Tools of pathway reconstruction and production of economically relevant plant secondary metabolites in recombinant microorganisms

Orthogonal Assays Clarify the Oxidative Biochemistry of Taxol P450 CYP725A4

(2016) Bradley Walters Biggs et al.   ACS Chemical Biology

Recent developments in the enzymatic O-glycosylation of flavonoids

(2016) Bernd Hofer   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Microbial production of natural and non-natural flavonoids: Pathway engineering, directed evolution and systems/synthetic biology

(2016) Ramesh Prasad Pandey et al.   BIOTECHNOLOGY ADVANCES

Into new territory: improved microbial synthesis through engineering of the essential metabolic network

(2016) Michael D Lynch   CURRENT OPINION IN BIOTECHNOLOGY

Protein engineering approaches to chemical biotechnology

(2016) Zhen Chen et al.   CURRENT OPINION IN BIOTECHNOLOGY

Engineering the shikimate pathway for biosynthesis of molecules with pharmaceutical activities in E. coli

(2016) Ming Jiang et al.   CURRENT OPINION IN BIOTECHNOLOGY

Biocatalysts from alkaloid producing plants

(2016) Hajo Kries et al.   CURRENT OPINION IN CHEMICAL BIOLOGY

Methylation of flavonoids: Chemical structures, bioactivities, progress and perspectives for biotechnological production

(2016) Niranjan Koirala et al.   ENZYME AND MICROBIAL TECHNOLOGY

Artemisinin-based antimalarial research: application of biotechnology to the production of artemisinin, its mode of action, and the mechanism of resistance of Plasmodium parasites

(2016) Paskorn Muangphrom et al.   Journal of Natural Medicines

Experimental and computational optimization of an Escherichia coli co-culture for the efficient production of flavonoids

(2016) J. Andrew Jones et al.   METABOLIC ENGINEERING

Heterologous production of raspberry ketone in the wine yeast Saccharomyces cerevisiae via pathway engineering and synthetic enzyme fusion

(2016) Danna Lee et al.   Microbial Cell Factories

CRISPR/Cas9 Platforms for Genome Editing in Plants: Developments and Applications

(2016) Xingliang Ma et al.   Molecular Plant

Overcoming heterologous protein interdependency to optimize P450-mediated Taxol precursor synthesis inEscherichia coli

(2016) Bradley Walters Biggs et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Microbial Factories for the Production of Benzylisoquinoline Alkaloids

(2016) Lauren Narcross et al.   TRENDS IN BIOTECHNOLOGY

Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli

(2016) Akira Nakagawa et al.   Nature Communications

Engineering biosynthesis of the anticancer alkaloid noscapine in yeast

(2016) Yanran Li et al.   Nature Communications

Transcriptional regulation of artemisinin biosynthesis in Artemisia annua L.

(2016) Qian Shen et al.   Science Bulletin

Engineering of Secondary Metabolism

(2015) Sarah E. O'Connor   Annual Review of Genetics

Lifespan and healthspan extension by resveratrol

(2015) Khushwant S. Bhullar et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The molecular targets of resveratrol

(2015) Sameer S. Kulkarni et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Expanding the chemical space of polyketides through structure-guided mutagenesis of Vitis vinifera stilbene synthase

(2015) Namita Bhan et al.   BIOCHIMIE

Characterization of a second secologanin synthase isoform producing both secologanin and secoxyloganin allows enhanced de novo assembly of a Catharanthus roseus transcriptome

(2015) Thomas Dugé de Bernonville et al.   BMC GENOMICS

Proteomic analysis of Artemisia annua – towards elucidating the biosynthetic pathways of the antimalarial pro-drug artemisinin

(2015) Laura Bryant et al.   BMC PLANT BIOLOGY

Metabolome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants

(2015) Jillian M. Hagel et al.   BMC PLANT BIOLOGY

Transcriptome analysis of 20 taxonomically related benzylisoquinoline alkaloid-producing plants

(2015) Jillian M. Hagel et al.   BMC PLANT BIOLOGY

Engineered biosynthesis of natural products in heterologous hosts

(2015) Yunzi Luo et al.   CHEMICAL SOCIETY REVIEWS

Unlocking the Diversity of Alkaloids in Catharanthus roseus: Nuclear Localization Suggests Metabolic Channeling in Secondary Metabolism

(2015) Anna Stavrinides et al.   CHEMISTRY & BIOLOGY

Papaverine 7-O-demethylase, a novel 2-oxoglutarate/Fe2+-dependent dioxygenase from opium poppy

(2015) Scott C. Farrow et al.   FEBS LETTERS

Engineering strategies for the fermentative production of plant alkaloids in yeast

(2015) Isis J. Trenchard et al.   METABOLIC ENGINEERING

De novo production of resveratrol from glucose or ethanol by engineered Saccharomyces cerevisiae

(2015) Mingji Li et al.   METABOLIC ENGINEERING

Stereochemical inversion of (S)-reticuline by a cytochrome P450 fusion in opium poppy

(2015) Scott C Farrow et al.   Nature Chemical Biology

Beyond editing: repurposing CRISPR–Cas9 for precision genome regulation and interrogation

(2015) Antonia A. Dominguez et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Monoterpenoid indole alkaloids biosynthesis and its regulation in Catharanthus roseus: a literature review from genes to metabolites

(2015) Qifang Pan et al.   PHYTOCHEMISTRY REVIEWS

Metabolic engineering for the production of plant isoquinoline alkaloids

(2015) Andrew Diamond et al.   PLANT BIOTECHNOLOGY JOURNAL

Transcript profiling of jasmonate-elicited Taxus cells reveals a β-phenylalanine-CoA ligase

(2015) Karla Ramírez-Estrada et al.   PLANT BIOTECHNOLOGY JOURNAL

Completion of the seven-step pathway from tabersonine to the anticancer drug precursor vindoline and its assembly in yeast

(2015) Yang Qu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

De novo production of the plant-derived alkaloid strictosidine in yeast

(2015) Stephanie Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Morphinan biosynthesis in opium poppy requires a P450-oxidoreductase fusion protein

(2015) T. Winzer et al.   SCIENCE

Complete biosynthesis of opioids in yeast

(2015) S. Galanie et al.   SCIENCE

Enhancing flavonoid production by systematically tuning the central metabolic pathways based on a CRISPR interference system in Escherichia coli

(2015) Junjun Wu et al.   Scientific Reports

Co-overexpression of geraniol-10-hydroxylase and strictosidine synthase improves anti-cancer drug camptothecin accumulation in Ophiorrhiza pumila

(2015) Lijie Cui et al.   Scientific Reports

Efficient Synthesis of Eriodictyol from l-Tyrosine in Escherichia coli

(2014) Saijie Zhu et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

Natural products - learning chemistry from plants

(2014) Agata Staniek et al.   Biotechnology Journal

Biosynthesis of methylated resveratrol analogs through the construction of an artificial biosynthetic pathway in E. coli

(2014) Sun-Young Kang et al.   BMC BIOTECHNOLOGY

Cytochrome P450-mediated metabolic engineering: current progress and future challenges

(2014) Hugues Renault et al.   CURRENT OPINION IN PLANT BIOLOGY

Making iridoids/secoiridoids and monoterpenoid indole alkaloids: progress on pathway elucidation

(2014) Vincenzo De Luca et al.   CURRENT OPINION IN PLANT BIOLOGY

Production of kaempferol 3-O-rhamnoside from glucose using engineered Escherichia coli

(2014) So-Mi Yang et al.   JOURNAL OF INDUSTRIAL MICROBIOLOGY & BIOTECHNOLOGY

Construction of Artificial Biosynthetic Pathways for Resveratrol Glucoside Derivatives

(2014) Oksik Choi et al.   JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY

Enzyme clustering accelerates processing of intermediates through metabolic channeling

(2014) Michele Castellana et al.   NATURE BIOTECHNOLOGY

Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development

(2014) Chris J. Paddon et al.   NATURE REVIEWS MICROBIOLOGY

Benzylisoquinoline alkaloid biosynthesis in opium poppy

(2014) Guillaume A. W. Beaudoin et al.   PLANTA

Total Synthesis of a Functional Designer Eukaryotic Chromosome

(2014) N. Annaluru et al.   SCIENCE

OMICtools: an informative directory for multi-omic data analysis

(2014) V. J. Henry et al.   Database-The Journal of Biological Databases and Curation

Recombinant protein expression in Escherichia coli: advances and challenges

(2014) Germán L. Rosano et al.   Frontiers in Microbiology

Design and Kinetic Analysis of a Hybrid Promoter–Regulator System for Malonyl-CoA Sensing in Escherichia coli

(2013) Peng Xu et al.   ACS Chemical Biology

Biosynthesis of bioactive O-methylated flavonoids in Escherichia coli

(2013) Min-Ji Kim et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Natural products - modifying metabolite pathways in plants

(2013) Agata Staniek et al.   Biotechnology Journal

From flavors and pharmaceuticals to advanced biofuels: Production of isoprenoids inSaccharomyces cerevisiae

(2013) Stefan Tippmann et al.   Biotechnology Journal

Pathway and protein engineering approaches to produce novel and commodity small molecules

(2013) Namita Bhan et al.   CURRENT OPINION IN BIOTECHNOLOGY

Overproduction of geraniol by enhanced precursor supply in Saccharomyces cerevisiae

(2013) Jidong Liu et al.   JOURNAL OF BIOTECHNOLOGY

Influence of resveratrol on oxidative stress resistance and life span inCaenorhabditis elegans

(2013) Wei Chen et al.   JOURNAL OF PHARMACY AND PHARMACOLOGY

High-level semi-synthetic production of the potent antimalarial artemisinin

(2013) C. J. Paddon et al.   NATURE

Comparative Transcriptome Analysis Using High Papaverine Mutant of Papaver somniferum Reveals Pathway and Uncharacterized Steps of Papaverine Biosynthesis

(2013) Sumya Pathak et al.   PLoS One

Microbial production of isoquinoline alkaloids as plant secondary metabolites based on metabolic engineering research

(2013) Fumihiko SATO et al.   PROCEEDINGS OF THE JAPAN ACADEMY SERIES B-PHYSICAL AND BIOLOGICAL SCIENCES

What makes a P450 tick?

(2013) Andrew W. Munro et al.   TRENDS IN BIOCHEMICAL SCIENCES

The Shikimate Pathway and Aromatic Amino Acid Biosynthesis in Plants

(2012) Hiroshi Maeda et al.   Annual Review of Plant Biology

Engineering specialized metabolic pathways—is there a room for enzyme improvements?

(2012) Arren Bar-Even et al.   CURRENT OPINION IN BIOTECHNOLOGY

Recent progress in the metabolic engineering of alkaloids in plant systems

(2012) Weslee S Glenn et al.   CURRENT OPINION IN BIOTECHNOLOGY

Metabolic engineering of Escherichia coli for (2S)-pinocembrin production from glucose by a modular metabolic strategy

(2012) Junjun Wu et al.   METABOLIC ENGINEERING

Engineering the third wave of biocatalysis

(2012) U. T. Bornscheuer et al.   NATURE

Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin

(2012) P. J. Westfall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Identification and treatment of heme depletion attributed to overexpression of a lineage of evolved P450 monooxygenases

(2012) J. K. Michener et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Introduction and expression of genes for metabolic engineering applications in Saccharomyces cerevisiae

(2011) Nancy A. Da Silva et al.   FEMS YEAST RESEARCH

Stepwise increase of resveratrol biosynthesis in yeast Saccharomyces cerevisiae by metabolic engineering

(2011) Yechun Wang et al.   METABOLIC ENGINEERING

Improving yeast strains using recyclable integration cassettes, for the production of plant terpenoids

(2011) Codruta Ignea et al.   Microbial Cell Factories

Synthesis of unnatural alkaloid scaffolds by exploiting plant polyketide synthase

(2011) H. Morita et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A bacterial platform for fermentative production of plant alkaloids

(2011) Akira Nakagawa et al.   Nature Communications

The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)

(2010) Geoffrey D. Brown   MOLECULES

Structure and function of the chalcone synthase superfamily of plant type III polyketide synthases

(2010) Ikuro Abe et al.   NATURAL PRODUCT REPORTS

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

(2010) P. K. Ajikumar et al.   SCIENCE

BglBricks: A flexible standard for biological part assembly

(2010) J Christopher Anderson et al.   Journal of Biological Engineering

Medicinally important secondary metabolites in recombinant microorganisms or plants: Progress in alkaloid biosynthesis

(2009) Holger Schäfer et al.   Biotechnology Journal

Phenylpropanoid Biosynthesis

(2009) Thomas Vogt   Molecular Plant

Programming cells by multiplex genome engineering and accelerated evolution

(2009) Harris H. Wang et al.   NATURE

Synthetic protein scaffolds provide modular control over metabolic flux

(2009) John E Dueber et al.   NATURE BIOTECHNOLOGY

Opportunities in metabolic engineering to facilitate scalable alkaloid production

(2009) Effendi Leonard et al.   Nature Chemical Biology

Enzymatic assembly of DNA molecules up to several hundred kilobases

(2009) Daniel G Gibson et al.   NATURE METHODS

VIGS – genomics goes functional

(2009) Annette Becker et al.   TRENDS IN PLANT SCIENCE

Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid

(2008) Dae-Kyun Ro et al.   BMC BIOTECHNOLOGY

Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae

(2008) Kristy M Hawkins et al.   Nature Chemical Biology

Protein production and purification

(2008) Susanne Gräslund et al.   NATURE METHODS

Structure and function of enzymes involved in the biosynthesis of phenylpropanoids

(2008) J.-L. Ferrer et al.   PLANT PHYSIOLOGY AND BIOCHEMISTRY

A One Pot, One Step, Precision Cloning Method with High Throughput Capability

(2008) Carola Engler et al.   PLoS One

Microbial production of plant benzylisoquinoline alkaloids

(2008) H. Minami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Engineering microbial consortia: a new frontier in synthetic biology

(2008) Katie Brenner et al.   TRENDS IN BIOTECHNOLOGY

Potential for metabolic engineering of resveratrol biosynthesis

(2008) Coralie Halls et al.   TRENDS IN BIOTECHNOLOGY

Engineering BioBrick vectors from BioBrick parts

(2008) Reshma P Shetty et al.   Journal of Biological Engineering