The eNOS signalosome and its link to endothelial dysfunction

Pin1 inhibitor Juglone prevents diabetic vascular dysfunction

(2016) Sarah Costantino et al.   INTERNATIONAL JOURNAL OF CARDIOLOGY

TNFα reduces eNOS activity in endothelial cells through serine 116 phosphorylation and Pin1 binding: Confirmation of a direct, inhibitory interaction of Pin1 with eNOS

(2016) Simone Kennard et al.   VASCULAR PHARMACOLOGY

Pim1 kinase promotes angiogenesis through phosphorylation of endothelial nitric oxide synthase at Ser-633

(2015) Ming Chen et al.   CARDIOVASCULAR RESEARCH

Endothelial Connexin37 and Connexin40 participate in basal but not agonist-induced NO release

(2015) Merlijn J Meens et al.   Cell Communication and Signaling

The F-BAR Protein NOSTRIN Dictates the Localization of the Muscarinic M3 Receptor and Regulates Cardiovascular FunctionNovelty and Significance

(2015) Igor Kovacevic et al.   CIRCULATION RESEARCH

Direct Endothelial Nitric Oxide Synthase Activation Provides Atheroprotection in Diabetes-Accelerated Atherosclerosis

(2015) Arpeeta Sharma et al.   DIABETES

Interplay Between Connexin40 and Nitric Oxide Signaling During Hypertension

(2015) L. Le Gal et al.   HYPERTENSION

S-Nitrosylation of proline-rich tyrosine kinase 2 involves its activation induced by oxygen–glucose deprivation

(2015) Xian-Liang Yan et al.   NEUROSCIENCE LETTERS

Stromal cell–derived factor 2 is critical for Hsp90-dependent eNOS activation

(2015) Mauro Siragusa et al.   Science Signaling

Stromal cell–derived factor 2 is critical for Hsp90-dependent eNOS activation

(2015) Mauro Siragusa et al.   Science Signaling

Nox2-dependent glutathionylation of endothelial NOS leads to uncoupled superoxide production and endothelial barrier dysfunction in acute lung injury

(2014) Feng Wu et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Hemoglobin α/eNOS Coupling at Myoendothelial Junctions Is Required for Nitric Oxide Scavenging During Vasoconstriction

(2014) Adam C. Straub et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Targeting prolyl-isomerase Pin1 prevents mitochondrial oxidative stress and vascular dysfunction: insights in patients with diabetes

(2014) Francesco Paneni et al.   EUROPEAN HEART JOURNAL

Tetrahydrobiopterin Improves Endothelial Function in Cardiovascular Disease: A Systematic Review

(2014) Qiongying Wang et al.   Evidence-based Complementary and Alternative Medicine

Stromal cell derived factor-2 (Sdf2): A novel protein expressed in mouse

(2014) Aline R. Lorenzon-Ojea et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Endothelial Nitric-oxide Synthase (eNOS) Is Activated through G-protein-coupled Receptor Kinase-interacting Protein 1 (GIT1) Tyrosine Phosphorylation and Src Protein

(2014) Songling Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Ubiquitin E3 Ligase NOSIP Modulates Protein Phosphatase 2A Activity in Craniofacial Development

(2014) Meike Hoffmeister et al.   PLoS One

Glutathionylation Mediates Angiotensin II–Induced eNOS Uncoupling, Amplifying NADPH Oxidase‐Dependent Endothelial Dysfunction

(2014) Keyvan Karimi Galougahi et al.   Journal of the American Heart Association

Ilk conditional deletion in adult animals increases cyclic GMP-dependent vasorelaxation

(2013) Isabel Serrano et al.   CARDIOVASCULAR RESEARCH

Arginase as a potential target in the treatment of cardiovascular disease: reversal of arginine steal?

(2013) John Pernow et al.   CARDIOVASCULAR RESEARCH

A Pivotal Role for Tryptophan 447 in Enzymatic Coupling of Human Endothelial Nitric Oxide Synthase (eNOS)

(2013) Matthew A. Benson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Protein Microarray Characterization of theS-Nitrosoproteome

(2013) Yun-Il Lee et al.   MOLECULAR & CELLULAR PROTEOMICS

Quantitative Analysis of Hsp90-Client Interactions Reveals Principles of Substrate Recognition

(2012) Mikko Taipale et al.   CELL

Systemic and Vascular Oxidation Limits the Efficacy of Oral Tetrahydrobiopterin Treatment in Patients With Coronary Artery Disease

(2012) Colin Cunnington et al.   CIRCULATION

Arginase Inhibition Improves Endothelial Function in Patients With Coronary Artery Disease and Type 2 Diabetes Mellitus

(2012) Alexey Shemyakin et al.   CIRCULATION

The F-BAR protein NOSTRIN participates in FGF signal transduction and vascular development

(2012) Igor Kovacevic et al.   EMBO JOURNAL

G-protein-coupled Receptor Kinase Interactor-1 (GIT1) Is a New Endothelial Nitric-oxide Synthase (eNOS) Interactor with Functional Effects on Vascular Homeostasis

(2012) Songling Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Endothelial cell expression of haemoglobin α regulates nitric oxide signalling

(2012) Adam C. Straub et al.   NATURE

Proteomic Identification of S-Nitrosylated Golgi Proteins: New Insights into Endothelial Cell Regulation by eNOS-Derived NO

(2012) Panjamaporn Sangwung et al.   PLoS One

Arginase 1 contributes to diminished coronary arteriolar dilation in patients with diabetes

(2011) Timea Beleznai et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Intravenous Gene Therapy With PIM-1 Via a Cardiotropic Viral Vector Halts the Progression of Diabetic Cardiomyopathy Through Promotion of Prosurvival Signaling

(2011) Rajesh Katare et al.   CIRCULATION RESEARCH

Integrin-Linked Kinase Regulates Vasomotor Function by Preventing Endothelial Nitric Oxide Synthase Uncoupling

(2011) Beatriz Herranz et al.   CIRCULATION RESEARCH

Pin1 Deficiency Causes Endothelial Dysfunction and Hypertension

(2011) Valorie L. Chiasson et al.   HYPERTENSION

Bone Morphogenetic Protein Receptor II Is a Novel Mediator of Endothelial Nitric-oxide Synthase Activation

(2011) Archana Gangopahyay et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A noninhibitory mutant of the caveolin-1 scaffolding domain enhances eNOS-derived NO synthesis and vasodilation in mice

(2011) Pascal Bernatchez et al.   JOURNAL OF CLINICAL INVESTIGATION

Loss of connexin40 is associated with decreased endothelium-dependent relaxations and eNOS levels in the mouse aorta

(2010) Florian Alonso et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Gap Junction Protein Cx37 Interacts With Endothelial Nitric Oxide Synthase in Endothelial Cells

(2010) Anna Pfenniger et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Pin1 Prolyl Isomerase Regulates Endothelial Nitric Oxide Synthase

(2010) Ling Ruan et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Involvement of Phosphoinositide 3-Kinase γ in Angiogenesis and Healing of Experimental Myocardial Infarction in Mice

(2010) Mauro Siragusa et al.   CIRCULATION RESEARCH

S-glutathionylation uncouples eNOS and regulates its cellular and vascular function

(2010) Chun-An Chen et al.   NATURE

Integrins and proximal signaling mechanisms in cardiovascular disease

(2009) Hind Lal   Frontiers in Bioscience-Landmark

Angiotensin II impairs endothelial function via tyrosine phosphorylation of the endothelial nitric oxide synthase

(2009) Annemarieke E. Loot et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Molecular mechanisms underlying the activation of eNOS

(2009) Ingrid Fleming   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Role of integrin-linked kinase for functional capacity of endothelial progenitor cells in patients with stable coronary artery disease

(2008) Christian Werner et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Endothelial Arginase II

(2008) Sungwoo Ryoo et al.   CIRCULATION RESEARCH

Inhibition of Endothelial Nitric Oxide Synthase Activity by Proline-Rich Tyrosine Kinase 2 in Response to Fluid Shear Stress and Insulin

(2008) Beate Fisslthaler et al.   CIRCULATION RESEARCH

Arginase and vascular aging

(2008) Lakshmi Santhanam et al.   JOURNAL OF APPLIED PHYSIOLOGY

The structural basis of integrin-linked kinase-PINCH interactions

(2008) B. P. Chiswell et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Agonist-Stimulated Endothelial Nitric Oxide Synthase Activation and Vascular Relaxation

(2007) David Fulton et al.   CIRCULATION RESEARCH

Diabetes-induced Coronary Vascular Dysfunction Involves Increased Arginase Activity

(2007) Maritza J. Romero et al.   CIRCULATION RESEARCH