The role of organic anion transporting polypeptides in drug absorption, distribution, excretion and drug-drug interactions
Published 2016 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
The role of organic anion transporting polypeptides in drug absorption, distribution, excretion and drug-drug interactions
Authors
Keywords
-
Journal
Expert Opinion on Drug Metabolism & Toxicology
Volume 13, Issue 4, Pages 409-424
Publisher
Informa UK Limited
Online
2016-10-27
DOI
10.1080/17425255.2017.1253679
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- Primary-like human hepatocytes genetically engineered to obtain proliferation competence display hepatic differentiation characteristics in monolayer and organotypical spheroid cultures
- (2016) Natalie Herzog et al. CELL BIOLOGY INTERNATIONAL
- Identification of Transporters Involved in Beraprost Sodium Transport In Vitro
- (2016) Keiyu Oshida et al. EUROPEAN JOURNAL OF DRUG METABOLISM AND PHARMACOKINETICS
- Investigation of Fluorescein Derivatives as Substrates of Organic Anion Transporting Polypeptide (OATP) 1B1 To Develop Sensitive Fluorescence-Based OATP1B1 Inhibition Assays
- (2016) Saki Izumi et al. MOLECULAR PHARMACEUTICS
- Role of Organic Anion-Transporting Polypeptides (OATPs) in Cancer Therapy
- (2015) Nilay Thakkar et al. AAPS Journal
- Functional expression of the 11 human Organic Anion Transporting Polypeptides in insect cells reveals that sodium fluorescein is a general OATP substrate
- (2015) Izabel Patik et al. BIOCHEMICAL PHARMACOLOGY
- OATP2A1/SLCO2A1-mediated prostaglandin E2 loading into intracellular acidic compartments of macrophages contributes to exocytotic secretion
- (2015) Hiroaki Shimada et al. BIOCHEMICAL PHARMACOLOGY
- Organic Anion Transporting Polypeptide (OATP)1B1 and OATP1B3 as Important Regulators of the Pharmacokinetics of Substrate Drugs
- (2015) Kazuya Maeda BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Human organic anion transporting polypeptide 1A2 (OATP1A2) mediates cellular uptake of all-trans-retinol in human retinal pigmented epithelial cells
- (2015) Ting Chan et al. BRITISH JOURNAL OF PHARMACOLOGY
- Specific expression of OATPs in primary small cell lung cancer (SCLC) cells as novel biomarkers for diagnosis and therapy
- (2015) Stefan Brenner et al. CANCER LETTERS
- Cancer-Type Organic Anion Transporting Polypeptide 1B3: Current Knowledge of the Gene Structure, Expression Profile, Functional Implications and Future Perspectives
- (2015) Tomomi Furihata et al. CURRENT DRUG METABOLISM
- Contribution of Hepatic Organic Anion-Transporting Polypeptides to Docetaxel Uptake and Clearance
- (2015) H. H. Lee et al. MOLECULAR CANCER THERAPEUTICS
- Preclinical Mouse Models To Study Human OATP1B1- and OATP1B3-Mediated Drug–Drug Interactions in Vivo
- (2015) Selvi Durmus et al. MOLECULAR PHARMACEUTICS
- Inherited disorders of bilirubin clearance
- (2015) Naureen Memon et al. PEDIATRIC RESEARCH
- SLCO1B1 polymorphism markedly affects the pharmacokinetics of lovastatin acid
- (2015) Aleksi Tornio et al. Pharmacogenetics and Genomics
- Prostaglandin Transporter (PGT/SLCO2A1) Protects the Lung from Bleomycin-Induced Fibrosis
- (2015) Takeo Nakanishi et al. PLoS One
- A Hereditary Enteropathy Caused by Mutations in the SLCO2A1 Gene, Encoding a Prostaglandin Transporter
- (2015) Junji Umeno et al. PLoS Genetics
- Mechanism of an unusual, but clinically significant, digoxin-bupropion drug interaction
- (2014) Jiake He et al. BIOPHARMACEUTICS & DRUG DISPOSITION
- Pitavastatin is a more sensitive and selective organic anion-transporting polypeptide 1B clinical probe than rosuvastatin
- (2014) Thomayant Prueksaritanont et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- Green Tea Ingestion Greatly Reduces Plasma Concentrations of Nadolol in Healthy Subjects
- (2014) S Misaka et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- In vivodisposition of doxorubicin is affected by mouse Oatp1a/1b and human OATP1A/1B transporters
- (2014) Selvi Durmus et al. INTERNATIONAL JOURNAL OF CANCER
- Human OATP1B1, OATP1B3 and OATP1A2 can mediate thein vivouptake and clearance of docetaxel
- (2014) Dilek Iusuf et al. INTERNATIONAL JOURNAL OF CANCER
- No impact of SLCO1B1 521T>C, 388A>G and 411G>A polymorphisms on response to statin therapy in the Greek population
- (2014) E. Giannakopoulou et al. MOLECULAR BIOLOGY REPORTS
- Interaction of Digitalis-Like Compounds with Liver Uptake Transporters NTCP, OATP1B1, and OATP1B3
- (2014) Elnaz Gozalpour et al. MOLECULAR PHARMACEUTICS
- Expression of Drug Transporters and Drug Metabolizing Enzymes in the Bladder Urothelium in Man and Affinity of the Bladder Spasmolytic Trospium Chloride to Transporters Likely Involved in Its Pharmacokinetics
- (2014) Maria Bexten et al. MOLECULAR PHARMACEUTICS
- Organic anion transporting polypeptides and organic cation transporter 1 contribute to the cellular uptake of the flavonoid quercetin
- (2014) Hartmut Glaeser et al. NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY
- Correction: A Dominant EV71-Specific CD4+ T Cell Epitope Is Highly Conserved among Human Enteroviruses
- (2014) Ruicheng Wei et al. PLoS One
- Recent advances in 2D and 3D in vitro systems using primary hepatocytes, alternative hepatocyte sources and non-parenchymal liver cells and their use in investigating mechanisms of hepatotoxicity, cell signaling and ADME
- (2013) Patricio Godoy et al. ARCHIVES OF TOXICOLOGY
- The multispecific thyroid hormone transporter OATP1C1 mediates cell-specific sulforhodamine 101-labeling of hippocampal astrocytes
- (2013) Christian Schnell et al. Brain Structure & Function
- Contribution of OATP1B1 and OATP1B3 to the Disposition of Sorafenib and Sorafenib-Glucuronide
- (2013) E. I. Zimmerman et al. CLINICAL CANCER RESEARCH
- OATP1B3 Is Expressed in Pancreatic -Islet Cells and Enhances the Insulinotropic Effect of the Sulfonylurea Derivative Glibenclamide
- (2013) H. E. Meyer zu Schwabedissen et al. DIABETES
- The SLCO (former SLC21) superfamily of transporters
- (2013) Bruno Hagenbuch et al. MOLECULAR ASPECTS OF MEDICINE
- Modulation of OATP1B-Type Transporter Function Alters Cellular Uptake and Disposition of Platinum Chemotherapeutics
- (2013) C. S. Lancaster et al. MOLECULAR CANCER THERAPEUTICS
- Polymorphisms of the androgen transporting gene SLCO2B1 may influence the castration resistance of prostate cancer and the racial differences in response to androgen deprivation
- (2013) N Fujimoto et al. PROSTATE CANCER AND PROSTATIC DISEASES
- Enhanced expression of organic anion transporting polypeptides (OATPs) in androgen receptor-positive prostate cancer cells: Possible role of OATP1A2 in adaptive cell growth under androgen-depleted conditions
- (2012) Hiroshi Arakawa et al. BIOCHEMICAL PHARMACOLOGY
- Clinical significance of organic anion transporting polypeptides (OATPs) in drug disposition: their roles in hepatic clearance and intestinal absorption
- (2012) Yoshihisa Shitara et al. BIOPHARMACEUTICS & DRUG DISPOSITION
- Use of Radioactive Compounds and Autoradiography to Determine Drug Tissue Distribution
- (2012) Eric G. Solon CHEMICAL RESEARCH IN TOXICOLOGY
- Influence of Human OATP1B1, OATP1B3, and OATP1A2 on the Pharmacokinetics of Methotrexate and Paclitaxel in Humanized Transgenic Mice
- (2012) E. van de Steeg et al. CLINICAL CANCER RESEARCH
- Understanding the Critical Disposition Pathways of Statins to Assess Drug–Drug Interaction Risk During Drug Development: It's Not Just About OATP1B1
- (2012) R Elsby et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Impact of Genetic Variation in OATP Transporters to Drug Disposition and Response
- (2012) Inna Y. Gong et al. Drug Metabolism and Pharmacokinetics
- Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver
- (2012) Evita van de Steeg et al. JOURNAL OF CLINICAL INVESTIGATION
- Classification of Inhibitors of Hepatic Organic Anion Transporting Polypeptides (OATPs): Influence of Protein Expression on Drug–Drug Interactions
- (2012) Maria Karlgren et al. JOURNAL OF MEDICINAL CHEMISTRY
- Localization and Functional Characterization of the Rat Oatp4c1 Transporter in an In Vitro Cell System and Rat Tissues
- (2012) Kuei-Ling Kuo et al. PLoS One
- Hydrophilic anti-migraine triptans are substrates for OATP1A2, a transporter expressed at human blood-brain barrier
- (2012) Ziqiang Cheng et al. XENOBIOTICA
- A Genome-Wide Scan of Ashkenazi Jewish Crohn's Disease Suggests Novel Susceptibility Loci
- (2012) Eimear E. Kenny et al. PLoS Genetics
- In vitro models for liver toxicity testing
- (2012) Valerie Y. Soldatow et al. Toxicology Research
- Oral drug delivery utilizing intestinal OATP transporters
- (2011) Ikumi Tamai ADVANCED DRUG DELIVERY REVIEWS
- Exome Sequencing Identifies SLCO2A1 Mutations as a Cause of Primary Hypertrophic Osteoarthropathy
- (2011) Zhenlin Zhang et al. AMERICAN JOURNAL OF HUMAN GENETICS
- The Expression and Function of Organic Anion Transporting Polypeptides in Normal Tissues and in Cancer
- (2011) Amanda Obaidat et al. Annual Review of Pharmacology and Toxicology
- Alteration in placental expression of bile acids transporters OATP1A2, OATP1B1, OATP1B3 in intrahepatic cholestasis of pregnancy
- (2011) Huimin Wang et al. ARCHIVES OF GYNECOLOGY AND OBSTETRICS
- Association of SLCO1B3 Polymorphism with Intracellular Accumulation of Imatinib in Leukocytes in Patients with Chronic Myeloid Leukemia
- (2011) Takeru Nambu et al. BIOLOGICAL & PHARMACEUTICAL BULLETIN
- Influence of SLCO1B3 haplotype-tag SNPs on docetaxel disposition in Chinese nasopharyngeal cancer patients
- (2011) Sin Chi Chew et al. BRITISH JOURNAL OF CLINICAL PHARMACOLOGY
- OATPs, OATs and OCTs: the organic anion and cation transporters of the SLCO and SLC22A gene superfamilies
- (2011) Megan Roth et al. BRITISH JOURNAL OF PHARMACOLOGY
- The analysis of organic anion transporting polypeptide (OATP) mRNA and protein patterns in primary and metastatic liver cancer
- (2011) Katrin Wlcek et al. CANCER BIOLOGY & THERAPY
- Expression and localization of the uptake transporters OATP2B1, OATP3A1 and OATP5A1 in non-malignant and malignant breast tissue
- (2011) Juergen Kindla et al. CANCER BIOLOGY & THERAPY
- Expression of SLCO Transport Genes in Castration-Resistant Prostate Cancer and Impact of Genetic Variation in SLCO1B3 and SLCO2B1 on Prostate Cancer Outcomes
- (2011) J. L. Wright et al. CANCER EPIDEMIOLOGY BIOMARKERS & PREVENTION
- Pharmacokinetic Impact of SLCO1A2 Polymorphisms on Imatinib Disposition in Patients With Chronic Myeloid Leukemia
- (2011) Y Yamakawa et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Role of Organic Anion-Transporting Polypeptides for Cellular Mesalazine (5-Aminosalicylic Acid) Uptake
- (2011) J. Konig et al. DRUG METABOLISM AND DISPOSITION
- Sodium fluorescein is a probe substrate for hepatic drug transport mediated by OATP1B1 and OATP1B3
- (2011) Tom De Bruyn et al. JOURNAL OF PHARMACEUTICAL SCIENCES
- Identification of common variants influencing risk of the tauopathy progressive supranuclear palsy
- (2011) Günter U Höglinger et al. NATURE GENETICS
- In Vitro and In Silico Strategies to Identify OATP1B1 Inhibitors and Predict Clinical Drug–Drug Interactions
- (2011) Maria Karlgren et al. PHARMACEUTICAL RESEARCH
- Organic Anion Transporting Polypeptide 1B1: a Genetically Polymorphic Transporter of Major Importance for Hepatic Drug Uptake
- (2011) M. Niemi et al. PHARMACOLOGICAL REVIEWS
- Impact ofSLCO1B1(OATP1B1) andABCG2(BCRP) genetic polymorphisms and inhibition on LDL-C lowering and myopathy of statins
- (2011) Grant T. Generaux et al. XENOBIOTICA
- Mesomelia-Synostoses Syndrome Results from Deletion of SULF1 and SLCO5A1 Genes at 8q13
- (2010) Bertrand Isidor et al. AMERICAN JOURNAL OF HUMAN GENETICS
- Altered expression of organic anion transporter polypeptide (OATP) genes in human breast carcinoma
- (2010) Katrin Wlcek et al. CANCER BIOLOGY & THERAPY
- Common Nonsynonymous Substitutions in SLCO1B1 Predispose to Statin Intolerance in Routinely Treated Individuals With Type 2 Diabetes: A Go-DARTS Study
- (2010) L A Donnelly et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Transport of Estrone 3-sulfate Mediated by Organic Anion Transporter OATP4C1: Estrone 3-sulfate binds to the Different Recognition Site for Digoxin in OATP4C1
- (2010) Hiroaki Yamaguchi et al. Drug Metabolism and Pharmacokinetics
- Organic anion transporting polypeptide 1a/1b–knockout mice provide insights into hepatic handling of bilirubin, bile acids, and drugs
- (2010) Evita van de Steeg et al. JOURNAL OF CLINICAL INVESTIGATION
- Intestinal Absorption Mechanism of Tebipenem Pivoxil, a Novel Oral Carbapenem: Involvement of Human OATP Family in Apical Membrane Transport
- (2010) Kazuhiko Kato et al. MOLECULAR PHARMACEUTICS
- The search beyond statins
- (2010) Melinda Wenner Moyer NATURE MEDICINE
- Intestinal Absorption of HMG-CoA Reductase Inhibitor Pravastatin Mediated by Organic Anion Transporting Polypeptide
- (2010) Yoshiyuki Shirasaka et al. PHARMACEUTICAL RESEARCH
- Disposition of ezetimibe is influenced by polymorphisms of the hepatic uptake carrier OATP1B1
- (2010) Stefan Oswald et al. Pharmacogenetics and Genomics
- Mechanisms of pH-gradient driven transport mediated by organic anion polypeptide transporters
- (2009) Simone Leuthold et al. AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY
- Human Skeletal Muscle Drug Transporters Determine Local Exposure and Toxicity of Statins
- (2009) Michael J. Knauer et al. CIRCULATION RESEARCH
- The International Transporter Consortium: A Collaborative Group of Scientists From Academia, Industry, and the FDA
- (2009) S-M Huang et al. CLINICAL PHARMACOLOGY & THERAPEUTICS
- Blood−brain barrier transporters and response to CNS-active drugs
- (2009) Bradley L. Urquhart et al. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
- Species Difference in the Effect of Grapefruit Juice on Intestinal Absorption of Talinolol between Human and Rat
- (2009) Y. Shirasaka et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- Influence of Cyclooxygenase Inhibitors on the Function of the Prostaglandin Transporter Organic Anion-Transporting Polypeptide 2A1 Expressed in Human Gastroduodenal Mucosa
- (2009) K. Mandery et al. JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS
- The SLCO1B1*5Genetic Variant Is Associated With Statin-Induced Side Effects
- (2009) Deepak Voora et al. JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY
- Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche
- (2009) Toshiro Sato et al. NATURE
- Absorption of montelukast is transporter mediated: a common variant of OATP2B1 is associated with reduced plasma concentrations and poor response
- (2009) Edward B. Mougey et al. Pharmacogenetics and Genomics
- Interplay between the Nuclear Receptor Pregnane X Receptor and the Uptake Transporter Organic Anion Transporter Polypeptide 1A2 Selectively Enhances Estrogen Effects in Breast Cancer
- (2008) H. E. Meyer zu Schwabedissen et al. CANCER RESEARCH
- Effect of SLCO1B3 Haplotype on Testosterone Transport and Clinical Outcome in Caucasian Patients with Androgen-Independent Prostatic Cancer
- (2008) A. Hamada et al. CLINICAL CANCER RESEARCH
- Methotrexate Pharmacokinetics in Transgenic Mice with Liver-Specific Expression of Human Organic Anion-Transporting Polypeptide 1B1 (SLCO1B1)
- (2008) E. van de Steeg et al. DRUG METABOLISM AND DISPOSITION
- Effect of pregnane X receptor ligands on transport mediated by human OATP1B1 and OATP1B3
- (2008) Chunshan Gui et al. EUROPEAN JOURNAL OF PHARMACOLOGY
- Different Effects ofSLCO1B1Polymorphism on the Pharmacokinetics and Pharmacodynamics of Repaglinide and Nateglinide
- (2008) Annikka Kalliokoski et al. JOURNAL OF CLINICAL PHARMACOLOGY
- Expression and localization of prostaglandin transporter in Alzheimer disease brains and age-matched controls
- (2008) Koyi Choi et al. JOURNAL OF NEUROIMMUNOLOGY
- Profiling SLCO and SLC22 genes in the NCI-60 cancer cell lines to identify drug uptake transporters
- (2008) M. Okabe et al. MOLECULAR CANCER THERAPEUTICS
- Targeted Disruption of Murine Organic Anion-Transporting Polypeptide 1b2 (oatp1b2/Slco1b2) Significantly Alters Disposition of Prototypical Drug Substrates Pravastatin and Rifampin
- (2008) H. Zaher et al. MOLECULAR PHARMACOLOGY
- Role of the Murine Organic Anion-Transporting Polypeptide 1b2 (Oatp1b2) in Drug Disposition and Hepatotoxicity
- (2008) R. Evers et al. MOLECULAR PHARMACOLOGY
- SLCO1B1Variants and Statin-Induced Myopathy — A Genomewide Study
- (2008) NEW ENGLAND JOURNAL OF MEDICINE
- Characterization of Organic Anion Transporting Polypeptide 1b2-null Mice: Essential Role in Hepatic Uptake/Toxicity of Phalloidin and Microcystin-LR
- (2008) Hong Lu et al. TOXICOLOGICAL SCIENCES
- Xenobiotic transporters of the human organic anion transporting polypeptides (OATP) family
- (2008) B. Hagenbuch et al. XENOBIOTICA
Find the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
SearchAdd your recorded webinar
Do you already have a recorded webinar? Grow your audience and get more views by easily listing your recording on Peeref.
Upload Now