A new era for understanding amyloid structures and disease

In Situ Structure of Neuronal C9orf72 Poly-GA Aggregates Reveals Proteasome Recruitment

(2018) Qiang Guo et al.   CELL

Tau protein liquid–liquid phase separation can initiate tau aggregation

(2018) Susanne Wegmann et al.   EMBO JOURNAL

Membrane remodeling by amyloidogenic and non-amyloidogenic proteins studied by EPR

(2017) Jobin Varkey et al.   JOURNAL OF MAGNETIC RESONANCE

Molecular Origins of the Compatibility between Glycosaminoglycans and Aβ40 Amyloid Fibrils

(2017) Katie L. Stewart et al.   JOURNAL OF MOLECULAR BIOLOGY

Using an NMR metabolomics approach to investigate the pathogenicity of amyloid-beta and alpha-synuclein

(2017) M. M. Phelan et al.   Metabolomics

Structural variation in amyloid-β fibrils from Alzheimer's disease clinical subtypes

(2017) Wei Qiang et al.   NATURE

Cryo-EM structures of tau filaments from Alzheimer’s disease

(2017) Anthony W. P. Fitzpatrick et al.   NATURE

Structure-based inhibitors of tau aggregation

(2017) P. M. Seidler et al.   Nature Chemistry

Biomolecular condensates: organizers of cellular biochemistry

(2017) Salman F. Banani et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Atomic structure of a toxic, oligomeric segment of SOD1 linked to amyotrophic lateral sclerosis (ALS)

(2017) Smriti Sangwan et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein homeostasis of a metastable subproteome associated with Alzheimer’s disease

(2017) Rishika Kundra et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Zinc-binding structure of a catalytic amyloid from solid-state NMR

(2017) Myungwoon Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The cytotoxic Staphylococcus aureus PSMα3 reveals a cross-α amyloid-like fibril

(2017) Einav Tayeb-Fligelman et al.   SCIENCE

Structural basis of membrane disruption and cellular toxicity by α-synuclein oligomers

(2017) Giuliana Fusco et al.   SCIENCE

Fibril structure of amyloid-β(1–42) by cryo–electron microscopy

(2017) Lothar Gremer et al.   SCIENCE

Understanding co-polymerization in amyloid formation by direct observation of mixed oligomers

(2017) Lydia M. Young et al.   Chemical Science

Atomic structures of fibrillar segments of hIAPP suggest tightly mated β-sheets are important for cytotoxicity

(2017) Pascal Krotee et al.   eLife

Alzheimer's Disease and the Amyloid-β Peptide

(2017) M. Paul Murphy et al.   JOURNAL OF ALZHEIMERS DISEASE

Distinct Mechanisms Determine α-Synuclein Fibril Morphology during Growth and Maturation

(2016) Arshdeep Sidhu et al.   ACS Chemical Neuroscience

Amyloid fibril proteins and amyloidosis: chemical identification and clinical classification International Society of Amyloidosis 2016 Nomenclature Guidelines

(2016) Jean D. Sipe et al.   AMYLOID-JOURNAL OF PROTEIN FOLDING DISORDERS

Amyloid Aggregates Arise from Amino Acid Condensations under Prebiotic Conditions

(2016) Jason Greenwald et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Emergence and evolution of yeast prion and prion-like proteins

(2016) Lu An et al.   BMC EVOLUTIONARY BIOLOGY

Adaptation to Stressors by Systemic Protein Amyloidogenesis

(2016) Timothy E. Audas et al.   DEVELOPMENTAL CELL

Cellular proteostasis: degradation of misfolded proteins by lysosomes

(2016) M. P. Jackson et al.   Essays in Biochemistry

Alzheimer’s and Parkinson’s Diseases: Expected Economic Impact on Europe—A Call for a Uniform European Strategy

(2016) Petra Maresova et al.   JOURNAL OF ALZHEIMERS DISEASE

CJD and Scrapie Require Agent-Associated Nucleic Acids for Infection

(2016) Sotirios Botsios et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Monomeric Alpha-Synuclein Exerts a Physiological Role on Brain ATP Synthase

(2016) M. H. R. Ludtmann et al.   JOURNAL OF NEUROSCIENCE

Atomic Details of the Interactions of Glycosaminoglycans with Amyloid-β Fibrils

(2016) Katie L. Stewart et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Atomic Resolution Structure of Monomorphic Aβ42 Amyloid Fibrils

(2016) Michael T. Colvin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Molecular mechanisms of protein aggregation from global fitting of kinetic models

(2016) Georg Meisl et al.   Nature Protocols

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Age at onset and Parkinson disease phenotype

(2016) Gennaro Pagano et al.   NEUROLOGY

Phenotypic spectrum of alpha-synuclein mutations: New insights from patients and cellular models

(2016) Simona Petrucci et al.   PARKINSONISM & RELATED DISORDERS

Electron tomography reveals the fibril structure and lipid interactions in amyloid deposits

(2016) Marius Kollmer et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Aβ42 assembles into specific β-barrel pore-forming oligomers in membrane-mimicking environments

(2016) Montserrat Serra-Batiste et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic development of small molecules to inhibit specific microscopic steps of Aβ42 aggregation in Alzheimer’s disease

(2016) Johnny Habchi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

High-speed atomic force microscopy reveals structural dynamics of amyloid β1–42aggregates

(2016) Takahiro Watanabe-Nakayama et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Ab initio structure determination from prion nanocrystals at atomic resolution by MicroED

(2016) Michael R. Sawaya et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic-resolution structure of a disease-relevant Aβ(1–42) amyloid fibril

(2016) Marielle Aulikki Wälti et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo aspects of protein folding and quality control

(2016) D. Balchin et al.   SCIENCE

Pathological  -synuclein transmission initiated by binding lymphocyte-activation gene 3

(2016) X. Mao et al.   SCIENCE

Kinetic analysis reveals the diversity of microscopic mechanisms through which molecular chaperones suppress amyloid formation

(2016) Paolo Arosio et al.   Nature Communications

Solid-state NMR structure of a pathogenic fibril of full-length human α-synuclein

(2016) Marcus D Tuttle et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

The Prion-Like Properties of Amyloid-β Assemblies: Implications for Alzheimer's Disease

(2016) Lary C. Walker et al.   Cold Spring Harbor Perspectives in Medicine

Staphylococcal Bap Proteins Build Amyloid Scaffold Biofilm Matrices in Response to Environmental Signals

(2016) Agustina Taglialegna et al.   PLoS Pathogens

Binding affinity of amyloid oligomers to cellular membranes is a generic indicator of cellular dysfunction in protein misfolding diseases

(2016) Elisa Evangelisti et al.   Scientific Reports

Mass Determination of Entire Amyloid Fibrils by Using Mass Spectrometry

(2015) Tristan Doussineau et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Mirror movements in progressive hemifacial atrophy

(2015) Rajesh Verma et al.   Annals of Indian Academy of Neurology

Rapidly progressive Alzheimer’s disease features distinct structures of amyloid-β

(2015) Mark L. Cohen et al.   BRAIN

Widespread Proteome Remodeling and Aggregation in Aging C. elegans

(2015) Dirk M. Walther et al.   CELL

The LC Domain of hnRNPA2 Adopts Similar Conformations in Hydrogel Polymers, Liquid-like Droplets, and Nuclei

(2015) Siheng Xiang et al.   CELL

α-Synuclein Amyloid Fibrils with Two Entwined, Asymmetrically Associated Protofibrils

(2015) Altaira D. Dearborn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Amyloid-β Receptors: The Good, the Bad, and the Prion Protein

(2015) Heledd H. Jarosz-Griffiths et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Surviving protein quality control catastrophes - from cells to organisms

(2015) K. Schneider et al.   JOURNAL OF CELL SCIENCE

High Resolution Structural Characterization of Aβ42 Amyloid Fibrils by Magic Angle Spinning NMR

(2015) Michael T. Colvin et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Structure of the toxic core of α-synuclein from invisible crystals

(2015) Jose A. Rodriguez et al.   NATURE

Lipid vesicles trigger α-synuclein aggregation by stimulating primary nucleation

(2015) Céline Galvagnion et al.   Nature Chemical Biology

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

pH-induced molecular shedding drives the formation of amyloid fibril-derived oligomers

(2015) Kevin W. Tipping et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cytoplasmic protein aggregates interfere with nucleocytoplasmic transport of protein and RNA

(2015) A. C. Woerner et al.   SCIENCE

Amyloid Fibres: Inert End-Stage Aggregates or Key Players in Disease?

(2015) Kevin W. Tipping et al.   TRENDS IN BIOCHEMICAL SCIENCES

Supersaturation is a major driving force for protein aggregation in neurodegenerative diseases

(2015) Prajwal Ciryam et al.   TRENDS IN PHARMACOLOGICAL SCIENCES

Aβ(1–42) fibril structure illuminates self-recognition and replication of amyloid in Alzheimer's disease

(2015) Yiling Xiao et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Aβ42-oligomer Interacting Peptide (AIP) neutralizes toxic amyloid-β42 species and protects synaptic structure and function

(2015) Christian Barucker et al.   Scientific Reports

Single-molecule FRET studies on alpha-synuclein oligomerization of Parkinson’s disease genetically related mutants

(2015) Laura Tosatto et al.   Scientific Reports

Link between type 2 diabetes and Alzheimer’s disease: from epidemiology to mechanism and treatment

(2015) Xiaohua Li et al.   Clinical Interventions in Aging

Hydrogen/Deuterium Exchange-Protected Oligomers Populated during Aβ Fibril Formation Correlate with Neuronal Cell Death

(2014) Bernat Serra-Vidal et al.   ACS Chemical Biology

Atomic-Resolution Three-Dimensional Structure of Amyloid β Fibrils Bearing the Osaka Mutation

(2014) Anne K. Schütz et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Polyglutamine (PolyQ) Diseases: Genetics to Treatments

(2014) Hueng-Chuen Fan et al.   CELL TRANSPLANTATION

Functional amyloid: widespread in Nature, diverse in purpose

(2014) Chi L.L. Pham et al.   Essays in Biochemistry

β2-Microglobulin Amyloid Fibrils Are Nanoparticles That Disrupt Lysosomal Membrane Protein Trafficking and Inhibit Protein Degradation by Lysosomes

(2014) Toral Jakhria et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Catalytic Mechanism and Mode of Action of the Periplasmic Alginate Epimerase AlgG

(2014) Francis Wolfram et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The H50Q Mutation Enhances α-Synuclein Aggregation, Secretion, and Toxicity

(2014) Ossama Khalaf et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Functional Amyloids in the Mouse Sperm Acrosome

(2014) B. Guyonnet et al.   MOLECULAR AND CELLULAR BIOLOGY

Unraveling the mechanism of cell death induced by chemical fibrils

(2014) Olivier Julien et al.   Nature Chemical Biology

Neural compensation in older people with brain amyloid-β deposition

(2014) Jeremy A Elman et al.   NATURE NEUROSCIENCE

The amyloid state and its association with protein misfolding diseases

(2014) Tuomas P. J. Knowles et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Unlike Twins: An NMR Comparison of Two α-Synuclein Polymorphs Featuring Different Toxicity

(2014) Julia Gath et al.   PLoS One

β2-Microglobulin Amyloid Fibril-Induced Membrane Disruption Is Enhanced by Endosomal Lipids and Acidic pH

(2014) Sophia C. Goodchild et al.   PLoS One

Solution conditions determine the relative importance of nucleation and growth processes in  -synuclein aggregation

(2014) A. K. Buell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The Resolution Revolution

(2014) W. Kuhlbrandt   SCIENCE

Advanced Solid-State NMR Approaches for Structure Determination of Membrane Proteins and Amyloid Fibrils

(2013) Ming Tang et al.   ACCOUNTS OF CHEMICAL RESEARCH

Evidence for Age-Dependent in Vivo Conformational Rearrangement within Aβ Amyloid Deposits

(2013) Sofie Nyström et al.   ACS Chemical Biology

Superresolution Imaging of Amyloid Fibrils with Binding-Activated Probes

(2013) Jonas Ries et al.   ACS Chemical Neuroscience

G51D α-synuclein mutation causes a novel Parkinsonian-pyramidal syndrome

(2013) Suzanne Lesage et al.   ANNALS OF NEUROLOGY

Molecular Chaperone Functions in Protein Folding and Proteostasis

(2013) Yujin E. Kim et al.   Annual Review of Biochemistry

ATR-FTIR: A “rejuvenated” tool to investigate amyloid proteins

(2013) Rabia Sarroukh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Yet another polymorph of α-synuclein: solid-state sequential assignments

(2013) Julia Gath et al.   Biomolecular NMR Assignments

Prion-like spreading of pathological α-synuclein in brain

(2013) Masami Masuda-Suzukake et al.   BRAIN

Dissecting phenotypic traits linked to human resilience to Alzheimer’s pathology

(2013) Beatriz G. Perez-Nievas et al.   BRAIN

Molecular Structure of β-Amyloid Fibrils in Alzheimer’s Disease Brain Tissue

(2013) Jun-Xia Lu et al.   CELL

Structure, Folding Dynamics, and Amyloidogenesis of D76N β2-Microglobulin

(2013) P. Patrizia Mangione et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Polymorph-Specific Kinetics and Thermodynamics of β-Amyloid Fibril Growth

(2013) Wei Qiang et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Ion Mobility Spectrometry–Mass Spectrometry Defines the Oligomeric Intermediates in Amylin Amyloid Formation and the Mode of Action of Inhibitors

(2013) Lydia M. Young et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

Alpha-synuclein p.H50Q, a novel pathogenic mutation for Parkinson's disease

(2013) Silke Appel-Cresswell et al.   MOVEMENT DISORDERS

Direct Observation of Heterogeneous Amyloid Fibril Growth Kinetics via Two-Color Super-Resolution Microscopy

(2013) Dorothea Pinotsi et al.   NANO LETTERS

Update on novel familial forms of Parkinson's disease and multiple system atrophy

(2013) Shinsuke Fujioka et al.   PARKINSONISM & RELATED DISORDERS

Correction: Heterologous Reconstitution of the Intact Geodin Gene Cluster in Aspergillus nidulans through a Simple and Versatile PCR Based Approach

(2013) Morten Thrane Nielsen et al.   PLoS One

Drug resistance confounding prion therapeutics

(2013) D. B. Berry et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Pulsed hydrogen–deuterium exchange mass spectrometry probes conformational changes in amyloid beta (Aβ) peptide aggregation

(2013) Ying Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic structure and hierarchical assembly of a cross-  amyloid fibril

(2013) A. W. P. Fitzpatrick et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Proliferation of amyloid- 42 aggregates occurs through a secondary nucleation mechanism

(2013) S. I. A. Cohen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Impaired autophagy and APP processing in Alzheimer's disease: The potential role of Beclin 1 interactome

(2013) Antero Salminen et al.   PROGRESS IN NEUROBIOLOGY

Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity

(2013) Andrew J. Nicoll et al.   Nature Communications

Structural and functional characterization of two alpha-synuclein strains

(2013) Luc Bousset et al.   Nature Communications

 -Synuclein in Parkinson's Disease

(2013) L. Stefanis   Cold Spring Harbor Perspectives in Medicine

Acquisition of Drug Resistance and Dependence by Prions

(2013) Anja M. Oelschlegel et al.   PLoS Pathogens

The Amyloid State of Proteins in Human Diseases

(2012) David Eisenberg et al.   CELL

Metal ions and amyloid fiber formation in neurodegenerative diseases. Copper, zinc and iron in Alzheimer's, Parkinson's and prion diseases

(2012) John H. Viles   COORDINATION CHEMISTRY REVIEWS

Transgenic Mouse Models of Alzheimer Disease: Developing a Better Model as a Tool for Therapeutic Interventions

(2012) Masashi Kitazawa et al.   CURRENT PHARMACEUTICAL DESIGN

Role of α-synuclein penetration into the membrane in the mechanisms of oligomer pore formation

(2012) Igor F. Tsigelny et al.   FEBS Journal

Correlation of Alzheimer Disease Neuropathologic Changes With Cognitive Status: A Review of the Literature

(2012) Peter T. Nelson et al.   JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY

Phenylalanine assembly into toxic fibrils suggests amyloid etiology in phenylketonuria

(2012) Lihi Adler-Abramovich et al.   Nature Chemical Biology

Direct three-dimensional visualization of membrane disruption by amyloid fibrils

(2012) L. Milanesi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Heritable yeast prions have a highly organized three-dimensional architecture with interfiber structures

(2012) H. R. Saibil et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Antiparallel  -sheet architecture in Iowa-mutant  -amyloid fibrils

(2012) W. Qiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Tafamidis, a potent and selective transthyretin kinetic stabilizer that inhibits the amyloid cascade

(2012) C. E. Bulawa et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Purified and synthetic Alzheimer's amyloid beta (A ) prions

(2012) J. Stohr et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Atomic View of a Toxic Amyloid Small Oligomer

(2012) Arthur Laganowsky et al.   SCIENCE

Disulfide Bonds Reduce the Toxicity of the Amyloid Fibrils Formed by an Extracellular Protein

(2011) Maria F. Mossuto et al.   ANGEWANDTE CHEMIE-INTERNATIONAL EDITION

Biophysics of α-synuclein membrane interactions

(2011) Candace M. Pfefferkorn et al.   BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES

Amyloid-like Aggregates Sequester Numerous Metastable Proteins with Essential Cellular Functions

(2011) Heidi Olzscha et al.   CELL

Peptides Released by Physiological Cleavage of Semen Coagulum Proteins Form Amyloids that Enhance HIV Infection

(2011) Nadia R. Roan et al.   Cell Host & Microbe

In Vivo and In Vitro Analyses of Toxic Mutants of HET-s: FTIR Antiparallel Signature Correlates with Amyloid Toxicity

(2011) Karine Berthelot et al.   JOURNAL OF MOLECULAR BIOLOGY

In Situ Measurements of the Formation and Morphology of Intracellular β-Amyloid Fibrils by Super-Resolution Fluorescence Imaging

(2011) Gabriele S. Kaminski Schierle et al.   JOURNAL OF THE AMERICAN CHEMICAL SOCIETY

A Diversity of Assembly Mechanisms of a Generic Amyloid Fold

(2011) Timo Eichner et al.   MOLECULAR CELL

Structure-based design of non-natural amino-acid inhibitors of amyloid fibril formation

(2011) Stuart A. Sievers et al.   NATURE

Expanded GGGGCC Hexanucleotide Repeat in Noncoding Region of C9ORF72 Causes Chromosome 9p-Linked FTD and ALS

(2011) Mariely DeJesus-Hernandez et al.   NEURON

A Hexanucleotide Repeat Expansion in C9ORF72 Is the Cause of Chromosome 9p21-Linked ALS-FTD

(2011) Alan E. Renton et al.   NEURON

Islet Amyloid Polypeptide, Islet Amyloid, and Diabetes Mellitus

(2011) Per Westermark et al.   PHYSIOLOGICAL REVIEWS

Human Apolipoprotein A-I-Derived Amyloid: Its Association with Atherosclerosis

(2011) Nahuel A. Ramella et al.   PLoS One

SNCA Triplication Parkinson's Patient's iPSC-derived DA Neurons Accumulate α-Synuclein and Are Susceptible to Oxidative Stress

(2011) Blake Byers et al.   PLoS One

Molecular basis for amyloid-  polymorphism

(2011) J.-P. Colletier et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

In vivo demonstration that  -synuclein oligomers are toxic

(2011) B. Winner et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Recombinant prion protein induces a new transmissible prion disease in wild-type animals

(2010) Natallia Makarava et al.   ACTA NEUROPATHOLOGICA

Characterizing the Assembly of the Sup35 Yeast Prion Fragment, GNNQQNY: Structural Changes Accompany a Fiber-to-Crystal Switch

(2010) Karen E. Marshall et al.   BIOPHYSICAL JOURNAL

Stacked Sets of Parallel, In-register β-Strands of β2-Microglobulin in Amyloid Fibrils Revealed by Site-directed Spin Labeling and Chemical Labeling

(2010) Carol L. Ladner et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Glucagon Fibril Polymorphism Reflects Differences in Protofilament Backbone Structure

(2010) Christian Beyschau Andersen et al.   JOURNAL OF MOLECULAR BIOLOGY

Structural polymorphism of Alzheimer Aβ and other amyloid fibrils

(2010) Marcus Fändrich et al.   Prion

Amyloid fibers provide structural integrity to Bacillus subtilis biofilms

(2010) D. Romero et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Thioflavine T interaction with synthetic Alzheimer's disease β-amyloid peptides: Detection of amyloid aggregation in solution

(2010) Harry Levine   PROTEIN SCIENCE

Darwinian Evolution of Prions in Cell Culture

(2010) J. Li et al.   SCIENCE

CAG Expansion in the Huntington Disease Gene Is Associated with a Specific and Targetable Predisposing Haplogroup

(2009) Simon C. Warby et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Prion Diseases and Their Biochemical Mechanisms†

(2009) Nathan J. Cobb et al.   BIOCHEMISTRY

Mitochondrial dysfunction in Parkinson's disease

(2009) Konstanze F. Winklhofer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Agitation and High Ionic Strength Induce Amyloidogenesis of a Folded PDZ Domain in Native Conditions

(2009) Alessandro Sicorello et al.   BIOPHYSICAL JOURNAL

Molecular Modeling of the Misfolded Insulin Subunit and Amyloid Fibril

(2009) Jay H. Choi et al.   BIOPHYSICAL JOURNAL

A Systematic Survey Identifies Prions and Illuminates Sequence Features of Prionogenic Proteins

(2009) Simon Alberti et al.   CELL

Oxidative Stress and Neurodegenerative Diseases: A Review of Upstream and Downstream Antioxidant Therapeutic Options

(2009) Bayani Uttara et al.   Current Neuropharmacology

Yeast Cell Adhesion Molecules Have Functional Amyloid-Forming Sequences

(2009) Caleen B. Ramsook et al.   EUKARYOTIC CELL

β arcades: recurring motifs in naturally occurring and disease-related amyloid fibrils

(2009) Andrey V. Kajava et al.   FASEB JOURNAL

Globular Tetramers of β2-Microglobulin Assemble into Elaborate Amyloid Fibrils

(2009) Helen E. White et al.   JOURNAL OF MOLECULAR BIOLOGY

A Generic Mechanism of β2-Microglobulin Amyloid Assembly at Neutral pH Involving a Specific Proline Switch

(2009) Timo Eichner et al.   JOURNAL OF MOLECULAR BIOLOGY

Prions: Protein Aggregation and Infectious Diseases

(2009) Adriano Aguzzi et al.   PHYSIOLOGICAL REVIEWS

Measurement of amyloid fibril mass-per-length by tilted-beam transmission electron microscopy

(2009) B. Chen et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Prion Diseases: From Protein to Cell Pathology

(2008) Gabor G. Kovacs et al.   AMERICAN JOURNAL OF PATHOLOGY

The Prion's Elusive Reason for Being

(2008) Adriano Aguzzi et al.   Annual Review of Neuroscience

A Common β-Sheet Architecture Underliesin Vitroandin Vivoβ2-Microglobulin Amyloid Fibrils

(2008) Thomas R. Jahn et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of Familial Alzheimer’s Disease Mutations on the Folding Nucleation of the Amyloid β-Protein

(2008) Mary Griffin Krone et al.   JOURNAL OF MOLECULAR BIOLOGY

Amyloid formation by globular proteins under native conditions

(2008) Fabrizio Chiti et al.   Nature Chemical Biology

Amyloid-β protein dimers isolated directly from Alzheimer's brains impair synaptic plasticity and memory

(2008) Ganesh M Shankar et al.   NATURE MEDICINE

AA-Amyloidosis Can Be Transferred by Peripheral Blood Monocytes

(2008) Jana Sponarova et al.   PLoS One

Paired  -sheet structure of an A (1-40) amyloid fibril revealed by electron microscopy

(2008) C. Sachse et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Systematic analysis of nucleation-dependent polymerization reveals new insights into the mechanism of amyloid self-assembly

(2008) Wei-Feng Xue et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Kuru prions and sporadic Creutzfeldt-Jakob disease prions have equivalent transmission properties in transgenic and wild-type mice

(2008) J. D. F. Wadsworth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Molecular structural basis for polymorphism in Alzheimer's  -amyloid fibrils

(2008) A. K. Paravastu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The fold of  -synuclein fibrils

(2008) M. Vilar et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Spontaneous β-helical fold in prion protein: The case of PrP(82-146)

(2008) Gloria A.A. Saracino et al.   PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS

Amyloid Fibrils of the HET-s(218-289) Prion Form a   Solenoid with a Triangular Hydrophobic Core

(2008) C. Wasmer et al.   SCIENCE

An Intersubunit Active Site between Supercoiled Parallel β Helices in the Trimeric Tailspike Endorhamnosidase of Shigella flexneri Phage Sf6

(2008) Jürgen J. Müller et al.   STRUCTURE

FTIR reveals structural differences between native β-sheet proteins and amyloid fibrils

(2004) Giorgia Zandomeneghi et al.   PROTEIN SCIENCE