Artemisinin-based antimalarial research: application of biotechnology to the production of artemisinin, its mode of action, and the mechanism of resistance of Plasmodium parasites

A Unique Plasmodium falciparum K13 Gene Mutation in Northwest Ethiopia

(2016) Abebe Genetu Bayih et al.   AMERICAN JOURNAL OF TROPICAL MEDICINE AND HYGIENE

Efflux transporter engineering markedly improves amorphadiene production inEscherichia coli

(2016) Congqiang Zhang et al.   BIOTECHNOLOGY AND BIOENGINEERING

Efficient Agrobacterium-mediated transformation of Artemisia annua L. using young inflorescence

(2016) Jingxue Wang et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT

Dual symbiosis between Piriformospora indica and Azotobacter chroococcum enhances the artemisinin content in Artemisia annua L.

(2016) Monika Arora et al.   WORLD JOURNAL OF MICROBIOLOGY & BIOTECHNOLOGY

Artemisinin Resistance at the China-Myanmar Border and Association with Mutations in the K13 Propeller Gene

(2015) Zenglei Wang et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Experimental design-aided systematic pathway optimization of glucose uptake and deoxyxylulose phosphate pathway for improved amorphadiene production

(2015) Congqiang Zhang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

From hybrid compounds to targeted drug delivery in antimalarial therapy

(2015) Rudi Oliveira et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Plasmodium falciparum kelch 13: a potential molecular marker for tackling artemisinin-resistant malaria parasites

(2015) Toshihiro Mita et al.   Expert Review of Anti-Infective Therapy

Plasmodium falciparumglucose-6-phosphate dehydrogenase 6-phosphogluconolactonase is a potential drug target

(2015) Stacey M. Allen et al.   FEBS Journal

Variations in key artemisinic and other metabolites throughout plant development in Artemisia annua L. for potential therapeutic use

(2015) Melissa J. Towler et al.   INDUSTRIAL CROPS AND PRODUCTS

Kinetic Mechanism and the Rate-limiting Step ofPlasmodium vivaxSerine Hydroxymethyltransferase

(2015) Somchart Maenpuen et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Haemoglobin degradation underpins the sensitivity of early ring stagePlasmodium falciparumto artemisinins

(2015) Stanley C. Xie et al.   JOURNAL OF CELL SCIENCE

Inhibitors of Plasmodial Serine Hydroxymethyltransferase (SHMT): Cocrystal Structures of Pyrazolopyrans with Potent Blood- and Liver-Stage Activities

(2015) Matthias C. Witschel et al.   JOURNAL OF MEDICINAL CHEMISTRY

PfMDR2 and PfMDR5 are dispensable for Plasmodium falciparum asexual parasite multiplication but change in vitro susceptibility to anti-malarial drugs

(2015) Maarten van der Velden et al.   MALARIA JOURNAL

Enhanced artemisinin yield by expression of rol genes in Artemisia annua

(2015) Erum Dilshad et al.   MALARIA JOURNAL

A Basic Leucine Zipper Transcription Factor, AabZIP1, Connects Abscisic Acid Signaling with Artemisinin Biosynthesis in Artemisia annua

(2015) Fangyuan Zhang et al.   Molecular Plant

A molecular mechanism of artemisinin resistance in Plasmodium falciparum malaria

(2015) Alassane Mbengue et al.   NATURE

Recovery of Artemisinin from a Complex Reaction Mixture Using Continuous Chromatography and Crystallization

(2015) Zoltán Horváth et al.   ORGANIC PROCESS RESEARCH & DEVELOPMENT

Expression of β-glucosidase increases trichome density and artemisinin content in transgenicArtemisia annuaplants

(2015) Nameirakpam Dolendro Singh et al.   PLANT BIOTECHNOLOGY JOURNAL

The activity of the artemisinic aldehyde Δ11(13) reductase promoter is important for artemisinin yield in different chemotypes of Artemisia annua L.

(2015) Ke Yang et al.   PLANT MOLECULAR BIOLOGY

Dried whole-plantArtemisia annuaslows evolution of malaria drug resistance and overcomes resistance to artemisinin

(2015) Mostafa A. Elfawal et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Updates on artemisinin: an insight to mode of actions and strategies for enhanced global production

(2015) Neha Pandey et al.   PROTOPLASMA

The discovery of artemisinin and the Nobel Prize in Physiology or Medicine

(2015) Xin-Zhuan Su et al.   Science China-Life Sciences

Haem-activated promiscuous targeting of artemisinin in Plasmodium falciparum

(2015) Jigang Wang et al.   Nature Communications

Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance

(2015) Con Dogovski et al.   PLOS BIOLOGY

Functional analysis of orthologous artemisinic aldehyde Δ11(13)-reductase reveals potential artemisinin-producing activity in non-artemisinin-producing Artemisia absinthium

(2015) Paskorn Muangphrom et al.   Plant Biotechnology

Genetic Transformation of Artemisia carvifolia Buch with rol Genes Enhances Artemisinin Accumulation

(2015) Erum Dilshad et al.   PLoS One

Assessing Subunit Dependency of the Plasmodium Proteasome Using Small Molecule Inhibitors and Active Site Probes

(2014) Hao Li et al.   ACS Chemical Biology

Overexpression of artemisinic aldehyde Δ11 (13) reductase gene-enhanced artemisinin and its relative metabolite biosynthesis in transgenicArtemisia annuaL.

(2014) Yuan Yuan et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Molecular Dynamics of Interactions between Rigid and Flexible Antifolates and Dihydrofolate Reductase from Pyrimethamine-Sensitive and Pyrimethamine-ResistantPlasmodium falciparum

(2014) Wanwimon Mokmak et al.   Chemical Biology & Drug Design

Molecular Assessment of Artemisinin Resistance Markers, Polymorphisms in the K13 Propeller, and a Multidrug-Resistance Gene in the Eastern and Western Border Areas of Myanmar

(2014) M. H. Nyunt et al.   CLINICAL INFECTIOUS DISEASES

Distinct biochemical properties of human serine hydroxymethyltransferase compared with thePlasmodiumenzyme: implications for selective inhibition

(2014) Chatchadaporn Pinthong et al.   FEBS Journal

Development of efficient miniprep transformation methods for Artemisia annua using Agrobacterium tumefaciens and Agrobacterium rhizogenes

(2014) Bushra Hafeez Kiani et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT

Changes in key constituents of clonally propagated Artemisia annua L. during preparation of compressed leaf tablets for possible therapeutic use

(2014) Pamela J. Weathers et al.   INDUSTRIAL CROPS AND PRODUCTS

Metabolic engineering of chloroplasts for artemisinic acid biosynthesis and impact on plant growth

(2014) Bhawna Saxena et al.   JOURNAL OF BIOSCIENCES

Pharmacokinetics of artemisinin delivered by oral consumption of Artemisia annua dried leaves in healthy vs. Plasmodium chabaudi-infected mice

(2014) Pamela J. Weathers et al.   JOURNAL OF ETHNOPHARMACOLOGY

New Orally Active Amino- and Hydroxy-Functionalized 11-Azaartemisinins and Their Derivatives with High Order of Antimalarial Activity against Multidrug-Resistant Plasmodium yoelii in Swiss Mice1

(2014) Chandan Singh et al.   JOURNAL OF MEDICINAL CHEMISTRY

Transcriptome responses involved in artemisinin production in Artemisia annua L. under UV-B radiation

(2014) Wei Song Pan et al.   JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY

Spread of Artemisinin Resistance in Plasmodium falciparum Malaria

(2014) Elizabeth A. Ashley et al.   NEW ENGLAND JOURNAL OF MEDICINE

Effects of overexpression of AaWRKY1 on artemisinin biosynthesis in transgenic Artemisia annua plants

(2014) Junli Han et al.   PHYTOCHEMISTRY

Cloning and Characterization of AabHLH1, a bHLH Transcription Factor that Positively Regulates Artemisinin Biosynthesis in Artemisia annua

(2014) Yunpeng Ji et al.   PLANT AND CELL PHYSIOLOGY

Enhancement of artemisinin content and relative expression of genes of artemisinin biosynthesis in Artemisia annua by exogenous MeJA treatment

(2014) Lien Xiang et al.   PLANT GROWTH REGULATION

K13-propeller mutations confer artemisinin resistance in Plasmodium falciparum clinical isolates

(2014) J. Straimer et al.   SCIENCE

Population transcriptomics of human malaria parasites reveals the mechanism of artemisinin resistance

(2014) S. Mok et al.   SCIENCE

Advances in the Chemical Synthesis of Artemisinin

(2014) Zhonglei Wang et al.   SYNTHETIC COMMUNICATIONS

A novel Plasmodium-specific prodomain fold regulates the malaria drug target SUB1 subtilase

(2014) David Giganti et al.   Nature Communications

A sugar phosphatase regulates the methylerythritol phosphate (MEP) pathway in malaria parasites

(2014) Ann M. Guggisberg et al.   Nature Communications

Chemical signatures and new drug targets for gametocytocidal drug development

(2014) Wei Sun et al.   Scientific Reports

Structures ofPlasmodium vivaxserine hydroxymethyltransferase: implications for ligand-binding specificity and functional control

(2014) Penchit Chitnumsub et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

The structure ofPlasmodium falciparumserine hydroxymethyltransferase reveals a novel redox switch that regulates its activities

(2014) Penchit Chitnumsub et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Evidence for Pyronaridine as a Highly Effective Partner Drug for Treatment of Artemisinin-Resistant Malaria in a Rodent Model

(2013) Philipp P. Henrich et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Enhancing isoprenoid production through systematically assembling and modulating efflux pumps in Escherichia coli

(2013) Jian-Feng Wang et al.   APPLIED MICROBIOLOGY AND BIOTECHNOLOGY

An Endoperoxide-Based Hybrid Approach to Deliver Falcipain Inhibitors Inside Malaria Parasites

(2013) Rudi Oliveira et al.   ChemMedChem

Iron and heme metabolism in Plasmodium falciparum and the mechanism of action of artemisinins

(2013) Nectarios Klonis et al.   CURRENT OPINION IN MICROBIOLOGY

Rapid kill of malaria parasites by artemisinin and semi-synthetic endoperoxides involves ROS-dependent depolarization of the membrane potential

(2013) Thomas Antoine et al.   JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY

Simulated digestion of dried leaves of Artemisia annua consumed as a treatment (pACT) for malaria

(2013) Pamela J. Weathers et al.   JOURNAL OF ETHNOPHARMACOLOGY

Novel phenotypic assays for the detection of artemisinin-resistant Plasmodium falciparum malaria in Cambodia: in-vitro and ex-vivo drug-response studies

(2013) Benoit Witkowski et al.   LANCET INFECTIOUS DISEASES

High-level semi-synthetic production of the potent antimalarial artemisinin

(2013) C. J. Paddon et al.   NATURE

A molecular marker of artemisinin-resistant Plasmodium falciparum malaria

(2013) Frédéric Ariey et al.   NATURE

Validation of N-myristoyltransferase as an antimalarial drug target using an integrated chemical biology approach

(2013) Megan H. Wright et al.   Nature Chemistry

Multiple populations of artemisinin-resistant Plasmodium falciparum in Cambodia

(2013) Olivo Miotto et al.   NATURE GENETICS

The metabolite chemotype ofNicotiana benthamianatransiently expressing artemisinin biosynthetic pathway genes is a function ofCYP71AV1type and relative gene dosage

(2013) Hieng-Ming Ting et al.   NEW PHYTOLOGIST

AaORA, a trichome-specific AP2/ERF transcription factor ofArtemisia annua, is a positive regulator in the artemisinin biosynthetic pathway and in disease resistance toBotrytis cinerea

(2013) Xu Lu et al.   NEW PHYTOLOGIST

Molecular Cloning and Characterization of a Trichome-Specific Promoter of Artemisinic Aldehyde Δ11(13) Reductase (DBR2) in Artemisia annua

(2013) Weimin Jiang et al.   PLANT MOLECULAR BIOLOGY REPORTER

Overexpression of the Artemisia Orthologue of ABA Receptor, AaPYL9, Enhances ABA Sensitivity and Improves Artemisinin Content in Artemisia annua L

(2013) Fangyuan Zhang et al.   PLoS One

The Use of Combining Ability Analysis to Identify Elite Parents for Artemisia annua F1 Hybrid Production

(2013) Theresa Townsend et al.   PLoS One

Combining Genotype Improvement and Statistical Media Optimization for Isoprenoid Production in E. coli

(2013) Congqiang Zhang et al.   PLoS One

Protein complex directs hemoglobin-to-hemozoin formation in Plasmodium falciparum

(2013) M. Chugh et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Reduced Artemisinin Susceptibility of Plasmodium falciparum Ring Stages in Western Cambodia

(2012) B. Witkowski et al.   ANTIMICROBIAL AGENTS AND CHEMOTHERAPY

Molecular interaction of artemisinin with translationally controlled tumor protein (TCTP) of Plasmodium falciparum

(2012) Tolga Eichhorn et al.   BIOCHEMICAL PHARMACOLOGY

Comparative functional analysis of CYP71AV1 natural variants reveals an important residue for the successive oxidation of amorpha-4,11-diene

(2012) Aya Komori et al.   FEBS LETTERS

Overexpression of the cytochrome P450 monooxygenase (cyp71av1) and cytochrome P450 reductase (cpr) genes increased artemisinin content in Artemisia annua (Asteraceae)

(2012) Q. Shen et al.   GENETICS AND MOLECULAR RESEARCH

A survey of artemisinic and dihydroartemisinic acid contents in glasshouse and global field-grown populations of the artemisinin-producing plant Artemisia annua L.

(2012) Tony R. Larson et al.   INDUSTRIAL CROPS AND PRODUCTS

Metabolic engineering of microorganisms for the synthesis of plant natural products

(2012) Jan Marienhagen et al.   JOURNAL OF BIOTECHNOLOGY

Artemisinin-resistant Plasmodium falciparum in Pursat province, western Cambodia: a parasite clearance rate study

(2012) Chanaki Amaratunga et al.   LANCET INFECTIOUS DISEASES

The stacked over-expression of FPS, CYP71AV1 and CPR genes leads to the increase of artemisinin level in Artemisia annua L.

(2012) Yunfei Chen et al.   Plant Biotechnology Reports

The effect of roots and media constituents on trichomes and artemisinin production in Artemisia annua L.

(2012) Khanhvan T. Nguyen et al.   PLANT CELL REPORTS

Screening a diverse collection of Artemisia annua germplasm accessions for the antimalarial compound, artemisinin

(2012) James Cockram et al.   Plant Genetic Resources-Characterization and Utilization

Trichome-specific expression of the amorpha-4,11-diene 12-hydroxylase (cyp71av1) gene, encoding a key enzyme of artemisinin biosynthesis in Artemisia annua, as reported by a promoter-GUS fusion

(2012) Hongzhen Wang et al.   PLANT MOLECULAR BIOLOGY

Expression and Localization of Amorpha-4,11-diene Synthase in Artemisia annua L.

(2012) Gao-Bin Pu et al.   PLANT MOLECULAR BIOLOGY REPORTER

Dried Whole Plant Artemisia annua as an Antimalarial Therapy

(2012) Mostafa A. Elfawal et al.   PLoS One

Production of amorphadiene in yeast, and its conversion to dihydroartemisinic acid, precursor to the antimalarial agent artemisinin

(2012) P. J. Westfall et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Genetic loci associated with delayed clearance of Plasmodium falciparum following artemisinin treatment in Southeast Asia

(2012) S. Takala-Harrison et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Malarial dihydrofolate reductase as a paradigm for drug development against a resistance-compromised target

(2012) Y. Yuthavong et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A Major Genome Region Underlying Artemisinin Resistance in Malaria

(2012) I. H. Cheeseman et al.   SCIENCE

Synergistic effect of Glomus mosseae and nitrogen fixing Bacillus subtilis strain Daz26 on artemisinin content in Artemisia annua L.

(2011) Ashutosh Awasthi et al.   APPLIED SOIL ECOLOGY

Effects of vegetative and flowering stages on the biosynthesis of artemisinin in Artemisia species

(2011) Abdul Mannan et al.   ARCHIVES OF PHARMACAL RESEARCH

Relative expression of genes of terpene metabolism in different tissues of Artemisia annua L

(2011) Linda Olofsson et al.   BMC PLANT BIOLOGY

Artemisinin: Discovery from the Chinese Herbal Garden

(2011) Louis H. Miller et al.   CELL

Trichomes + roots + ROS = artemisinin: regulating artemisinin biosynthesis in Artemisia annua L.

(2011) Khanhvan T. Nguyen et al.   IN VITRO CELLULAR & DEVELOPMENTAL BIOLOGY-PLANT

Cloning and characterization of trichome-specific promoter of cpr71av1 gene involved in artemisinin biosynthesis in Artemisia annua L.

(2011) Yueyue Wang et al.   MOLECULAR BIOLOGY

The Jasmonate-Responsive AP2/ERF Transcription Factors AaERF1 and AaERF2 Positively Regulate Artemisinin Biosynthesis in Artemisia annua L.

(2011) Zong-Xia Yu et al.   Molecular Plant

The discovery of artemisinin (qinghaosu) and gifts from Chinese medicine

(2011) Youyou Tu   NATURE MEDICINE

Over-expression of HMG-CoA reductase and amorpha-4,11-diene synthase genes in Artemisia annua L. and its influence on artemisinin content

(2011) Pravej Alam et al.   PLANT CELL REPORTS

Identification of Putative Artemisia annua ABCG Transporter Unigenes Related to Artemisinin Yield Following Expression Analysis in Different Plant Tissues and in Response to Methyl Jasmonate and Abscisic Acid Treatments

(2011) Ling Zhang et al.   PLANT MOLECULAR BIOLOGY REPORTER

Artemisinin activity against Plasmodium falciparum requires hemoglobin uptake and digestion

(2011) N. Klonis et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Role of Heme and the Mitochondrion in the Chemical and Molecular Mechanisms of Mammalian Cell Death Induced by the Artemisinin Antimalarials

(2010) Amy E. Mercer et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Survey of artemisinin production by diverse Artemisia species in northern Pakistan

(2010) Abdul Mannan et al.   MALARIA JOURNAL

The Biosynthesis of Artemisinin (Qinghaosu) and the Phytochemistry of Artemisia annua L. (Qinghao)

(2010) Geoffrey D. Brown   MOLECULES

The Molecular Mechanism of Action of Artemisinin—The Debate Continues

(2010) Paul M. O’Neill et al.   MOLECULES

Dissection of the phytohormonal regulation of trichome formation and biosynthesis of the antimalarial compound artemisinin in Artemisia annua plants

(2010) Lies Maes et al.   NEW PHYTOLOGIST

In vitro antiplasmodial and phytochemical study of five Artemisia species from Iran and in vivo activity of two species

(2010) Ali Ramazani et al.   PARASITOLOGY RESEARCH

Methyl jasmonate and miconazole differently affect arteminisin production and gene expression in Artemisia annua suspension cultures

(2010) S. Caretto et al.   PLANT BIOLOGY

Overexpression of farnesyl pyrophosphate synthase (FPS) gene affected artemisinin content and growth of Artemisia annua L.

(2010) Waleerat Banyai et al.   PLANT CELL TISSUE AND ORGAN CULTURE

Characterization of the Jasmonate Biosynthetic Gene Allene Oxide Cyclase in Artemisia annua L., Source of the Antimalarial Drug Artemisinin

(2010) Xu Lu et al.   PLANT MOLECULAR BIOLOGY REPORTER

Reproductive Development Modulates Gene Expression and Metabolite Levels with Possible Feedback Inhibition of Artemisinin in Artemisia annua

(2010) P. R. Arsenault et al.   PLANT PHYSIOLOGY

The Molecular Cloning of Dihydroartemisinic Aldehyde Reductase and its Implication in Artemisinin Biosynthesis inArtemisia annua

(2010) Anna-Margareta Rydén et al.   PLANTA MEDICA

Artemisinin Directly Targets Malarial Mitochondria through Its Specific Mitochondrial Activation

(2010) Juan Wang et al.   PLoS One

Nicotiana benthamiana as a Production Platform for Artemisinin Precursors

(2010) Teun W. J. M. van Herpen et al.   PLoS One

The Genetic Map of Artemisia annua L. Identifies Loci Affecting Yield of the Antimalarial Drug Artemisinin

(2010) I. A. Graham et al.   SCIENCE

A Novel Semi-biosynthetic Route for Artemisinin Production Using Engineered Substrate-Promiscuous P450BM3

(2009) Jeffrey A. Dietrich et al.   ACS Chemical Biology

Molecular cloning of an aldehyde dehydrogenase implicated in artemisinin biosynthesis in Artemisia annuaThis paper is one of a selection of papers published in a Special Issue from the National Research Council of Canada – Plant Biotechnology Institute.

(2009) Keat H. Teoh et al.   Botany

Artemisia Species: From Traditional Medicines to Modern Antimalarials—and Back Again

(2009) Merlin Willcox   JOURNAL OF ALTERNATIVE AND COMPLEMENTARY MEDICINE

Discovery of Artemisinin (Qinghaosu)

(2009) Fulong Liao   MOLECULES

Artemisinin Resistance inPlasmodium falciparumMalaria

(2009) Arjen M. Dondorp et al.   NEW ENGLAND JOURNAL OF MEDICINE

Artemisinin biosynthesis in growing plants of Artemisia annua. A 13CO2 study

(2009) Nicholas Schramek et al.   PHYTOCHEMISTRY

Volatile components of four Ethiopian Artemisia species extracts and their in vitro antitrypanosomal and cytotoxic activities

(2009) Endalkachew Nibret et al.   PHYTOMEDICINE

Isolation and Characterization of AaWRKY1, an Artemisia annua Transcription Factor that Regulates the Amorpha-4,11-diene Synthase Gene, a Key Gene of Artemisinin Biosynthesis

(2009) Dongming Ma et al.   PLANT AND CELL PHYSIOLOGY

High-Level Production of Amorpha-4,11-Diene, a Precursor of the Antimalarial Agent Artemisinin, in Escherichia coli

(2009) Hiroko Tsuruta et al.   PLoS One

Accumulation of artemisinin trioxane derivatives within neutral lipids of Plasmodium falciparum malaria parasites is endoperoxide-dependent

(2008) Carmony L. Hartwig et al.   BIOCHEMICAL PHARMACOLOGY

Development of transgenic Artemisia annua (Chinese wormwood) plants with an enhanced content of artemisinin, an effective anti-malarial drug, by hairpin-RNA-mediated gene silencing

(2008) Ling Zhang et al.   BIOTECHNOLOGY AND APPLIED BIOCHEMISTRY

Developing an industrial artemisinic acid fermentation process to support the cost-effective production of antimalarial artemisinin-based combination therapies

(2008) Jacob R. Lenihan et al.   BIOTECHNOLOGY PROGRESS

Induction of multiple pleiotropic drug resistance genes in yeast engineered to produce an increased level of anti-malarial drug precursor, artemisinic acid

(2008) Dae-Kyun Ro et al.   BMC BIOTECHNOLOGY

The Molecular Cloning of Artemisinic Aldehyde Δ11(13) Reductase and Its Role in Glandular Trichome-dependent Biosynthesis of Artemisinin inArtemisia annua

(2008) Yansheng Zhang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Artemisia annua as a self-reliant treatment for malaria in developing countries

(2008) Sanne de Ridder et al.   JOURNAL OF ETHNOPHARMACOLOGY

Optimization of the mevalonate-based isoprenoid biosynthetic pathway in Escherichia coli for production of the anti-malarial drug precursor amorpha-4,11-diene

(2008) Jennifer R. Anthony et al.   METABOLIC ENGINEERING

Effects of irradiance on growth, photosynthetic characteristics, and artemisinin content of Artemisia annua L.

(2008) M. L. Wang et al.   PHOTOSYNTHETICA

Making artemisinin☆

(2008) Patrick S. Covello   PHYTOCHEMISTRY

Tissue Specificity and Developmental Pattern of Amorpha-4,11-diene Synthase (ADS) Proved by ADS Promoter-Driven GUS Expression in the Heterologous Plant, Arabidopsis thaliana

(2008) Soon-Hee Kim et al.   PLANTA MEDICA