Methylglyoxal, a highly reactive dicarbonyl compound, in diabetes, its vascular complications and other age-related diseases

Ameliorating Methylglyoxal-Induced Progenitor Cell Dysfunction for Tissue Repair in Diabetes.

(2019) Hainan Li et al.   DIABETES

The Global Epidemiology of Diabetes and Kidney Disease

(2018) Digsu N. Koye et al.   ADVANCES IN CHRONIC KIDNEY DISEASE

Impairing L-Threonine Catabolism Promotes Healthspan through Methylglyoxal-Mediated Proteohormesis

(2018) Meenakshi Ravichandran et al.   Cell Metabolism

Elevated Levels of the Reactive Metabolite Methylglyoxal Recapitulate Progression of Type 2 Diabetes

(2018) Alexandra Moraru et al.   Cell Metabolism

Dysfunctional Wound Healing in Diabetic Foot Ulcers: New Crossroads

(2018) Frank M. Davis et al.   Current Diabetes Reports

Risk Factors for Incident Diabetic Polyneuropathy in a Cohort With Screen-Detected Type 2 Diabetes Followed for 13 Years: ADDITION-Denmark

(2018) Signe T. Andersen et al.   DIABETES CARE

Investigating the longitudinal association between diabetes and anxiety: a systematic review and meta-analysis

(2018) K. J. Smith et al.   DIABETIC MEDICINE

Advanced glycation end products in the pathogenesis of chronic kidney disease

(2018) Naila Rabbani et al.   KIDNEY INTERNATIONAL

Type 1 diabetes

(2018) Linda A DiMeglio et al.   LANCET

Diabetes Mellitus as a Risk Factor for Parkinson’s Disease: a Molecular Point of View

(2018) Alice Biosa et al.   MOLECULAR NEUROBIOLOGY

Cognitive decline and dementia in diabetes mellitus: mechanisms and clinical implications

(2018) Geert Jan Biessels et al.   Nature Reviews Endocrinology

CKD in diabetes: diabetic kidney disease versus nondiabetic kidney disease

(2018) Hans-Joachim Anders et al.   Nature Reviews Nephrology

Arginase: A Multifaceted Enzyme Important in Health and Disease

(2018) R. William Caldwell et al.   PHYSIOLOGICAL REVIEWS

Endothelial Cell Metabolism

(2018) Guy Eelen et al.   PHYSIOLOGICAL REVIEWS

Endothelial Cell Metabolism in Health and Disease

(2018) Katerina Rohlenova et al.   TRENDS IN CELL BIOLOGY

Vascular cognitive impairment

(2018) Wiesje M. van der Flier et al.   Nature Reviews Disease Primers

The Role of Advanced Glycation End Products in Aging and Metabolic Diseases: Bridging Association and Causality

(2018) Jyotiska Chaudhuri et al.   Cell Metabolism

Microvascular Dysfunction and Hyperglycemia: A Vicious Cycle With Widespread Consequences

(2018) Coen D.A. Stehouwer   DIABETES

A new era for understanding amyloid structures and disease

(2018) Matthew G. Iadanza et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Genetics, Genomics, and Precision Medicine in End-Stage Kidney Disease

(2018) Jeffrey B. Kopp et al.   SEMINARS IN NEPHROLOGY

Methylglyoxal accumulation de-regulates HoxA5 expression, thereby impairing angiogenesis in glyoxalase 1 knock-down mouse aortic endothelial cells

(2018) Cecilia Nigro et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Methylglyoxal stress, the glyoxalase system, and diabetic chronic kidney disease

(2018) Nordin M.J. Hanssen et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

A carnosine analog mitigates metabolic disorders of obesity by reducing carbonyl stress

(2018) Ethan J. Anderson et al.   JOURNAL OF CLINICAL INVESTIGATION

Measuring progress from 1990 to 2017 and projecting attainment to 2030 of the health-related Sustainable Development Goals for 195 countries and territories: a systematic analysis for the Global Burden of Disease Study 2017

(2018) Rafael Lozano et al.   LANCET

Diabetic Microvascular Disease: An Endocrine Society Scientific Statement

(2017) Eugene J Barrett et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Polyphenols with antiglycation activity and mechanisms of action: A review of recent findings

(2017) Wan-Ju Yeh et al.   JOURNAL OF FOOD AND DRUG ANALYSIS

The specific localization of advanced glycation end-products (AGEs) in rat pancreatic islets

(2017) Yuta Morioka et al.   JOURNAL OF PHARMACOLOGICAL SCIENCES

A comparison of dicarbonyl stress and advanced glycation endproducts in lifelong endurance athletes vs. sedentary controls

(2017) Martijn F.H. Maessen et al.   JOURNAL OF SCIENCE AND MEDICINE IN SPORT

Glomerular Hyperfiltration in Diabetes: Mechanisms, Clinical Significance, and Treatment

(2017) Lennart Tonneijck et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Type 2 diabetes

(2017) Sudesna Chatterjee et al.   LANCET

Advanced glycation end-products: Mechanics of aged collagen from molecule to tissue

(2017) Alfonso Gautieri et al.   MATRIX BIOLOGY

Global aetiology and epidemiology of type 2 diabetes mellitus and its complications

(2017) Yan Zheng et al.   Nature Reviews Endocrinology

The inner blood-retinal barrier: Cellular basis and development

(2017) Mónica Díaz-Coránguez et al.   VISION RESEARCH

Hormesis enables cells to handle accumulating toxic metabolites during increased energy flux

(2017) Johanna Zemva et al.   Redox Biology

Vitamin E Paradox in Alzheimer's Disease: It Does Not Prevent Loss of Cognition and May Even Be Detrimental

(2017) Ana Lloret et al.   JOURNAL OF ALZHEIMERS DISEASE

Effect of methylglyoxal modification on the structure and properties of human small heat shock protein HspB6 (Hsp20)

(2016) Lydia K. Muranova et al.   CELL STRESS & CHAPERONES

Metformin Scavenges Methylglyoxal To Form a Novel Imidazolinone Metabolite in Humans

(2016) Owen R. Kinsky et al.   CHEMICAL RESEARCH IN TOXICOLOGY

MicroRNA-181b Improves Glucose Homeostasis and Insulin Sensitivity by Regulating Endothelial Function in White Adipose TissueNovelty and Significance

(2016) Xinghui Sun et al.   CIRCULATION RESEARCH

A Caenorhabditis elegans Model Elucidates a Conserved Role for TRPA1-Nrf Signaling in Reactive α-Dicarbonyl Detoxification

(2016) Jyotiska Chaudhuri et al.   CURRENT BIOLOGY

Improved Glycemic Control and Vascular Function in Overweight and Obese Subjects by Glyoxalase 1 Inducer Formulation

(2016) Mingzhan Xue et al.   DIABETES

Methylglyoxal is associated with changes in kidney function among individuals with screen-detected Type 2 diabetes mellitus

(2016) T. M. Jensen et al.   DIABETIC MEDICINE

RAGE and glyoxalase in kidney disease

(2016) Reiko Inagi   GLYCOCONJUGATE JOURNAL

Dicarbonyl stress in clinical obesity

(2016) Jinit Masania et al.   GLYCOCONJUGATE JOURNAL

Targeting advanced glycation with pharmaceutical agents: where are we now?

(2016) Danielle J. Borg et al.   GLYCOCONJUGATE JOURNAL

Loss of Glyoxalase 1 Induces Compensatory Mechanism to Achieve Dicarbonyl Detoxification in Mammalian Schwann Cells

(2016) Jakob Morgenstern et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Methylglyoxal induces cell death through endoplasmic reticulum stress-associated ROS production and mitochondrial dysfunction

(2016) Chi-Ming Chan et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

Effects of intensive blood pressure lowering on cardiovascular and renal outcomes: updated systematic review and meta-analysis

(2016) Xinfang Xie et al.   LANCET

Methylglyoxal-induced neuroinflammatory response in in vitro astrocytic cultures and hippocampus of experimental animals

(2016) John M. T. Chu et al.   METABOLIC BRAIN DISEASE

The eNOS signalosome and its link to endothelial dysfunction

(2016) Mauro Siragusa et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Methylglyoxal can mediate behavioral and neurochemical alterations in rat brain

(2016) Fernanda Hansen et al.   PHYSIOLOGY & BEHAVIOR

Glyoxalase 1-knockdown in human aortic endothelial cells – effect on the proteome and endothelial function estimates

(2016) Bernd Stratmann et al.   Scientific Reports

Generation and characterization of antibodies against arginine-derived advanced glycation endproducts

(2015) Tina Wang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases

(2015) Dionne E.M. Maessen et al.   CLINICAL SCIENCE

Delayed Intervention With Pyridoxamine Improves Metabolic Function and Prevents Adipose Tissue Inflammation and Insulin Resistance in High-Fat Diet–Induced Obese Mice

(2015) Dionne E. Maessen et al.   DIABETES

Post–Glucose Load Plasma α-Dicarbonyl Concentrations Are Increased in Individuals With Impaired Glucose Metabolism and Type 2 Diabetes: The CODAM Study

(2015) Dionne E. Maessen et al.   DIABETES CARE

Vascular AGE-ing by methylglyoxal: the past, the present and the future

(2015) Casper G. Schalkwijk   DIABETOLOGIA

Creatine Is a Scavenger for Methylglyoxal under Physiological Conditions via Formation of N-(4-Methyl-5-oxo-1-imidazolin-2-yl)sarcosine (MG-HCr)

(2015) Jürgen Löbner et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Methylglyoxal, a reactive glucose metabolite, enhances autophagy flux and suppresses proliferation of human retinal pigment epithelial ARPE-19 cells

(2015) Yo-Chen Chang et al.   TOXICOLOGY IN VITRO

Chronic Running Exercise Alleviates Early Progression of Nephropathy with Upregulation of Nitric Oxide Synthases and Suppression of Glycation in Zucker Diabetic Rats

(2015) Daisuke Ito et al.   PLoS One

CD74 indicates microglial activation in experimental diabetic retinopathy and exogenous methylglyoxal mimics the response in normoglycemic retina

(2014) Jing Wang et al.   ACTA DIABETOLOGICA

Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation

(2014) Airi Jo-Watanabe et al.   AGING CELL

Diabetes Mellitus and Ischemic Diseases

(2014) Kiave Yune Howangyin et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Methylglyoxal and glyoxalase I in atherosclerosis

(2014) Nordin M.J. Hanssen et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

The Receptor for Advanced Glycation End Products (RAGE) Specifically Recognizes Methylglyoxal-Derived AGEs

(2014) Jing Xue et al.   BIOCHEMISTRY

Prevalence and causes of vision loss in high-income countries and in Eastern and Central Europe: 1990–2010

(2014) Rupert R A Bourne et al.   BRITISH JOURNAL OF OPHTHALMOLOGY

Glyoxalase 1 overexpression does not affect atherosclerotic lesion size and severity in ApoE−/− mice with or without diabetes

(2014) Nordin M.J. Hanssen et al.   CARDIOVASCULAR RESEARCH

SnapShot: Histone Modifications

(2014) He Huang et al.   CELL

Characterization of the Deoxyguanosine–Lysine Cross-Link of Methylglyoxal

(2014) Katya V. Petrova et al.   CHEMICAL RESEARCH IN TOXICOLOGY

Skin Advanced Glycation End Products Glucosepane and Methylglyoxal Hydroimidazolone Are Independently Associated With Long-term Microvascular Complication Progression of Type 1 Diabetes

(2014) Saul Genuth et al.   DIABETES

Dicarbonyl Stress in the Absence of Hyperglycemia Increases Endothelial Inflammation and Atherogenesis Similar to That Observed in Diabetes

(2014) Chris Tikellis et al.   DIABETES

High Tissue Glucose Alters Intersomitic Blood Vessels in Zebrafish via Methylglyoxal Targeting the VEGF Receptor Signaling Cascade

(2014) Kristina Jörgens et al.   DIABETES

Impaired proteostasis: role in the pathogenesis of diabetes mellitus

(2014) Stéphane Jaisson et al.   DIABETOLOGIA

Quercetin Inhibits Advanced Glycation End Product Formation by Trapping Methylglyoxal and Glyoxal

(2014) Xiaoming Li et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Effects of methylglyoxal and pyridoxamine in rat brain mitochondria bioenergetics and oxidative status

(2014) Susana Cardoso et al.   JOURNAL OF BIOENERGETICS AND BIOMEMBRANES

Extending the Spectrum of α-Dicarbonyl Compounds in Vivo

(2014) Christian Henning et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The prevalence of Parkinson's disease: A systematic review and meta-analysis

(2014) Tamara Pringsheim et al.   MOVEMENT DISORDERS

Understanding nucleotide excision repair and its roles in cancer and ageing

(2014) Jurgen A. Marteijn et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Follow-up of Blood-Pressure Lowering and Glucose Control in Type 2 Diabetes

(2014) Sophia Zoungas et al.   NEW ENGLAND JOURNAL OF MEDICINE

Integrated genomic and functional analyses reveal glyoxalase I as a novel metabolic oncogene in human gastric cancer

(2014) F Hosoda et al.   ONCOGENE

Hydrogen Sulfide Releasing Aspirin, ACS14, Attenuates High Glucose-Induced Increased Methylglyoxal and Oxidative Stress in Cultured Vascular Smooth Muscle Cells

(2014) Qian Huang et al.   PLoS One

Advanced Glycation End-Products Reduce Collagen Molecular Sliding to Affect Collagen Fibril Damage Mechanisms but Not Stiffness

(2014) Gion Fessel et al.   PLoS One

Dietary Carnosine Prevents Early Atherosclerotic Lesion Formation in Apolipoprotein E–Null Mice

(2013) Oleg A. Barski et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

The glyoxalase pathway: the first hundred years… and beyond

(2013) Marta Sousa Silva et al.   BIOCHEMICAL JOURNAL

Calorie Restriction is a Major Determinant of the Short-Term Metabolic Effects of Gastric Bypass Surgery in Obese Type 2 Diabetic Patients

(2013) Mirjam A. Lips et al.   CLINICAL ENDOCRINOLOGY

Update on Cardiovascular Outcomes at 30 Years of the Diabetes Control and Complications Trial/Epidemiology of Diabetes Interventions and Complications Study

(2013) John M. Lachin et al.   DIABETES CARE

Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes

(2013) Olaf Brouwers et al.   DIABETOLOGIA

The methylglyoxal-derived AGE tetrahydropyrimidine is increased in plasma of individuals with type 1 diabetes mellitus and in atherosclerotic lesions and is associated with sVCAM-1

(2013) M. G. A. van Eupen et al.   DIABETOLOGIA

Aging-Dependent Reduction in Glyoxalase 1 Delays Wound Healing

(2013) Thomas H. Fleming et al.   GERONTOLOGY

Reactive carbonyl species and their roles in sarcoplasmic reticulum Ca2+ cycling defect in the diabetic heart

(2013) Chengju Tian et al.   HEART FAILURE REVIEWS

A novel mechanism of methylglyoxal cytotoxicity in prostate cancer cells

(2013) Cinzia Antognelli et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Metabolic Transit of Dietary Methylglyoxal

(2013) Julia Degen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Neuroprotective and anti-apoptotic effects of liraglutide on SH-SY5Y cells exposed to methylglyoxal stress

(2013) Mohit K. Sharma et al.   JOURNAL OF NEUROCHEMISTRY

Advanced glycation end-products diminish tendon collagen fiber sliding

(2013) Yufei Li et al.   MATRIX BIOLOGY

Aberrant Schwann Cell Lipid Metabolism Linked to Mitochondrial Deficits Leads to Axon Degeneration and Neuropathy

(2013) Andreu Viader et al.   NEURON

Methylglyoxal Evokes Pain by Stimulating TRPA1

(2013) David A. Andersson et al.   PLoS One

Suppression of methylglyoxal hyperactivity by mangiferin can prevent diabetes-associated cognitive decline in rats

(2013) Yao-Wu Liu et al.   PSYCHOPHARMACOLOGY

A novel natural Nrf2 activator with PPARγ-agonist (monascin) attenuates the toxicity of methylglyoxal and hyperglycemia

(2013) Wei-Hsuan Hsu et al.   TOXICOLOGY AND APPLIED PHARMACOLOGY

Sugar for the brain: the role of glucose in physiological and pathological brain function

(2013) Philipp Mergenthaler et al.   TRENDS IN NEUROSCIENCES

Glycation exacerbates the neuronal toxicity of β-amyloid

(2013) X-H Li et al.   Cell Death & Disease

Dietary Fructose Feeding Increases Adipose Methylglyoxal Accumulation in Rats in Association with Low Expression and Activity of Glyoxalase-2

(2013) Christopher Masterjohn et al.   Nutrients

Diabetes: a 21st century challenge

(2013) Paul Z Zimmet et al.   Lancet Diabetes & Endocrinology

Possible link between the cognitive dysfunction associated with diabetes mellitus and the neurotoxicity of methylglyoxal

(2012) Xiaobo Huang et al.   BRAIN RESEARCH

Nucleotide Excision DNA Repair Is Associated With Age-Related Vascular Dysfunction

(2012) Matej Durik et al.   CIRCULATION

Current therapeutic interventions in the glycation pathway: evidence from clinical studies

(2012) L. Engelen et al.   DIABETES OBESITY & METABOLISM

Accumulation of argpyrimidine, a methylglyoxal-derived advanced glycation end product, increases apoptosis of lens epithelial cells bothin vitroandin vivo

(2012) Junghyun Kim et al.   EXPERIMENTAL AND MOLECULAR MEDICINE

Molecular Basis of Arterial Stiffening: Role of Glycation – A Mini-Review

(2012) David R. Sell et al.   GERONTOLOGY

Human DJ-1 and its homologs are novel glyoxalases

(2012) Ju-young Lee et al.   HUMAN MOLECULAR GENETICS

1,2-Dicarbonyl Compounds in Commonly Consumed Foods

(2012) Julia Degen et al.   JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY

Methylglyoxal Activates Nociceptors through Transient Receptor Potential Channel A1 (TRPA1)

(2012) Mirjam J. Eberhardt et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glyoxalase 1 increases anxiety by reducing GABAA receptor agonist methylglyoxal

(2012) Margaret G. Distler et al.   JOURNAL OF CLINICAL INVESTIGATION

Methylglyoxal activates the human transient receptor potential ankyrin 1 channel

(2012) Susumu Ohkawara et al.   JOURNAL OF TOXICOLOGICAL SCIENCES

Targeting the Glyoxalase Pathway Enhances TRAIL Efficacy in Cancer Cells by Downregulating the Expression of Antiapoptotic Molecules

(2012) H. Taniguchi et al.   MOLECULAR CANCER THERAPEUTICS

Expression of Transient Receptor Potential Ankyrin 1 (TRPA1) and Its Role in Insulin Release from Rat Pancreatic Beta Cells

(2012) De-Shou Cao et al.   PLoS One

Methylglyoxal Mediates Adipocyte Proliferation by Increasing Phosphorylation of Akt1

(2012) Xuming Jia et al.   PLoS One

Angiogenesis Impairment in Diabetes: Role of Methylglyoxal-Induced Receptor for Advanced Glycation Endproducts, Autophagy and Vascular Endothelial Growth Factor Receptor 2

(2012) Hongtao Liu et al.   PLoS One

Role of advanced glycation endproducts and glyoxalase I in diabetic peripheral sensory neuropathy

(2012) Megan Jack et al.   Translational Research

Glyoxalase I Retards Renal Senescence

(2011) Yoichiro Ikeda et al.   AMERICAN JOURNAL OF PATHOLOGY

Mutagenesis and Repair Induced by the DNA Advanced Glycation End ProductN2-1-(Carboxyethyl)-2′-deoxyguanosine in Human Cells

(2011) Daniel Tamae et al.   BIOCHEMISTRY

Methylglyoxal induces mitochondria-dependent apoptosis in sarcoma

(2011) A. Ghosh et al.   BIOCHEMISTRY-MOSCOW

Insulin glycation by methylglyoxal results in native-like aggregation and inhibition of fibril formation

(2011) Luis MA Oliveira et al.   BMC BIOCHEMISTRY

Schizophrenia with the 22q11.2 deletion and additional genetic defects: case history

(2011) M. Toyosima et al.   BRITISH JOURNAL OF PSYCHIATRY

Regulation of calcium in pancreatic α- and β-cells in health and disease

(2011) Patrik Rorsman et al.   CELL CALCIUM

NF-κB, Inflammation, and Metabolic Disease

(2011) Rebecca G. Baker et al.   Cell Metabolism

Cellular and molecular mechanisms of metformin: an overview

(2011) Benoit Viollet et al.   CLINICAL SCIENCE

Glycation of LDL by Methylglyoxal Increases Arterial Atherogenicity: A Possible Contributor to Increased Risk of Cardiovascular Disease in Diabetes

(2011) N. Rabbani et al.   DIABETES

Carbonylation Contributes to SERCA2a Activity Loss and Diastolic Dysfunction in a Rat Model of Type 1 Diabetes

(2011) Chun Hong Shao et al.   DIABETES

Diabetes and the Risk of Developing Parkinson's Disease in Denmark

(2011) E. Schernhammer et al.   DIABETES CARE

Regulation of hypoxia-inducible factor 1 and the loss of the cellular response to hypoxia in diabetes

(2011) C. F. Bento et al.   DIABETOLOGIA

Methylglyoxal impairs insulin signalling and insulin action on glucose-induced insulin secretion in the pancreatic beta cell line INS-1E

(2011) F. Fiory et al.   DIABETOLOGIA

Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology

(2011) A. K. Berner et al.   DIABETOLOGIA

Effects of alagebrium, an advanced glycation endproduct breaker, on exercise tolerance and cardiac function in patients with chronic heart failure

(2011) Jasper W.L. Hartog et al.   EUROPEAN JOURNAL OF HEART FAILURE

Increased glyoxalase I levels inhibit accumulation of oxidative stress and an advanced glycation end product in mouse mesangial cells cultured in high glucose

(2011) Ki Mo Kim et al.   EXPERIMENTAL CELL RESEARCH

Protection from diabetes-induced peripheral sensory neuropathy — A role for elevated glyoxalase I?

(2011) M.M. Jack et al.   EXPERIMENTAL NEUROLOGY

Losartan modulates muscular capillary density and reverses thiazide diuretic-exacerbated insulin resistance in fructose-fed rats

(2011) Qi Guo et al.   HYPERTENSION RESEARCH

Role of the Glyoxalase System in Astrocyte-Mediated Neuroprotection

(2011) M. Belanger et al.   JOURNAL OF NEUROSCIENCE

Relationship of methylglyoxal-adduct biogenesis to LDL and triglyceride levels in diabetics

(2011) Zdenka Turk et al.   LIFE SCIENCES

Methylglyoxal, glyoxalase 1 and the dicarbonyl proteome

(2010) Naila Rabbani et al.   AMINO ACIDS

Early- and advanced non-enzymatic glycation in diabetic vascular complications: the search for therapeutics

(2010) Casper G. Schalkwijk et al.   AMINO ACIDS

Enhanced Carbonyl Stress in a Subpopulation of Schizophrenia

(2010) Makoto Arai et al.   ARCHIVES OF GENERAL PSYCHIATRY

Mutagenic Potential of DNA Glycation: Miscoding by (R)- and (S)-N2-(1-Carboxyethyl)-2′-deoxyguanosine

(2010) Gerald E. Wuenschell et al.   BIOCHEMISTRY

Cytotoxic role of methylglyoxal in rat retinal pericytes: Involvement of a nuclear factor-kappaB and inducible nitric oxide synthase pathway

(2010) Junghyun Kim et al.   CHEMICO-BIOLOGICAL INTERACTIONS

Increased plasma methylglyoxal level, inflammation, and vascular endothelial dysfunction in diabetic nephropathy

(2010) Jianxin Lu et al.   CLINICAL BIOCHEMISTRY

Increased Glycation and Oxidative Damage to Apolipoprotein B100 of LDL Cholesterol in Patients With Type 2 Diabetes and Effect of Metformin

(2010) N. Rabbani et al.   DIABETES

Deletion of the Receptor for Advanced Glycation End Products Reduces Glomerulosclerosis and Preserves Renal Function in the Diabetic OVE26 Mouse

(2010) Nina Reiniger et al.   DIABETES

Increased protein damage in renal glomeruli, retina, nerve, plasma and urine and its prevention by thiamine and benfotiamine therapy in a rat model of diabetes

(2010) N. Karachalias et al.   DIABETOLOGIA

Delayed intervention with AGE inhibitors attenuates the progression of diabetes-accelerated atherosclerosis in diabetic apolipoprotein E knockout mice

(2010) A. M. D. Watson et al.   DIABETOLOGIA

Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress

(2010) O. Brouwers et al.   DIABETOLOGIA

Epidemiology of Type 1 Diabetes

(2010) David M. Maahs et al.   ENDOCRINOLOGY AND METABOLISM CLINICS OF NORTH AMERICA

Methylglyoxal-induced imbalance in the ratio of vascular endothelial growth factor to angiopoietin 2 secreted by retinal pigment epithelial cells leads to endothelial dysfunction

(2010) C. F. Bento et al.   EXPERIMENTAL PHYSIOLOGY

Anaerobic vs aerobic pathways of carbonyl and oxidant stress in human lens and skin during aging and in diabetes: A comparative analysis

(2010) Xingjun Fan et al.   FREE RADICAL BIOLOGY AND MEDICINE

GLO1-A novel amplified gene in human cancer

(2010) Thomas Santarius et al.   GENES CHROMOSOMES & CANCER

Methylglyoxal Is a Predictor in Type 2 Diabetic Patients of Intima-Media Thickening and Elevation of Blood Pressure

(2010) Susumu Ogawa et al.   HYPERTENSION

The carbonyl scavenger carnosine ameliorates dyslipidaemia and renal function in Zucker obese rats

(2010) Giancarlo Aldini et al.   JOURNAL OF CELLULAR AND MOLECULAR MEDICINE

LC-MS/MS analysis of carboxymethylated and carboxyethylated phosphatidylethanolamines in human erythrocytes and blood plasma

(2010) Naoki Shoji et al.   JOURNAL OF LIPID RESEARCH

Pathologic Classification of Diabetic Nephropathy

(2010) T. W. C. Tervaert et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Critical role for osteopontin in diabetic nephropathy

(2010) Susanne B. Nicholas et al.   KIDNEY INTERNATIONAL

Diabetic retinopathy

(2010) Ning Cheung et al.   LANCET

Endothelial dysfunction in diabetes: potential application of circulating markers as advanced diagnostic and prognostic tools

(2010) Worku Abebe et al.   EPMA Journal

Vascular actions of insulin with implications for endothelial dysfunction

(2009) Maria Assunta Potenza et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Interaction of Methylglyoxal and Hydrogen Sulfide in Rat Vascular Smooth Muscle Cells

(2009) Tuanjie Chang et al.   ANTIOXIDANTS & REDOX SIGNALING

Methylglyoxal-induced mitochondrial dysfunction in vascular smooth muscle cells

(2009) Hui Wang et al.   BIOCHEMICAL PHARMACOLOGY

Reductive Metabolism of AGE Precursors: A Metabolic Route for Preventing AGE Accumulation in Cardiovascular Tissue

(2009) S. P. Baba et al.   DIABETES

C. elegans as Model for the Study of High Glucose- Mediated Life Span Reduction

(2009) A. Schlotterer et al.   DIABETES

The vascular actions of insulin control its delivery to muscle and regulate the rate-limiting step in skeletal muscle insulin action

(2009) E. J. Barrett et al.   DIABETOLOGIA

Microvascular lesions of diabetic retinopathy: clues towards understanding pathogenesis?

(2009) T M Curtis et al.   EYE

Aldose reductase inhibitors in the treatment of diabetic peripheral neuropathy: a review

(2009) Kate E. Schemmel et al.   JOURNAL OF DIABETES AND ITS COMPLICATIONS

Attenuation of hypertension development by scavenging methylglyoxal in fructose-treated rats

(2009) Xiaoxia Wang et al.   JOURNAL OF HYPERTENSION

Methylglyoxal contributes to the development of insulin resistance and salt sensitivity in Sprague–Dawley rats

(2009) Qi Guo et al.   JOURNAL OF HYPERTENSION

Polymorphisms in glyoxalase 1 gene are not associated with vascular complications: the Hoorn and CoDAM studies

(2009) Lian Engelen et al.   JOURNAL OF HYPERTENSION

Phosphorylation on Thr-106 and NO-modification of glyoxalase I suppress the TNF-induced transcriptional activity of NF-κB

(2009) Virginie de Hemptinne et al.   MOLECULAR AND CELLULAR BIOCHEMISTRY

The impact of copy number variation on local gene expression in mouse hematopoietic stem and progenitor cells

(2009) Patrick Cahan et al.   NATURE GENETICS

Diabetes and the Risk of Multi-System Aging Phenotypes: A Systematic Review and Meta-Analysis

(2009) Feng-Ping Lu et al.   PLoS One

Understanding the Warburg Effect: The Metabolic Requirements of Cell Proliferation

(2009) M. G. Vander Heiden et al.   SCIENCE

Increased retinopathy occurrence in type 1 diabetes patients with increased serum levels of the advanced glycation endproduct hydroimidazolone

(2008) Dag S. Fosmark et al.   ACTA OPHTHALMOLOGICA

What is the mechanism of microalbuminuria in diabetes: a role for the glomerular endothelium?

(2008) S. C. Satchell et al.   DIABETOLOGIA

High-dose thiamine therapy for patients with type 2 diabetes and microalbuminuria: a randomised, double-blind placebo-controlled pilot study

(2008) N. Rabbani et al.   DIABETOLOGIA

Modulation of Insulin Action by Advanced Glycation Endproducts: A New Player in the Field

(2008) C. Schalkwijk et al.   HORMONE AND METABOLIC RESEARCH

Decreasing Intracellular Superoxide Corrects Defective Ischemia-induced New Vessel Formation in Diabetic Mice

(2008) Daniel J. Ceradini et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Transient high glucose causes persistent epigenetic changes and altered gene expression during subsequent normoglycemia

(2008) Assam El-Osta et al.   JOURNAL OF EXPERIMENTAL MEDICINE

The metabolism and anti-atherogenic properties of HDL

(2008) Kerry-Anne Rye et al.   JOURNAL OF LIPID RESEARCH

A novel mechanism of methylglyoxal cytotoxicity in neuroglial cells

(2008) Hyun Kyoung Lee et al.   JOURNAL OF NEUROCHEMISTRY

Long-Term Follow-up after Tight Control of Blood Pressure in Type 2 Diabetes

(2008) Rury R. Holman et al.   NEW ENGLAND JOURNAL OF MEDICINE

Methylglyoxal and high glucose co-treatment induces apoptosis or necrosis in human umbilical vein endothelial cells

(2007) Wen-Hsiung Chan et al.   JOURNAL OF CELLULAR BIOCHEMISTRY