Mechanisms and functions of Hedgehog signalling across the metazoa

Processing and turnover of the Hedgehog protein in the endoplasmic reticulum

(2011) Xin Chen et al.   JOURNAL OF CELL BIOLOGY

Hedgehog/Wnt feedback supports regenerative proliferation of epithelial stem cells in bladder

(2011) Kunyoo Shin et al.   NATURE

Small molecule modulation of HH-GLI signaling: Current leads, trials and tribulations

(2010) Christophe Mas et al.   BIOCHEMICAL PHARMACOLOGY

Gli2a protein localization reveals a role for Iguana/DZIP1 in primary ciliogenesis and a dependence of Hedgehog signal transduction on primary cilia in the zebrafish

(2010) Hyejeong Kim et al.   BMC BIOLOGY

Hedgehog signaling controls mesenchymal growth in the developing mammalian digestive tract

(2010) J. Mao et al.   DEVELOPMENT

The Long-Range Activity of Hedgehog Is Regulated in the Apical Extracellular Space by the Glypican Dally and the Hydrolase Notum

(2010) Katie L. Ayers et al.   DEVELOPMENTAL CELL

Role of Lipid Metabolism in Smoothened Derepression in Hedgehog Signaling

(2010) Amir Yavari et al.   DEVELOPMENTAL CELL

The output of Hedgehog signaling is controlled by the dynamic association between Suppressor of Fused and the Gli proteins

(2010) E. W. Humke et al.   GENES & DEVELOPMENT

Genetic and biochemical definition of the Hedgehog receptor

(2010) X. Zheng et al.   GENES & DEVELOPMENT

Interactions between Hedgehog proteins and their binding partners come into view

(2010) P. A. Beachy et al.   GENES & DEVELOPMENT

G protein-coupled receptor kinase 2 promotes high-level Hedgehog signaling by regulating the active state of Smo through kinase-dependent and kinase-independent mechanisms in Drosophila

(2010) Y. Chen et al.   GENES & DEVELOPMENT

Midline Signaling and Evolution of the Forebrain in Chordates: A Focus on the Lamprey Hedgehog Case

(2010) Sylvie Rétaux et al.   INTEGRATIVE AND COMPARATIVE BIOLOGY

A mechanism for vertebrate Hedgehog signaling: recruitment to cilia and dissociation of SuFu–Gli protein complexes

(2010) Hanna Tukachinsky et al.   JOURNAL OF CELL BIOLOGY

DrosophilaBoi limits Hedgehog levels to suppress follicle stem cell proliferation

(2010) Tiffiney R. Hartman et al.   JOURNAL OF CELL BIOLOGY

Clinical Experience With Hedgehog Pathway Inhibitors

(2010) Jennifer A. Low et al.   JOURNAL OF CLINICAL ONCOLOGY

The Amphimedon queenslandica genome and the evolution of animal complexity

(2010) Mansi Srivastava et al.   NATURE

The primary cilium: a signalling centre during vertebrate development

(2010) Sarah C. Goetz et al.   NATURE REVIEWS GENETICS

Dally-like core protein and its mammalian homologues mediate stimulatory and inhibitory effects on Hedgehog signal response

(2010) E. H. Williams et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The crystal structure of a bacterial Sufu-like protein defines a novel group of bacterial proteins that are similar to the N-terminal domain of human Sufu

(2010) Debanu Das et al.   PROTEIN SCIENCE

Hedgehog Signaling Regulates Segment Formation in the Annelid Platynereis

(2010) N. Dray et al.   SCIENCE

Evaluating Smoothened as a G-protein-coupled receptor for Hedgehog signalling

(2010) Katie L. Ayers et al.   TRENDS IN CELL BIOLOGY

Sufu recruits GSK3β for efficient processing of Gli3

(2009) Yoshiaki Kise et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

The Extracellular Domain of Smoothened Regulates Ciliary Localization and Is Required for High-Level Hh Signaling

(2009) Pia Aanstad et al.   CURRENT BIOLOGY

The Mammalian Cos2 Homolog Kif7 Plays an Essential Role in Modulating Hh Signal Transduction during Development

(2009) Setsu Endoh-Yamagami et al.   CURRENT BIOLOGY

Hedgehog signaling patterns mesoderm in the sea urchin

(2009) Katherine D. Walton et al.   DEVELOPMENTAL BIOLOGY

The Zn Finger protein Iguana impacts Hedgehog signaling by promoting ciliogenesis

(2009) Andrew M. Glazer et al.   DEVELOPMENTAL BIOLOGY

The iguana/DZIP1 protein is a novel component of the ciliogenic pathway essential for axonemal biogenesis

(2009) Shang Yew Tay et al.   DEVELOPMENTAL DYNAMICS

Sonic-hedgehog-mediated proliferation requires the localization of PKA to the cilium base

(2009) M. Barzi et al.   JOURNAL OF CELL SCIENCE

Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis

(2009) Christopher W. Wilson et al.   NATURE

Structural insights into hedgehog ligand sequestration by the human hedgehog-interacting protein HHIP

(2009) Benjamin Bishop et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Sonic Hedgehog Guides Axons through a Noncanonical, Src-Family-Kinase-Dependent Signaling Pathway

(2009) Patricia T. Yam et al.   NEURON

Mouse Kif7/Costal2 is a cilia-associated protein that regulates Sonic hedgehog signaling

(2009) K. F. Liem et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Planarian Hedgehog/Patched establishes anterior–posterior polarity by regulating Wnt signaling

(2009) Shigenobu Yazawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A wound-induced Wnt expression program controls planarian regeneration polarity

(2009) C. P. Petersen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Planarian Hh Signaling Regulates Regeneration Polarity and Links Hh Pathway Evolution to Cilia

(2009) J. C. Rink et al.   SCIENCE

The Kinesin Protein Kif7 Is a Critical Regulator of Gli Transcription Factors in Mammalian Hedgehog Signaling

(2009) H. O.-L. Cheung et al.   Science Signaling

The Hedgehog Signaling Pathway: Where Did It Come From?

(2009) George Hausmann et al.   PLOS BIOLOGY

Shh and forebrain evolution in the blind cavefish Astyanax mexicanus

(2008) Sylvie Rétaux et al.   BIOLOGY OF THE CELL

Evolution of hedgehog and hedgehog-related genes, their origin from Hog proteins in ancestral eukaryotes and discovery of a novel Hint motif

(2008) Thomas R Bürglin   BMC GENOMICS

Nanoscale Organization of Hedgehog Is Essential for Long-Range Signaling

(2008) Neha Vyas et al.   CELL

Costal2 Functions as a Kinesin-like Protein in the Hedgehog Signal Transduction Pathway

(2008) Shohreh F. Farzan et al.   CURRENT BIOLOGY

Notochord-derived Shh concentrates in close association with the apically positioned basal body in neural target cells and forms a dynamic gradient during neural patterning

(2008) C. E. Chamberlain et al.   DEVELOPMENT

Pattern formation in the vertebrate neural tube: a sonic hedgehog morphogen-regulated transcriptional network

(2008) E. Dessaud et al.   DEVELOPMENT

Hedgehog signaling pathway function conserved in Tribolium segmentation

(2008) Laila Farzana et al.   DEVELOPMENT GENES AND EVOLUTION

Phosphorylation of Gli2 by protein kinase A is required for Gli2 processing and degradation and the Sonic Hedgehog-regulated mouse development

(2008) Yong Pan et al.   DEVELOPMENTAL BIOLOGY

tsunami, the Dictyostelium homolog of the Fused kinase, is required for polarization and chemotaxis

(2008) L. Tang et al.   GENES & DEVELOPMENT

A genome-scale analysis of the cis-regulatory circuitry underlying sonic hedgehog-mediated patterning of the mammalian limb

(2008) S. A. Vokes et al.   GENES & DEVELOPMENT

Smoothened Signaling in Vertebrates Is Facilitated by a G Protein-coupled Receptor Kinase

(2008) Melanie Philipp et al.   MOLECULAR BIOLOGY OF THE CELL

Our fly cousins' gut

(2008) Chrysoula Pitsouli et al.   NATURE

G protein Gαi functions immediately downstream of Smoothened in Hedgehog signalling

(2008) Stacey K. Ogden et al.   NATURE

The behaviour of Drosophila adult hindgut stem cells is controlled by Wnt and Hh signalling

(2008) Shigeo Takashima et al.   NATURE

The mode of Hedgehog binding to Ihog homologues is not conserved across different phyla

(2008) Jason S. McLellan et al.   NATURE

The Trichoplax genome and the nature of placozoans

(2008) Mansi Srivastava et al.   NATURE

The genome of the choanoflagellate Monosiga brevicollis and the origin of metazoans

(2008) Nicole King et al.   NATURE

Kinome siRNA Screen Identifies Regulators of Ciliogenesis and Hedgehog Signal Transduction

(2008) M. Evangelista et al.   Science Signaling

The Hedgehog protein family

(2008) Thomas R Bürglin   GENOME BIOLOGY

The Hedgehog gene family of the cnidarian, Nematostella vectensis, and implications for understanding metazoan Hedgehog pathway evolution

(2007) David Q. Matus et al.   DEVELOPMENTAL BIOLOGY

Smed- catenin-1 Is Required for Anteroposterior Blastema Polarity in Planarian Regeneration

(2007) C. P. Petersen et al.   SCIENCE