Impaired proteostasis: role in the pathogenesis of diabetes mellitus

Autophagy: The missing link between non-enzymatically glycated proteins inducing apoptosis and premature senescence of endothelial cells?

(2014) Susann Patschan et al.   Autophagy

Improvement of Insulin Sensitivity by a Novel Drug Candidate, BGP-15, in Different Animal Studies

(2014) Botond Literáti-Nagy et al.   Metabolic Syndrome and Related Disorders

Molecular chaperones and proteostasis regulation during redox imbalance

(2014) Katerina Niforou et al.   Redox Biology

High glucose and diabetes modulate cellular proteasome function: Implications in the pathogenesis of diabetes complications

(2013) Saeed Yadranji Aghdam et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Genetic variability in enzymes of metabolic pathways conferring protection against non-enzymatic glycation versus diabetes-related morbidity and mortality

(2013) Veronika Tanhäuserová et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Glycated Albumin Causes Pancreatic β-Cells Dysfunction Through Autophagy Dysfunction

(2013) Young Mi Song et al.   ENDOCRINOLOGY

Usefulness of non-enzymatic post-translational modification derived products (PTMDPs) as biomarkers of chronic diseases

(2013) Philippe Gillery et al.   Journal of Proteomics

Protein oxidation in aging and the removal of oxidized proteins

(2013) Annika Höhn et al.   Journal of Proteomics

Diversity in the origins of proteostasis networks — a driver for protein function in evolution

(2013) Evan T. Powers et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Enhancement of 26S Proteasome Functionality Connects Oxidative Stress and Vascular Endothelial Inflammatory Response in Diabetes Mellitus

(2012) Hongtao Liu et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Inhibition of lysosomal function in macrophages incubated with elevated glucose concentrations: A potential contributory factor in diabetes-associated atherosclerosis

(2012) Fatemeh Moheimani et al.   ATHEROSCLEROSIS

Autophagy plays a protective role in endoplasmic reticulum stress-mediated pancreatic β cell death

(2012) Alberto Bartolome et al.   Autophagy

Advanced-glycation-end-product-induced formation of immunoproteasomes: involvement of RAGE and Jak2/STAT1

(2012) Stefanie Grimm et al.   BIOCHEMICAL JOURNAL

Impaired protein quality control system underlies mitochondrial dysfunction in skeletal muscle of streptozotocin-induced diabetic rats

(2012) Ana Isabel Padrão et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

The novel proteasome inhibitor BSc2118 protects against cerebral ischaemia through HIF1A accumulation and enhanced angioneurogenesis

(2012) Thorsten R. Doeppner et al.   BRAIN

Proteasome Dysfunction Mediates Obesity-Induced Endoplasmic Reticulum Stress and Insulin Resistance in the Liver

(2012) T. Otoda et al.   DIABETES

Failure of the Adaptive Unfolded Protein Response in Islets of Obese Mice Is Linked With Abnormalities in  -Cell Gene Expression and Progression to Diabetes

(2012) J. Y. Chan et al.   DIABETES

Stimulation of Autophagy Improves Endoplasmic Reticulum Stress-Induced Diabetes

(2012) E. Bachar-Wikstrom et al.   DIABETES

Reactive oxygen and nitrogen species generation, antioxidant defenses, and β-cell function: a critical role for amino acids

(2012) P Newsholme et al.   JOURNAL OF ENDOCRINOLOGY

C-Terminal Heat Shock Protein 90 Inhibitor Decreases Hyperglycemia-induced Oxidative Stress and Improves Mitochondrial Bioenergetics in Sensory Neurons

(2012) Liang Zhang et al.   JOURNAL OF PROTEOME RESEARCH

Microarray analysis of isolated human islet transcriptome in type 2 diabetes and the role of the ubiquitin–proteasome system in pancreatic beta cell dysfunction

(2012) Marco Bugliani et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Protein damage, repair and proteolysis

(2012) Niki Chondrogianni et al.   MOLECULAR ASPECTS OF MEDICINE

Tyrosine Nitration of PA700 Links Proteasome Activation to Endothelial Dysfunction in Mouse Models with Cardiovascular Risk Factors

(2012) Jian Xu et al.   PLoS One

Angiogenesis Impairment in Diabetes: Role of Methylglyoxal-Induced Receptor for Advanced Glycation Endproducts, Autophagy and Vascular Endothelial Growth Factor Receptor 2

(2012) Hongtao Liu et al.   PLoS One

Multitasking in the mitochondrion by the ATP-dependent Lon protease

(2011) Sundararajan Venkatesh et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR CELL RESEARCH

Estimated incidence of cardiovascular complications related to type 2 diabetes in Mexico using the UKPDS outcome model and a population-based survey

(2011) Nancy Reynoso-Noverón et al.   Cardiovascular Diabetology

Genetic variability of the fructosamine 3-kinase gene in diabetic patients

(2011) Lorena Mosca et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

Improvement of Cardiac Functions by Chronic Metformin Treatment Is Associated With Enhanced Cardiac Autophagy in Diabetic OVE26 Mice

(2011) Z. Xie et al.   DIABETES

Downregulation of mitochondrial lon protease impairs mitochondrial function and causes hepatic insulin resistance in human liver SK-HEP-1 cells

(2011) H. J. Lee et al.   DIABETOLOGIA

Effect of streptozocin-induced diabetes mellitus on expression of methionine sulfoxide reductases and accumulation of their substrates in mouse lenses

(2011) Yi Li et al.   EXPERIMENTAL EYE RESEARCH

Allelic variations in superoxide dismutase-1 (SOD1) gene are associated with increased risk of diabetic nephropathy in type 1 diabetic subjects

(2011) Kamel Mohammedi et al.   MOLECULAR GENETICS AND METABOLISM

Substrate-Favored Lysosomal and Proteasomal Pathways Participate in the Normal Balance Control of Insulin Precursor Maturation and Disposal in β-Cells

(2011) Xiaoping Zhang et al.   PLoS One

Glyoxalase in diabetes, obesity and related disorders

(2011) Naila Rabbani et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Oxidative protein damage and the proteasome

(2010) S. Grimm et al.   AMINO ACIDS

Enzymatic repair of Amadori products

(2010) Emile Van Schaftingen et al.   AMINO ACIDS

The double-edged effect of autophagy in pancreatic beta cells and diabetes

(2010) Ze-fang Chen et al.   Autophagy

The chaperone proteins HSP70, HSP40/DnaJ and GRP78/BiP suppress misfolding and formation of β-sheet-containing aggregates by human amylin: a potential role for defective chaperone biology in Type 2 diabetes

(2010) Vita Chien et al.   BIOCHEMICAL JOURNAL

Deleterious effects of reactive aldehydes and glycated proteins on macrophage proteasomal function: Possible links between diabetes and atherosclerosis

(2010) Fatemeh Moheimani et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Overview of macroautophagy regulation in mammalian cells

(2010) Maryam Mehrpour et al.   CELL RESEARCH

Modeling general proteostasis: proteome balance in health and disease

(2010) Daniela M Roth et al.   CURRENT OPINION IN CELL BIOLOGY

 -Cell Dysfunctional ERAD/Ubiquitin/Proteasome System in Type 2 Diabetes Mediated by Islet Amyloid Polypeptide-Induced UCH-L1 Deficiency

(2010) S. Costes et al.   DIABETES

Mechanisms of mitophagy

(2010) Richard J. Youle et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

The elimination of accumulated and aggregated proteins: A role for aggrephagy in neurodegeneration

(2010) Ai Yamamoto et al.   NEUROBIOLOGY OF DISEASE

Islets and their antioxidant defense

(2010) Jhankar D. Acharya et al.   Islets

Aging: Central role for autophagy and the lysosomal degradative system

(2009) Yogendra S. Rajawat et al.   AGEING RESEARCH REVIEWS

Effects of fructosamine-3-kinase deficiency on function and survival of mouse pancreatic islets after prolonged culture in high glucose or ribose concentrations

(2009) S. M. A. Pascal et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Heat Shock Proteins in Diabetes and Wound Healing

(2009) Mustafa Atalay et al.   CURRENT PROTEIN & PEPTIDE SCIENCE

Hyperglycemia Impairs Proteasome Function by Methylglyoxal

(2009) M. A. Queisser et al.   DIABETES

Autophagy in human type 2 diabetes pancreatic beta cells

(2009) M. Masini et al.   DIABETOLOGIA

The proteasomal system

(2009) Tobias Jung et al.   MOLECULAR ASPECTS OF MEDICINE

Emerging roles for the ubiquitin-proteasome system and autophagy in pancreatic β-cells

(2008) Taila Hartley et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

The UPS in diabetes and obesity

(2008) Simon S Wing   BMC BIOCHEMISTRY

Loss of Autophagy Diminishes Pancreatic β Cell Mass and Function with Resultant Hyperglycemia

(2008) Hye Seung Jung et al.   Cell Metabolism

Inflammation, heat shock proteins, and type 2 diabetes

(2008) Philip L. Hooper et al.   CELL STRESS & CHAPERONES

Targeting proteasomes for cardioprotection

(2008) Xichun Yu et al.   CURRENT OPINION IN PHARMACOLOGY

Cardiac Muscle Protein Catabolism in Diabetes Mellitus: Activation of the Ubiquitin-Proteasome System by Insulin Deficiency

(2008) Junping Hu et al.   ENDOCRINOLOGY

HSP72 protects against obesity-induced insulin resistance

(2008) J. Chung et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA