RAGE and glyoxalase in kidney disease

Diabetes-associated cardiac fibrosis: Cellular effectors, molecular mechanisms and therapeutic opportunities

(2016) Ilaria Russo et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Kallistatin protects against diabetic nephropathy in  db/db mice by suppressing AGE-RAGE-induced oxidative stress

(2016) Wai Han Yiu et al.   KIDNEY INTERNATIONAL

RAGE axis in neuroinflammation, neurodegeneration and its emerging role in the pathogenesis of amyotrophic lateral sclerosis

(2016) Rashmi Ray et al.   NEUROSCIENCE AND BIOBEHAVIORAL REVIEWS

Impact of ER stress-regulated ATF4/p16 signaling on the premature senescence of renal tubular epithelial cells in diabetic nephropathy

(2015) Jun Liu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Dicarbonyl stress in cell and tissue dysfunction contributing to ageing and disease

(2015) Naila Rabbani et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Effects of Sevelamer Carbonate on Advanced Glycation End Products and Antioxidant/Pro-Oxidant Status in Patients with Diabetic Kidney Disease

(2015) E. M. Yubero-Serrano et al.   Clinical Journal of the American Society of Nephrology

The role of methylglyoxal and the glyoxalase system in diabetes and other age-related diseases

(2015) Dionne E.M. Maessen et al.   CLINICAL SCIENCE

Receptor for advanced glycation endproducts and progressive kidney disease

(2015) Kei Fukami et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Molecular aspects of renal senescence

(2015) Roland Schmitt et al.   Current Opinion in Organ Transplantation

Relationship Between Levels of Advanced Glycation End Products and Their Soluble Receptor and Adverse Outcomes in Adults With Type 2 Diabetes

(2015) Merlin C. Thomas et al.   DIABETES CARE

Soluble receptor for advanced glycation end products inhibits disease progression in autosomal dominant polycystic kidney disease by down-regulating cell proliferation

(2015) Eun Ji Lee et al.   FASEB JOURNAL

Peroxynitrite-mediated glyoxalase I epigenetic inhibition drives apoptosis in airway epithelial cells exposed to crystalline silica via a novel mechanism involving argpyrimidine-modified Hsp70, JNK, and NF-κB

(2015) Cinzia Antognelli et al.   FREE RADICAL BIOLOGY AND MEDICINE

SIRT1 suppresses cardiomyocyte apoptosis in diabetic cardiomyopathy: An insight into endoplasmic reticulum stress response mechanism

(2015) Rong Guo et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

Autophagy-Lysosome Pathway in Renal Tubular Epithelial Cells Is Disrupted by Advanced Glycation End Products in Diabetic Nephropathy

(2015) Wei Jing Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Advanced oxidation protein products induce apoptosis in podocytes through induction of endoplasmic reticulum stress

(2015) Guang Rong et al.   JOURNAL OF PHYSIOLOGY AND BIOCHEMISTRY

Role of Uremic Toxins in Erythropoiesis-Stimulating Agent Resistance in Chronic Kidney Disease and Dialysis Patients

(2015) Masaomi Nangaku et al.   JOURNAL OF RENAL NUTRITION

Uremic Toxicity of Advanced Glycation End Products in CKD

(2015) A. E. M. Stinghen et al.   JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY

Emerging role of post-translational modifications in chronic kidney disease and cardiovascular disease

(2015) Prathibha R. Gajjala et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Epigenetic Changes in Endothelial Progenitors as a Possible Cellular Basis for Glycemic Memory in Diabetic Vascular Complications

(2015) Poojitha Rajasekar et al.   Journal of Diabetes Research

Glyoxalase I reduces glycative and oxidative stress and prevents age-related endothelial dysfunction through modulation of endothelial nitric oxide synthase phosphorylation

(2014) Airi Jo-Watanabe et al.   AGING CELL

Possible role of methylglyoxal and glyoxalase in arthritis

(2014) Usman Ahmed et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Glycative stress and glyoxalase in kidney disease and aging: Figure 1

(2014) Reiko Inagi   BIOCHEMICAL SOCIETY TRANSACTIONS

Glyoxalase 1 overexpression does not affect atherosclerotic lesion size and severity in ApoE−/− mice with or without diabetes

(2014) Nordin M.J. Hanssen et al.   CARDIOVASCULAR RESEARCH

Angiotensin-(1–7) abolishes AGE-induced cellular hypertrophy and myofibroblast transformation via inhibition of ERK1/2

(2014) Ebaa M. Alzayadneh et al.   CELLULAR SIGNALLING

Advanced glycation end product accumulation

(2014) Sandeep K. Mallipattu et al.   CURRENT OPINION IN NEPHROLOGY AND HYPERTENSION

Dicarbonyl Stress in the Absence of Hyperglycemia Increases Endothelial Inflammation and Atherogenesis Similar to That Observed in Diabetes

(2014) Chris Tikellis et al.   DIABETES

daf-16/FOXO and glod-4/glyoxalase-1 are required for the life-prolonging effect of human insulin under high glucose conditions in Caenorhabditis elegans

(2014) Michael Mendler et al.   DIABETOLOGIA

Effect of Metformin on Methylglyoxal Metabolism in Patients with Type 2 Diabetes

(2014) Z. Kender et al.   EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES

Pathophysiological importance of aggregated damaged proteins

(2014) Annika Höhn et al.   FREE RADICAL BIOLOGY AND MEDICINE

Targeting of Receptor for Advanced Glycation End Products Suppresses Cyst Growth in Polycystic Kidney Disease

(2014) Eun Young Park et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Stress in the kidney is the road to pERdition: is endoplasmic reticulum stress a pathogenic mediator of diabetic nephropathy?

(2014) Aowen Zhuang et al.   JOURNAL OF ENDOCRINOLOGY

Chromatin Decondensation and T Cell Hyperresponsiveness in Diabetes-Associated Hyperglycemia

(2014) Nuria Martinez et al.   JOURNAL OF IMMUNOLOGY

Activation of the receptor for advanced glycation end products induces nuclear inhibitor of protein phosphatase-1 suppression

(2014) Marita Liebisch et al.   KIDNEY INTERNATIONAL

Histone deacetylase 4 selectively contributes to podocyte injury in diabetic nephropathy

(2014) Xiaojie Wang et al.   KIDNEY INTERNATIONAL

Proteostasis in endoplasmic reticulum—new mechanisms in kidney disease

(2014) Reiko Inagi et al.   Nature Reviews Nephrology

Plasma S100A12 and soluble receptor of advanced glycation end product levels and mortality in chronic kidney disease Stage 5 patients

(2014) N. Isoyama et al.   NEPHROLOGY DIALYSIS TRANSPLANTATION

Lycopene supplementation reduces TNF-α via RAGE in the kidney of obese rats

(2014) D T Pierine et al.   Nutrition & Diabetes

Serum Carboxymethyllysine, an Advanced Glycation End Product, and Age-Related Macular Degeneration

(2014) Richard D. Semba et al.   JAMA Ophthalmology

Impairment of the proteasome is crucial for glucose-induced lifespan reduction in the mev-1 mutant of Caenorhabditis elegans

(2013) Elena Fitzenberger et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Activation of the endoplasmic reticulum stress response by the amyloid-beta 1–40 peptide in brain endothelial cells

(2013) Ana Catarina R.G. Fonseca et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Receptor for advanced glycation end-products promotes premature senescence of proximal tubular epithelial cells via activation of endoplasmic reticulum stress-dependent p21 signaling

(2013) Jun Liu et al.   CELLULAR SIGNALLING

Advanced glycation end-products induce endoplasmic reticulum stress in human aortic endothelial cells

(2013) Christos Adamopoulos et al.   CLINICAL CHEMISTRY AND LABORATORY MEDICINE

DNA Aptamer Raised Against AGEs Blocks the Progression of Experimental Diabetic Nephropathy

(2013) Yusuke Kaida et al.   DIABETES

Glyoxalase-1 overexpression reduces endothelial dysfunction and attenuates early renal impairment in a rat model of diabetes

(2013) Olaf Brouwers et al.   DIABETOLOGIA

Intracellular accumulation of advanced glycation end products induces apoptosis via endoplasmic reticulum stress in chondrocytes

(2013) Soichiro Yamabe et al.   FEBS Journal

Molecular effects of advanced glycation end products on cell signalling pathways, ageing and pathophysiology

(2013) O. Nedić et al.   FREE RADICAL RESEARCH

Aging-Dependent Reduction in Glyoxalase 1 Delays Wound Healing

(2013) Thomas H. Fleming et al.   GERONTOLOGY

Exploring glyoxalase 1 expression in prostate cancer tissues: Targeting the enzyme by ethyl pyruvate defangs some malignancy-associated properties

(2013) Martin Baunacke et al.   PROSTATE

Endoplasmic reticulum stress signal impairs erythropoietin production: a role for ATF4

(2012) Chih-Kang Chiang et al.   AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY

Methylglyoxal modification of Nav1.8 facilitates nociceptive neuron firing and causes hyperalgesia in diabetic neuropathy

(2012) Angelika Bierhaus et al.   NATURE MEDICINE

Downregulation of miR-205 Modulates Cell Susceptibility to Oxidative and Endoplasmic Reticulum Stresses in Renal Tubular Cells

(2012) Shiyo Muratsu-Ikeda et al.   PLoS One

Role of advanced glycation endproducts and glyoxalase I in diabetic peripheral sensory neuropathy

(2012) Megan Jack et al.   Translational Research

Glyoxalase I Retards Renal Senescence

(2011) Yoichiro Ikeda et al.   AMERICAN JOURNAL OF PATHOLOGY

Effect of Irbesartan treatment on plasma and urinary markers of protein damage in patients with type 2 diabetes and microalbuminuria

(2011) Naila Rabbani et al.   AMINO ACIDS

Role of the Glyoxalase System in Astrocyte-Mediated Neuroprotection

(2011) M. Belanger et al.   JOURNAL OF NEUROSCIENCE

Endoplasmic reticulum stress as a progression factor for kidney injury

(2010) Reiko Inagi   CURRENT OPINION IN PHARMACOLOGY

Overexpression of Glyoxalase-I Reduces Hyperglycemia-induced Levels of Advanced Glycation End Products and Oxidative Stress in Diabetic Rats

(2010) Olaf Brouwers et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Metabolic memory and diabetic nephropathy: potential role for epigenetic mechanisms

(2010) Stephen Tonna et al.   Nature Reviews Nephrology

Glyoxalase-1 prevents mitochondrial protein modification and enhances lifespan in Caenorhabditis elegans

(2008) Michael Morcos et al.   AGING CELL