mTOR as a Key Regulator in Maintaining Skeletal Muscle Mass

Resistance exercise initiates mechanistic target of rapamycin (mTOR) translocation and protein complex co-localisation in human skeletal muscle

(2017) Zhe Song et al.   Scientific Reports

From Nutrient to MicroRNA: a Novel Insight into Cell Signaling Involved in Skeletal Muscle Development and Disease

(2016) Yong Zhang et al.   International Journal of Biological Sciences

mTORC1 and muscle regeneration are regulated by the LINC00961-encoded SPAR polypeptide

(2016) Akinobu Matsumoto et al.   NATURE

Effect of age on basal muscle protein synthesis and mTORC1 signaling in a large cohort of young and older men and women

(2015) Melissa M. Markofski et al.   EXPERIMENTAL GERONTOLOGY

Rapid Mitogenic Regulation of the mTORC1 Inhibitor, DEPTOR, by Phosphatidic Acid

(2015) Mee-Sup Yoon et al.   MOLECULAR CELL

The regulation of muscle mass by endogenous glucocorticoids

(2015) Theodore P. Braun et al.   Frontiers in Physiology

Spatial Control of the TSC Complex Integrates Insulin and Nutrient Regulation of mTORC1 at the Lysosome

(2014) Suchithra Menon et al.   CELL

TGFβ and BMP signaling in skeletal muscle: potential significance for muscle-related disease

(2014) Roberta Sartori et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

The Intriguing Regulators of Muscle Mass in Sarcopenia and Muscular Dystrophy

(2014) Kunihiro Sakuma et al.   Frontiers in Aging Neuroscience

Reductions in serum IGF-1 during aging impair health span

(2013) Zhenwei Gong et al.   AGING CELL

Signalling pathways regulating muscle mass in ageing skeletal muscle. The role of the IGF1-Akt-mTOR-FoxO pathway

(2013) M. Sandri et al.   BIOGERONTOLOGY

Sustained Activation of mTORC1 in Skeletal Muscle Inhibits Constitutive and Starvation-Induced Autophagy and Causes a Severe, Late-Onset Myopathy

(2013) Perrine Castets et al.   Cell Metabolism

The role of insulin-like-growth factor binding protein 2 (IGFBP2) and phosphatase and tensin homologue (PTEN) in the regulation of myoblast differentiation and hypertrophy

(2013) Adam P. Sharples et al.   GROWTH HORMONE & IGF RESEARCH

The Role of Diacylglycerol Kinase ζ and Phosphatidic Acid in the Mechanical Activation of Mammalian Target of Rapamycin (mTOR) Signaling and Skeletal Muscle Hypertrophy

(2013) Jae-Sung You et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Eccentric contractions increase the phosphorylation of tuberous sclerosis complex-2 (TSC2) and alter the targeting of TSC2 and the mechanistic target of rapamycin to the lysosome

(2013) Brittany L. Jacobs et al.   JOURNAL OF PHYSIOLOGY-LONDON

Impaired hypertrophy in myoblasts is improved with testosterone administration

(2013) Colleen S. Deane et al.   JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY

mTOR is a key modulator of ageing and age-related disease

(2013) Simon C. Johnson et al.   NATURE

Signal integration by mTORC1 coordinates nutrient input with biosynthetic output

(2013) Christian C. Dibble et al.   NATURE CELL BIOLOGY

Preserving Youth: Does Rapamycin Deliver?

(2013) S. C. Johnson et al.   Science Translational Medicine

Gene expression analysis of mTOR pathway: association with human longevity

(2012) Willemijn M. Passtoors et al.   AGING CELL

mTOR Signaling in Growth Control and Disease

(2012) Mathieu Laplante et al.   CELL

TOR Signaling and Rapamycin Influence Longevity by Regulating SKN-1/Nrf and DAF-16/FoxO

(2012) Stacey Robida-Stubbs et al.   Cell Metabolism

Sarcopenia in older adults

(2012) Jeremy D. Walston   CURRENT OPINION IN RHEUMATOLOGY

Follistatin-mediated skeletal muscle hypertrophy is regulated by Smad3 and mTOR independently of myostatin

(2012) Catherine E. Winbanks et al.   JOURNAL OF CELL BIOLOGY

Reduced AMPK-ACC and mTOR signaling in muscle from older men, and effect of resistance exercise

(2012) Mengyao Li et al.   MECHANISMS OF AGEING AND DEVELOPMENT

Rapamycin Reverses Elevated mTORC1 Signaling in Lamin A/C-Deficient Mice, Rescues Cardiac and Skeletal Muscle Function, and Extends Survival

(2012) F. J. Ramos et al.   Science Translational Medicine

Myostatin promotes the wasting of human myoblast cultures through promoting ubiquitin-proteasome pathway-mediated loss of sarcomeric proteins

(2011) Sudarsanareddy Lokireddy et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Crosstalk between Glucocorticoid Receptor and Nutritional Sensor mTOR in Skeletal Muscle

(2011) Noriaki Shimizu et al.   Cell Metabolism

Mechanotransduction and the regulation of mTORC1 signaling in skeletal muscle

(2011) Troy A. Hornberger   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Class III PI-3-kinase activates phospholipase D in an amino acid–sensing mTORC1 pathway

(2011) Mee-Sup Yoon et al.   JOURNAL OF CELL BIOLOGY

IGF-II is regulated by microRNA-125b in skeletal myogenesis

(2011) Yejing Ge et al.   JOURNAL OF CELL BIOLOGY

Lysosomal positioning coordinates cellular nutrient responses

(2011) Viktor I. Korolchuk et al.   NATURE CELL BIOLOGY

Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis

(2011) Christopher S Fry et al.   Skeletal Muscle

Regulation of skeletal muscle growth by the IGF1-Akt/PKB pathway: insights from genetic models

(2011) Stefano Schiaffino et al.   Skeletal Muscle

CCAAT/enhancer binding protein-δ expression is increased in fast skeletal muscle by food deprivation and regulates myostatin transcription in vitro

(2010) David L. Allen et al.   AMERICAN JOURNAL OF PHYSIOLOGY-REGULATORY INTEGRATIVE AND COMPARATIVE PHYSIOLOGY

Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids

(2010) Yasemin Sancak et al.   CELL

Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster

(2010) Ivana Bjedov et al.   Cell Metabolism

Anabolic and catabolic pathways regulating skeletal muscle mass

(2010) John J McCarthy et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

Pharmacological Vasodilation Improves Insulin-Stimulated Muscle Protein Anabolism but Not Glucose Utilization in Older Adults

(2010) K. L. Timmerman et al.   DIABETES

Mechanisms involved in the enhancement of mammalian target of rapamycin signalling and hypertrophy in skeletal muscle of myostatin-deficient mice

(2010) Christopher Lipina et al.   FEBS LETTERS

Mammalian target of rapamycin regulates miRNA-1 and follistatin in skeletal myogenesis

(2010) Yuting Sun et al.   JOURNAL OF CELL BIOLOGY

Myostatin reduces Akt/TORC1/p70S6K signaling, inhibiting myoblast differentiation and myotube size

(2009) Anne Ulrike Trendelenburg et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Smad2 and 3 transcription factors control muscle mass in adulthood

(2009) Roberta Sartori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Stimulation of skeletal muscle myofibrillar protein synthesis, p70 S6 kinase phosphorylation, and ribosomal protein S6 phosphorylation by inhibition of myostatin in mature mice

(2009) Stephen Welle et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Muscle inactivation of mTOR causes metabolic and dystrophin defects leading to severe myopathy

(2009) Valérie Risson et al.   JOURNAL OF CELL BIOLOGY

The role of phosphoinositide 3-kinase and phosphatidic acid in the regulation of mammalian target of rapamycin following eccentric contractions

(2009) T. K. O’Neil et al.   JOURNAL OF PHYSIOLOGY-LONDON

Effects of Chronic Overload on Muscle Hypertrophy and mTOR Signaling in Young Adult and Aged Rats

(2009) A. Chale-Rush et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Molecular mechanisms of mTOR-mediated translational control

(2009) Xiaoju Max Ma et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

DNA Binding Site Sequence Directs Glucocorticoid Receptor Structure and Activity

(2009) S. H. Meijsing et al.   SCIENCE

The TSC1–TSC2 complex: a molecular switchboard controlling cell growth

(2008) Jingxiang Huang et al.   BIOCHEMICAL JOURNAL

Fast/Glycolytic Muscle Fiber Growth Reduces Fat Mass and Improves Metabolic Parameters in Obese Mice

(2008) Yasuhiro Izumiya et al.   Cell Metabolism

Skeletal Muscle-Specific Ablation of raptor, but Not of rictor, Causes Metabolic Changes and Results in Muscle Dystrophy

(2008) C. Florian Bentzinger et al.   Cell Metabolism

Down-Regulation of Akt/Mammalian Target of Rapamycin Signaling Pathway in Response to Myostatin Overexpression in Skeletal Muscle

(2008) Adel Amirouche et al.   ENDOCRINOLOGY

Hypoxia regulates TSC1/2 mTOR signaling and tumor suppression through REDD1-mediated 14 3 3 shuttling

(2008) M. P. DeYoung et al.   GENES & DEVELOPMENT

Skeletal muscle protein anabolic response to resistance exercise and essential amino acids is delayed with aging

(2008) Micah J. Drummond et al.   JOURNAL OF APPLIED PHYSIOLOGY

Mechanisms of glucocorticoid-induced myopathy

(2008) O Schakman et al.   JOURNAL OF ENDOCRINOLOGY

Human Sarcopenia Reveals an Increase in SOCS-3 and Myostatin and a Reduced Efficiency of Akt Phosphorylation

(2008) Bertrand Léger et al.   REJUVENATION RESEARCH

The Rag GTPases Bind Raptor and Mediate Amino Acid Signaling to mTORC1

(2008) Y. Sancak et al.   SCIENCE

A functional insulin-like growth factor receptor is not necessary for load-induced skeletal muscle hypertrophy

(2007) Espen E. Spangenburg et al.   JOURNAL OF PHYSIOLOGY-LONDON