Article
Biochemistry & Molecular Biology
Andrey R. Suprun, Alexandra S. Dubrovina, Alexey P. Tyunin, Konstantin Kiselev
Summary: This study analyzed phenolic compounds in Russian wines for the first time and found that red wines contain more stilbenes, phenolic acids, and flavonols than white wines, with young red wines being a rich source of phenolic compounds.
Review
Chemistry, Medicinal
Lucia E. Schimith, Michele G. dos Santos, Bruno D. Arbo, Corinne Andre-Miral, Ana L. Muccillo-Baisch, Mariana A. Hort
Summary: Polydatin exhibits neuroprotective effects in central nervous system disorders through its antioxidant and anti-inflammatory properties, improving neurological dysfunctions and potentially offering therapeutic benefits.
PHYTOTHERAPY RESEARCH
(2022)
Article
Chemistry, Multidisciplinary
Julien Vinet, Amandine L. Flourat, Cedric Peyrot, Fanny Brunois, Fanny Brunissen, Florent Allais
Summary: This study explores a new method for synthesizing piceid dimers using AgOAc in ethanol, which has a higher yield, better environmental score, and more economic usage compared to the laccase-mediated method.
ACS SUSTAINABLE CHEMISTRY & ENGINEERING
(2022)
Article
Biochemistry & Molecular Biology
Didem Sohretoglu, Burak Barut, Suat Sari, Arzu Ozel, Ayse Kuruuzum-Uz, Randolph Arroo
Summary: Polydatin, a compound found in grapes, peanuts, wine, beer, and cacao products, has been shown to have anticancer activity. This study found that Polydatin protects DNA from damage and inhibits the activity of topoisomerase II, suggesting it may have potential as an anticancer agent.
CHEMISTRY & BIODIVERSITY
(2022)
Article
Plant Sciences
Zlata V. Ogneva, Vlada V. Volkonskaia, Alexandra S. Dubrovina, Andrey R. Suprun, Olga A. Aleynova, Konstantin V. Kiselev
Summary: The study found that the application of trans-resveratrol and trans-piceid can enhance Arabidopsis thaliana plants' tolerance to UV-B, increasing leaf survival rates. This improvement in tolerance is more effective than using precursors but slightly less effective than using a UV-B absorber. Furthermore, trans-resveratrol also increased the expression of antioxidant and stress-inducible genes.
Article
Biochemistry & Molecular Biology
Olga A. Aleynova, Konstantin V. Kiselev, Andrey R. Suprun, Alexey A. Ananev, Alexandra S. Dubrovina
Summary: CMLs are important plant calcium sensor proteins that sense and decode changes in intracellular calcium concentration. This study found that VaCML92 plays a positive regulatory role in the rapid response to cold stress and stress resistance in Vitis amurensis, as well as increased stilbene production.
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
(2023)
Article
Biochemistry & Molecular Biology
Chaohui Yan, Na Yang, Xinqi Wang, Yuejin Wang
Summary: The beta-glycoside hydrolase gene VqBGH40a from Chinese wild grapevine has been found to play a role in regulating plant resistance to powdery mildew. The enzyme encoded by VqBGH40a can hydrolyze piceid to enhance resveratrol content and participate in grapevine defense mechanism against powdery mildew.
Article
Horticulture
Konstantin V. Kiselev, Zlata V. Ogneva, Olga A. Aleynova, Andrey R. Suprun, Alexey A. Ananev, Nikolay N. Nityagovsky, Alexandra S. Dubrovina
Summary: Modern plant biotechnology often struggles with obtaining a stable and powerful vector for gene overexpression. It has been found that genes with introns can greatly enhance transgene expression and biological functions in plants and plant cell cultures.
Article
Biochemistry & Molecular Biology
Andrey R. Suprun, Alexandra S. Dubrovina, Olga A. Aleynova, Konstantin Kiselev
Summary: Stilbenes are phenolic compounds found in plants, with high levels of stilbenes being of interest due to their health benefits and antifungal properties. Analysis of Picea jezoensis bark and wood extracted multiple stilbenes, with the bark showing particularly high levels of trans-isorhapontin. Overall, the bark of P. jezoensis is a rich source of stilbenes, particularly trans-isorhapontin.
Article
Biochemistry & Molecular Biology
Hajer Ben Ghozlen, Sven Mangelinckx, Stefaan P. O. Werbrouck
Summary: Stilbenes, including resveratrol, are bioactive compounds in peanuts. This study investigates the production of these compounds from Arachis hypogaea using in vitro systems, specifically callus cultures and cell suspension cultures. Biotic elicitors from various fungi were found to enhance the production of stilbenes, indicating a potential method for production and a new opportunity for obtaining resveratrol and its derivatives.
PROCESS BIOCHEMISTRY
(2023)
Article
Plant Sciences
Islam M. Khattab, Vaidurya P. Sahi, Raymonde Baltenweck, Alessandra Maia-Grondard, Philippe Hugueney, Eva Bieler, Markus Duerrenberger, Michael Riemann, Peter Nick
Summary: Research on European wild grapevines from the last viable population in Germany along the Rhine river has identified a resistant chemotype against grapevine trunk diseases, providing a way to breed for resistance against grapevine Botryosphaeriaceae-related dieback. This resistant chemotype accumulates more bioactive stilbenes and shows specific phenylpropanoid metabolism patterns, contrasting with susceptible genotypes.
Article
Forestry
Andrey R. Suprun, Alexandra S. Dubrovina, Valeria P. Grigorchuk, Konstantin V. Kiselev
Summary: This study described the seasonal variations in stilbene compositions and contents in different parts of Pinus koraiensis. HPLC-ESI-MS analysis showed the presence of seven stilbenes in P. koraiensis. The complete protein-coding sequences of three stilbene synthase genes were obtained from the P. koraiensis needles.
Article
Plant Sciences
Z. Ogneva, O. A. Aleynova, A. R. Suprun, Y. A. Karetin, A. S. Dubrovina, K. Kiselev
Summary: This study demonstrated that overexpression of VaSTS1 and VaSTS7 genes significantly increased plant tolerance to UV-B and UV-C in A. thaliana plants, while not affecting tolerance to other abiotic stresses. Overexpression of VaSTS1 gene led to the highest levels of trans-piceid and trans-resveratrol in transgenic plants.
BIOLOGIA PLANTARUM
(2021)
Article
Microbiology
Daniel Bojar, Rani K. Powers, Diogo M. Camacho, James J. Collins
Summary: This study illustrates how machine learning and bioinformatics methods can be used to study the role of glycans in host-pathogen interactions, showing the ability to predict glycan immunogenicity, pathogenicity, and molecular mimicry using deep-learning models and glycan alignment methods. This expands our understanding of host-microbe interactions by identifying and studying the glycan motifs involved in immunogenicity, pathogenicity, molecular mimicry, and immune evasion.
CELL HOST & MICROBE
(2021)
Article
Agricultural Engineering
Yanzhe Shang, Ping Zhang, Wenping Wei, Jin Li, Bang-Ce Ye
Summary: By optimizing carbon metabolism, increasing gene copies, and blocking degradation, a high yield of polydatin was successfully produced in Y. lipolytica, demonstrating its great potential for glycoside synthesis.
BIORESOURCE TECHNOLOGY
(2023)
Article
Biotechnology & Applied Microbiology
Biplav Shrestha, Ramesh Prasad Pandey, Sumangala Darsandhari, Prakash Parajuli, Jae Kyung Sohng
MICROBIAL CELL FACTORIES
(2019)
Article
Chemistry, Multidisciplinary
Ramesh Prasad Pandey, Ha Young Jung, Prakash Parajuli, Thi Huyen Trang Nguyen, Puspalata Bashyal, Jae Kyung Sohng
APPLIED SCIENCES-BASEL
(2019)
Article
Chemistry, Physical
Puspalata Bashyal, Prakash Parajuli, Ramesh Prasad Pandey, Jae Kyung Sohng
Review
Biotechnology & Applied Microbiology
Anil Shrestha, Ramesh Prasad Pandey, Jae Kyung Sohng
APPLIED MICROBIOLOGY AND BIOTECHNOLOGY
(2019)
Article
Biotechnology & Applied Microbiology
Yu Jeong Lee, Puspalata Bashyal, Ramesh Prasad Pandey, Jae Kyung Sohng
BIOTECHNOLOGY AND BIOPROCESS ENGINEERING
(2019)
Article
Chemistry, Multidisciplinary
Sumangala Darsandhari, Biplav Shrestha, Ramesh Prasad Pandey, Sanghun Lee, Hye Jin Jung, Yeon Ju Kim, Jae Kyung Sohng
APPLIED SCIENCES-BASEL
(2019)
Review
Biochemistry & Molecular Biology
Samir Bahadur Thapa, Ramesh Prasad Pandey, Yong Il Park, Jae Kyung Sohng
Article
Chemistry, Multidisciplinary
Puspalata Bashyal, Ramesh Prasad Pandey, Samir Bahadur Thapa, Min-Kyoung Kang, Chang-Jin Kim, Jae Kyung Sohng
Article
Biochemistry & Molecular Biology
Luan Luong Chu, Ramesh Prasad Pandey, Dipesh Dhakal, Jae Kyung Sohng
APPLIED BIOCHEMISTRY AND BIOTECHNOLOGY
(2020)
Article
Microbiology
Kyung Taek Heo, Byeongsan Lee, Jae-Hyuk Jang, Jung-Oh Ahn, Young-Soo Hong
Summary: A cDNA clone named pnpks was obtained from Piper nigrum leaves, showing high homology to known types of chalcone synthase-like polyketide synthase (PKS). The protein encoded by pnpks catalyzes the formation of styrylpyrone through lactonization with ferulic acid. By heterologous expression in Escherichia coli, the biosynthesis of 11-methoxy-bisnoryangonin was achieved, providing a potential pathway for the biological production of styrylpyrone compounds.
FRONTIERS IN MICROBIOLOGY
(2021)
Article
Plant Sciences
Gwi Ja Hwang, Mina Jang, Sangkeun Son, Gil Soo Kim, Byeongsan Lee, Kyung Taek Heo, Geum Jin Kim, Hyukjae Choi, Jae-Seoun Hur, Jun-Pil Jang, Sung-Kyun Ko, Young-Soo Hong, Jong Seog Ahn, Jae-Hyuk Jang
Summary: In this study, a new secondary metabolite, ulleungdolin, was isolated from the co-culture of an actinomycete and a fungus. Ulleundolin exhibited antimigration effect on breast cancer cells.
JOURNAL OF NATURAL PRODUCTS
(2022)
Article
Chemistry, Multidisciplinary
Gil Soo Kim, Jun-Pil Jang, Mincheol Kwon, Tae Hoon Oh, Kyung Taek Heo, Byeongsan Lee, Jung-Sook Lee, Sung-Kyun Ko, Young-Soo Hong, Jong Seog Ahn, Jae-Hyuk Jang
Summary: A bioassay-guided investigation led to the isolation of three new carbazole glycosides, jejucarbazoles A-C (1-3), from Streptomyces sp. KCB15JA151, with established structures and inhibitory activity against IDO1 enzyme.
Article
Biotechnology & Applied Microbiology
Trang Thi Huyen Nguyen, Hee Jeong Shin, Ramesh Prasad Pandey, Hye Jin Jung, Kwangkyoung Liou, Jae Kyung Sohng
JOURNAL OF MICROBIOLOGY AND BIOTECHNOLOGY
(2020)
Article
Biochemistry & Molecular Biology
Niranjan Koirala, Ramesh Prasad Pandey, Nguyen Huy Thuan, Gopal Prasad Ghimire, Hye Jin Jung, Tae-Jin Oh, Jae Kyung Sohng
BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY
(2019)
Article
Biochemistry & Molecular Biology
Puspalata Bashyal, Ha Young Jung, Ramesh Prasad Pandey, Jae Kyung Sohng
INDIAN JOURNAL OF BIOCHEMISTRY & BIOPHYSICS
(2019)