An allosteric mechanism for potent inhibition of human ATP-citrate lyase
Published 2019 View Full Article
- Home
- Publications
- Publication Search
- Publication Details
Title
An allosteric mechanism for potent inhibition of human ATP-citrate lyase
Authors
Keywords
-
Journal
NATURE
Volume 568, Issue 7753, Pages 566-570
Publisher
Springer Nature
Online
2019-04-04
DOI
10.1038/s41586-019-1094-6
References
Ask authors/readers for more resources
Related references
Note: Only part of the references are listed.- ATP citrate lyase (ACLY) inhibitors: An anti-cancer strategy at the crossroads of glucose and lipid metabolism
- (2018) Carlotta Granchi EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
- New tools for automated high-resolution cryo-EM structure determination in RELION-3
- (2018) Jasenko Zivanov et al. eLife
- UCSF ChimeraX: Meeting modern challenges in visualization and analysis
- (2017) Thomas D. Goddard et al. PROTEIN SCIENCE
- Binding of hydroxycitrate to human ATP-citrate lyase
- (2017) Jinhong Hu et al. Acta Crystallographica Section D-Structural Biology
- Accelerated cryo-EM structure determination with parallelisation using GPUs in RELION-2
- (2016) Dari Kimanius et al. eLife
- OPLS3: A Force Field Providing Broad Coverage of Drug-like Small Molecules and Proteins
- (2015) Edward Harder et al. Journal of Chemical Theory and Computation
- CTFFIND4: Fast and accurate defocus estimation from electron micrographs
- (2015) Alexis Rohou et al. JOURNAL OF STRUCTURAL BIOLOGY
- Accurate and Reliable Prediction of Relative Ligand Binding Potency in Prospective Drug Discovery by Way of a Modern Free-Energy Calculation Protocol and Force Field
- (2015) Lingle Wang et al. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY
- Sampling the conformational space of the catalytic subunit of human γ-secretase
- (2015) Xiao-chen Bai et al. eLife
- Structure of GTP-specific succinyl-CoA synthetase in complex with CoA
- (2015) Ji Huang et al. Acta Crystallographica Section F-Structural Biology Communications
- Glucose-dependentde NovoLipogenesis in B Lymphocytes
- (2014) Fay J. Dufort et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Modeling Local Structural Rearrangements Using FEP/REST: Application to Relative Binding Affinity Predictions of CDK2 Inhibitors
- (2013) Lingle Wang et al. Journal of Chemical Theory and Computation
- Quantifying the local resolution of cryo-EM density maps
- (2013) Alp Kucukelbir et al. NATURE METHODS
- ATP-citrate lyase: A mini-review
- (2012) Melanie Chypre et al. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
- On the Catalytic Mechanism of Human ATP Citrate Lyase
- (2012) Fan Fan et al. BIOCHEMISTRY
- ATP-Citrate Lyase: A Key Player in Cancer Metabolism
- (2012) N. Zaidi et al. CANCER RESEARCH
- Structure and function of biotin-dependent carboxylases
- (2012) Liang Tong CELLULAR AND MOLECULAR LIFE SCIENCES
- On achieving high accuracy and reliability in the calculation of relative protein-ligand binding affinities
- (2012) L. Wang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Iterative Stable Alignment and Clustering of 2D Transmission Electron Microscope Images
- (2012) Zhengfan Yang et al. STRUCTURE
- ADP–Mg2+bound to the ATP-grasp domain of ATP-citrate lyase
- (2011) Tianjun Sun et al. Acta Crystallographica Section F-Structural Biology and Crystallization Communications
- Replica Exchange with Solute Scaling: A More Efficient Version of Replica Exchange with Solute Tempering (REST2)
- (2011) Lingle Wang et al. JOURNAL OF PHYSICAL CHEMISTRY B
- Identification of the Citrate-binding Site of Human ATP-Citrate Lyase Using X-ray Crystallography
- (2010) Tianjun Sun et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Crystal structure of Salmonella typhimurium 2-methylcitrate synthase: Insights on domain movement and substrate specificity
- (2010) Sagar Chittori et al. JOURNAL OF STRUCTURAL BIOLOGY
- ATP-Citrate Lyase Links Cellular Metabolism to Histone Acetylation
- (2009) K. E. Wellen et al. SCIENCE
- Searching protein structure databases with DaliLite v.3
- (2008) L. Holm et al. BIOINFORMATICS
Publish scientific posters with Peeref
Peeref publishes scientific posters from all research disciplines. Our Diamond Open Access policy means free access to content and no publication fees for authors.
Learn MoreFind the ideal target journal for your manuscript
Explore over 38,000 international journals covering a vast array of academic fields.
Search