Protection against methylglyoxal-derived AGEs by regulation of glyoxalase 1 prevents retinal neuroglial and vasodegenerative pathology

Candesartan Attenuates Diabetic Retinal Vascular Pathology by Restoring Glyoxalase-I Function

(2010) A. G. Miller et al.   DIABETES

Hyperglycaemia-induced pro-inflammatory responses by retinal Müller glia are regulated by the receptor for advanced glycation end-products (RAGE)

(2010) H. Zong et al.   DIABETOLOGIA

Müller glial dysfunction during diabetic retinopathy in rats is linked to accumulation of advanced glycation end-products and advanced lipoxidation end-products

(2010) T. M. Curtis et al.   DIABETOLOGIA

Hyperglycaemia-induced impairment of endothelium-dependent vasorelaxation in rat mesenteric arteries is mediated by intracellular methylglyoxal levels in a pathway dependent on oxidative stress

(2010) O. Brouwers et al.   DIABETOLOGIA

Overexpression of Glyoxalase-I Reduces Hyperglycemia-induced Levels of Advanced Glycation End Products and Oxidative Stress in Diabetic Rats

(2010) Olaf Brouwers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Modulation of Angiogenesis by Erythropoiesis-Stimulating Agents in a Mouse Model of Ischaemic Retinopathy

(2010) Carmel M. McVicar et al.   PLoS One

The Chaperone-Dependent Ubiquitin Ligase CHIP Targets HIF-1α for Degradation in the Presence of Methylglyoxal

(2010) Carla Figueira Bento et al.   PLoS One

Hyperglycemia Impairs Proteasome Function by Methylglyoxal

(2009) M. A. Queisser et al.   DIABETES

Altered expression of genes related to blood–retina barrier disruption in streptozotocin-induced diabetes

(2009) Ingeborg Klaassen et al.   EXPERIMENTAL EYE RESEARCH

Mitogen-activated protein kinase-signaling regulates the ability of Müller glia to proliferate and protect retinal neurons against excitotoxicity

(2009) Andy J. Fischer et al.   GLIA

Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans

(2008) Michael Morcos et al.   AGING CELL

A new advanced glycation inhibitor, LR-90, prevents experimental diabetic retinopathy in rats

(2008) A Bhatwadekar et al.   BRITISH JOURNAL OF OPHTHALMOLOGY