Monophosphoryl Lipid-A: A Promising Tool for Alzheimer’s Disease Toll

Identification of QS-21 as an Inflammasome-activating Molecular Component of Saponin Adjuvants

(2015) Robyn Marty-Roix et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Is there still any hope for amyloid-based immunotherapy for Alzheimerʼs disease?

(2014) Francesco Panza et al.   CURRENT OPINION IN PSYCHIATRY

Phagocytosis of Microglia in the Central Nervous System Diseases

(2014) Ruying Fu et al.   MOLECULAR NEUROBIOLOGY

Age-associated dysregulation of microglial activation is coupled with enhanced blood-brain barrier permeability and pathology in APP/PS1 mice

(2014) Aedín M. Minogue et al.   NEUROBIOLOGY OF AGING

Peptide-Based Anti-PCSK9 Vaccines - An Approach for Long-Term LDLc Management

(2014) Gergana Galabova et al.   PLoS One

Unleashing the potential of NOD- and Toll-like agonists as vaccine adjuvants

(2014) C. Maisonneuve et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Innate Immunity in Alzheimer’s Disease: A Complex Affair

(2013) Marie-Victoire Guillot-Sestier et al.   CNS & Neurological Disorders-Drug Targets

How Do Immune Cells Support and Shape the Brain in Health, Disease, and Aging?

(2013) M. Schwartz et al.   JOURNAL OF NEUROSCIENCE

Toll-like receptor 4 stimulation with the detoxified ligand monophosphoryl lipid A improves Alzheimer's disease-related pathology

(2013) J.-P. Michaud et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Universal vaccine against influenza virus: Linking TLR signaling to anti-viral protection

(2012) Nicole Schmitz et al.   EUROPEAN JOURNAL OF IMMUNOLOGY

Innate immunity in the central nervous system

(2012) Richard M. Ransohoff et al.   JOURNAL OF CLINICAL INVESTIGATION

Preventive immunization of aged and juvenile non-human primates to beta-amyloid

(2012) Julia Kofler et al.   Journal of Neuroinflammation

Extended results of the Alzheimer’s disease anti-inflammatory prevention trial

(2011) John C. Breitner et al.   Alzheimers & Dementia

Toll-like receptors in health and disease in the brain: mechanisms and therapeutic potential

(2011) Mark L. Hanke et al.   CLINICAL SCIENCE

Recent clinical experience with vaccines using MPL- and QS-21-containing Adjuvant Systems

(2011) Nathalie Garçon et al.   Expert Review of Vaccines

Sequence-independent Control of Peptide Conformation in Liposomal Vaccines for Targeting Protein Misfolding Diseases

(2011) David T. Hickman et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

TLR2 Is a Primary Receptor for Alzheimer's Amyloid   Peptide To Trigger Neuroinflammatory Activation

(2011) S. Liu et al.   JOURNAL OF IMMUNOLOGY

The Second-Generation Active A  Immunotherapy CAD106 Reduces Amyloid Accumulation in APP Transgenic Mice While Minimizing Potential Side Effects

(2011) C. Wiessner et al.   JOURNAL OF NEUROSCIENCE

Neuroinflammatory and oxidative stress phenomena in MPS IIIA mouse model: The positive effect of long-term aspirin treatment

(2011) Audrey Arfi et al.   MOLECULAR GENETICS AND METABOLISM

Both MHC and non-MHC genes regulate inflammation and T-cell response after traumatic brain injury

(2010) Faiez Al Nimer et al.   BRAIN BEHAVIOR AND IMMUNITY

Progressive accumulation of amyloid-β oligomers in Alzheimer’s disease and in amyloid precursor protein transgenic mice is accompanied by selective alterations in synaptic scaffold proteins

(2010) Emiley Pham et al.   FEBS Journal

Important aspects of Toll-like receptors, ligands and their signaling pathways

(2010) Z. L. Chang   INFLAMMATION RESEARCH

Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease

(2010) Martin Fuhrmann et al.   NATURE NEUROSCIENCE

Targeting Toll-like receptors: emerging therapeutics?

(2010) Elizabeth J. Hennessy et al.   NATURE REVIEWS DRUG DISCOVERY

Can Alzheimer disease be prevented by amyloid-β immunotherapy?

(2010) Cynthia A. Lemere et al.   Nature Reviews Neurology

The safety profile of ACI-24, an oligo-specific amyloid beta vaccine, demonstrated decrease of large microbleedings in brain of aged Alzheimer's disease mouse model

(2009) Maria Pihlgren et al.   Alzheimers & Dementia

Clearance of Amyloid-β Peptide Across the Blood-Brain Barrier: Implication for Therapies in Alzheimers Disease

(2009) R. Deane et al.   CNS & Neurological Disorders-Drug Targets

AS04, an Aluminum Salt- and TLR4 Agonist-Based Adjuvant System, Induces a Transient Localized Innate Immune Response Leading to Enhanced Adaptive Immunity

(2009) A. M. Didierlaurent et al.   JOURNAL OF IMMUNOLOGY

The structural basis of lipopolysaccharide recognition by the TLR4–MD-2 complex

(2009) Beom Seok Park et al.   NATURE

Biology of Immune Responses to Vaccines in Elderly Persons

(2008) Birgit Weinberger et al.   CLINICAL INFECTIOUS DISEASES

Toll-like receptor 4-dependent upregulation of cytokines in a transgenic mouse model of Alzheimer's disease

(2008) Jing-Ji Jin et al.   Journal of Neuroinflammation

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE