Total biosynthesis of opiates by stepwise fermentation using engineered Escherichia coli

De novo production of the key branch point benzylisoquinoline alkaloid reticuline in yeast

(2015) Isis J. Trenchard et al.   METABOLIC ENGINEERING

Distributing a metabolic pathway among a microbial consortium enhances production of natural products

(2015) Kang Zhou et al.   NATURE BIOTECHNOLOGY

Stereochemical inversion of (S)-reticuline by a cytochrome P450 fusion in opium poppy

(2015) Scott C Farrow et al.   Nature Chemical Biology

An enzyme-coupled biosensor enables (S)-reticuline production in yeast from glucose

(2015) William C DeLoache et al.   Nature Chemical Biology

Morphinan biosynthesis in opium poppy requires a P450-oxidoreductase fusion protein

(2015) T. Winzer et al.   SCIENCE

Complete biosynthesis of opioids in yeast

(2015) S. Galanie et al.   SCIENCE

Synthesis of Morphinan Alkaloids in Saccharomyces cerevisiae

(2015) Elena Fossati et al.   PLoS One

Biosynthetic Pathway for the Cyanide-Free Production of Phenylacetonitrile in Escherichia coli by Utilizing Plant Cytochrome P450 79A2 and Bacterial Aldoxime Dehydratase

(2014) Yuta Miki et al.   APPLIED AND ENVIRONMENTAL MICROBIOLOGY

A microbial biomanufacturing platform for natural and semisynthetic opioids

(2014) Kate Thodey et al.   Nature Chemical Biology

Reconstitution of a 10-gene pathway for synthesis of the plant alkaloid dihydrosanguinarine in Saccharomyces cerevisiae

(2014) Elena Fossati et al.   Nature Communications

(R,S)-Tetrahydropapaveroline production by stepwise fermentation using engineered Escherichia coli

(2014) Akira Nakagawa et al.   Scientific Reports

High-level semi-synthetic production of the potent antimalarial artemisinin

(2013) C. J. Paddon et al.   NATURE

Rice P450 reductases differentially affect P450-mediated metabolism in bacterial expression systems

(2012) Sangkyu Park et al.   BIOPROCESS AND BIOSYSTEMS ENGINEERING

Engineering of l-tyrosine oxidation in Escherichia coli and microbial production of hydroxytyrosol

(2012) Yasuharu Satoh et al.   METABOLIC ENGINEERING

A bacterial platform for fermentative production of plant alkaloids

(2011) Akira Nakagawa et al.   Nature Communications

Production of serotonin by dual expression of tryptophan decarboxylase and tryptamine 5-hydroxylase in Escherichia coli

(2010) Sangkyu Park et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

CYP719B1 Is Salutaridine Synthase, the C-C Phenol-coupling Enzyme of Morphine Biosynthesis in Opium Poppy

(2009) Andreas Gesell et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Mammalian Cytochrome P450 Enzymes Catalyze the Phenol-coupling Step in Endogenous Morphine Biosynthesis

(2009) Nadja Grobe et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Production of benzylisoquinoline alkaloids in Saccharomyces cerevisiae

(2008) Kristy M Hawkins et al.   Nature Chemical Biology

Microbial production of plant benzylisoquinoline alkaloids

(2008) H. Minami et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA