation response genes determine the oncogenic phenotype of basal cell carcinoma and tumour-initiating pancreatic cancer cells

(2012) Markus Eberl et al.   EMBO Molecular Medicine

MMPBSA.py: An Efficient Program for End-State Free Energy Calculations

(2012) Bill R. Miller et al.   Journal of Chemical Theory and Computation

FRED and HYBRID docking performance on standardized datasets

(2012) Mark McGann   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Hedgehog pathway inhibitor saridegib (IPI-926) increases lifespan in a mouse medulloblastoma model

(2012) M. J. Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Hedgehog Signal Transduction Network

(2012) D. J. Robbins et al.   Science Signaling

Hedgehog Fights Back: Mechanisms of Acquired Resistance against Smoothened Antagonists

(2011) C. Metcalfe et al.   CANCER RESEARCH

Heterotrimeric GiProteins Link Hedgehog Signaling to Activation of Rho Small GTPases to Promote Fibroblast Migration

(2011) Ariel H. Polizio et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

FRED Pose Prediction and Virtual Screening Accuracy

(2011) Mark McGann   Journal of Chemical Information and Modeling

Sonic hedgehog signaling is decoded by calcium spike activity in the developing spinal cord

(2011) Y. H. Belgacem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Common Botanical Compounds Inhibit the Hedgehog Signaling Pathway in Prostate Cancer

(2010) A. Slusarz et al.   CANCER RESEARCH

Small Molecule Inhibition of GDC-0449 Refractory Smoothened Mutants and Downstream Mechanisms of Drug Resistance

(2010) Gerrit J. P. Dijkgraaf et al.   CANCER RESEARCH

The expanding role of marine microbes in pharmaceutical development

(2010) Amanda L Waters et al.   CURRENT OPINION IN BIOTECHNOLOGY

Hedgehog controls neural stem cells through p53-independent regulation of Nanog

(2010) Agnese Po et al.   EMBO JOURNAL

Conformer Generation with OMEGA: Algorithm and Validation Using High Quality Structures from the Protein Databank and Cambridge Structural Database

(2010) Paul C. D. Hawkins et al.   Journal of Chemical Information and Modeling

Predicting the Binding Mode of Known NCp7 Inhibitors To Facilitate the Design of Novel Modulators

(2010) Mattia Mori et al.   Journal of Chemical Information and Modeling

Virtual Screening-Based Discovery and Mechanistic Characterization of the Acylthiourea MRT-10 Family as Smoothened Antagonists

(2010) F. Manetti et al.   MOLECULAR PHARMACOLOGY

Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

(2010) S. Buonamici et al.   Science Translational Medicine

Recent patents for Hedgehog pathway inhibitors for the treatment of malignancy

(2009) Martin R Tremblay et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Sonic Hedgehog Guides Axons through a Noncanonical, Src-Family-Kinase-Dependent Signaling Pathway

(2009) Patricia T. Yam et al.   NEURON

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

(2009) Charles M. Rudin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

(2009) R. L. Yauch et al.   SCIENCE

Mechanisms of Hedgehog pathway activation in cancer and implications for therapy

(2009) Suzie J. Scales et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Conformations of 3-carboxylic esters essential for neurotoxicity in veratrum alkaloids are loosely restricted and fluctuate

(2008) Ai Niitsu et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Structure–activity relationship of antibacterial chalcones

(2008) Hugo Pereira Ávila et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Acquisition of Granule Neuron Precursor Identity Is a Critical Determinant of Progenitor Cell Competence to Form Shh-Induced Medulloblastoma

(2008) Ulrich Schüller et al.   CANCER CELL

Medulloblastoma Can Be Initiated by Deletion of Patched in Lineage-Restricted Progenitors or Stem Cells

(2008) Zeng-Jie Yang et al.   CANCER CELL

A paracrine requirement for hedgehog signalling in cancer

(2008) Robert L. Yauch et al.   NATURE