Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61

Tautomers of a Fluorescent G Surrogate and Their Distinct Photophysics Provide Additional Information Channels

(2016) Marianna Sholokh et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Molecular insights to the bioactive form of BV02 , a reference inhibitor of 14-3-3σ protein–protein interactions

(2016) Daniela Valensin et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

One Hundred Faces of Cyclopamine

(2016) Valentina Iovine et al.   CURRENT PHARMACEUTICAL DESIGN

2015 FDA drug approvals

(2016) Asher Mullard   NATURE REVIEWS DRUG DISCOVERY

Mycobacterial carbonic anhydrase inhibition with phenolic acids and esters: kinetic and computational investigations

(2016) Ylenia Cau et al.   ORGANIC & BIOMOLECULAR CHEMISTRY

Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype

(2016) Paola Infante et al.   Cell Death & Disease

Targeting the Sonic Hedgehog Signaling Pathway: Review of Smoothened and GLI Inhibitors

(2016) Tadas Rimkus et al.   Cancers

Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma

(2015) Scott X. Atwood et al.   CANCER CELL

Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma

(2015) Hayley J. Sharpe et al.   CANCER CELL

Molecular Dynamics Simulations and Structural Analysis of Giardia duodenalis 14-3-3 Protein–Protein Interactions

(2015) Ylenia Cau et al.   Journal of Chemical Information and Modeling

Targeting GLI factors to inhibit the Hedgehog pathway

(2015) Paola Infante et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Targeting the Hedgehog signaling pathway in cancer: beyond Smoothened

(2015) Annelies Gonnissen et al.   Oncotarget

Hedgehog Inhibitors in Rhabdomyosarcoma: A Comparison of Four Compounds and Responsiveness of Four Cell Lines

(2015) Rosalie Ridzewski et al.   Frontiers in Oncology

Mode and specificity of binding of the small molecule GANT61 to GLI determines inhibition of GLI-DNA binding

(2015) Akwasi Agyeman et al.   Oncotarget

Functional and Structural Characterization of 2-Amino-4-phenylthiazole Inhibitors of the HIV-1 Nucleocapsid Protein with Antiviral Activity

(2014) Mattia Mori et al.   ACS Chemical Biology

Discovery of the first potent and selective Mycobacterium tuberculosis Zmp1 inhibitor

(2014) Mattia Mori et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Druggable glycolytic requirement for Hedgehog-dependent neuronal and medulloblastoma growth

(2014) Laura Di Magno et al.   CELL CYCLE

Getting to the Source: Selective Drug Targeting of Cancer Stem Cells

(2014) Fatima Ismail et al.   ChemMedChem

Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors

(2014) P. Infante et al.   EMBO JOURNAL

Synthesis and cytotoxicity studies of Hedgehog enzyme inhibitors SANT-1 and GANT-61 as anticancer agents

(2014) Venugopal Chenna et al.   JOURNAL OF ENVIRONMENTAL SCIENCE AND HEALTH PART A-TOXIC/HAZARDOUS SUBSTANCES & ENVIRONMENTAL ENGINEERING

Targeting of Smoothened for therapeutic gain

(2014) Martial Ruat et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Understanding and targeting cancer stem cells: therapeutic implications and challenges

(2013) Ke Chen et al.   ACTA PHARMACOLOGICA SINICA

Stereochemical Preference of 2'-Deoxycytidine for Chiral Bis(diamido)-bridged Basket Resorcin[4]arenes

(2013) Ilaria D'Acquarica et al.   CHIRALITY

Hedgehog signal inhibitors suppress the invasion of human rhabdomyosarcoma cells

(2013) Takaharu Oue et al.   PEDIATRIC SURGERY INTERNATIONAL

Discovery of a New Class of Potent MMP Inhibitors by Structure-Based Optimization of the Arylsulfonamide Scaffold

(2013) Mattia Mori et al.   ACS Medicinal Chemistry Letters

Control of stem cells and cancer stem cells by Hedgehog signaling: Pharmacologic clues from pathway dissection

(2012) Sonia Coni et al.   BIOCHEMICAL PHARMACOLOGY

MMPBSA.py: An Efficient Program for End-State Free Energy Calculations

(2012) Bill R. Miller et al.   Journal of Chemical Theory and Computation

Vismodegib

(2012) Andrzej Dlugosz et al.   NATURE REVIEWS DRUG DISCOVERY

Hedgehog Fights Back: Mechanisms of Acquired Resistance against Smoothened Antagonists

(2011) C. Metcalfe et al.   CANCER RESEARCH

Correction to "Antipsychotic Drugs Regulate Hedgehog Signaling by Modulation of 7-Dehydrocholesterol Reductase Levels"

(2011)   MOLECULAR PHARMACOLOGY

Molecular Dynamics and DFT Study on HIV-1 Nucleocapsid Protein-7 in Complex with Viral Genome

(2010) Mattia Mori et al.   Journal of Chemical Information and Modeling

Predicting the Binding Mode of Known NCp7 Inhibitors To Facilitate the Design of Novel Modulators

(2010) Mattia Mori et al.   Journal of Chemical Information and Modeling

HILIC and mixed-mode chromatography: The rising stars in separation science

(2010) Michael Lämmerhofer   JOURNAL OF SEPARATION SCIENCE

HILIC methods in pharmaceutical analysis

(2010) Bieke Dejaegher et al.   JOURNAL OF SEPARATION SCIENCE

Antipsychotic Drugs Regulate Hedgehog Signaling by Modulation of 7-Dehydrocholesterol Reductase Levels

(2010) M. Lauth et al.   MOLECULAR PHARMACOLOGY

Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

(2010) S. Buonamici et al.   Science Translational Medicine

Human colon cancer epithelial cells harbour active HEDGEHOG-GLI signalling that is essential for tumour growth, recurrence, metastasis and stem cell survival and expansion

(2009) Frédéric Varnat et al.   EMBO Molecular Medicine

AutoDock4 and AutoDockTools4: Automated docking with selective receptor flexibility

(2009) Garrett M. Morris et al.   JOURNAL OF COMPUTATIONAL CHEMISTRY

Hedgehog signalling is essential for maintenance of cancer stem cells in myeloid leukaemia

(2009) Chen Zhao et al.   NATURE

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

(2009) R. L. Yauch et al.   SCIENCE

Role of Biotransformation Studies in Minimizing Metabolism-Related Liabilities in Drug Discovery

(2008) Yue-Zhong Shu et al.   AAPS Journal

Hedgehog: functions and mechanisms

(2008) M. Varjosalo et al.   GENES & DEVELOPMENT

The advantages of ESI-MS detection in conjunction with HILIC mode separations: Fundamentals and applications

(2008) Hien P. Nguyen et al.   JOURNAL OF SEPARATION SCIENCE

An Integrated Approach Identifies Nhlh1 and Insm1 as Sonic Hedgehog-regulated Genes in Developing Cerebellum and Medulloblastoma

(2008) Enrico De Smaele et al.   NEOPLASIA