Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions

Sildenafil (Viagra) attenuates ischemic cardiomyopathy and improves left ventricular function in mice

(2017) Fadi N. Salloum et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Tadalafil in the treatment of erectile dysfunction

(2016) Robert Coward et al.   Therapeutics and Clinical Risk Management

Interplay of Palmitoylation and Phosphorylation in the Trafficking and Localization of Phosphodiesterase 10A: Implications for the Treatment of Schizophrenia

(2013) E. I. Charych et al.   JOURNAL OF NEUROSCIENCE

SOD and inhaled nitric oxide normalize phosphodiesterase 5 expression and activity in neonatal lambs with persistent pulmonary hypertension

(2010) Kathryn N. Farrow et al.   AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY

Update on Pulmonary Hypertension 2009

(2010) Mark T. Gladwin et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

A Phosphodiesterase-5 Inhibitor Vardenafil Enhances Angiogenesis Through a Protein Kinase G–Dependent Hypoxia-Inducible Factor-1/Vascular Endothelial Growth Factor Pathway

(2010) Makoto Sahara et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Phosphodiesterase inhibitors in the management of autoimmune disease

(2010) Padmanabha Shenoy et al.   AUTOIMMUNITY REVIEWS

Antidepressant-like properties of phosphodiesterase type 5 inhibitors and cholinergic dependency in a genetic rat model of depression

(2010) Nico Liebenberg et al.   BEHAVIOURAL PHARMACOLOGY

Selective SUMO modification of cAMP-specific phosphodiesterase-4D5 (PDE4D5) regulates the functional consequences of phosphorylation by PKA and ERK

(2010) Xiang Li et al.   BIOCHEMICAL JOURNAL

8-isoprostane F2α up-regulates the expression of type 5 phosphodiesterase in cavernosal vascular smooth muscle cells: inhibition with sildenafil, iloprost, nitric oxide and picotamide

(2010) Matthew Hotston et al.   BJU INTERNATIONAL

Oxidative Stress Regulates Left Ventricular PDE5 Expression in the Failing Heart

(2010) Zhongbing Lu et al.   CIRCULATION

Adding Cilostazol to Dual Antiplatelet Therapy Achieves Greater Platelet Inhibition than High Maintenance Dose Clopidogrel in Patients With Acute Myocardial Infarction

(2010) Young-Hoon Jeong et al.   Circulation-Cardiovascular Interventions

Impact of persistence with antiplatelet therapy on recurrent ischemic stroke and predictors of nonpersistence among ischemic stroke survivors

(2010) James P. Burke et al.   CURRENT MEDICAL RESEARCH AND OPINION

Phosphodiesterase Inhibitors as Potential Cognition Enhancing Agents

(2010) Christopher Schmidt   CURRENT TOPICS IN MEDICINAL CHEMISTRY

Attenuated Proliferation andTrans-Differentiation of Prostatic Stromal Cells Indicate Suitability of Phosphodiesterase Type 5 Inhibitors for Prevention and Treatment of Benign Prostatic Hyperplasia

(2010) Christoph Zenzmaier et al.   ENDOCRINOLOGY

Inhaled phosphodiesterase type 5 inhibitors restore chloride transport in cystic fibrosis mice

(2010) B. Lubamba et al.   EUROPEAN RESPIRATORY JOURNAL

Phosphodiesterase type 5 (PDE5) inhibitors for the treatment of erectile dysfunction

(2010) Philip Dorsey et al.   EXPERT OPINION ON PHARMACOTHERAPY

Conformation Changes, N-terminal Involvement, and cGMP Signal Relay in the Phosphodiesterase-5 GAF Domain

(2010) Huanchen Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of Imidazo[1,5-a]pyrido[3,2-e]pyrazines as a New Class of Phosphodiesterase 10A Inhibitiors

(2010) Norbert Höfgen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Design, Synthesis, and Biological Evaluation of 3-[4-(2-Hydroxyethyl)piperazin-1-yl]-7-(6-methoxypyridin-3-yl)-1-(2-propoxyethyl)pyrido[3,4-b]pyrazin-2(1H)-one, a Potent, Orally Active, Brain Penetrant Inhibitor of Phosphodiesterase 5 (PDE5)

(2010) Robert O. Hughes et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phosphodiesterase 8A (PDE8A) regulates excitation–contraction coupling in ventricular myocytes

(2010) Enrico Patrucco et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Mechanistic Basis for the Failure of Cone Transducin to Translocate: Why Cones Are Never Blinded by Light

(2010) E. S. Lobanova et al.   JOURNAL OF NEUROSCIENCE

Durability of Response Following Cessation of Tadalafil Taken Once Daily as Treatment for Erectile Dysfunction

(2010) Hartmut Porst et al.   Journal of Sexual Medicine

Early treatment with aspirin plus extended-release dipyridamole for transient ischaemic attack or ischaemic stroke within 24 h of symptom onset (EARLY trial): a randomised, open-label, blinded-endpoint trial

(2010) Reinhard Dengler et al.   LANCET NEUROLOGY

Cross Talk between Phosphatidylinositol 3-Kinase and Cyclic AMP (cAMP)-Protein Kinase A Signaling Pathways at the Level of a Protein Kinase B/ -Arrestin/cAMP Phosphodiesterase 4 Complex

(2010) E. Bjorgo et al.   MOLECULAR AND CELLULAR BIOLOGY

The High-Affinity cAMP-Specific Phosphodiesterase 8B Controls Steroidogenesis in the Mouse Adrenal Gland

(2010) L.-C. L. Tsai et al.   MOLECULAR PHARMACOLOGY

Putting the lid on phosphodiesterase 4

(2010) Miles D Houslay et al.   NATURE BIOTECHNOLOGY

Treatment of Peyronie's disease with PDE5 inhibitors: an antifibrotic strategy

(2010) Nestor F. Gonzalez-Cadavid et al.   Nature Reviews Urology

cGMP-Dependent Protein Kinases and cGMP Phosphodiesterases in Nitric Oxide and cGMP Action

(2010) S. H. Francis et al.   PHARMACOLOGICAL REVIEWS

PDE8 Regulates Rapid Teff Cell Adhesion and Proliferation Independent of ICER

(2010) Amanda G. Vang et al.   PLoS One

Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes

(2010) M. P. Kelly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy

(2010) C. M. Adamo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cardiac hypertrophy is not amplified by deletion of cGMP-dependent protein kinase I in cardiomyocytes

(2010) R. Lukowski et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

A phosphodiesterase 4 inhibitor, roflumilast N-oxide, inhibits human lung fibroblast functions in vitro

(2010) F. Sabatini et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

The preclinical pharmacology of roflumilast – A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease

(2010) Armin Hatzelmann et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Haplotype Analysis of the Promoter Region of Phosphodiesterase Type 8B (PDE8B) in Correlation with Inactivating PDE8B Mutation and the Serum Thyroid-Stimulating Hormone Levels

(2010) Anelia Horvath et al.   THYROID

Effect of sildenafil on digital ulcers in systemic sclerosis: analysis from a single centre pilot study

(2009) C. S. Brueckner et al.   ANNALS OF THE RHEUMATIC DISEASES

Differential regulation of adipocyte PDE3B in distinct membrane compartments by insulin and the β3-adrenergic receptor agonist CL316243: effects of caveolin-1 knockdown on formation/maintenance of macromolecular signalling complexes

(2009) Faiyaz Ahmad et al.   BIOCHEMICAL JOURNAL

Inhibition of PDE3, PDE4 and PDE7 potentiates glucocorticoid-induced apoptosis and overcomes glucocorticoid resistance in CEM T leukemic cells

(2009) Hongli Dong et al.   BIOCHEMICAL PHARMACOLOGY

The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents

(2009) Michael P. DeNinno et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of selective PDE4B inhibitors

(2009) Kenji Naganuma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Identification, synthesis and SAR of amino substituted pyrido[3,2b]pyrazinones as potent and selective PDE5 inhibitors

(2009) Dafydd R. Owen et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Quinolines as a novel structural class of potent and selective PDE4 inhibitors. Optimisation for inhaled administration

(2009) Michael D. Woodrow et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Apremilast, a cAMP phosphodiesterase-4 inhibitor, demonstrates anti-inflammatory activity in vitro and in a model of psoriasis

(2009) PH Schafer et al.   BRITISH JOURNAL OF PHARMACOLOGY

cAMP signal transduction in the heart: understanding spatial control for the development of novel therapeutic strategies

(2009) Manuela Zaccolo   BRITISH JOURNAL OF PHARMACOLOGY

cGMP-phosphodiesterase 6, transducin and Wnt5a/Frizzled-2-signaling control cGMP and Ca2+ homeostasis in melanoma cells

(2009) Alexandr V. Bazhin et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Phosphodiesterase 7A inhibitor ASB16165 suppresses proliferation and cytokine production of NKT cells

(2009) Megumi Goto et al.   CELLULAR IMMUNOLOGY

Allosteric-site and catalytic-site ligand effects on PDE5 functions are associated with distinct changes in physical form of the enzyme

(2009) Jackie D. Corbin et al.   CELLULAR SIGNALLING

Synthesis, Structural Analysis, and Biological Evaluation of Thioxoquinazoline Derivatives as Phosphodiesterase 7 Inhibitors

(2009) Tania Castaño et al.   ChemMedChem

Tadalafil Therapy for Pulmonary Arterial Hypertension

(2009) Nazzareno Galiè et al.   CIRCULATION

Phosphodiesterase-5 Inhibitor, Tadalafil, Protects Against Myocardial Ischemia/Reperfusion Through Protein-Kinase G-Dependent Generation of Hydrogen Sulfide

(2009) F. N. Salloum et al.   CIRCULATION

Role of Ca 2+ /Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterase 1 in Mediating Cardiomyocyte Hypertrophy

(2009) Clint L. Miller et al.   CIRCULATION RESEARCH

Decreased Expression and Activity of cAMP Phosphodiesterases in Cardiac Hypertrophy and Its Impact on β-Adrenergic cAMP Signals

(2009) Aniella Abi-Gerges et al.   CIRCULATION RESEARCH

Multidrug resistance protein 4 mediates cAMP efflux from rat preglomerular vascular smooth muscle cells

(2009) Dongmei Cheng et al.   CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY

Phosphodiesterase-5 inhibitors and benign prostatic hyperplasia

(2009) Chunyu Wang   CURRENT OPINION IN UROLOGY

Cyclic GMP from the surrounding somatic cells regulates cyclic AMP and meiosis in the mouse oocyte

(2009) R. P. Norris et al.   DEVELOPMENT

Compartmentalized signalling: spatial regulation of cAMP by the action of compartmentalized phosphodiesterases

(2009) George S. Baillie   FEBS Journal

A scanning peptide array approach uncovers association sites within the JNK/βarrestin signalling complex

(2009) Xiang Li et al.   FEBS LETTERS

ASB16165, a novel inhibitor for phosphodiesterase 7A (PDE7A), suppresses IL-12-induced IFN-γ production by mouse activated T lymphocytes

(2009) Kumiko Kadoshima-Yamaoka et al.   IMMUNOLOGY LETTERS

Characterization of Human Cone Phosphodiesterase-6 Ectopically Expressed inXenopus laevisRods

(2009) Hakim Muradov et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Probing the Catalytic Sites and Activation Mechanism of Photoreceptor Phosphodiesterase Using Radiolabeled Phosphodiesterase Inhibitors

(2009) Yu-Ting Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Identification of a Brain Penetrant PDE9A Inhibitor Utilizing Prospective Design and Chemical Enablement as a Rapid Lead Optimization Strategy

(2009) Patrick R. Verhoest et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia†† Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1).

(2009) Patrick R. Verhoest et al.   JOURNAL OF MEDICINAL CHEMISTRY

Intravenous Sildenafil in the Treatment of Neonates with Persistent Pulmonary Hypertension

(2009) Robin H. Steinhorn et al.   JOURNAL OF PEDIATRICS

Phosphodiesterase 5A Inhibitors Improve Functional Recovery after Stroke in Rats: Optimized Dosing Regimen with Implications for Mechanism

(2009) F. S. Menniti et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Interactions between Cyclic Nucleotide Phosphodiesterase 11 Catalytic Site and Substrates or Tadalafil and Role of a Critical Gln-869 Hydrogen Bond

(2009) J. L. Weeks et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

cGMP-Hydrolytic Activity and Its Inhibition by Sildenafil in Normal and Failing Human and Mouse Myocardium

(2009) F. Vandeput et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Phosphodiesterase 10A Inhibitor Activity in Preclinical Models of the Positive, Cognitive, and Negative Symptoms of Schizophrenia

(2009) S. M. Grauer et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Anxiolytic Effects of Phosphodiesterase-2 Inhibitors Associated with Increased cGMP Signaling

(2009) A. Masood et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

ORIGINAL RESEARCH–COUPLES' SEXUAL DYSFUNCTIONS: Impact on Erectile Function and Sexual Quality of Life of Couples: A Double-Blind, Randomized, Placebo-Controlled Trial of Tadalafil Taken Once Daily

(2009) Eusebio Rubio-Aurioles et al.   Journal of Sexual Medicine

Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G

(2009) H. N. Tinsley et al.   MOLECULAR CANCER THERAPEUTICS

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

(2009) Alex B Burgin et al.   NATURE BIOTECHNOLOGY

Phosphodiesterase 1C is dispensable for rapid response termination of olfactory sensory neurons

(2009) Katherine D Cygnar et al.   NATURE NEUROSCIENCE

Phosphodiesterase 10 inhibition reduces striatal excitotoxicity in the quinolinic acid model of Huntington's disease

(2009) Carmela Giampà et al.   NEUROBIOLOGY OF DISEASE

Phosphodiesterase Inhibitors Enhance Object Memory Independent of Cerebral Blood Flow and Glucose Utilization in Rats

(2009) Kris Rutten et al.   NEUROPSYCHOPHARMACOLOGY

Sildenafil for the Treatment of Pulmonary Hypertension in Pediatric Patients

(2009) Alice J. Huddleston et al.   PEDIATRIC CARDIOLOGY

Regulation of Phosphodiesterase 3 in the Pulmonary Arteries During the Perinatal Period in Sheep

(2009) Bernadette Chen et al.   PEDIATRIC RESEARCH

Cyclic GMP signaling in cardiovascular pathophysiology and therapeutics

(2009) Emily J. Tsai et al.   PHARMACOLOGY & THERAPEUTICS

Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity

(2009) E. Puxeddu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct

(2009) J. Pandit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic Nucleotide Binding GAF Domains from Phosphodiesterases: Structural and Mechanistic Insights

(2009) Clemens C. Heikaus et al.   STRUCTURE

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

(2009) Miles D. Houslay   TRENDS IN BIOCHEMICAL SCIENCES

Distinct phosphodiesterase-4D variants integrate into protein kinase A-based signaling complexes in cardiac and vascular myocytes

(2008) Daniel R. Raymond et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Phosphodiesterase 5 Inhibitors and Cystic Fibrosis

(2008) Lane L. Clarke   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Homocysteine and copper interact to promote type 5 phosphodiesterase expression in rabbit cavernosal smooth muscle cells

(2008) Matthew Hotston et al.   ASIAN JOURNAL OF ANDROLOGY

An insight into the pharmacophores of phosphodiesterase-5 inhibitors from synthetic and crystal structural studies

(2008) Gong Chen et al.   BIOCHEMICAL PHARMACOLOGY

Kinetic and Structural Studies of Phosphodiesterase-8A and Implication on the Inhibitor Selectivity†‡

(2008) Huanchen Wang et al.   BIOCHEMISTRY

Superoxide from NADPH oxidase upregulates type 5 phosphodiesterase in human vascular smooth muscle cells: inhibition with iloprost and NONOate

(2008) S Muzaffar et al.   BRITISH JOURNAL OF PHARMACOLOGY

In cardiac myocytes, cAMP elevation triggers the down-regulation of transcripts and promoter activity for cyclic AMP phosphodiesterase-4A10 (PDE4A10)

(2008) Angela McCahill et al.   CELLULAR SIGNALLING

Ndel1 alters its conformation by sequestering cAMP-specific phosphodiesterase-4D3 (PDE4D3) in a manner that is dynamically regulated through Protein Kinase A (PKA)

(2008) Daniel M. Collins et al.   CELLULAR SIGNALLING

Spatiotemporal Dynamics of β-Adrenergic cAMP Signals and L-Type Ca 2+ Channel Regulation in Adult Rat Ventricular Myocytes

(2008) Jérôme Leroy et al.   CIRCULATION RESEARCH

The Role of Phosphodiesterases in Schizophrenia

(2008) Judith A Siuciak   CNS DRUGS

Signaling from β1- and β2-adrenergic receptors is defined by differential interactions with PDE4

(2008) Wito Richter et al.   EMBO JOURNAL

Increased phosphodiesterase 3A/4B expression after angioplasty and the effect on VASP phosphorylation

(2008) Hong Zhao et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Phosphodiesterase 2 and 5 inhibition attenuates the object memory deficit induced by acute tryptophan depletion

(2008) Eva L. van Donkelaar et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Inhibition of phosphodiesterase 4 enhances lung alveolarisation in neonatal mice exposed to hyperoxia

(2008) K. Woyda et al.   EUROPEAN RESPIRATORY JOURNAL

A Randomised, Placebo-Controlled Study to Assess the Efficacy of Twice-Daily Vardenafil in the Treatment of Lower Urinary Tract Symptoms Secondary to Benign Prostatic Hyperplasia

(2008) Christian G. Stief et al.   EUROPEAN UROLOGY

Phosphodiesterase-5 inhibitors for the treatment of Raynaud's: a novel indication

(2008) Alfonso J De LaVega et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Phosphodiesterase inhibition in heart failure

(2008) Matthew Movsesian et al.   HEART FAILURE REVIEWS

Molecular mechanisms that could contribute to prolonged effectiveness of PDE5 inhibitors to improve erectile function

(2008) S H Francis et al.   INTERNATIONAL JOURNAL OF IMPOTENCE RESEARCH

Solution Structure of the cGMP Binding GAF Domain from Phosphodiesterase 5

(2008) Clemens C. Heikaus et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Structure of the GAF A Domain from Phosphodiesterase 6C Reveals Determinants of cGMP Binding, a Conserved Binding Surface, and a Large cGMP-dependent Conformational Change

(2008) Sergio E. Martinez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Crystal Structure of the GAF-B Domain from Human Phosphodiesterase 10A Complexed with Its Ligand, cAMP

(2008) Noriko Handa et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Critical Role of PDE4D in β2-Adrenoceptor-dependent cAMP Signaling in Mouse Embryonic Fibroblasts

(2008) Matthew D. Bruss et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Combined Use of PDE5 Inhibitors and Nitrates in the Treatment of Pulmonary Arterial Hypertension in Patients With Heart Failure

(2008) Josef Stehlik et al.   JOURNAL OF CARDIAC FAILURE

Increased social interaction in mice deficient of the striatal medium spiny neuron-specific phosphodiesterase 10A2

(2008) Hiromi Sano et al.   JOURNAL OF NEUROCHEMISTRY

Effects of Long-Term Sildenafil Treatment for Pulmonary Hypertension in Infants with Chronic Lung Disease

(2008) Peter M. Mourani et al.   JOURNAL OF PEDIATRICS

Inhibition of Phosphodiesterase 10A Increases the Responsiveness of Striatal Projection Neurons to Cortical Stimulation

(2008) S. Threlfell et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Phosphorylation Increases Affinity of the Phosphodiesterase-5 Catalytic Site for Tadalafil

(2008) E. P. Bessay et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Preclinical Characterization of Selective Phosphodiesterase 10A Inhibitors: A New Therapeutic Approach to the Treatment of Schizophrenia

(2008) C. J. Schmidt et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Drug-Eluting Stenting Followed by Cilostazol Treatment Reduces Late Restenosis in Patients With Diabetes Mellitus

(2008) Seung-Whan Lee et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Constitutive activation of the G-protein subunit G s within forebrain neurons causes PKA-dependent alterations in fear conditioning and cortical Arc mRNA expression

(2008) M. P. Kelly et al.   LEARNING & MEMORY

Sarcolemma-localized nNOS is required to maintain activity after mild exercise

(2008) Yvonne M. Kobayashi et al.   NATURE

Expression, Activity, and Function of Phosphodiesterases in the Mature and Immature Ductus Arteriosus

(2008) Hanguan Liu et al.   PEDIATRIC RESEARCH

Compartmentation and compartment-specific regulation of PDE5 by protein kinase G allows selective cGMP-mediated regulation of platelet functions

(2008) L. S. Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Structural basis for the catalytic mechanism of human phosphodiesterase 9

(2008) S. Liu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia

(2008) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Use of Sildenafil to Facilitate Weaning From Inhaled Nitric Oxide in Children With Pulmonary Hypertension Following Surgery for Congenital Heart Disease

(2008) Jaclyn E. Lee et al.   JOURNAL OF INTENSIVE CARE MEDICINE

Preclinical Evidence that Sildenafil and Vardenafil Activate Chloride Transport in Cystic Fibrosis

(2007) Bob Lubamba et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Hyperoxia Increases Phosphodiesterase 5 Expression and Activity in Ovine Fetal Pulmonary Artery Smooth Muscle Cells

(2007) Kathryn N. Farrow et al.   CIRCULATION RESEARCH

Diminished Phosphodiesterase-8B Potentiates Biphasic Insulin Response to Glucose

(2007) Avital Dov et al.   ENDOCRINOLOGY