RIPK1 mediates a disease-associated microglial response in Alzheimer’s disease

The interplay of IKK, NF-κB and RIPK1 signaling in the regulation of cell death, tissue homeostasis and inflammation

(2017) Vangelis Kondylis et al.   IMMUNOLOGICAL REVIEWS

EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells

(2017) Florian Wanke et al.   Cell Reports

Cystatin F is a biomarker of prion pathogenesis in mice

(2017) Mario Nuvolone et al.   PLoS One

K45A mutation of RIPK1 results in poor necroptosis and cytokine signaling in macrophages, which impacts inflammatory responses in vivo

(2016) B Shutinoski et al.   CELL DEATH AND DIFFERENTIATION

Alzheimer’s disease-like APP processing in wild-type mice identifies synaptic defects as initial steps of disease progression

(2016) Mickael Audrain et al.   Molecular Neurodegeneration

RIPK1 mediates axonal degeneration by promoting inflammation and necroptosis in ALS

(2016) Yasushi Ito et al.   SCIENCE

Targeting macrophage necroptosis for therapeutic and diagnostic interventions in atherosclerosis

(2016) D. Karunakaran et al.   Science Advances

Alzheimer’s Disease Risk Genes and Mechanisms of Disease Pathogenesis

(2015) Celeste M. Karch et al.   BIOLOGICAL PSYCHIATRY

TREM2 Lipid Sensing Sustains the Microglial Response in an Alzheimer’s Disease Model

(2015) Yaming Wang et al.   CELL

TREM2 deficiency eliminates TREM2+inflammatory macrophages and ameliorates pathology in Alzheimer’s disease mouse models

(2015) Taylor R. Jay et al.   JOURNAL OF EXPERIMENTAL MEDICINE

An anti-pyroglutamate-3 Aβ vaccine reduces plaques and improves cognition in APPswe/PS1ΔE9 mice

(2015) Jeffrey L. Frost et al.   NEUROBIOLOGY OF AGING

Activation of Necroptosis in Multiple Sclerosis

(2015) Dimitry Ofengeim et al.   Cell Reports

Induction of a common microglia gene expression signature by aging and neurodegenerative conditions: a co-expression meta-analysis

(2015) Inge R Holtman et al.   Acta Neuropathologica Communications

Lysosome and calcium dysregulation in Alzheimer's disease: partners in crime

(2015) MaryKate McBrayer et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Accelerated microglial pathology is associated with Aβ plaques in mouse models of Alzheimer's disease

(2014) Rona Baron et al.   AGING CELL

Autophagy in microglia degrades extracellular β-amyloid fibrils and regulates the NLRP3 inflammasome

(2014) Mi-Hyang Cho et al.   Autophagy

Cutting Edge: RIPK1 Kinase Inactive Mice Are Viable and Protected from TNF-Induced Necroptosis In Vivo

(2014) Apostolos Polykratis et al.   JOURNAL OF IMMUNOLOGY

Cutting Edge: RIP1 Kinase Activity Is Dispensable for Normal Development but Is a Key Regulator of Inflammation in SHARPIN-Deficient Mice

(2014) S. B. Berger et al.   JOURNAL OF IMMUNOLOGY

Single App knock-in mouse models of Alzheimer's disease

(2014) Takashi Saito et al.   NATURE NEUROSCIENCE

Isolation of glia from Alzheimer's mice reveals inflammation and dysfunction

(2014) Marie Orre et al.   NEUROBIOLOGY OF AGING

The Evolving Biology of Microglia in Alzheimer’s Disease

(2014) Tarja M. Malm et al.   Neurotherapeutics

Evidence of Trem2 Variant Associated with Triple Risk of Alzheimer’s Disease

(2014) Zainularifeen Abduljaleel et al.   PLoS One

25-Hydroxycholesterol acts as an amplifier of inflammatory signaling

(2014) E. S. Gold et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cystatin F Regulates Proteinase Activity in IL-2-activated Natural Killer Cells

(2014) Katarina Maher et al.   PROTEIN AND PEPTIDE LETTERS

Activity of Protein Kinase RIPK3 Determines Whether Cells Die by Necroptosis or Apoptosis

(2014) K. Newton et al.   SCIENCE

Necroptosis in health and diseases

(2014) Wen Zhou et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Atherosclerosis and Alzheimer - diseases with a common cause? Inflammation, oxysterols, vasculature

(2014) Richard Lathe et al.   BMC Geriatrics

Involvement of interleukin-1β in the autophagic process of microglia: relevance to Alzheimer’s disease

(2013) Arnaud François et al.   Journal of Neuroinflammation

Meta-analysis of 74,046 individuals identifies 11 new susceptibility loci for Alzheimer's disease

(2013) Jean-Charles Lambert et al.   NATURE GENETICS

The microglial sensome revealed by direct RNA sequencing

(2013) Suzanne E Hickman et al.   NATURE NEUROSCIENCE

Regulation of RIP1 kinase signalling at the crossroads of inflammation and cell death

(2013) Dimitry Ofengeim et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

A Neurodegeneration-Specific Gene-Expression Signature of Acutely Isolated Microglia from an Amyotrophic Lateral Sclerosis Mouse Model

(2013) Isaac M. Chiu et al.   Cell Reports

Cystatins in Immune System

(2013) Špela Magister et al.   Journal of Cancer

Microglia and Inflammation in Alzheimers Disease

(2012) Shweta Mandrekar-Colucci et al.   CNS & Neurological Disorders-Drug Targets

Regulation of cathepsins S and L by cystatin F during maturation of dendritic cells

(2012) Špela Magister et al.   EUROPEAN JOURNAL OF CELL BIOLOGY

Variant of TREM2 Associated with the Risk of Alzheimer's Disease

(2012) Thorlakur Jonsson et al.   NEW ENGLAND JOURNAL OF MEDICINE

A novel role for RIP1 kinase in mediating TNFα production

(2012) D E Christofferson et al.   Cell Death & Disease

Therapeutic effects of remediating autophagy failure in a mouse model of Alzheimer disease by enhancing lysosomal proteolysis

(2011) Dun-Sheng Yang et al.   Autophagy

The role of the ubiquitin proteasome system in Alzheimer's disease

(2011) Beat M Riederer et al.   EXPERIMENTAL BIOLOGY AND MEDICINE

Microglial cystatin F expression is a sensitive indicator for ongoing demyelination with concurrent remyelination

(2011) Jianmei Ma et al.   JOURNAL OF NEUROSCIENCE RESEARCH

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

(2011) Paul Hollingworth et al.   NATURE GENETICS

Mechanism mediating oligomeric Aβ clearance by naïve primary microglia

(2011) Cheng-Ning Yang et al.   NEUROBIOLOGY OF DISEASE

Biochemical and behavioral characterization of the double transgenic mouse model (APPswe/PS1dE9) of Alzheimer’s disease

(2011) Huaqi Xiong et al.   Neuroscience Bulletin

Cholesterol-related genes in Alzheimer's disease

(2010) M. Axel Wollmer   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The role of microglia in amyloid clearance from the AD brain

(2010) C. Y. Daniel Lee et al.   JOURNAL OF NEURAL TRANSMISSION

Microglia in neurodegenerative disease

(2010) V. Hugh Perry et al.   Nature Reviews Neurology

Glycosylation Directs Targeting and Activation of Cystatin F from Intracellular and Extracellular Sources

(2009) Jeff D Colbert et al.   TRAFFIC

Cystatin F is a cathepsin C-directed protease inhibitor regulated by proteolysis

(2008) Garth Hamilton et al.   EMBO JOURNAL

Identification of RIP1 kinase as a specific cellular target of necrostatins

(2008) Alexei Degterev et al.   Nature Chemical Biology