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Title
The mercapturic acid pathway
Authors
Keywords
-
Journal
CRITICAL REVIEWS IN TOXICOLOGY
Volume 49, Issue 10, Pages 819-929
Publisher
Informa UK Limited
Online
2020-01-17
DOI
10.1080/10408444.2019.1692191
References
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- Reduction of Dimethylarsinic Acid to the Highly Toxic Dimethylarsinous Acid by Rats and Rat Liver Cytosol
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- FDA-approved drugs and other compounds tested as inhibitors of human glutathione transferase P1-1
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- Donor substrate specificity of bovine kidney gamma-glutamyltransferase
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- Aminoacylase I deficiency due to ACY1 mRNA exon skipping
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- Tosedostat for the treatment of relapsed and refractory acute myeloid leukemia
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- Mitochondria are targets for peroxisome-derived oxidative stress in cultured mammalian cells
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- Overexpression of aminoacylase 1 is associated with colorectal cancer progression
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- Novel Insights into Eukaryotic γ-Glutamyltranspeptidase 1 from the Crystal Structure of the Glutamate-bound Human Enzyme
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- A Role for Glutathione Transferase Omega 1 (GSTO1-1) in the Glutathionylation Cycle
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- The Impact of Nitric Oxide Toxicity on the Evolution of the Glutathione Transferase Superfamily
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- Using multiple measures for quantitative trait association analyses: application to estimated glomerular filtration rate
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- Hybrid Molecule from O2-(2,4-Dinitrophenyl)diazeniumdiolate and Oleanolic Acid: A Glutathione S-Transferase π-Activated Nitric Oxide Prodrug with Selective Anti-Human Hepatocellular Carcinoma Activity and Improved Stability
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- Serum aminoacylase-1 is a novel biomarker with potential prognostic utility for long-term outcome in patients with delayed graft function following renal transplantation
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- Use of Bru-Seq and BruChase-Seq for genome-wide assessment of the synthesis and stability of RNA
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- Analysis of the Human Tissue-specific Expression by Genome-wide Integration of Transcriptomics and Antibody-based Proteomics
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- The SLCO (former SLC21) superfamily of transporters
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- Exploration of structural and physicochemical requirements and search of virtual hits for aminopeptidase N inhibitors
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- The Interaction of the Chemotherapeutic Drug Chlorambucil with Human Glutathione Transferase A1-1: Kinetic and Structural Analysis
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- Structural Insights into Omega-Class Glutathione Transferases: A Snapshot of Enzyme Reduction and Identification of a Non-Catalytic Ligandin Site
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- Identification of orally bioavailable small-molecule inhibitors of hematopoietic prostaglandin D2 synthase using X-ray fragment based drug discovery
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- Cysteine-reactive chemical probes based on a modular 4-aminopiperidine scaffold
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- Renal Organic Anion Transporters (SLC22 Family): Expression, Regulation, Roles in Toxicity, and Impact on Injury and Disease
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- MAP3K7 and GSTZ1 are associated with human longevity: a two-stage case–control study using a multilocus genotyping
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- An Inhibitor of Glutathione S-Transferase Omega 1 that Selectively Targets Apoptotic Cells
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- Glutathione-S-Transferases As Determinants of Cell Survival and Death
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- Association of glutathione S-transferase Ω 1-1 polymorphisms (A140D and E208K) with the expression of interleukin-8 (IL-8), transforming growth factor beta (TGF-β), and apoptotic protease-activating factor 1 (Apaf-1) in humans chronically exposed to arsenic in drinking water
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- Metabolism of arsenic and its toxicological relevance
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- Probing the Donor and Acceptor Substrate Specificity of the γ-Glutamyl Transpeptidase
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- New Insights into the Mechanism of JNK1 Inhibition by Glutathione Transferase P1-1
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- Glutathione and glutathione analogues; Therapeutic potentials
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- Glutathione transferases, regulators of cellular metabolism and physiology
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- Glutathione catalysis and the reaction mechanisms of glutathione-dependent enzymes
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- Aminoacylase 1-catalysed deacetylation of bioactives epoxides mycotoxin-derived mercapturates; 3,4-epoxyprecocenes as models of cytotoxic epoxides
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- Rapid and efficient synthesis of a novel series of substituted aminobenzosuberone derivatives as potent, selective, non-peptidic neutral aminopeptidase inhibitors
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- Design, synthesis and biological evaluation of novel amino acid ureido derivatives as aminopeptidase N/CD13 inhibitors
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- Novel indoline-2,3-dione derivatives as inhibitors of aminopeptidase N (APN)
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- Investigation of the binding pocket of human hematopoietic prostaglandin (PG) D2 synthase (hH-PGDS): A tale of two waters
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- γ-Glutamyltranspeptidases: sequence, structure, biochemical properties, and biotechnological applications
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- Identifying and Characterizing Binding Sites on the Irreversible Inhibition of Human Glutathione S-Transferase P1-1 by S-Thiocarbamoylation
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- Universal Caging Group for the in-Cell Detection of Glutathione Transferase Applied to 19F NMR and Bioluminogenic Probes
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- The Characteristics, Functions and Inhibitors of Three Aminopeptidases Belonging to the M1 Family
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- Inhibition and induction of glutathione S-transferases by flavonoids: possible pharmacological and toxicological consequences
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- Aminoacylase 3 binds to and cleaves the N-terminus of the hepatitis C virus core protein
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- The impact of glutathione transferase kappa deficiency on adiponectin multimerisation in vivo
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- Human hematopoietic prostaglandin D synthase inhibitor complex structures
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- GlutathioneS-Transferase Omega 1 Activity Is Sufficient to Suppress Neurodegeneration in aDrosophilaModel of Parkinson Disease
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- Biochemical Inhibition of the Acetyltransferases ATase1 and ATase2 Reduces β-Secretase (BACE1) Levels and Aβ Generation
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- The X-ray Crystal Structure of Human Aminopeptidase N Reveals a Novel Dimer and the Basis for Peptide Processing
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- Design, synthesis and preliminary activity evaluation of novel 3-amino-2-hydroxyl-3-phenylpropanoic acid derivatives as aminopeptidase N/CD13 inhibitors
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- Synthesis and Study of 2-(Pyrrolesulfonylmethyl)-N-arylimines: A New Class of Inhibitors for Human Glutathione Transferase A1-1
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- Structural Insights into the Dehydroascorbate Reductase Activity of Human Omega-Class Glutathione Transferases
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- Rational Design of Highly Sensitive Fluorescence Probes for Protease and Glycosidase Based on Precisely Controlled Spirocyclization
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- Glutathione S-transferase omega genes in Alzheimer and Parkinson disease risk, age-at-diagnosis and brain gene expression: an association study with mechanistic implications
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- Synthesis and Modifications of Phosphinic Dipeptide Analogues
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- The first ratiometric fluorescent probes for aminopeptidase N cell imaging
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- PharmGKB summary
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- Structural basis for multifunctional roles of mammalian aminopeptidase N
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- Synthesis, cellular evaluation, and mechanism of action of piperlongumine analogs
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- Design, Synthesis, and Activity Evaluation of a New 5-fluorouracil Prodrug Containing an Asn-Gly-Arg(NO2)COOCH3 Tripeptide
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- Inhibition of aminoacylase 3 protects rat brain cortex neuronal cells from the toxicity of 4-hydroxy-2-nonenal mercapturate and 4-hydroxy-2-nonenal
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- Human cytosolic glutathione transferases: structure, function, and drug discovery
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- Proteomic analysis of glutathione S-transferase isoforms in mouse liver mitochondria
- (2012) Hai-Dan Sun WORLD JOURNAL OF GASTROENTEROLOGY
- Hydrolysis of S-aryl-cysteinylglycine conjugates catalyzed by porcine kidney cortex membrane dipeptidase
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- Development of Synthetic Aminopeptidase N/CD13 Inhibitors to Overcome Cancer Metastasis and Angiogenesis
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- Computational Evidence for the Catalytic Mechanism of Human Glutathione S-Transferase A3-3: A QM/MM Investigation
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- Structural Bases of Coronavirus Attachment to Host Aminopeptidase N and Its Inhibition by Neutralizing Antibodies
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- Glutathione transferase pi (GSTpi) expression in breast cancer: An immunohistochemical and molecular study
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- Gamma-glutamyl compounds: Substrate specificity of gamma-glutamyl transpeptidase enzymes
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- Niemann-Pick C1-Like 1 (NPC1L1) Protein in Intestinal and Hepatic Cholesterol Transport
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- Functional studies of single-nucleotide polymorphic variants of human glutathione transferase T1-1 involving residues in the dimer interface
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- The role of a membrane-bound glutathione transferase in the peroxynitrite-induced mitochondrial permeability transition pore: Formation of a disulfide-linked protein complex
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- Crystal structures and kinetic studies of human Kappa class glutathione transferase provide insights into the catalytic mechanism
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- The molecular basis of aminoacylase 1 deficiency
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- A novel amino-benzosuberone derivative is a picomolar inhibitor of mammalian aminopeptidase N/CD13
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- Amino-benzosuberone: A novel warhead for selective inhibition of human aminopeptidase-N/CD13
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- Novel potent 2,5-pyrrolidinedione peptidomimetics as aminopeptidase N inhibitors. Design, synthesis and activity evaluation
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- OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies
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- Studies of Glutathione Transferase P1-1 Bound to a Platinum(IV)-Based Anticancer Compound Reveal the Molecular Basis of Its Activation
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- Recent Advance in Aminopeptidase N (APN/CD13) Inhibitor Research
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- The Many Faces of Glutathione Transferase Pi
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- Susceptibility to Breast Cancer and Three Polymorphisms of GSTZ1
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- Interactions of glutathione transferases with 4-hydroxynonenal
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- The glutathione transferase kappa family
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- Mechanisms of induction of cytosolic and microsomal glutathione transferase (GST) genes by xenobiotics and pro-inflammatory agents
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- Regulation of the cardiac muscle ryanodine receptor by glutathione transferases
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- Glutathione transferases: a structural perspective
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- Susceptibility to exudative age-related macular degeneration and three genetic polymorphisms of glutathione S-transferase Z1 (GSTZ1)
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- Aminopeptidase N (EC 3.4.11.2) inhibitors (2006 – 2010): a patent review
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- Dual localization of glutathione S-transferase in the cytosol and mitochondria: implications in oxidative stress, toxicity and disease
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- The role of glutathione S-transferase P in signaling pathways and S-glutathionylation in cancer
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- Growth-inhibitory and chemosensitizing effects of the glutathione-S-transferase-π-activated nitric oxide donor PABA/NO in malignant gliomas
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- Autocatalytic Cleavage of Human γ-Glutamyl Transpeptidase Is Highly Dependent onN-Glycosylation at Asparagine 95
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- Inference of Functional Properties from Large-scale Analysis of Enzyme Superfamilies
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- Mechanism of peptide hydrolysis by co-catalytic metal centers containing leucine aminopeptidase enzyme: a DFT approach
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- Human Polymorphisms in the Glutathione Transferase Zeta 1/Maleylacetoacetate Isomerase Gene Influence the Toxicokinetics of Dichloroacetate
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- Divergent effects of compounds on the hydrolysis and transpeptidation reactions of γ-glutamyl transpeptidase
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- Structural and mechanistic comparisons of the metal-binding members of the vicinal oxygen chelate (VOC) superfamily
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- Inhibition of GlutathioneS-Transferase M1 by New Gabosine Analogues Is Essential for Overcoming Cisplatin Resistance in Lung Cancer Cells
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- Remarkable Potential of the α-Aminophosphonate/Phosphinate Structural Motif in Medicinal Chemistry
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- Binding of GSH conjugates to π-GST: A cross-docking approach
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- Preventive Effect of GGsTop, a Novel and Selective -Glutamyl Transpeptidase Inhibitor, on Ischemia/Reperfusion-Induced Renal Injury in Rats
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- Molecular characterization and expression of dipeptidase 3, a testis-specific membrane-bound dipeptidase: complex formation with TEX101, a germ-cell-specific antigen in the mouse testis
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- Potent and Selective Inhibitors of GlutathioneS-Transferase Omega 1 That Impair Cancer Drug Resistance
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- Synthesis and Characterization of a Series of Highly Fluorogenic Substrates for Glutathione Transferases, a General Strategy
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- Glutathione transferase kappa deficiency causes glomerular nephropathy without overt oxidative stress
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- LYP, a bestatin dimethylaminoethyl ester, inhibited cancer angiogenesis both in vitro and in vivo
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- Fluorescent labeling of membrane proteins on the surface of living cells by a self-catalytic glutathione S-transferase omega 1 tag
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- Targeting GSTP1-1 induces JNK activation and leads to apoptosis in cisplatin-sensitive and -resistant human osteosarcoma cell lines
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- Characterization of New Potential Anticancer Drugs Designed To Overcome Glutathione Transferase Mediated Resistance
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- Human metabolic individuality in biomedical and pharmaceutical research
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- GSTO1*E155del polymorphism associated with increased risk for late-onset Alzheimer's disease: Association hypothesis for an uncommon genetic variant
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- Role of MGST1 in reactive intermediate-induced injury
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- Isozyme-Specific Fluorescent Inhibitor of GlutathioneS-Transferase Omega 1
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- High-quality crystals of human haematopoietic prostaglandin D synthase with novel inhibitors
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- Glutathione transferases and development of new principles to overcome drug resistance
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- The alkylating prodrug J1 can be activated by aminopeptidase N, leading to a possible target directed release of melphalan
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- Class Pi Glutathione Transferase Unfolds via a Dimeric and Not Monomeric Intermediate: Functional Implications for an Unstable Monomer
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- Residue 234 is a master switch of the alternative-substrate activity profile of human and rodent theta class glutathione transferase T1-1☆
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- Stability of the domain interface contributes towards the catalytic function at the H-site of class alpha glutathione transferase A1-1
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- Metallo-aminopeptidase inhibitors
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- Activation of Rat Liver Microsomal Glutathione Transferase by Hepsin
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- New aromatic monoesters of α-aminoaralkylphosphonic acids as inhibitors of aminopeptidase N/CD13
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- Identification of very potent inhibitor of human aminopeptidase N (CD13)
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- Activity and safety of NGR-hTNF, a selective vascular-targeting agent, in previously treated patients with advanced hepatocellular carcinoma
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- Aminopeptidase N (CD13) as a target for cancer chemotherapy
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- Glutathione transferases as mediators of signaling pathways involved in cell proliferation and cell death
- (2010) E Laborde CELL DEATH AND DIFFERENTIATION
- Differences among allelic variants of human glutathione transferase A2-2 in the activation of azathioprine
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- NPC1L1 and cholesterol transport
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- Multiple roles of microsomal glutathione transferase 1 in cellular protection: A mechanistic study
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- Polymorphisms in the human glutathione transferase Kappa (GSTK1) promoter alter gene expression
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- Differential aminoacylase expression in neuroblastoma
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- LYP, a novel bestatin derivative, inhibits cell growth and suppresses APN/CD13 activity in human ovarian carcinoma cells more potently than bestatin
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- Molecular Identification of NAT8 as the Enzyme That Acetylates CysteineS-Conjugates to Mercapturic Acids
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- AT-1 is the ER membrane acetyl-CoA transporter and is essential for cell viability
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- CD13 is a therapeutic target in human liver cancer stem cells
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- The evaluation of novel natural products as inhibitors of human glutathione transferase P1-1
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- Novel Oxadiazole Analogues Derived from Ethacrynic Acid: Design, Synthesis, and Structure−Activity Relationships in Inhibiting the Activity of GlutathioneS-Transferase P1-1 and Cancer Cell Proliferation
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- Development and Characterization of New Inhibitors of the Human and Mouse Hematopoietic Prostaglandin D2Synthases
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- Structural Basis for Featuring of Steroid Isomerase Activity in Alpha Class Glutathione Transferases
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- Mitochondrion as a Novel Site of Dichloroacetate Biotransformation by Glutathione Transferase 1
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- Glutathione Transferase A1-1: Catalytic Importance of Arginine 15
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- Catalysis of Carboxypeptidase A: Promoted-Water versus Nucleophilic Pathways
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- Glutathione Transferase Classes Alpha, Pi, and Mu: GSH Activation Mechanism
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- Transport of Inorganic Mercury and Methylmercury in Target Tissues and Organs
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- Inhibition of mitochondrial membrane bound-glutathione transferase by mitochondrial permeability transition inhibitors including cyclosporin A
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- New loci associated with kidney function and chronic kidney disease
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- Genetic loci influencing kidney function and chronic kidney disease
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- Structures of aminoacylase 3 in complex with acetylated substrates
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- Common structural features of mapeg-a widespread superfamily of membrane associated proteins with highly divergent functions in eicosanoid and glutathione metabolism
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- Association between three genetic polymorphisms of glutathione S-transferase Z1 (GSTZ1) and susceptibility to schizophrenia
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- MRP2 and the handling of mercuric ions in rats exposed acutely to inorganic and organic species of mercury
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- Discovery of an Oral Potent Selective Inhibitor of Hematopoietic Prostaglandin D Synthase (HPGDS)
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- Dendritic Cells Express Hematopoietic Prostaglandin D Synthase and Function as a Source of Prostaglandin D2 in the Skin
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- Characterization of a new fluorogenic substrate for microsomal glutathione transferase 1
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- Microsomal glutathione transferase 1 exhibits one-third-of-the-sites-reactivity towards glutathione
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- Single-nucleotide polymorphic variants of human glutathione transferase T1-1 differ in stability and functional properties
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- Phenylalanine-induced leucopenia in genetic and dichloroacetic acid generated deficiency of glutathione transferase Zeta
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- Crystal Structure of Acivicin-Inhibited γ-Glutamyltranspeptidase Reveals Critical Roles for Its C-Terminus in Autoprocessing and Catalysis†‡
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- Monomer−Dimer Equilibrium in Glutathione Transferases: A Critical Re-Examination
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- Role of Glutathione Transferases in the Mechanism of Brostallicin Activation
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- The human hGSTA5 gene encodes an enzymatically active protein
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- Arginine 15 stabilizes an SNAr reaction transition state and the binding of anionic ligands at the active site of human glutathione transferase A1-1
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- Impact of OATP transporters on pharmacokinetics
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- Structural Basis for the Binding of the Anticancer Compound 6-(7-Nitro-2,1,3-Benzoxadiazol-4-Ylthio)Hexanol to Human Glutathione S-Transferases
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- Structural determinants in domain II of human glutathione transferase M2-2 govern the characteristic activities with aminochrome, 2-cyano-1, 3-dimethyl-1-nitrosoguanidine, and 1, 2-dichloro-4-nitrobenzene
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- Novel Role for GlutathioneS-Transferase π
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- In vivo optical imaging of CD13/APN-expression in tumor xenografts
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- Novel Prostaglandin D Synthase Inhibitors Generated by Fragment-Based Drug Design†
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- The Anti-cancer Drug Chlorambucil as a Substrate for the Human Polymorphic Enzyme Glutathione Transferase P1-1: Kinetic Properties and Crystallographic Characterisation of Allelic Variants
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- Crystal Structures of Escherichia coli γ-Glutamyltranspeptidase in Complex with Azaserine and Acivicin: Novel Mechanistic Implication for Inhibition by Glutamine Antagonists
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- Design and Synthesis of Highly Sensitive Fluorogenic Substrates for Glutathione S-Transferase and Application for Activity Imaging in Living Cells
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- Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology
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- Amino Acid Transport Across Mammalian Intestinal and Renal Epithelia
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- Novel function of glutathione transferase in rat liver mitochondrial membrane: Role for cytochrome c release from mitochondria☆⁎Some of the data were presented at the ISSX (International Society for Study of Xenobiotics) Meeting, Oct.12, 2007, in Sendai, Japan.
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- Contribution of liver mitochondrial membrane-bound glutathione transferase to mitochondrial permeability transition pores
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- The moonlighting enzyme CD13: old and new functions to target
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- S-(4-Nitrophenacyl)glutathione is a specific substrate for glutathione transferase omega 1-1
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- A high performance gel filtration chromatography method for γ-glutamyltransferase fraction analysis
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- Chemical Toxicology of Reactive Intermediates Formed by the Glutathione-Dependent Bioactivation of Halogen-Containing Compounds
- (2007) M. W. Anders CHEMICAL RESEARCH IN TOXICOLOGY
- Structural Determinants of Glutathione Transferases with Azathioprine Activity Identified by DNA Shuffling of Alpha Class Members
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- NMR spectroscopy of aminoacylase 1 deficiency, a novel inborn error of metabolism
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