Role of the Toll Like Receptor (TLR) Radical Cycle in Chronic Inflammation: Possible Treatments Targeting the TLR4 Pathway

Alzheimer's Disease and Peripheral Infections: The Possible Contribution from Periodontal Infections, Model and Hypothesis

(2017) Angela R. Kamer et al.   JOURNAL OF ALZHEIMERS DISEASE

In depression, bacterial translocation may drive inflammatory responses, oxidative and nitrosative stress (O&NS), and autoimmune responses directed against O&NS-damaged neoepitopes

(2012) M. Maes et al.   ACTA PSYCHIATRICA SCANDINAVICA

Ozone Enhances Pulmonary Innate Immune Response to a Toll-Like Receptor–2 Agonist

(2012) Judy L. Oakes et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

N-acetylcysteine reduces inflammation in the small intestine by regulating redox, EGF and TLR4 signaling

(2012) Yongqing Hou et al.   AMINO ACIDS

Increased expression of toll-like receptor 4 and inflammatory cytokines, interleukin-6 in particular, in islets from a mouse model of obesity and type 2 diabetes

(2012) Mette Ladefoged et al.   APMIS

Inflammasome formation and IL-1β release by human blood monocytes in response to silver nanoparticles

(2012) Eun-Jeong Yang et al.   BIOMATERIALS

Protective effects of hydrogen-rich saline in a rat model of permanent focal cerebral ischemia via reducing oxidative stress and inflammatory cytokines

(2012) Jianjun Li et al.   BRAIN RESEARCH

Molecular Mechanisms of Hypertension—Reactive Oxygen Species and Antioxidants: A Basic Science Update for the Clinician

(2012) Augusto C. Montezano et al.   CANADIAN JOURNAL OF CARDIOLOGY

Ketamine Inhibits Lipopolysaccharide-Induced Astrocytes Activation by Suppressing TLR4/NF-?B Pathway

(2012) Yuqing Wu et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

Increased Toll-Like Receptor Activity in Patients With Metabolic Syndrome

(2012) I. Jialal et al.   DIABETES CARE

Functional polymorphisms of Toll-like receptors 2 and 4 alter the risk for colorectal carcinoma in Europeans

(2012) Pedro Pimentel-Nunes et al.   DIGESTIVE AND LIVER DISEASE

Metal allergens nickel and cobalt facilitate TLR4 homodimerization independently of MD2

(2012) Badrinarayanan Raghavan et al.   EMBO REPORTS

Ozone-induced lung injury and sterile inflammation. Role of toll-like receptor 4

(2012) Agnieszka J. Connor et al.   EXPERIMENTAL AND MOLECULAR PATHOLOGY

Evaluation of systemic markers of inflammation in atomic-bomb survivors with special reference to radiation and age effects

(2012) Tomonori Hayashi et al.   FASEB JOURNAL

Impact of emerging pollutants on pulmonary inflammation in asthmatic rats: ethanol vapors and agglomerated TiO2nanoparticles

(2012) A. Scarino et al.   INHALATION TOXICOLOGY

TLR4 antagonist reduces early-stage atherosclerosis in diabetic apolipoprotein E-deficient mice

(2012) Zhongyang Lu et al.   JOURNAL OF ENDOCRINOLOGY

Glycyrrhizin and isoliquiritigenin suppress the LPS sensor Toll-like receptor 4/MD-2 complex signaling in a different manner

(2012) Hiroe Honda et al.   JOURNAL OF LEUKOCYTE BIOLOGY

α-lipoic acid prevents non-alcoholic fatty liver disease in OLETF rats

(2012) Tae Sik Jung et al.   LIVER INTERNATIONAL

Aluminum as an adjuvant in Crohn’s disease induction

(2012) A Lerner   LUPUS

A neuro-immune model of Myalgic Encephalomyelitis/Chronic fatigue syndrome

(2012) Gerwyn Morris et al.   METABOLIC BRAIN DISEASE

Molecular Hydrogen as an Emerging Therapeutic Medical Gas for Neurodegenerative and Other Diseases

(2012) Kinji Ohno et al.   Oxidative Medicine and Cellular Longevity

Prevention and Mitigation of Acute Radiation Syndrome in Mice by Synthetic Lipopeptide Agonists of Toll-Like Receptor 2 (TLR2)

(2012) Alexander N. Shakhov et al.   PLoS One

Lipopolysaccharides Impair Insulin Gene Expression in Isolated Islets of Langerhans via Toll-Like Receptor-4 and NF-κB Signalling

(2012) Julie Amyot et al.   PLoS One

Therapeutic Inhibition of Pro-Inflammatory Signaling and Toxicity to Staphylococcal Enterotoxin B by a Synthetic Dimeric BB-Loop Mimetic of MyD88

(2012) Teri L. Kissner et al.   PLoS One

Toll-Like Receptor (TLR2 and TLR4) Polymorphisms and Chronic Obstructive Pulmonary Disease

(2012) Simona E. Budulac et al.   PLoS One

N-acetylcysteine possesses antidepressant-like activity through reduction of oxidative stress: Behavioral and biochemical analyses in rats

(2012) Irena Smaga et al.   PROGRESS IN NEURO-PSYCHOPHARMACOLOGY & BIOLOGICAL PSYCHIATRY

Silver nanoparticles induce apoptosis through the Toll-like receptor 2 pathway

(2012) An-Sook Kim et al.   Oral Surgery Oral Medicine Oral Pathology Oral Radiology

The Role of TLR2 in Infection and Immunity

(2012) Laura Oliveira-Nascimento et al.   Frontiers in Immunology

Hyaluronic acid is radioprotective in the intestine through a TLR4 and COX-2-mediated mechanism

(2011) Terrence E. Riehl et al.   AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY

Determination of cell surface expression of Toll-like receptor 4 by cellular enzyme-linked immunosorbent assay and radiolabeling

(2011) Szczepan Józefowski et al.   ANALYTICAL BIOCHEMISTRY

Extra domain A of fibronectin primes leukotriene biosynthesis and stimulates neutrophil migration through activation of Toll-like receptor 4

(2011) Julie S. Lefebvre et al.   ARTHRITIS AND RHEUMATISM

Differential expression of Toll-like receptor 4 and human monocyte subsets in acute myocardial infarction

(2011) Manabu Kashiwagi et al.   ATHEROSCLEROSIS

Biophysical Mechanisms of Endotoxin Neutralization by Cationic Amphiphilic Peptides

(2011) Yani Kaconis et al.   BIOPHYSICAL JOURNAL

Therapeutic targeting of innate immunity with Toll-like receptor 4 (TLR4) antagonists

(2011) Francesco Peri et al.   BIOTECHNOLOGY ADVANCES

Pathways of cholesterol oxidation via non-enzymatic mechanisms

(2011) Luigi Iuliano   CHEMISTRY AND PHYSICS OF LIPIDS

Chronic Fine Particulate Matter Exposure Induces Systemic Vascular Dysfunction via NADPH Oxidase and TLR4 Pathways

(2011) Thomas Kampfrath et al.   CIRCULATION RESEARCH

α-Lipoic acid prevents mild portal endotoxaemia-induced hepatic inflammation and β cell dysfunction

(2011) Yu-Feng Tian et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

Effects of intrathecal epigallocatechin gallate, an inhibitor of Toll-like receptor 4, on chronic neuropathic pain in rats

(2011) Xin Kuang et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Oxidized phospholipid-induced inflammation is mediated by Toll-like receptor 2

(2011) Alexandra Kadl et al.   FREE RADICAL BIOLOGY AND MEDICINE

Baicalin suppresses expression of TLR2/4 and NF-κB in chlamydia trachomatis–infected mice

(2011) Huang Hao et al.   IMMUNOPHARMACOLOGY AND IMMUNOTOXICOLOGY

Aryl hydrocarbon receptor negatively regulates LPS-induced IL-6 production through suppression of histamine production in macrophages

(2011) Kazuya Masuda et al.   INTERNATIONAL IMMUNOLOGY

Nickel allergy-promoting effects of microbial or inflammatory substances at the sensitization step in mice

(2011) Harue Takahashi et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Advances in Carcinogenic Metal Toxicity and Potential Molecular Markers

(2011) Preeyaporn Koedrith et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

A Resveratrol and Polyphenol Preparation Suppresses Oxidative and Inflammatory Stress Response to a High-Fat, High-Carbohydrate Meal

(2011) Husam Ghanim et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Differential cardioprotective effects of salvianolic acid and tanshinone on acute myocardial infarction are mediated by unique signaling pathways

(2011) Xiaoying Wang et al.   JOURNAL OF ETHNOPHARMACOLOGY

Lipoic Acid Attenuates Innate Immune Infiltration and Activation in the Visceral Adipose Tissue of Obese Insulin Resistant Mice

(2011) J. A. Deiuliis et al.   LIPIDS

Prevalence of Small Intestinal Bacterial Overgrowth in Parkinson's Disease

(2011) Maurizio Gabrielli et al.   MOVEMENT DISORDERS

The role of long-lived reactive oxygen intermediates in the reaction of ozone with aerosol particles

(2011) Manabu Shiraiwa et al.   Nature Chemistry

Role of hippocampal TLR4 in neurotoxicity in mice following toluene exposure

(2011) Tin-Tin Win-Shwe et al.   NEUROTOXICOLOGY AND TERATOLOGY

Spinal TLR4 mediates the transition to a persistent mechanical hypersensitivity after the resolution of inflammation in serum-transferred arthritis

(2011) Christina A. Christianson et al.   PAIN

Anesthetic Propofol Reduces Endotoxic Inflammation by Inhibiting Reactive Oxygen Species-regulated Akt/IKKβ/NF-κB Signaling

(2011) Chung-Hsi Hsing et al.   PLoS One

Mucin Secretion Induced by Titanium Dioxide Nanoparticles

(2011) Eric Y. T. Chen et al.   PLoS One

Hyaluronan Signaling during Ozone-Induced Lung Injury Requires TLR4, MyD88, and TIRAP

(2011) Zhuowei Li et al.   PLoS One

N-acetylcysteine for major depressive episodes in bipolar disorder

(2011) Pedro V Magalhães et al.   REVISTA BRASILEIRA DE PSIQUIATRIA

Effects of nano-scale TiO2, ZnO and their bulk counterparts on zebrafish: Acute toxicity, oxidative stress and oxidative damage

(2011) Daowen Xiong et al.   SCIENCE OF THE TOTAL ENVIRONMENT

Development of Sensor Cells Using NF-κB Pathway Activation for Detection of Nanoparticle-Induced Inflammation

(2011) Peng Chen et al.   SENSORS

The innate and adaptive immune response induced by alveolar macrophages exposed to ambient particulate matter

(2011) Ryohei Miyata et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Effect of baicalin on toll-like receptor 4-mediated ischemia/reperfusion inflammatory responses in alcoholic fatty liver condition

(2011) Seok-Joo Kim et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Intrinsic and Extrinsic Regulation of Innate Immune Receptors

(2011) Eunshil Jeong et al.   YONSEI MEDICAL JOURNAL

Enhanced peripheral toll-like receptor responses in psychosis: further evidence of a pro-inflammatory phenotype

(2011) D P McKernan et al.   Translational Psychiatry

Gut, bugs, and brain: Role of commensal bacteria in the control of central nervous system disease

(2010) Javier Ochoa-Repáraz et al.   ANNALS OF NEUROLOGY

Neurotoxicological effects and the impairment of spatial recognition memory in mice caused by exposure to TiO2 nanoparticles

(2010) Renping Hu et al.   BIOMATERIALS

Neural injury following stroke: are Toll-like receptors the link between the immune system and the CNS?

(2010) Catherine E Downes et al.   BRITISH JOURNAL OF PHARMACOLOGY

Novel interactions of a microbial superantigen with TLR2 and TLR4 differentially regulate IL-17 and Th17-associated cytokines

(2010) Hong-Hua Mu et al.   CELLULAR MICROBIOLOGY

Neurotoxins: Free Radical Mechanisms and Melatonin Protection

(2010) Russel J. Reiter et al.   Current Neuropharmacology

Top-Down and Bottom-Up Mechanisms in Mind-Body Medicine: Development of an Integrative Framework for Psychophysiological Research

(2010) Ann Gill Taylor et al.   Explore-The Journal of Science and Healing

Substance P primes lipoteichoic acid- and Pam3CysSerLys4-mediated activation of human mast cells by up-regulating Toll-like receptor 2

(2010) Brian P. Tancowny et al.   IMMUNOLOGY

Baicalin Inhibits TLR2/4 Signaling Pathway in Rat Brain Following Permanent Cerebral Ischemia

(2010) Xian-kun Tu et al.   INFLAMMATION

Reactive Oxygen Species and the Pathogenesis of Radiocontrast-Induced Nephropathy

(2010) Samuel N. Heyman et al.   INVESTIGATIVE RADIOLOGY

Signaling pathway of inflammatory responses in the mouse liver caused by TiO2 nanoparticles

(2010) Yaling Cui et al.   JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A

Crucial role for human Toll-like receptor 4 in the development of contact allergy to nickel

(2010) Marc Schmidt et al.   NATURE IMMUNOLOGY

Toll-like receptor 2 and 4 genes influence susceptibility to adverse effects of traffic-related air pollution on childhood asthma

(2010) M. Kerkhof et al.   THORAX

TLR4 Is Necessary for Hyaluronan-mediated Airway Hyperresponsiveness after Ozone Inhalation

(2009) Stavros Garantziotis et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

TBK1-Targeted Suppression of TRIF-Dependent Signaling Pathway of Toll-Like Receptors by 6-Shogaol, an Active Component of Ginger

(2009) Se-Jeong PARK et al.   BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY

Potential Mechanism for Pentachlorophenol-Induced Carcinogenicity: A Novel Mechanism for Metal-Independent Production of Hydroxyl Radicals

(2009) Ben-Zhan Zhu et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Propofol inhibits lipoteichoic acid-induced iNOS gene expression in macrophages possibly through downregulation of toll-like receptor 2-mediated activation of Raf-MEK1/2-ERK1/2-IKK-NFκB

(2009) Wen-Ta Chiu et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Phase 2 trial of eritoran tetrasodium (E5564), a Toll-like receptor 4 antagonist, in patients with severe sepsis*

(2009) Mark Tidswell et al.   CRITICAL CARE MEDICINE

The emerging role of the gut in chronic heart failure

(2009) Anja Sandek et al.   CURRENT OPINION IN CLINICAL NUTRITION AND METABOLIC CARE

AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity

(2009) A. M. Didierlaurent et al.   JOURNAL OF IMMUNOLOGY

Cinnamon Extract Protects against Acute Alcohol-Induced Liver Steatosis in Mice

(2009) Giridhar Kanuri et al.   JOURNAL OF NUTRITION

CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer

(2009) Cameron R Stewart et al.   NATURE IMMUNOLOGY

N-Acetyl Cysteine for Depressive Symptoms in Bipolar Disorder—A Double-Blind Randomized Placebo-Controlled Trial

(2008) Michael Berk et al.   BIOLOGICAL PSYCHIATRY

Identification of Oxidative Stress and Toll-like Receptor 4 Signaling as a Key Pathway of Acute Lung Injury

(2008) Yumiko Imai et al.   CELL

Effects of possible endocrine disruptors on MyD88-independent TLR4 signaling

(2008) Takahiro Ohnishi et al.   FEMS IMMUNOLOGY AND MEDICAL MICROBIOLOGY

Hydroxyl radicals (OH) are associated with titanium dioxide (TiO2) nanoparticle-induced cytotoxicity and oxidative DNA damage in fish cells

(2008) James F. Reeves et al.   MUTATION RESEARCH-FUNDAMENTAL AND MOLECULAR MECHANISMS OF MUTAGENESIS

Toll-Like Receptor 4 Is Involved in Subacute Stress–Induced Neuroinflammation and in the Worsening of Experimental Stroke

(2008) Javier R. Caso et al.   STROKE

Newspapers and Newspaper Ink Contain Agonists for the Ah Receptor

(2008) Jessica E. S. Bohonowych et al.   TOXICOLOGICAL SCIENCES

Potential neurological lesion after nasal instillation of TiO2 nanoparticles in the anatase and rutile crystal phases

(2008) J WANG et al.   TOXICOLOGY LETTERS

Stress Mediators Regulate Brain Prostaglandin Synthesis and Peroxisome Proliferator-Activated Receptor-γ Activation after Stress in Rats

(2007) Borja García-Bueno et al.   ENDOCRINOLOGY