M1 aminopeptidases as drug targets: broad applications or therapeutic niche?

Structural basis for substrate specificity of Helicobacter pylori M17 aminopeptidase

(2016) Joyanta K. Modak et al.   BIOCHIMIE

Discovery of potent and selective inhibitors of human aminopeptidases ERAP1 and ERAP2 by screening libraries of phosphorus-containing amino acid and dipeptide analogues

(2016) Ewelina Węglarz-Tomczak et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Renin-angiotensin system as a potential therapeutic target in stroke and retinopathy: experimental and clinical evidence

(2016) A. Y. Fouda et al.   CLINICAL SCIENCE

A structural insight into the P1 S1 binding mode of diaminoethylphosphonic and phosphinic acids, selective inhibitors of alanine aminopeptidases

(2016) Ewelina Węglarz-Tomczak et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

Potent dual inhibitors of Plasmodium falciparum M1 and M17 aminopeptidases through optimization of S1 pocket interactions

(2016) Nyssa Drinkwater et al.   EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY

ConSurf 2016: an improved methodology to estimate and visualize evolutionary conservation in macromolecules

(2016) Haim Ashkenazy et al.   NUCLEIC ACIDS RESEARCH

Screening Identifies Thimerosal as a Selective Inhibitor of Endoplasmic Reticulum Aminopeptidase 1

(2016) Athanasios Stamogiannos et al.   ACS Medicinal Chemistry Letters

Bufexamac ameliorates LPS-induced acute lung injury in mice by targeting LTA4H

(2016) Qiang Xiao et al.   Scientific Reports

Crystal Structure of Insulin-Regulated Aminopeptidase with Bound Substrate Analogue Provides Insight on Antigenic Epitope Precursor Recognition and Processing

(2015) Anastasia Mpakali et al.   JOURNAL OF IMMUNOLOGY

The Anopheles-midgut APN1 structure reveals a new malaria transmission–blocking vaccine epitope

(2015) Sarah C Atkinson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

ERAP1 biology and assessment in Ankylosing Spondylitis

(2015) Philip C. Robinson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Anopheles-midgut APN1 structure reveals a new malaria transmission–blocking vaccine epitope

(2015) Sarah C Atkinson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

A new strategy for treating hypertension by blocking the activity of the brain renin–angiotensin system with aminopeptidase A inhibitors

(2014) Ji Gao et al.   CLINICAL SCIENCE

Regulating adaptive immune responses using small molecule modulators of aminopeptidases that process antigenic peptides

(2014) Efstratios Stratikos   CURRENT OPINION IN CHEMICAL BIOLOGY

Genetic associations and functional characterization of M1 aminopeptidases and immune-mediated diseases

(2014) N Agrawal et al.   GENES AND IMMUNITY

Two-Pronged Attack: Dual Inhibition of Plasmodium falciparum M1 and M17 Metalloaminopeptidases by a Novel Series of Hydroxamic Acid-Based Inhibitors

(2014) Shailesh N. Mistry et al.   JOURNAL OF MEDICINAL CHEMISTRY

Binding of Pro-Gly-Pro at the active site of leukotriene A4 hydrolase/aminopeptidase and development of an epoxide hydrolase selective inhibitor

(2014) A. Stsiapanava et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structure of human insulin-regulated aminopeptidase with specificity for cyclic peptides

(2014) Stefan J. Hermans et al.   PROTEIN SCIENCE

Membrane ectopeptidases targeted by human coronaviruses

(2014) Berend Jan Bosch et al.   Current Opinion in Virology

Novel selective inhibitors of aminopeptidases that generate antigenic peptides

(2013) Athanasios Papakyriakou et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Synthetic and Natural Protease Inhibitors Provide Insights into Parasite Development, Virulence and Pathogenesis

(2013) A. Rascon et al.   CURRENT MEDICINAL CHEMISTRY

Recombinant expression and biochemical characterisation of two alanyl aminopeptidases of Trypanosoma congolense

(2013) Davita Pillay et al.   EXPERIMENTAL PARASITOLOGY

Antibodies to a Single, Conserved Epitope in Anopheles APN1 Inhibit Universal Transmission of Plasmodium falciparum and Plasmodium vivax Malaria

(2013) Jennifer S. Armistead et al.   INFECTION AND IMMUNITY

Structural Insights into Central Hypertension Regulation by Human Aminopeptidase A

(2013) Yang Yang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Synthesis and Structure–Activity Relationships of Phosphonic Arginine Mimetics as Inhibitors of the M1 and M17 Aminopeptidases from Plasmodium falciparum

(2013) Komagal Kannan Sivaraman et al.   JOURNAL OF MEDICINAL CHEMISTRY

Rationally designed inhibitor targeting antigen-trimming aminopeptidases enhances antigen presentation and cytotoxic T-cell responses

(2013) E. Zervoudi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Aminopeptidase Inhibitor CHR-2863 Is an Orally Bioavailable Inhibitor of Murine Malaria

(2012) Tina S. Skinner-Adams et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

An integrated approach to the ligand binding specificity of Neisseria meningitidis M1 alanine aminopeptidase by fluorogenic substrate profiling, inhibitory studies and molecular modeling

(2012) Ewelina Węglarz-Tomczak et al.   BIOCHIMIE

Design, synthesis and biological evaluation of novel amino acid ureido derivatives as aminopeptidase N/CD13 inhibitors

(2012) Li Su et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Central Antihypertensive Effects of Orally Active Aminopeptidase A Inhibitors in Spontaneously Hypertensive Rats

(2012) Yannick Marc et al.   HYPERTENSION

A novel recombinant Leishmania donovani p45, a partial coding region of methionine aminopeptidase, generates protective immunity by inducing a Th1 stimulatory response against experimental visceral leishmaniasis

(2012) Reema Gupta et al.   INTERNATIONAL JOURNAL FOR PARASITOLOGY

The leucine aminopeptidase of Staphylococcus aureus is secreted and contributes to biofilm formation

(2012) Arun Kumar Singh et al.   INTERNATIONAL JOURNAL OF INFECTIOUS DISEASES

The X-ray Crystal Structure of Human Aminopeptidase N Reveals a Novel Dimer and the Basis for Peptide Processing

(2012) Alan H. M. Wong et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The extracellular matrix: A dynamic niche in cancer progression

(2012) Pengfei Lu et al.   JOURNAL OF CELL BIOLOGY

Structure–Activity Relationships and Blood Distribution of Antiplasmodial Aminopeptidase-1 Inhibitors

(2012) Rebecca Deprez-Poulain et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structural basis for multifunctional roles of mammalian aminopeptidase N

(2012) L. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural Bases of Coronavirus Attachment to Host Aminopeptidase N and Its Inhibition by Neutralizing Antibodies

(2012) Juan Reguera et al.   PLoS Pathogens

The role of multifunctional M1 metallopeptidases in cell cycle progression

(2011) Wendy Ann Peer   ANNALS OF BOTANY

The Crystal Structure of Human Endoplasmic Reticulum Aminopeptidase 2 Reveals the Atomic Basis for Distinct Roles in Antigen Processing

(2011) James R. Birtley et al.   BIOCHEMISTRY

The major leucyl aminopeptidase of Trypanosoma cruzi (LAPTc) assembles into a homohexamer and belongs to the M17 family of metallopeptidases

(2011) Gloria Cadavid-Restrepo et al.   BMC BIOCHEMISTRY

Identification and development of specific inhibitors for insulin-regulated aminopeptidase as a new class of cognitive enhancers

(2011) Anthony L Albiston et al.   BRITISH JOURNAL OF PHARMACOLOGY

EMA revokes marketing authorization for bufexamac

(2011) Wolfgang Uter et al.   CONTACT DERMATITIS

Aminopeptidase-N/CD13 is a potential proapoptotic target in human myeloid tumor cells

(2011) Marion Piedfer et al.   FASEB JOURNAL

Synthesis of New (−)-Bestatin-Based Inhibitor Libraries Reveals a Novel Binding Mode in the S1 Pocket of the Essential Malaria M1 Metalloaminopeptidase

(2011) Geetha Velmourougane et al.   JOURNAL OF MEDICINAL CHEMISTRY

MEROPS: the database of proteolytic enzymes, their substrates and inhibitors

(2011) N. D. Rawlings et al.   NUCLEIC ACIDS RESEARCH

Bestatin-based chemical biology strategy reveals distinct roles for malaria M1- and M17-family aminopeptidases

(2011) M. B. Harbut et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming

(2011) G. Kochan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The recombinant gut-associated M17 leucine aminopeptidase in combination with different adjuvants confers a high level of protection against Fasciola hepatica infection in sheep

(2011) Gabriela Maggioli et al.   VACCINE

Metallo-aminopeptidase inhibitors

(2010) Artur Mucha et al.   BIOCHIMIE

Aminopeptidase N (CD13) as a target for cancer chemotherapy

(2010) Malin Wickström et al.   CANCER SCIENCE

Phase I/II Clinical Study of Tosedostat, an Inhibitor of Aminopeptidases, in Patients With Acute Myeloid Leukemia and Myelodysplasia

(2010) Bob Löwenberg et al.   JOURNAL OF CLINICAL ONCOLOGY

A Critical Role for LTA4H in Limiting Chronic Pulmonary Neutrophilic Inflammation

(2010) R. J. Snelgrove et al.   SCIENCE

Structural basis for the inhibition of the essentialPlasmodium falciparumM1 neutral aminopeptidase

(2009) Sheena McGowan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structure-Based Dissection of the Active Site Chemistry of Leukotriene A4 Hydrolase: Implications for M1 Aminopeptidases and Inhibitor Design

(2008) Fredrik Tholander et al.   CHEMISTRY & BIOLOGY

Identification and characterization of a new cognitive enhancer based on inhibition of insulin-regulated aminopeptidase

(2008) Anthony L. Albiston et al.   FASEB JOURNAL

Orally Active Aminopeptidase A Inhibitors Reduce Blood Pressure

(2008) Laurence Bodineau et al.   HYPERTENSION

The moonlighting enzyme CD13: old and new functions to target

(2008) Paola Mina-Osorio   TRENDS IN MOLECULAR MEDICINE

Flipping the paradigm on malaria transmission-blocking vaccines

(2008) Rhoel R. Dinglasan et al.   TRENDS IN PARASITOLOGY