Understanding nucleotide excision repair and its roles in cancer and ageing

Mutations in ERCC4, Encoding the DNA-Repair Endonuclease XPF, Cause Fanconi Anemia

(2013) Massimo Bogliolo et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Malfunction of Nuclease ERCC1-XPF Results in Diverse Clinical Manifestations and Causes Cockayne Syndrome, Xeroderma Pigmentosum, and Fanconi Anemia

(2013) Kazuya Kashiyama et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Transcription Recovery after DNA Damage Requires Chromatin Priming by the H3.3 Histone Chaperone HIRA

(2013) Salomé Adam et al.   CELL

DNA Quality Control by a Lesion Sensor Pocket of the Xeroderma Pigmentosum Group D Helicase Subunit of TFIIH

(2013) Nadine Mathieu et al.   CURRENT BIOLOGY

RNF111/Arkadia is a SUMO-targeted ubiquitin ligase that facilitates the DNA damage response

(2013) Sara L. Poulsen et al.   JOURNAL OF CELL BIOLOGY

Cockayne syndrome: The expanding clinical and mutational spectrum

(2013) Vincent Laugel   MECHANISMS OF AGEING AND DEVELOPMENT

Regulation of DNA Damage Responses by Ubiquitin and SUMO

(2013) Stephen P. Jackson et al.   MOLECULAR CELL

Enhanced Chromatin Dynamics by FACT Promotes Transcriptional Restart after UV-Induced DNA Damage

(2013) Christoffel Dinant et al.   MOLECULAR CELL

Mammalian Transcription-Coupled Excision Repair

(2013) W. Vermeulen et al.   Cold Spring Harbor Perspectives in Biology

Nucleotide Excision Repair in Eukaryotes

(2013) O. D. Scharer   Cold Spring Harbor Perspectives in Biology

Disruption of TTDA Results in Complete Nucleotide Excision Repair Deficiency and Embryonic Lethality

(2013) Arjan F. Theil et al.   PLoS Genetics

ATP-Dependent Chromatin Remodeling by Cockayne Syndrome Protein B and NAP1-Like Histone Chaperones Is Required for Efficient Transcription-Coupled DNA Repair

(2013) Iltaeg Cho et al.   PLoS Genetics

Histone Methyltransferase DOT1L Drives Recovery of Gene Expression after a Genotoxic Attack

(2013) Valentyn Oksenych et al.   PLoS Genetics

Ubiquitin-Binding Proteins: Decoders of Ubiquitin-Mediated Cellular Functions

(2012) Koraljka Husnjak et al.   Annual Review of Biochemistry

The Ubiquitin Code

(2012) David Komander et al.   Annual Review of Biochemistry

Ubiquitylation and degradation of elongating RNA polymerase II: The last resort

(2012) Marcus D. Wilson et al.   Biochimica et Biophysica Acta-Gene Regulatory Mechanisms

PARPs and the DNA damage response

(2012) F. G. Sousa et al.   CARCINOGENESIS

RNF168 Ubiquitinates K13-15 on H2A/H2AX to Drive DNA Damage Signaling

(2012) Francesca Mattiroli et al.   CELL

Generation of DNA single-strand displacement by compromised nucleotide excision repair

(2012) Camille Godon et al.   EMBO JOURNAL

KIAA1530 Protein Is Recruited by Cockayne Syndrome Complementation Group Protein A (CSA) to Participate in Transcription-coupled Repair (TCR)

(2012) Jia Fei et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Recognition of DNA damage by XPC coincides with disruption of the XPC–RAD23 complex

(2012) Steven Bergink et al.   JOURNAL OF CELL BIOLOGY

Nucleotide excision repair–initiating proteins bind to oxidative DNA lesions in vivo

(2012) Hervé Menoni et al.   JOURNAL OF CELL BIOLOGY

PARP1 promotes nucleotide excision repair through DDB2 stabilization and recruitment of ALC1

(2012) Alex Pines et al.   JOURNAL OF CELL BIOLOGY

DDB2 promotes chromatin decondensation at UV-induced DNA damage

(2012) Martijn S. Luijsterburg et al.   JOURNAL OF CELL BIOLOGY

Shining a Light on Xeroderma Pigmentosum

(2012) John J. DiGiovanna et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

Prime, Repair, Restore: The Active Role of Chromatin in the DNA Damage Response

(2012) Gaston Soria et al.   MOLECULAR CELL

Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass

(2012) Lou K. Povlsen et al.   NATURE CELL BIOLOGY

Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair

(2012) Yuka Nakazawa et al.   NATURE GENETICS

Mutations in UVSSA cause UV-sensitive syndrome and destabilize ERCC6 in transcription-coupled DNA repair

(2012) Xue Zhang et al.   NATURE GENETICS

UV-sensitive syndrome protein UVSSA recruits USP7 to regulate transcription-coupled repair

(2012) Petra Schwertman et al.   NATURE GENETICS

TFIIH: when transcription met DNA repair

(2012) Emmanuel Compe et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Y-family DNA polymerases and their role in tolerance of cellular DNA damage

(2012) Julian E. Sale et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

ATP-dependent chromatin remodeling in the DNA-damage response

(2012) Hannes Lans et al.   Epigenetics & Chromatin

A Broad Requirement for TLS Polymerases η and κ, and Interacting Sumoylation and Nuclear Pore Proteins, in Lesion Bypass during C. elegans Embryogenesis

(2012) Sophie F. Roerink et al.   PLoS Genetics

ATR signalling: more than meeting at the fork

(2011) Edward A. Nam et al.   BIOCHEMICAL JOURNAL

The chromatin remodeling factor BRG1 stimulates nucleotide excision repair by facilitating recruitment of XPC to sites of DNA damage

(2011) Ling Zhang et al.   CELL CYCLE

The DNA repair endonuclease XPG interacts directly and functionally with the WRN helicase defective in Werner syndrome

(2011) Kelly S. Trego et al.   CELL CYCLE

Uncovering Ubiquitin and Ubiquitin-like Signaling Networks

(2011) Alfred C. O. Vertegaal   CHEMICAL REVIEWS

Regulation of endonuclease activity in human nucleotide excision repair

(2011) Adebanke F. Fagbemi et al.   DNA REPAIR

Physiological consequences of defects in ERCC1–XPF DNA repair endonuclease

(2011) Siobhán Q. Gregg et al.   DNA REPAIR

Dynamics of mammalian NER proteins

(2011) Wim Vermeulen   DNA REPAIR

Regulation of translocation polarity by helicase domain 1 in SF2B helicases

(2011) Robert A Pugh et al.   EMBO JOURNAL

Beyond ATM: The protein kinase landscape of the DNA damage response

(2011) Ariel Bensimon et al.   FEBS LETTERS

Detecting UV-lesions in the genome: The modular CRL4 ubiquitin ligase does it best!

(2011) Andrea Scrima et al.   FEBS LETTERS

Critical Roles of Ring Finger Protein RNF8 in Replication Stress Responses

(2011) Shirley M.-H. Sy et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Replication protein A safeguards genome integrity by controlling NER incision events

(2011) René M. Overmeer et al.   JOURNAL OF CELL BIOLOGY

Xeroderma pigmentosum and other diseases of human premature aging and DNA repair: Molecules to patients

(2011) Laura J. Niedernhofer et al.   MECHANISMS OF AGEING AND DEVELOPMENT

More than just a focus: The chromatin response to DNA damage and its role in genome integrity maintenance

(2011) Jiri Lukas et al.   NATURE CELL BIOLOGY

Human exonuclease 1 connects nucleotide excision repair (NER) processing with checkpoint activation in response to UV irradiation

(2011) S. Sertic et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

How Chromatin Is Remodelled during DNA Repair of UV-Induced DNA Damage in Saccharomyces cerevisiae

(2011) Shirong Yu et al.   PLoS Genetics

Transcription-Dependent Cytosine Deamination Is a Novel Mechanism in Ultraviolet Light-Induced Mutagenesis

(2010) Giel Hendriks et al.   CURRENT BIOLOGY

Stochastic and reversible assembly of a multiprotein DNA repair complex ensures accurate target site recognition and efficient repair

(2010) Martijn S. Luijsterburg et al.   JOURNAL OF CELL BIOLOGY

A Ubiquitin-Binding Domain in Cockayne Syndrome B Required for Transcription-Coupled Nucleotide Excision Repair

(2010) Roy Anindya et al.   MOLECULAR CELL

Evidence that Transcript Cleavage Is Essential for RNA Polymerase II Transcription and Cell Viability

(2010) Stefan Sigurdsson et al.   MOLECULAR CELL

Exo1 Competes with Repair Synthesis, Converts NER Intermediates to Long ssDNA Gaps, and Promotes Checkpoint Activation

(2010) Michele Giannattasio et al.   MOLECULAR CELL

Three DNA Polymerases, Recruited by Different Mechanisms, Carry Out NER Repair Synthesis in Human Cells

(2010) Tomoo Ogi et al.   MOLECULAR CELL

UV-Induced Association of the CSB Remodeling Protein with Chromatin Requires ATP-Dependent Relief of N-Terminal Autorepression

(2010) Robert J. Lake et al.   MOLECULAR CELL

GCN5 and E2F1 stimulate nucleotide excision repair by promoting H3K9 acetylation at sites of damage

(2010) Ruifeng Guo et al.   NUCLEIC ACIDS RESEARCH

INO80 chromatin remodeling complex promotes the removal of UV lesions by the nucleotide excision repair pathway

(2010) Y. Jiang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Endogenous versus Exogenous DNA Adducts: Their Role in Carcinogenesis, Epidemiology, and Risk Assessment

(2010) J. A. Swenberg et al.   TOXICOLOGICAL SCIENCES

Involvement of Global Genome Repair, Transcription Coupled Repair, and Chromatin Remodeling in UV DNA Damage Response Changes during Development

(2010) Hannes Lans et al.   PLoS Genetics

An Overview of Chemical Processes That Damage Cellular DNA: Spontaneous Hydrolysis, Alkylation, and Reactions with Radicals

(2009) Kent S. Gates   CHEMICAL RESEARCH IN TOXICOLOGY

Regulation of DNA damage response pathways by the cullin-RING ubiquitin ligases

(2009) Jeffrey Hannah et al.   DNA REPAIR

Molecular insights into the recruitment of TFIIH to sites of DNA damage

(2009) Valentyn Oksenych et al.   EMBO JOURNAL

Coordination of dual incision and repair synthesis in human nucleotide excision repair

(2009) Lidija Staresincic et al.   EMBO JOURNAL

The XPA-binding domain of ERCC1 Is Required for Nucleotide Excision Repair but Not Other DNA Repair Pathways

(2009) Barbara Orelli et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Modulation of Nucleotide Excision Repair by Mammalian SWI/SNF Chromatin-remodeling Complex

(2009) Qun Zhao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Nucleotide excision repair–induced H2A ubiquitination is dependent on MDC1 and RNF8 and reveals a universal DNA damage response

(2009) Jurgen A. Marteijn et al.   JOURNAL OF CELL BIOLOGY

CUL4A Abrogation Augments DNA Damage Response and Protection against Skin Carcinogenesis

(2009) Liren Liu et al.   MOLECULAR CELL

Two-Step Recognition of DNA Damage for Mammalian Nucleotide Excision Repair: Directional Binding of the XPC Complex and DNA Strand Scanning

(2009) Kaoru Sugasawa et al.   MOLECULAR CELL

The DNA-damage response in human biology and disease

(2009) Stephen P. Jackson et al.   NATURE

Principles of ubiquitin and SUMO modifications in DNA repair

(2009) Steven Bergink et al.   NATURE

DNA Damage, Aging, and Cancer

(2009) Jan H.J. Hoeijmakers   NEW ENGLAND JOURNAL OF MEDICINE

A UV-sensitive syndrome patient with a specific CSA mutation reveals separable roles for CSA in response to UV and oxidative DNA damage

(2009) T. Nardo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Differentiation Driven Changes in the Dynamic Organization of Basal Transcription Initiation

(2009) Giuseppina Giglia-Mari et al.   PLOS BIOLOGY

The Cullin 4B-Based UV-Damaged DNA-Binding Protein Ligase Binds to UV-Damaged Chromatin and Ubiquitinates Histone H2A

(2008) J. Guerrero-Santoro et al.   CANCER RESEARCH

Structure of the DNA Repair Helicase XPD

(2008) Huanting Liu et al.   CELL

XPD Helicase Structures and Activities: Insights into the Cancer and Aging Phenotypes from XPD Mutations

(2008) Li Fan et al.   CELL

Structural Basis of UV DNA-Damage Recognition by the DDB1–DDB2 Complex

(2008) Andrea Scrima et al.   CELL

Cell-type-specific consequences of nucleotide excision repair deficiencies: Embryonic stem cells versus fibroblasts

(2008) H DEWAARD et al.   DNA REPAIR

Nucleotide excision repair deficient mouse models and neurological disease

(2008) Laura J. Niedernhofer   DNA REPAIR

The 8,5′-cyclopurine-2′-deoxynucleosides: Candidate neurodegenerative DNA lesions in xeroderma pigmentosum, and unique probes of transcription and nucleotide excision repair

(2008) P.J. Brooks   DNA REPAIR

Versatile DNA damage detection by the global genome nucleotide excision repair protein XPC

(2008) D. Hoogstraten et al.   JOURNAL OF CELL SCIENCE

The role of Cockayne Syndrome group B (CSB) protein in base excision repair and aging

(2008) Tinna Stevnsner et al.   MECHANISMS OF AGEING AND DEVELOPMENT

An Xpb Mouse Model for Combined Xeroderma Pigmentosum and Cockayne Syndrome Reveals Progeroid Features upon Further Attenuation of DNA Repair

(2008) J.-O. Andressoo et al.   MOLECULAR AND CELLULAR BIOLOGY

Nucleotide Excision Repair Driven by the Dissociation of CAK from TFIIH

(2008) Frédéric Coin et al.   MOLECULAR CELL

DNA damage and ageing: new-age ideas for an age-old problem

(2008) George A. Garinis et al.   NATURE CELL BIOLOGY

Transcription-coupled DNA repair: two decades of progress and surprises

(2008) Philip C. Hanawalt et al.   NATURE REVIEWS MOLECULAR CELL BIOLOGY

Crystal Structure of the FeS Cluster–Containing Nucleotide Excision Repair Helicase XPD

(2008) Stefanie C Wolski et al.   PLOS BIOLOGY

Delayed and Accelerated Aging Share Common Longevity Assurance Mechanisms

(2008) Björn Schumacher et al.   PLoS Genetics