Pharmacologic Stimulation of Cytochrome P450 46A1 and Cerebral Cholesterol Turnover in Mice

Alterations in Brain Cholesterol Metabolism in the APPSLxPS1mut mouse, a Model for Alzheimer's Disease

(2017) Tim Vanmierlo et al.   JOURNAL OF ALZHEIMERS DISEASE

Binding of a Cyano- and Fluoro-containing Drug Bicalutamide to Cytochrome P450 46A1

(2013) Natalia Mast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Is It Possible to Improve Memory Function by Upregulation of the Cholesterol 24S-Hydroxylase (CYP46A1) in the Brain?

(2013) Silvia Maioli et al.   PLoS One

Sample Prefractionation for Mass Spectrometry Quantification of Low-Abundance Membrane Proteins

(2012) Meiyao Wang et al.   ANALYTICAL CHEMISTRY

Increase in Standard Cholesterol and Large HDL Particle Subclasses in Antiretroviral-Naïve Patients Prescribed Efavirenz Compared to Atazanavir/Ritonavir

(2012) Daria Gotti et al.   HIV CLINICAL TRIALS

Enhanced production of 24S-hydroxycholesterol is not sufficient to drive liver X receptor target genes in vivo

(2011) M. Shafaati et al.   JOURNAL OF INTERNAL MEDICINE

Role of carglumic acid in the treatment of acute hyperammonemia due to N-acetylglutamate synthase deficiency

(2011) Johannes Häberle   Therapeutics and Clinical Risk Management

Marked variability in hepatic expression of cytochromes CYP7A1 and CYP27A1 as compared to cerebral CYP46A1. Lessons from a dietary study with omega 3 fatty acids in hamsters

(2010) Natalia Mast et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

Structural Basis of Drug Binding to CYP46A1, an Enzyme That Controls Cholesterol Turnover in the Brain

(2010) Natalia Mast et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

SIRT1 Modulation as a Novel Approach to the Treatment of Diseases of Aging

(2010) Charles A. Blum et al.   JOURNAL OF MEDICINAL CHEMISTRY

Quantification of Cholesterol-Metabolizing P450s CYP27A1 and CYP46A1 in Neural Tissues Reveals a Lack of Enzyme−Product Correlations in Human Retina but Not Human Brain

(2010) Wei-Li Liao et al.   JOURNAL OF PROTEOME RESEARCH

ACAT1 gene ablation increases 24(S)-hydroxycholesterol content in the brain and ameliorates amyloid pathology in mice with AD

(2010) E. Y. Bryleva et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cholesterol 24-Hydroxylase: An Enzyme of Cholesterol Turnover in the Brain

(2009) David W. Russell et al.   Annual Review of Biochemistry

Combined use of mass spectrometry and heterologous expression for identification of membrane-interacting peptides in cytochrome P450 46A1 and NADPH-cytochrome P450 oxidoreductase

(2009) Natalia Mast et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Fragment-Based Computation of Binding Free Energies by Systematic Sampling

(2009) Matthew Clark et al.   Journal of Chemical Information and Modeling

Adeno-associated Virus Gene Therapy With Cholesterol 24-Hydroxylase Reduces the Amyloid Pathology Before or After the Onset of Amyloid Plaques in Mouse Models of Alzheimer's Disease

(2009) Eloise Hudry et al.   MOLECULAR THERAPY

Liver X receptor activation restores memory in aged AD mice without reducing amyloid

(2009) Tim Vanmierlo et al.   NEUROBIOLOGY OF AGING

Use of complementary cation and anion heavy-atom salt derivatives to solve the structure of cytochrome P450 46A1

(2008) Mark Andrew White et al.   ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY

Effects of nevirapine and efavirenz on HDL cholesterol levels and reverse cholesterol transport in mice

(2008) Junichiro Tohyama et al.   ATHEROSCLEROSIS

Neuronal expression and subcellular localization of cholesterol 24-hydroxylase in the mouse brain

(2008) Denise M.O. Ramirez et al.   JOURNAL OF COMPARATIVE NEUROLOGY

Crystal structures of substrate-bound and substrate-free cytochrome P450 46A1, the principal cholesterol hydroxylase in the brain

(2008) N. Mast et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA