Overcoming heterologous protein interdependency to optimize P450-mediated Taxol precursor synthesis inEscherichia coli

Optimization of recombinant expression enables discovery of novel cytochrome P450 activity in rice diterpenoid biosynthesis

(2015) Naoki Kitaoka et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

Impact of synthetic biology and metabolic engineering on industrial production of fine chemicals

(2015) David Jullesson et al.   BIOTECHNOLOGY ADVANCES

Metabolic pathway balancing and its role in the production of biofuels and chemicals

(2015) J Andrew Jones et al.   CURRENT OPINION IN BIOTECHNOLOGY

Distributing a metabolic pathway among a microbial consortium enhances production of natural products

(2015) Kang Zhou et al.   NATURE BIOTECHNOLOGY

Quantifying cellular capacity identifies gene expression designs with reduced burden

(2015) Francesca Ceroni et al.   NATURE METHODS

ePathOptimize: A Combinatorial Approach for Transcriptional Balancing of Metabolic Pathways

(2015) J. Andrew Jones et al.   Scientific Reports

Cytochromes P450 as promising catalysts for biotechnological application: chances and limitations

(2014) Rita Bernhardt et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

The chemical logic of plant natural product biosynthesis

(2014) Gülbenk Anarat-Cappillino et al.   CURRENT OPINION IN PLANT BIOLOGY

Cytochrome P450-mediated metabolic engineering: current progress and future challenges

(2014) Hugues Renault et al.   CURRENT OPINION IN PLANT BIOLOGY

A microbial biomanufacturing platform for natural and semisynthetic opioids

(2014) Kate Thodey et al.   Nature Chemical Biology

Semi-synthetic artemisinin: a model for the use of synthetic biology in pharmaceutical development

(2014) Chris J. Paddon et al.   NATURE REVIEWS MICROBIOLOGY

Investigation of terpene diversification across multiple sequenced plant genomes

(2014) Alexander M. Boutanaev et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-level semi-synthetic production of the potent antimalarial artemisinin

(2013) C. J. Paddon et al.   NATURE

Optimizations to achieve high-level expression of cytochrome P450 proteins using Escherichia coli expression systems

(2013) Susan Zelasko et al.   PROTEIN EXPRESSION AND PURIFICATION

What makes a P450 tick?

(2013) Andrew W. Munro et al.   TRENDS IN BIOCHEMICAL SCIENCES

Metabolic Engineering: Past and Future

(2013) Benjamin M. Woolston et al.   Annual Review of Chemical and Biomolecular Engineering

Synthetic biology devices as tools for metabolic engineering

(2012) Eric Shiue et al.   BIOCHEMICAL ENGINEERING JOURNAL

Impacts of Diversification of Cytochrome P450 on Plant Metabolism

(2012) Masaharu Mizutani   BIOLOGICAL & PHARMACEUTICAL BULLETIN

The early stages of taxol biosynthesis: An interim report on the synthesis and identification of early pathway metabolites

(2012) Jennifer Guerra-Bubb et al.   NATURAL PRODUCT REPORTS

Diversity of P450 enzymes in the biosynthesis of natural products

(2012) Larissa M. Podust et al.   NATURAL PRODUCT REPORTS

Empirical model and in vivo characterization of the bacterial response to synthetic gene expression show that ribosome allocation limits growth rate

(2011) Javier Carrera et al.   Biotechnology Journal

Cytochrome P450: taming a wild type enzyme

(2011) Sang Taek Jung et al.   CURRENT OPINION IN BIOTECHNOLOGY

Optimization of a heterologous pathway for the production of flavonoids from glucose

(2011) Christine Nicole S. Santos et al.   METABOLIC ENGINEERING

Fundamental relationship between operon organization and gene expression

(2011) H. N. Lim et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Characterization of the kaurene oxidase CYP701A3, a multifunctional cytochrome P450 from gibberellin biosynthesis

(2010) Dana Morrone et al.   BIOCHEMICAL JOURNAL

Natural Products Version 2.0: Connecting Genes to Molecules

(2010) Christopher T. Walsh et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Isoprenoid Pathway Optimization for Taxol Precursor Overproduction in Escherichia coli

(2010) P. K. Ajikumar et al.   SCIENCE

Interdependence of Cell Growth and Gene Expression: Origins and Consequences

(2010) M. Scott et al.   SCIENCE

Human cytochrome P450 4F11: Heterologous expression in bacteria, purification, and characterization of catalytic function

(2009) Zhongmei Tang et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Stabilized gene duplication enables long-term selection-free heterologous pathway expression

(2009) Keith E J Tyo et al.   NATURE BIOTECHNOLOGY

Plant NADPH-cytochrome P450 oxidoreductases

(2009) Kenneth Jensen et al.   PHYTOCHEMISTRY

Membrane integration of recombinant human P450 forms

(2009) A. Shukla et al.   XENOBIOTICA

Metabolic engineering of taxadiene biosynthesis in yeast as a first step towards Taxol (Paclitaxel) production

(2008) Benedikt Engels et al.   METABOLIC ENGINEERING

Terpenoid biomaterials

(2008) Jörg Bohlmann et al.   PLANT JOURNAL