Senescence-induced inflammation: an important player and key therapeutic target in atherosclerosis

Senolytics in idiopathic pulmonary fibrosis: Results from a first-in-human, open-label, pilot study

(2019) Jamie N. Justice et al.   EBioMedicine

Cells exhibiting strong p16INK4a promoter activation in vivo display features of senescence

(2019) Jie-Yu Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

GATA4-Twist1 Signalling in Disturbed Flow-Induced Atherosclerosis

(2019) Marwa Mahmoud et al.   CARDIOVASCULAR DRUGS AND THERAPY

The STATus of STAT3 in Lung Cell Senescence?

(2019) Serge Adnot et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Novel Antiatherosclerotic Therapies

(2019) Peter Libby et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Interleukin-18 promotes fibroblast senescence in pulmonary fibrosis through down-regulating Klotho expression

(2019) Li-Ming Zhang et al.   BIOMEDICINE & PHARMACOTHERAPY

Immunotherapy for cardiovascular disease

(2019) Esther Lutgens et al.   EUROPEAN HEART JOURNAL

Involvement of microRNA-34a in Age-Related Susceptibility to Oxidative Stress in ARPE-19 Cells by Targeting the Silent Mating Type Information Regulation 2 Homolog 1/p66shc Pathway: Implications for Age-Related Macular Degeneration

(2019) Nianting Tong et al.   Frontiers in Aging Neuroscience

Oxidation resistance 1 is a novel senolytic target

(2018) Xin Zhang et al.   AGING CELL

Human electronegative LDL induces mitochondrial dysfunction and premature senescence of vascular cells in vivo

(2018) Yu-Chen Wang et al.   AGING CELL

Major features of immunesenescence, including reduced thymic output, are ameliorated by high levels of physical activity in adulthood

(2018) Niharika Arora Duggal et al.   AGING CELL

Cellular senescence links aging and diabetes in cardiovascular disease

(2018) Hadis Shakeri et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

SIRT1 and SIRT6 Signaling Pathways in Cardiovascular Disease Protection

(2018) Nunzia D'Onofrio et al.   ANTIOXIDANTS & REDOX SIGNALING

FOXO3a (Forkhead Transcription Factor O Subfamily Member 3a) Links Vascular Smooth Muscle Cell Apoptosis, Matrix Breakdown, Atherosclerosis, and Vascular Remodeling Through a Novel Pathway Involving MMP13 (Matrix Metalloproteinase 13)Highlights

(2018) Haixiang Yu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

oxLDL-mediated cellular senescence is associated with increased NADPH oxidase p47phox recruitment to caveolae

(2018) Jing Wang et al.   BIOSCIENCE REPORTS

Impairment of an Endothelial NAD + -H 2 S Signaling Network Is a Reversible Cause of Vascular Aging

(2018) Abhirup Das et al.   CELL

Defective Base Excision Repair of Oxidative DNA Damage in Vascular Smooth Muscle Cells Promotes Atherosclerosis

(2018) Aarti Shah et al.   CIRCULATION

Vascular Smooth Muscle–Specific Progerin Expression Accelerates Atherosclerosis and Death in a Mouse Model of Hutchinson-Gilford Progeria Syndrome

(2018) Magda R. Hamczyk et al.   CIRCULATION

Levels of serum high mobility group box 1 were independently associated with cardiovascular risk in patients undergoing coronary angiography

(2018) Jun-Sing Wang et al.   CLINICA CHIMICA ACTA

A versatile drug delivery system targeting senescent cells

(2018) Daniel Muñoz‐Espín et al.   EMBO Molecular Medicine

Senescent cells: a therapeutic target for cardiovascular disease

(2018) Bennett G. Childs et al.   JOURNAL OF CLINICAL INVESTIGATION

Targeting CD40-Induced TRAF6 Signaling in Macrophages Reduces Atherosclerosis

(2018) Tom T.P. Seijkens et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Senolytics improve physical function and increase lifespan in old age

(2018) Ming Xu et al.   NATURE MEDICINE

Defective Autophagy in Atherosclerosis: To Die or to Senesce?

(2018) Mandy O. J. Grootaert et al.   Oxidative Medicine and Cellular Longevity

Evidence for the use of mineralocorticoid receptor antagonists in the treatment of coronary artery disease and post-angioplasty restenosis

(2018) Jochen Dutzmann et al.   VASCULAR PHARMACOLOGY

The senescence-associated secretory phenotype is potentiated by feedforward regulatory mechanisms involving Zscan4 and TAK1

(2018) Boyi Zhang et al.   Nature Communications

Lung cellular senescence is independent of aging in a mouse model of COPD/emphysema

(2018) Kahkashan Rashid et al.   Scientific Reports

Vasa Vasorum Angiogenesis: Key Player in the Initiation and Progression of Atherosclerosis and Potential Target for the Treatment of Cardiovascular Disease

(2018) Daniel G. Sedding et al.   Frontiers in Immunology

Age- and Tissue-Specific Expression of Senescence Biomarkers in Mice

(2018) Adam D. Hudgins et al.   Frontiers in Genetics

Cardiac Abnormalities in Patients With Hutchinson-Gilford Progeria Syndrome

(2018) Ashwin Prakash et al.   JAMA Cardiology

CHIP (Clonal Hematopoiesis of Indeterminate Potential)

(2018) Peter Libby et al.   CIRCULATION

Clearance of senescent glial cells prevents tau-dependent pathology and cognitive decline

(2018) Tyler J. Bussian et al.   NATURE

Fisetin is a senotherapeutic that extends health and lifespan

(2018) Matthew J. Yousefzadeh et al.   EBioMedicine

Low-Dose Methotrexate for the Prevention of Atherosclerotic Events

(2018) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Impaired immune surveillance accelerates accumulation of senescent cells and aging

(2018) Yossi Ovadya et al.   Nature Communications

Replicative senescence promotes prothrombotic responses in endothelial cells: Role of NADPH oxidase- and cyclooxygenase-derived oxidative stress

(2017) Grazielle Caroline Silva et al.   EXPERIMENTAL GERONTOLOGY

Identification of senescent cell surface targetable protein DPP4

(2017) Kyoung Mi Kim et al.   GENES & DEVELOPMENT

Cardiovascular Risk Factors Accelerate Progression of Vascular Aging in the General PopulationNovelty and Significance

(2017) Dimitrios Terentes-Printzios et al.   HYPERTENSION

Senescence and aging: Causes, consequences, and therapeutic avenues

(2017) Domhnall McHugh et al.   JOURNAL OF CELL BIOLOGY

AMPK activation enhances the anti-atherogenic effects of high density lipoproteins in apoE −/− mice

(2017) Ang Ma et al.   JOURNAL OF LIPID RESEARCH

Activation of NLRP3 inflammasomes contributes to hyperhomocysteinemia-aggravated inflammation and atherosclerosis in apoE-deficient mice

(2017) Renqing Wang et al.   LABORATORY INVESTIGATION

Senescence-associated reprogramming promotes cancer stemness

(2017) Maja Milanovic et al.   NATURE

Innate immune sensing of cytosolic chromatin fragments through cGAS promotes senescence

(2017) Selene Glück et al.   NATURE CELL BIOLOGY

Chemical screening identifies ATM as a target for alleviating senescence

(2017) Hyun Tae Kang et al.   Nature Chemical Biology

Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment

(2017) Ok Hee Jeon et al.   NATURE MEDICINE

Senescent cells: an emerging target for diseases of ageing

(2017) Bennett G. Childs et al.   NATURE REVIEWS DRUG DISCOVERY

Antiinflammatory Therapy with Canakinumab for Atherosclerotic Disease

(2017) Paul M Ridker et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of p53-knockout in vascular smooth muscle cells on atherosclerosis in mice

(2017) Richard Yang Cao et al.   PLoS One

Senescent cells expose and secrete an oxidized form of membrane-bound vimentin as revealed by a natural polyreactive antibody

(2017) David Frescas et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

cGAS is essential for cellular senescence

(2017) Hui Yang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Targeting vasa vasorum dysfunction to prevent atherosclerosis

(2017) Erin C. Boyle et al.   VASCULAR PHARMACOLOGY

miR-377 induces senescence in human skin fibroblasts by targeting DNA methyltransferase 1

(2017) Hong-fu Xie et al.   Cell Death & Disease

Cellular senescence mediates fibrotic pulmonary disease

(2017) Marissa J. Schafer et al.   Nature Communications

Identification of HSP90 inhibitors as a novel class of senolytics

(2017) Heike Fuhrmann-Stroissnigg et al.   Nature Communications

Cocktail of chemical compounds robustly promoting cell reprogramming protects liver against acute injury

(2017) Yuewen Tang et al.   Protein & Cell

mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass

(2017) Mee-Sup Yoon   Frontiers in Physiology

Expansions of Cytotoxic CD4+CD28− T Cells Drive Excess Cardiovascular Mortality in Rheumatoid Arthritis and Other Chronic Inflammatory Conditions and Are Triggered by CMV Infection

(2017) Iain Broadley et al.   Frontiers in Immunology

Cellular senescence in the aging and diseased kidney

(2017) F. A. Valentijn et al.   Journal of Cell Communication and Signaling

Telomeres and Cell Senescence - Size Matters Not

(2017) Stella Victorelli et al.   EBioMedicine

Cellular Senescence: A Translational Perspective

(2017) James L. Kirkland et al.   EBioMedicine

Short Leukocyte Telomere Length Precedes Clinical Expression of Atherosclerosis

(2017) Athanase Benetos et al.   CIRCULATION RESEARCH

Osteoprotegerin concentration and risk of cardiovascular outcomes in nine general population studies: Literature-based meta-analysis involving 26,442 participants

(2017) Lena Tschiderer et al.   PLoS One

RNAseq based transcriptomics study of SMCs from carotid atherosclerotic plaque: BMP2 and IDs proteins are crucial regulators of plaque stability

(2017) Iraide Alloza et al.   Scientific Reports

Local Production of Activated Factor X in Atherosclerotic Plaque Induced Vascular Smooth Muscle Cell Senescence

(2017) Fumihiro Sanada et al.   Scientific Reports

The FoxO3 gene and cause-specific mortality

(2016) Bradley J. Willcox et al.   AGING CELL

Chronic senolytic treatment alleviates established vasomotor dysfunction in aged or atherosclerotic mice

(2016) Carolyn M. Roos et al.   AGING CELL

Identification of a novel senolytic agent, navitoclax, targeting the Bcl-2 family of anti-apoptotic factors

(2016) Yi Zhu et al.   AGING CELL

Reversal of phenotypes of cellular senescence by pan-mTOR inhibition

(2016) Hannah E. Walters et al.   Aging-US

Discovery of piperlongumine as a potential novel lead for the development of senolytic agents

(2016) Yingying Wang et al.   Aging-US

How autophagy both activates and inhibits cellular senescence

(2016) Chanhee Kang et al.   Autophagy

Potential therapeutic effects of the MTOR inhibitors for preventing ageing and progeria-related disorders

(2016) Camilla Evangelisti et al.   BRITISH JOURNAL OF CLINICAL PHARMACOLOGY

In Vivo Amelioration of Age-Associated Hallmarks by Partial Reprogramming

(2016) Alejandro Ocampo et al.   CELL

Vascular Smooth Muscle Cells in Atherosclerosis

(2016) Martin R. Bennett et al.   CIRCULATION RESEARCH

From C-Reactive Protein to Interleukin-6 to Interleukin-1

(2016) Paul M Ridker   CIRCULATION RESEARCH

A senescence secretory switch mediated by PI3K/AKT/mTOR activation controls chemoprotective endothelial secretory responses

(2016) Eric H. Bent et al.   GENES & DEVELOPMENT

Effect of Losmapimod on Cardiovascular Outcomes in Patients Hospitalized With Acute Myocardial Infarction

(2016) Michelle L. O’Donoghue et al.   JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION

Preclinical Development of a MicroRNA-Based Therapy for Elderly Patients With Myocardial Infarction

(2016) Shashi Kumar Gupta et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Essential Role for Premature Senescence of Myofibroblasts in Myocardial Fibrosis

(2016) Kathleen Meyer et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Old cells, new tricks: chromatin structure in senescence

(2016) Aled John Parry et al.   MAMMALIAN GENOME

The Mitochondrial Basis of Aging

(2016) Nuo Sun et al.   MOLECULAR CELL

Naturally occurring p16Ink4a-positive cells shorten healthy lifespan

(2016) Darren J. Baker et al.   NATURE

Cellular senescence in renal ageing and disease

(2016) Ines Sturmlechner et al.   Nature Reviews Nephrology

“Inflammaging” as a Druggable Target: A Senescence-Associated Secretory Phenotype—Centered View of Type 2 Diabetes

(2016) Francesco Prattichizzo et al.   Oxidative Medicine and Cellular Longevity

Senescent intimal foam cells are deleterious at all stages of atherosclerosis

(2016) B. G. Childs et al.   SCIENCE

Senescence-associated secretory phenotype contributes to pathological angiogenesis in retinopathy

(2016) M. Oubaha et al.   Science Translational Medicine

Long noncoding RNA Chast promotes cardiac remodeling

(2016) Janika Viereck et al.   Science Translational Medicine

Bone Marrow-Derived Progenitor Cells Are Functionally Impaired in Ischemic Heart Disease

(2016) Evelien Nollet et al.   Journal of Cardiovascular Translational Research

Global and hepatocyte-specific ablation of Bmal1 induces hyperlipidaemia and enhances atherosclerosis

(2016) Xiaoyue Pan et al.   Nature Communications

Directed elimination of senescent cells by inhibition of BCL-W and BCL-XL

(2016) Reut Yosef et al.   Nature Communications

Cellular Senescence Promotes Adverse Effects of Chemotherapy and Cancer Relapse

(2016) Marco Demaria et al.   Cancer Discovery

XIAP-associating factor 1, a transcriptional target of BRD7, contributes to endothelial cell senescence

(2016) Jong-Ik Heo et al.   Oncotarget

Interventions to Slow Aging in Humans: Are We Ready?

(2015) Valter D. Longo et al.   AGING CELL

CMV seropositivity and T-cell senescence predict increased cardiovascular mortality in octogenarians: results from the Newcastle 85+ study

(2015) Ioakim Spyridopoulos et al.   AGING CELL

The Achilles’ heel of senescent cells: from transcriptome to senolytic drugs

(2015) Yi Zhu et al.   AGING CELL

Elevated Plasma Levels of MMP-12 Are Associated With Atherosclerotic Burden and Symptomatic Cardiovascular Disease in Subjects With Type 2 DiabetesSignificance

(2015) Isabel Goncalves et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Senescent Vascular Smooth Muscle Cells Drive Inflammation Through an Interleukin-1α–Dependent Senescence-Associated Secretory PhenotypeSignificance

(2015) Sarah E. Gardner et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Deriving a cardiac ageing signature to reveal MMP-9-dependent inflammatory signalling in senescence

(2015) Yonggang Ma et al.   CARDIOVASCULAR RESEARCH

Emerging translational approaches to target STAT3 signalling and its impact on vascular disease

(2015) Jochen Dutzmann et al.   CARDIOVASCULAR RESEARCH

Vascular Smooth Muscle Cell Senescence Promotes Atherosclerosis and Features of Plaque Vulnerability

(2015) Martin Bennett et al.   CIRCULATION

FOXO3: A Major Gene for Human Longevity - A Mini-Review

(2015) Brian J. Morris et al.   GERONTOLOGY

Matrix Metalloproteinases Promote Arterial Remodeling in Aging, Hypertension, and Atherosclerosis

(2015) M. Wang et al.   HYPERTENSION

Ageing induced vascular smooth muscle cell senescence in atherosclerosis

(2015) Anna K. Uryga et al.   JOURNAL OF PHYSIOLOGY-LONDON

Interleukin 18 function in atherosclerosis is mediated by the interleukin 18 receptor and the Na-Cl co-transporter

(2015) Jing Wang et al.   NATURE MEDICINE

Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice

(2015) Jianhui Chang et al.   NATURE MEDICINE

Cellular senescence in aging and age-related disease: from mechanisms to therapy

(2015) Bennett G Childs et al.   NATURE MEDICINE

JAK inhibition alleviates the cellular senescence-associated secretory phenotype and frailty in old age

(2015) Ming Xu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The DNA damage response induces inflammation and senescence by inhibiting autophagy of GATA4

(2015) C. Kang et al.   SCIENCE

BCL-2 is dispensable for thrombopoiesis and platelet survival

(2015) M A Debrincat et al.   Cell Death & Disease

Non-coding RNAs in ageing

(2014) T. Thum   AGEING RESEARCH REVIEWS

Atorvastatin induces T cell proliferation by a telomerase reverse transcriptase (TERT) mediated mechanism

(2014) Karim Bennaceur et al.   ATHEROSCLEROSIS

A novel BET bromodomain inhibitor, RVX-208, shows reduction of atherosclerosis in hyperlipidemic ApoE deficient mice

(2014) Ravi Jahagirdar et al.   ATHEROSCLEROSIS

P7C3 Neuroprotective Chemicals Function by Activating the Rate-Limiting Enzyme in NAD Salvage

(2014) Gelin Wang et al.   CELL

Mechanisms of Plaque Formation and Rupture

(2014) Jacob Fog Bentzon et al.   CIRCULATION RESEARCH

An Essential Role for Senescent Cells in Optimal Wound Healing through Secretion of PDGF-AA

(2014) Marco Demaria et al.   DEVELOPMENTAL CELL

Senescence and apoptosis: dueling or complementary cell fates?

(2014) B. G. Childs et al.   EMBO REPORTS

Anti-inflammatory therapies for cardiovascular disease

(2014) P. M. Ridker et al.   EUROPEAN HEART JOURNAL

Associations between the CDKN2A/B, ADTRP and PDGFD Polymorphisms and the Development of Coronary Atherosclerosis in Japanese Patients

(2014) Sariya Dechamethakun et al.   Journal of Atherosclerosis and Thrombosis

How Do We Prevent the Vulnerable Atherosclerotic Plaque From Rupturing? Insights From In Vivo Assessments of Plaque, Vascular Remodeling, and Local Endothelial Shear Stress

(2014) Ioannis Andreou et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY AND THERAPEUTICS

Hyperglycemia causes cellular senescence via a SGLT2- and p21-dependent pathway in proximal tubules in the early stage of diabetic nephropathy

(2014) Kento Kitada et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Rejuvenation of the muscle stem cell population restores strength to injured aged muscles

(2014) Benjamin D Cosgrove et al.   NATURE MEDICINE

Leucocyte telomere length and risk of cardiovascular disease: systematic review and meta-analysis

(2014) P. C. Haycock et al.   BMJ-British Medical Journal

Enhancing Chemotherapy Efficacy in Pten -Deficient Prostate Tumors by Activating the Senescence-Associated Antitumor Immunity

(2014) Alberto Toso et al.   Cell Reports

Noncoding RNAs regulate NF-κB signaling to modulate blood vessel inflammation

(2014) Henry S. Cheng et al.   Frontiers in Genetics

Simvastatin suppresses vascular inflammation and atherosclerosis in ApoE−/− mice by downregulating the HMGB1-RAGE axis

(2013) Ming Liu et al.   ACTA PHARMACOLOGICA SINICA

Monitoring Tumorigenesis and Senescence In Vivo with a p16INK4a-Luciferase Model

(2013) Christin E. Burd et al.   CELL

Senescence Is a Developmental Mechanism that Contributes to Embryonic Growth and Patterning

(2013) Mekayla Storer et al.   CELL

Senescent cells spread the word: non-cell autonomous propagation of cellular senescence

(2013) Nilgun Tasdemir et al.   EMBO JOURNAL

Inflammatory cytokines and risk of coronary heart disease: new prospective study and updated meta-analysis

(2013) S. Kaptoge et al.   EUROPEAN HEART JOURNAL

Cellular senescence and the senescent secretory phenotype: therapeutic opportunities

(2013) Tamara Tchkonia et al.   JOURNAL OF CLINICAL INVESTIGATION

MicroRNA-22 increases senescence and activates cardiac fibroblasts in the aging heart

(2012) Virginija Jazbutyte et al.   AGE

Effects of Aging on Angiogenesis

(2012) Johanna Lähteenvuo et al.   CIRCULATION RESEARCH

The Intersection Between Aging and Cardiovascular Disease

(2012) Brian J. North et al.   CIRCULATION RESEARCH

Aging and Atherosclerosis

(2012) Julie C. Wang et al.   CIRCULATION RESEARCH

Flavonoid Apigenin Is an Inhibitor of the NAD+ase CD38: Implications for Cellular NAD+ Metabolism, Protein Acetylation, and Treatment of Metabolic Syndrome

(2012) C. Escande et al.   DIABETES

Granule exocytosis mediates immune surveillance of senescent cells

(2012) A Sagiv et al.   ONCOGENE

The miRNA-212/132 family regulates both cardiac hypertrophy and cardiomyocyte autophagy

(2012) Ahmet Ucar et al.   Nature Communications

The NLRP3 Inflammasome Promotes Age-Related Thymic Demise and Immunosenescence

(2012) Yun-Hee Youm et al.   Cell Reports

HMGB1 Is a Therapeutic Target for Sterile Inflammation and Infection

(2011) Ulf Andersson et al.   Annual Review of Immunology

Cdkn2a Is an Atherosclerosis Modifier Locus That Regulates Monocyte/Macrophage Proliferation

(2011) Chao-Ling Kuo et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pioglitazone activates aortic telomerase and prevents stress-induced endothelial apoptosis

(2011) Christian Werner et al.   ATHEROSCLEROSIS

Expression of the aging gene p66Shc is increased in peripheral blood monocytes of patients with acute coronary syndrome but not with stable coronary artery disease

(2011) Fabian C. Franzeck et al.   ATHEROSCLEROSIS

MicroRNA therapeutics in cardiovascular medicine

(2011) Thomas Thum   EMBO Molecular Medicine

Rejuvenating senescent and centenarian human cells by reprogramming through the pluripotent state

(2011) L. Lapasset et al.   GENES & DEVELOPMENT

Control of the senescence-associated secretory phenotype by NF- B promotes senescence and enhances chemosensitivity

(2011) Y. Chien et al.   GENES & DEVELOPMENT

p66Shc Aging Protein in Control of Fibroblasts Cell Fate

(2011) Jan M. Suski et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Clearance of p16Ink4a-positive senescent cells delays ageing-associated disorders

(2011) Darren J. Baker et al.   NATURE

The Senescence-Associated Secretory Phenotype: The Dark Side of Tumor Suppression

(2010) Jean-Philippe Coppé et al.   Annual Review of Pathology-Mechanisms of Disease

Monocyte Chemoattractant Protein-1 Deficiency Protects Against Visceral Fat-Induced Atherosclerosis

(2010) Miina K. Öhman et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Expression of Chr9p21 genes CDKN2B (p15INK4b), CDKN2A (p16INK4a, p14ARF) and MTAP in human atherosclerotic plaque

(2010) Lesca Miriam Holdt et al.   ATHEROSCLEROSIS

Heat shock protein 90 inhibitors attenuate inflammatory responses in atherosclerosis

(2010) Julio Madrigal-Matute et al.   CARDIOVASCULAR RESEARCH

Downregulation of the Longevity-Associated Protein Sirtuin 1 in Insulin Resistance and Metabolic Syndrome: Potential Biochemical Mechanisms

(2010) S. V. de Kreutzenberg et al.   DIABETES

Pathophysiology of vascular calcification: Pivotal role of cellular senescence in vascular smooth muscle cells

(2010) D.G.A. Burton et al.   EXPERIMENTAL GERONTOLOGY

DNMT3a plays a role in switches between doxorubicin-induced senescence and apoptosis of colorectal cancer cells

(2010) Yu Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Inflammatory networks during cellular senescence: causes and consequences

(2010) Adam Freund et al.   TRENDS IN MOLECULAR MEDICINE

Is Age Really a Non-Modifiable Cardiovascular Risk Factor?

(2009) William B. Kannel et al.   AMERICAN JOURNAL OF CARDIOLOGY

Increased serum HMGB1 is related to the severity of coronary artery stenosis

(2009) Xiaorong Hu et al.   CLINICA CHIMICA ACTA

Inflammation in Atherosclerosis

(2009) Peter Libby et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

INK4/ARF Transcript Expression Is Associated with Chromosome 9p21 Variants Linked to Atherosclerosis

(2009) Yan Liu et al.   PLoS One

Matrix Metalloproteinase 12 Accelerates the Initiation of Atherosclerosis and Stimulates the Progression of Fatty Streaks to Fibrous Plaques in Transgenic Rabbits

(2008) Sohsuke Yamada et al.   AMERICAN JOURNAL OF PATHOLOGY

Osteoprotegerin, vascular calcification and atherosclerosis

(2008) Ann Van Campenhout et al.   ATHEROSCLEROSIS

FoxO transcription factors in oxidative stress response and ageing – a new fork on the way to longevity?

(2008) Daniel G. Sedding   BIOLOGICAL CHEMISTRY

Senescence of Activated Stellate Cells Limits Liver Fibrosis

(2008) Valery Krizhanovsky et al.   CELL

Aging and Disease as Modifiers of Efficacy of Cell Therapy

(2008) Stefanie Dimmeler et al.   CIRCULATION RESEARCH

p66ShcDeletion Confers Vascular Protection in Advanced Atherosclerosis in Hypercholesterolemic Apolipoprotein E Knockout Mice

(2008) Ines Martin-Padura et al.   ENDOTHELIUM-JOURNAL OF ENDOTHELIAL CELL RESEARCH

Hypertension Induces Somatic Cellular Senescence in Rats and Humans by Induction of Cell Cycle Inhibitor p16 INK4a

(2008) Jens H. Westhoff et al.   HYPERTENSION

Vascular endothelial senescence: from mechanisms to pathophysiology

(2008) Jorge D. Erusalimsky   JOURNAL OF APPLIED PHYSIOLOGY

MicroRNA-21 contributes to myocardial disease by stimulating MAP kinase signalling in fibroblasts

(2008) Thomas Thum et al.   NATURE

Senescence-Associated Secretory Phenotypes Reveal Cell-Nonautonomous Functions of Oncogenic RAS and the p53 Tumor Suppressor

(2008) Jean-Philippe Coppé et al.   PLOS BIOLOGY