Emerging translational approaches to target STAT3 signalling and its impact on vascular disease

Modulation of vascular smooth muscle cell phenotype by STAT-1 and STAT-3

(2014) Mayumi Namekata Kirchmer et al.   ATHEROSCLEROSIS

Inhibition of miR-92a improves re-endothelialization and prevents neointima formation following vascular injury

(2014) J.-M. Daniel et al.   CARDIOVASCULAR RESEARCH

STAT3, a key regulator of cell-to-cell communication in the heart

(2014) Arash Haghikia et al.   CARDIOVASCULAR RESEARCH

Adventitial Fibroblasts Induce a Distinct Proinflammatory/Profibrotic Macrophage Phenotype in Pulmonary Hypertension

(2014) Karim C. El Kasmi et al.   JOURNAL OF IMMUNOLOGY

Safety and efficacy profiles of tocilizumab monotherapy in Japanese patients with rheumatoid arthritis: meta-analysis of six initial trials and five long-term extensions

(2014) Norihiro Nishimoto et al.   Modern Rheumatology

Pathophysiology and epidemiology of peripartum cardiomyopathy

(2014) Denise Hilfiker-Kleiner et al.   Nature Reviews Cardiology

Tofacitinib versus Methotrexate in Rheumatoid Arthritis

(2014) Eun Bong Lee et al.   NEW ENGLAND JOURNAL OF MEDICINE

STAT3 Oligonucleotide Inhibits Tumor Angiogenesis in Preclinical Models of Squamous Cell Carcinoma

(2014) Jonah D. Klein et al.   PLoS One

Network Analysis of Inflammatory Genes and Their Transcriptional Regulators in Coronary Artery Disease

(2014) Jiny Nair et al.   PLoS One

Evaluation of the prevalence and prospective clinical impact of theJAK2 V617Fmutation in coronary patients

(2013) Axel Muendlein et al.   AMERICAN JOURNAL OF HEMATOLOGY

Effect of interleukin-6 receptor blockade on surrogates of vascular risk in rheumatoid arthritis: MEASURE, a randomised, placebo-controlled study

(2013) Iain B McInnes et al.   ANNALS OF THE RHEUMATIC DISEASES

Inhibition of VEGF expression through blockade of Hif1α and STAT3 signalling mediates the anti-angiogenic effect of melatonin in HepG2 liver cancer cells

(2013) S Carbajo-Pescador et al.   BRITISH JOURNAL OF CANCER

Inhibition of MicroRNA-92a Prevents Endothelial Dysfunction and Atherosclerosis in Mice

(2013) Xavier Loyer et al.   CIRCULATION RESEARCH

Selective JAK/STAT3 signalling regulates transcription of colony stimulating factor-2 and -3 in Concanavalin-A-activated mesenchymal stromal cells

(2013) Alain Zgheib et al.   CYTOKINE

STAT3 activity is necessary and sufficient for the development of immune-mediated myocarditis in mice and promotes progression to dilated cardiomyopathy

(2013) Annalisa Camporeale et al.   EMBO Molecular Medicine

Monocytes and smooth muscle cells cross-talk activates STAT3 and induces resistin and reactive oxygen species and production

(2013) Ana Maria Gan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Stat3β mitigates development of atherosclerosis in apolipoprotein E-deficient mice

(2013) Jihyun Lee et al.   JOURNAL OF MOLECULAR MEDICINE-JMM

Critical Role for the Advanced Glycation End‐Products Receptor in Pulmonary Arterial Hypertension Etiology

(2013) Jolyane Meloche et al.   Journal of the American Heart Association

Inhibition of STAT3 signaling prevents vascular smooth muscle cell proliferation and neointima formation

(2012) Jan-Marcus Daniel et al.   BASIC RESEARCH IN CARDIOLOGY

Small-Molecule Inhibitors of Signal Transducer and Activator of Transcription 3 Protect Against Angiotensin II–Induced Vascular Dysfunction and Hypertension

(2012) Andrew W. Johnson et al.   HYPERTENSION

From Macrophage Interleukin-13 Receptor to Foam Cell Formation

(2012) Valentin P. Yakubenko et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SB1578, a Novel Inhibitor of JAK2, FLT3, and c-Fms for the Treatment of Rheumatoid Arthritis

(2012) B. Madan et al.   JOURNAL OF IMMUNOLOGY

The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis

(2012)   LANCET

On-target JAK2/STAT3 inhibition slows disease progression in orthotopic xenografts of human glioblastoma brain tumor stem cells

(2012) Owen D. Stechishin et al.   NEURO-ONCOLOGY

A Double-Blind, Placebo-Controlled Trial of Ruxolitinib for Myelofibrosis

(2012) Srdan Verstovsek et al.   NEW ENGLAND JOURNAL OF MEDICINE

JAK Inhibition with Ruxolitinib versus Best Available Therapy for Myelofibrosis

(2012) Claire Harrison et al.   NEW ENGLAND JOURNAL OF MEDICINE

Tofacitinib, an Oral Janus Kinase Inhibitor, in Active Ulcerative Colitis

(2012) William J. Sandborn et al.   NEW ENGLAND JOURNAL OF MEDICINE

First-in-Human Trial of a STAT3 Decoy Oligonucleotide in Head and Neck Tumors: Implications for Cancer Therapy

(2012) Malabika Sen et al.   Cancer Discovery

A pilot study of endothelial dysfunction and aortic stiffness after interleukin-6 receptor inhibition in rheumatoid arthritis

(2011) A.D. Protogerou et al.   ATHEROSCLEROSIS

Anti-inflammatory, anti-proliferative and anti-atherosclerotic effects of quercetin in human in vitro and in vivo models

(2011) Robert Kleemann et al.   ATHEROSCLEROSIS

Oncostatin M is expressed in atherosclerotic lesions: A role for Oncostatin M in the pathogenesis of atherosclerosis

(2011) Adaia Albasanz-Puig et al.   ATHEROSCLEROSIS

Antiangiogenic and Antimetastatic Activity of JAK Inhibitor AZD1480

(2011) H. Xin et al.   CANCER RESEARCH

Erythropoietin Preserves the Endothelial Differentiation Capacity of Cardiac Progenitor Cells and Reduces Heart Failure during Anticancer Therapies

(2011) Melanie Hoch et al.   Cell Stem Cell

Signal Transducers and Activators of Transcription-3/Pim1 Axis Plays a Critical Role in the Pathogenesis of Human Pulmonary Arterial Hypertension

(2011) Roxane Paulin et al.   CIRCULATION

Interleukin-6 Protects Human Macrophages from Cellular Cholesterol Accumulation and Attenuates the Proinflammatory Response

(2011) Eric Frisdal et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

15-Lipoxygenase-1-enhanced Src-Janus Kinase 2-Signal Transducer and Activator of Transcription 3 Stimulation and Monocyte Chemoattractant Protein-1 Expression Require Redox-sensitive Activation of Epidermal Growth Factor Receptor in Vascular Wall Remodeling

(2011) Nikhlesh K. Singh et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Apigenin attenuates neointima formation via suppression of vascular smooth muscle cell phenotypic transformation

(2011) Hongjing Guan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Role for miR-204 in human pulmonary arterial hypertension

(2011) Audrey Courboulin et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular mechanisms and clinical applications of angiogenesis

(2011) Peter Carmeliet et al.   NATURE

Progress and challenges in translating the biology of atherosclerosis

(2011) Peter Libby et al.   NATURE

Indirubin-3′-Monoxime Blocks Vascular Smooth Muscle Cell Proliferation by Inhibition of Signal Transducer and Activator of Transcription 3 Signaling and Reduces Neointima Formation In Vivo

(2010) Andrea V. Schwaiberger et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Time-Course Analysis on the Differentiation of Bone Marrow-Derived Progenitor Cells Into Smooth Muscle Cells During Neointima Formation

(2010) Jan-Marcus Daniel et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

AAV/hSTAT3-gene delivery lowers aortic inflammatory cell infiltration in LDLR KO mice on high cholesterol

(2010) Junaid A. Khan et al.   ATHEROSCLEROSIS

Oncostatin M-enhanced vascular endothelial growth factor expression in human vascular smooth muscle cells involves PI3K-, p38 MAPK-, Erk1/2- and STAT1/STAT3-dependent pathways and is attenuated by interferon-γ

(2010) Svitlana Demyanets et al.   BASIC RESEARCH IN CARDIOLOGY

STAT3 inhibitor WP1066 as a novel therapeutic agent for renal cell carcinoma

(2010) A Horiguchi et al.   BRITISH JOURNAL OF CANCER

Vascular endothelial growth factor is crucial for erythropoietin-induced improvement of cardiac function in heart failure

(2010) B. Daan Westenbrink et al.   CARDIOVASCULAR RESEARCH

Continuous Glycoprotein-130–Mediated Signal Transducer and Activator of Transcription-3 Activation Promotes Inflammation, Left Ventricular Rupture, and Adverse Outcome in Subacute Myocardial Infarction

(2010) Denise Hilfiker-Kleiner et al.   CIRCULATION

Statins potently reduce the cytokine-mediated IL-6 release in SMC/MNC cocultures

(2010) Harald Loppnow et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Stat3-dependent acute Rantes production in vascular smooth muscle cells modulates inflammation following arterial injury in mice

(2010) Jason C. Kovacic et al.   JOURNAL OF CLINICAL INVESTIGATION

Stat3 as a Therapeutic Target for the Treatment of Psoriasis: A Clinical Feasibility Study with STA-21, a Stat3 Inhibitor

(2010) Ken Miyoshi et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Safety and Efficacy of INCB018424, a JAK1 and JAK2 Inhibitor, in Myelofibrosis

(2010) Srdan Verstovsek et al.   NEW ENGLAND JOURNAL OF MEDICINE

Suppressors of Cytokine Signaling Modulate JAK/STAT-Mediated Cell Responses During Atherosclerosis

(2009) Guadalupe Ortiz-Muñoz et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Interleukin-6 Modulates the Expression of the Bone Morphogenic Protein Receptor Type II Through a Novel STAT3–microRNA Cluster 17/92 Pathway

(2009) Matthias Brock et al.   CIRCULATION RESEARCH

Humanized Anti-Interleukin-6 Receptor Antibody Suppresses Tumor Angiogenesis and In vivo Growth of Human Oral Squamous Cell Carcinoma

(2009) S. Shinriki et al.   CLINICAL CANCER RESEARCH

Endothelin-1 Impairs Nitric Oxide Signaling in Endothelial Cells Through a Protein Kinase Cδ-Dependent Activation of STAT3 and Decreased Endothelial Nitric Oxide Synthase Expression

(2009) Neetu Sud et al.   DNA AND CELL BIOLOGY

Loss of SOCS3 expression in T cells reveals a regulatory role for interleukin-17 in atherosclerosis

(2009) Soraya Taleb et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Enantioselective Synthesis of Janus Kinase Inhibitor INCB018424 via an Organocatalytic Aza-Michael Reaction

(2009) Qiyan Lin et al.   ORGANIC LETTERS

A Novel Inhibitor of Signal Transducers And Activators Of Transcription 3 Activation Is Efficacious Against Established Central Nervous System Melanoma and Inhibits Regulatory T Cells

(2008) L.-Y. Kong et al.   CLINICAL CANCER RESEARCH

Pravastatin Prevents Aortic Atherosclerosis via Modulation of Signal Transduction and Activation of Transcription 3 (STAT3) to Attenuate Interleukin-6 (IL-6) Action in ApoE Knockout Mice

(2008) Xiaoxu Zhou et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A sonic hedgehog signaling domain in the arterial adventitia supports resident Sca1+ smooth muscle progenitor cells

(2008) J. N. Passman et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

STAT3: A critical transcription activator in angiogenesis

(2007) Zhong Chen et al.   MEDICINAL RESEARCH REVIEWS