Journal
CURRENT MEDICINAL CHEMISTRY
Volume 18, Issue 32, Pages 5011-5021Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/092986711797535155
Keywords
Aminopeptidase N; rational drug design; inhibitors; peptidomimetics; anti-tumor; structure activity relationship
Funding
- national high technology research and development program of china (863 project) [2007AA02Z314, 2009ZX09103-118]
- National Nature Science Foundation of China [90713041, 30772654]
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APN is an important zinc dependent metallo-exopeptidase, which can degrade the extracellular matrix, and plays an important role in tumor invasion, metastasis and angiogenesis. it has been considered as a suitable target for anti-cancer drug design. Recently, research of structure-based APN inhibitors is becoming an interesting field, and many APN inhibitors have been reported. Here we review a series of APN inhibitors and the recent progress in this field.
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