Phase 0 and phase III transport in various organs: Combined concept of phases in xenobiotic transport and metabolism

Phase I and II metabolism and MRP2-mediated export of bosentan in a MDCKII-OATP1B1-CYP3A4-UGT1A1-MRP2 quadruple-transfected cell line

(2013) C Fahrmayr et al.   BRITISH JOURNAL OF PHARMACOLOGY

P-glycoprotein Inhibition as a Therapeutic Approach for Overcoming Multidrug Resistance in Cancer: Current Status and Future Perspectives

(2013) Ziyad Binkhathlan et al.   CURRENT CANCER DRUG TARGETS

The SLC22 family with transporters of organic cations, anions and zwitterions

(2013) Hermann Koepsell   MOLECULAR ASPECTS OF MEDICINE

The heteromeric organic solute transporter, OSTα–OSTβ/SLC51: A transporter for steroid-derived molecules

(2013) Nazzareno Ballatori et al.   MOLECULAR ASPECTS OF MEDICINE

The SLCO (former SLC21) superfamily of transporters

(2013) Bruno Hagenbuch et al.   MOLECULAR ASPECTS OF MEDICINE

The human concentrative and equilibrative nucleoside transporter families, SLC28 and SLC29

(2013) James D. Young et al.   MOLECULAR ASPECTS OF MEDICINE

The ABCs of membrane transporters in health and disease (SLC series): Introduction

(2013) Matthias A. Hediger et al.   MOLECULAR ASPECTS OF MEDICINE

Multidrug and toxin extrusion family SLC47: Physiological, pharmacokinetic and toxicokinetic importance of MATE1 and MATE2-K

(2013) Hideyuki Motohashi et al.   MOLECULAR ASPECTS OF MEDICINE

Proton-coupled oligopeptide transporter family SLC15: Physiological, pharmacological and pathological implications

(2013) David E. Smith et al.   MOLECULAR ASPECTS OF MEDICINE

New Insight into P-Glycoprotein as a Drug Target

(2012) Albert Breier et al.   Anti-Cancer Agents in Medicinal Chemistry

Pharmacological and pathophysiological roles of carnitine/organic cation transporters (OCTNs: SLC22A4, SLC22A5 and Slc22a21)

(2012) Ikumi Tamai   BIOPHARMACEUTICS & DRUG DISPOSITION

Highlights from the International Transporter Consortium Second Workshop

(2012) M J Zamek-Gliszczynski et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Organic Cation Transporters: Physiology, Toxicology and Special Focus on Ethidium as a Novel Substrate

(2012) Wing-Kee Lee et al.   CURRENT DRUG METABOLISM

The Role of ABC and SLC Transporters in the Pharmacokinetics of Dietary and Herbal Phytochemicals and their Interactions with Xenobiotics

(2012) Yan Li et al.   CURRENT DRUG METABOLISM

Do ATP-Binding Cassette Transporters Cause Pharmacoresistance in Epilepsy? Problems and Approaches in Determining which Antiepileptic Drugs are Affected

(2012) Wolfgang Loscher et al.   CURRENT PHARMACEUTICAL DESIGN

Breast Cancer Resistance Protein and P-Glycoprotein in Brain Cancer: Two Gatekeepers Team Up

(2012) Sagar Agarwal et al.   CURRENT PHARMACEUTICAL DESIGN

Impact of drug transporter pharmacogenomics on pharmacokinetic and pharmacodynamic variability – considerations for drug development

(2012) Yurong Lai et al.   Expert Opinion on Drug Metabolism & Toxicology

Substrate recognition and processing by a Walker B mutant of the human mitochondrial AAA+ protein CLPX

(2012) Bradley R. Lowth et al.   JOURNAL OF STRUCTURAL BIOLOGY

Endothelin receptor antagonists for the treatment of pulmonary artery hypertension

(2012) Lewis J. Rubin   LIFE SCIENCES

BDDCS Class Prediction for New Molecular Entities

(2012) Fabio Broccatelli et al.   MOLECULAR PHARMACEUTICS

Drug transport by Organic Anion Transporters (OATs)

(2012) Gerhard Burckhardt   PHARMACOLOGY & THERAPEUTICS

BDDCS Applied to Over 900 Drugs

(2011) Leslie Z. Benet et al.   AAPS Journal

The Expression and Function of Organic Anion Transporting Polypeptides in Normal Tissues and in Cancer

(2011) Amanda Obaidat et al.   Annual Review of Pharmacology and Toxicology

ABC Transporters: Unvalidated Therapeutic Targets in Cancer and the CNS

(2011) Robert W. Robey et al.   Anti-Cancer Agents in Medicinal Chemistry

Importance of the multidrug and toxin extrusion MATE/SLC47A family to pharmacokinetics, pharmacodynamics/toxicodynamics and pharmacogenomics

(2011) Atsushi Yonezawa et al.   BRITISH JOURNAL OF PHARMACOLOGY

OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies

(2011) Megan Roth et al.   BRITISH JOURNAL OF PHARMACOLOGY

Contribution of Abcc10 (Mrp7) to In Vivo Paclitaxel Resistance as Assessed in Abcc10-/- Mice

(2011) E. A. Hopper-Borge et al.   CANCER RESEARCH

Influence of Efflux Transporters on Drug Metabolism

(2011) Pietro Fagiolino et al.   CLINICAL PHARMACOKINETICS

Genetically Polymorphic OCT1: Another Piece in the Puzzle of the Variable Pharmacokinetics and Pharmacodynamics of the Opioidergic Drug Tramadol

(2011) M V Tzvetkov et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Transporter-Mediated Drug Uptake and Efflux: Important Determinants of Adverse Drug Reactions

(2011) O Zolk et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Interplay of Drug Metabolizing CYP450 Enzymes and ABC Transporters in the Blood-Brain Barrier

(2011) Xavier Decleves et al.   CURRENT DRUG METABOLISM

ATP-Binding Cassette Efflux Transporters in Human Placenta

(2011) Zhanglin Ni et al.   CURRENT PHARMACEUTICAL BIOTECHNOLOGY

Interaction of fluvastatin with the liver-specific Na+-dependent taurocholate cotransporting polypeptide (NTCP)

(2011) Rick Greupink et al.   EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES

Elevated hepatic multidrug resistance-associated protein 3/ATP-binding cassette subfamily C 3 expression in human obstructive cholestasis is mediated through tumor necrosis factor alpha and c-Jun NH2-terminal kinase/stress-activated protein kinase-signali

(2011) Jin Chai et al.   HEPATOLOGY

Clinical Pharmacokinetics and Drug-Drug Interactions of Endothelin Receptor Antagonists in Pulmonary Arterial Hypertension

(2011) Jürgen Venitz et al.   JOURNAL OF CLINICAL PHARMACOLOGY

Overcoming tumor multidrug resistance using drugs able to evade P-glycoprotein or to exploit its expression

(2011) Stefania Nobili et al.   MEDICINAL RESEARCH REVIEWS

Transporters that translocate nucleosides and structural similar drugs: structural requirements for substrate recognition

(2011) Pedro Cano-Soldado et al.   MEDICINAL RESEARCH REVIEWS

Vectorial Transport of Fexofenadine across Caco-2 Cells: Involvement of Apical Uptake and Basolateral Efflux Transporters

(2011) Xin Ming et al.   MOLECULAR PHARMACEUTICS

The BCS, BDDCS, and Regulatory Guidances

(2011) Mei-Ling Chen et al.   PHARMACEUTICAL RESEARCH

Pharmacogenetics of drug transporters in the enterohepatic circulation

(2011) Bruno Stieger et al.   PHARMACOGENOMICS

A Critical Analysis of the Interplay between Cytochrome P450 3A and P-Glycoprotein: Recent Insights from Knockout and Transgenic Mice

(2011) R. A. B. van Waterschoot et al.   PHARMACOLOGICAL REVIEWS

Organic Anion Transporting Polypeptide 1B1: a Genetically Polymorphic Transporter of Major Importance for Hepatic Drug Uptake

(2011) M. Niemi et al.   PHARMACOLOGICAL REVIEWS

Drug Transporters and Imatinib Treatment: Implications for Clinical Practice

(2010) K. Eechoute et al.   CLINICAL CANCER RESEARCH

The FDA Should Eliminate the Ambiguities in the Current BCS Biowaiver Guidance and Make Public the Drugs for Which BCS Biowaivers Have Been Granted

(2010) L Z Benet et al.   CLINICAL PHARMACOLOGY & THERAPEUTICS

Regulation of Drug Metabolism and Transporters

(2010) Jordi Muntane   CURRENT DRUG METABOLISM

ABCC2/Abcc2: a multispecific transporter with dominant excretory functions

(2010) Katalin Jemnitz et al.   DRUG METABOLISM REVIEWS

Preclinical and Clinical Evidence for the Collaborative Transport and Renal Secretion of an Oxazolidinone Antibiotic by Organic Anion Transporter 3 (OAT3/SLC22A8) and Multidrug and Toxin Extrusion Protein 1 (MATE1/SLC47A1)

(2010) Y. Lai et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Chronic Myeloid Leukemia CD34+ cells have reduced uptake of imatinib due to low OCT-1 Activity

(2010) J R Engler et al.   LEUKEMIA

Membrane transporters in drug development

(2010)   NATURE REVIEWS DRUG DISCOVERY

OCT2 polymorphisms and in-vivo renal functional consequence: studies with metformin and cimetidine

(2010) Zhi-Jun Wang et al.   Pharmacogenetics and Genomics

Effects of OCT1 polymorphisms on the cellular uptake, plasma concentrations and efficacy of the 5-HT3 antagonists tropisetron and ondansetron

(2010) M V Tzvetkov et al.   PHARMACOGENOMICS JOURNAL

Xenobiotic, Bile Acid, and Cholesterol Transporters: Function and Regulation

(2010) C. D. Klaassen et al.   PHARMACOLOGICAL REVIEWS

Emerging New Technologies in Pharamcogenomics: Rapid SNP detection, molecular dynamic simulation, and QSAR analysis methods to validate clinically important genetic variants of human ABC Transporter ABCB1 (P-gp/MDR1)

(2010) Toshihisa Ishikawa et al.   PHARMACOLOGY & THERAPEUTICS

Breed distribution of the nt230(del4) MDR1 mutation in dogs

(2010) Irina Gramer et al.   VETERINARY JOURNAL

Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters

(2009) Simone Leuthold et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Drug transporters in the human blood-placental barrier

(2009) Kirsi Vähäkangas et al.   BRITISH JOURNAL OF PHARMACOLOGY

Absence of Both Cytochrome P450 3A and P-glycoprotein Dramatically Increases Docetaxel Oral Bioavailability and Risk of Intestinal Toxicity

(2009) R. A.B. van Waterschoot et al.   CANCER RESEARCH

Regulation of BCRP (ABCG2) and P-Glycoprotein (ABCB1) by Cytokines in a Model of the Human Blood–Brain Barrier

(2009) Birk Poller et al.   CELLULAR AND MOLECULAR NEUROBIOLOGY

Pharmacogenetics of Drug Transporters

(2009) R. Franke et al.   CURRENT PHARMACEUTICAL DESIGN

Transport of drugs by proton-coupled peptide transporters: pearls and pitfalls

(2009) Matthias Brandsch   Expert Opinion on Drug Metabolism & Toxicology

Multidrug efflux pumps: Substrate selection in ATP-binding cassette multidrug efflux pumps - first come, first served?

(2009) Robert Ernst et al.   FEBS Journal

The enterohepatic circulation of bile acids in mammals: form and functions

(2009) Alan et al.   Frontiers in Bioscience-Landmark

The Human Carnitine Transporter SLC22A16 Mediates High Affinity Uptake of the Anticancer Polyamine Analogue Bleomycin-A5

(2009) Mustapha Aouida et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Tyrosine Kinase Inhibitor Enhances the Bioavailability of Oral Irinotecan in Pediatric Patients With Refractory Solid Tumors

(2009) Wayne L. Furman et al.   JOURNAL OF CLINICAL ONCOLOGY

Coordinate regulation of metabolic enzymes and transporters by nuclear transcription factors in human liver disease

(2009) Mario Congiu et al.   JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY

Influence of Cyclooxygenase Inhibitors on the Function of the Prostaglandin Transporter Organic Anion-Transporting Polypeptide 2A1 Expressed in Human Gastroduodenal Mucosa

(2009) K. Mandery et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

The Drug Transporter−Metabolism Alliance: Uncovering and Defining the Interplay

(2009) Leslie Z. Benet   MOLECULAR PHARMACEUTICS

Comparative gene expression profiles of ABC transporters in brain microvessel endothelial cells and brain in five species including human

(2009) Mark S. Warren et al.   PHARMACOLOGICAL RESEARCH

Ostα-Ostβ is required for bile acid and conjugated steroid disposition in the intestine, kidney, and liver

(2008) Nazzareno Ballatori et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

An Update on Clinical Drug Interactions with the Herbal Antidepressant St. Johns wort

(2008) Shu-Feng Zhou et al.   CURRENT DRUG METABOLISM

The Inhibition of Human Multidrug and Toxin Extrusion 1 Is Involved in the Drug-Drug Interaction Caused by Cimetidine

(2008) S. Matsushima et al.   DRUG METABOLISM AND DISPOSITION

Regulation of Drug-Metabolizing Enzymes and Transporters in Infection, Inflammation, and Cancer

(2008) E. T. Morgan et al.   DRUG METABOLISM AND DISPOSITION

Organic Cation Transporters and their Pharmacokinetic and Pharmacodynamic Consequences

(2008) Min-Koo Choi et al.   Drug Metabolism and Pharmacokinetics

Pharmacogenomics of MRP Transporters (ABCC1-5) and BCRP (ABCG2)

(2008) Ulrike Gradhand et al.   DRUG METABOLISM REVIEWS

The effect of chronic renal failure on drug metabolism and transport

(2008) Albert W Dreisbach et al.   Expert Opinion on Drug Metabolism & Toxicology

Interplay of conjugating enzymes with OATP uptake transporters and ABCC/MRP efflux pumps in the elimination of drugs

(2008) Anne T Nies et al.   Expert Opinion on Drug Metabolism & Toxicology

6-mercaptopurine and 9-(2-phosphonyl-methoxyethyl) adenine (PMEA) transport altered by two missense mutations in the drug transporter gene ABCC4

(2008) Daniel Janke et al.   HUMAN MUTATION

ABC transporters, cytochromes P450 and their main transcription factors: expression at the human blood-brain barrier

(2008) Sandrine Dauchy et al.   JOURNAL OF NEUROCHEMISTRY

Pharmaceutical and pharmacological importance of peptide transporters

(2008) Matthias Brandsch et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

The pharmacogenomics of P-glycoprotein and its role in veterinary medicine

(2008) M. MARTINEZ et al.   JOURNAL OF VETERINARY PHARMACOLOGY AND THERAPEUTICS

Assembly and Channel Opening in a Bacterial Drug Efflux Machine

(2008) Vassiliy N. Bavro et al.   MOLECULAR CELL

The Transporter Classification Database: recent advances

(2008) M. H. Saier et al.   NUCLEIC ACIDS RESEARCH

Canine ABCB1 and macrocyclic lactones: Heartworm prevention and pharmacogenetics

(2008) Katrina L. Mealey   VETERINARY PARASITOLOGY

Ketoconazole and the modulation of multidrug resistance-mediated transport in Caco-2 and MDCKII-MDR1 drug transport models

(2008) Y. Fan et al.   XENOBIOTICA

Structure, function and regulation of P-glycoprotein and its clinical relevance in drug disposition

(2008) S.-F. Zhou   XENOBIOTICA

Organic cation transporters

(2008) G. Ciarimboli   XENOBIOTICA

A regulatory viewpoint on transporter-based drug interactions

(2008) L. Zhang et al.   XENOBIOTICA

Peptide transporters and their roles in physiological processes and drug disposition

(2008) I. Rubio-Aliaga et al.   XENOBIOTICA

The breast cancer resistance protein transporter ABCG2 is expressed in the human kidney proximal tubule apical membrane

(2007) M. Huls et al.   KIDNEY INTERNATIONAL