A Smo/Gli Multitarget Hedgehog Pathway Inhibitor Impairs Tumor Growth

Natural products inspired modulators of cancer stem cells-specific signaling pathways Notch and Hedgehog

(2019) Rocco Palermo et al.   CURRENT PHARMACEUTICAL DESIGN

Targeting Hedgehog Signalling through the Ubiquitylation Process: The Multiple Roles of the HECT-E3 Ligase Itch

(2019) Paola Infante et al.   Cells

Medulloblastoma

(2019) Paul A. Northcott et al.   Nature Reviews Disease Primers

ERAP1 promotes Hedgehog-dependent tumorigenesis by controlling USP47-mediated degradation of βTrCP

(2019) Francesca Bufalieri et al.   Nature Communications

Non-canonical Hedgehog Signaling Pathway in Cancer: Activation of GLI Transcription Factors Beyond Smoothened

(2019) Silvia Pietrobono et al.   Frontiers in Genetics

Synergistic inhibition of the Hedgehog pathway by newly designed Smo and Gli antagonists bearing the isoflavone scaffold

(2018) Simone Berardozzi et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Chemical, computational and functional insights into the chemical stability of the Hedgehog pathway inhibitor GANT61

(2018) Andrea Calcaterra et al.   JOURNAL OF ENZYME INHIBITION AND MEDICINAL CHEMISTRY

Strategies to target the Hedgehog signaling pathway for cancer therapy

(2018) Minhang Xin et al.   MEDICINAL RESEARCH REVIEWS

Itch/β-arrestin2-dependent non-proteolytic ubiquitylation of SuFu controls Hedgehog signalling and medulloblastoma tumorigenesis

(2018) Paola Infante et al.   Nature Communications

Current trends in Hedgehog signaling pathway inhibition by small molecules

(2018) Francesca Ghirga et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Targeting the Oncoprotein Smoothened by Small Molecules: Focus on Novel Acylguanidine Derivatives as Potent Smoothened Inhibitors

(2018) Silvia Pietrobono et al.   Cells

Hedgehog Signal Transduction: Key Players, Oncogenic Drivers, and Cancer Therapy

(2016) Ekaterina Pak et al.   DEVELOPMENTAL CELL

In vitro models of medulloblastoma: Choosing the right tool for the job

(2016) Delyan P. Ivanov et al.   JOURNAL OF BIOTECHNOLOGY

Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype

(2016) Paola Infante et al.   Cell Death & Disease

Smoothened Variants Explain the Majority of Drug Resistance in Basal Cell Carcinoma

(2015) Scott X. Atwood et al.   CANCER CELL

Genomic Analysis of Smoothened Inhibitor Resistance in Basal Cell Carcinoma

(2015) Hayley J. Sharpe et al.   CANCER CELL

Cooperative integration between HEDGEHOG-GLI signalling and other oncogenic pathways: implications for cancer therapy

(2015) Silvia Pandolfi et al.   EXPERT REVIEWS IN MOLECULAR MEDICINE

Vismodegib Exerts Targeted Efficacy Against Recurrent Sonic Hedgehog–Subgroup Medulloblastoma: Results From Phase II Pediatric Brain Tumor Consortium Studies PBTC-025B and PBTC-032

(2015) Giles W. Robinson et al.   JOURNAL OF CLINICAL ONCOLOGY

β-Catenin-Gli1 interaction regulates proliferation and tumor growth in medulloblastoma

(2015) Jenny Zinke et al.   Molecular Cancer

Targeting GLI factors to inhibit the Hedgehog pathway

(2015) Paola Infante et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Non-Canonical Hh Signaling in Cancer—Current Understanding and Future Directions

(2015) Dongsheng Gu et al.   Cancers

Targeting the Hedgehog Pathway in Pediatric Medulloblastoma

(2015) Sherri Huang et al.   Cancers

Isoflavones: Chemistry, Analysis, Functions and Effects on Health and Cancer

(2014) Kwang-Pil Ko   Asian Pacific Journal of Cancer Prevention

Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors

(2014) P. Infante et al.   EMBO JOURNAL

Epigenetic targeting of Hedgehog pathway transcriptional output through BET bromodomain inhibition

(2014) Yujie Tang et al.   NATURE MEDICINE

Context-dependent signal integration by the GLI code: The oncogenic load, pathways, modifiers and implications for cancer therapy

(2014) Fritz Aberger et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Targeting of Smoothened for therapeutic gain

(2014) Martial Ruat et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Lipidic cubic phase injector facilitates membrane protein serial femtosecond crystallography

(2014) Uwe Weierstall et al.   Nature Communications

Personalizing the Treatment of Pediatric Medulloblastoma: Polo-like Kinase 1 as a Molecular Target in High-Risk Children

(2013) J. Triscott et al.   CANCER RESEARCH

PCAF ubiquitin ligase activity inhibits Hedgehog/Gli1 signaling in p53-dependent response to genotoxic stress

(2013) D Mazzà et al.   CELL DEATH AND DIFFERENTIATION

Neuropilin-2 contributes to tumorigenicity in a mouse model of Hedgehog pathway medulloblastoma

(2013) Melanie G. Hayden Gephart et al.   JOURNAL OF NEURO-ONCOLOGY

Unraveling the therapeutic potential of the Hedgehog pathway in cancer

(2013) Dereck Amakye et al.   NATURE MEDICINE

The mechanisms of Hedgehog signalling and its roles in development and disease

(2013) James Briscoe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The Crosstalk of mTOR/S6K1 and Hedgehog Pathways

(2012) Yan Wang et al.   CANCER CELL

FRED and HYBRID docking performance on standardized datasets

(2012) Mark McGann   JOURNAL OF COMPUTER-AIDED MOLECULAR DESIGN

Vismodegib

(2012) Andrzej Dlugosz et al.   NATURE REVIEWS DRUG DISCOVERY

Inhibiting the Hedgehog Pathway in Patients with the Basal-Cell Nevus Syndrome

(2012) Jean Y. Tang et al.   NEW ENGLAND JOURNAL OF MEDICINE

The Hedgehog Signal Transduction Network

(2012) D. J. Robbins et al.   Science Signaling

Rapid, reliable, and reproducible molecular sub-grouping of clinical medulloblastoma samples

(2011) Paul A. Northcott et al.   ACTA NEUROPATHOLOGICA

Hedgehog Fights Back: Mechanisms of Acquired Resistance against Smoothened Antagonists

(2011) C. Metcalfe et al.   CANCER RESEARCH

FRED Pose Prediction and Virtual Screening Accuracy

(2011) Mark McGann   Journal of Chemical Information and Modeling

Histone deacetylase and Cullin3–RENKCTD11 ubiquitin ligase interplay regulates Hedgehog signalling through Gli acetylation

(2010) Gianluca Canettieri et al.   NATURE CELL BIOLOGY

Numb activates the E3 ligase Itch to control Gli1 function through a novel degradation signal

(2010) L Di Marcotullio et al.   ONCOGENE

Interfering with Resistance to Smoothened Antagonists by Inhibition of the PI3K Pathway in Medulloblastoma

(2010) S. Buonamici et al.   Science Translational Medicine

Treatment of Medulloblastoma with Hedgehog Pathway Inhibitor GDC-0449

(2009) Charles M. Rudin et al.   NEW ENGLAND JOURNAL OF MEDICINE

Smoothened Mutation Confers Resistance to a Hedgehog Pathway Inhibitor in Medulloblastoma

(2009) R. L. Yauch et al.   SCIENCE

Pediatric medulloblastoma: Toxicity of current treatment and potential role of protontherapy

(2008) Piero Fossati et al.   CANCER TREATMENT REVIEWS

Hedgehog: functions and mechanisms

(2008) M. Varjosalo et al.   GENES & DEVELOPMENT