Phosphodiesterase 10A: a novel target for selective inhibition of colon tumor cell growth and β-catenin-dependent TCF transcriptional activity

Sulindac Selectively Inhibits Colon Tumor Cell Growth by Activating the cGMP/PKG Pathway to Suppress Wnt/ -Catenin Signaling

(2013) N. Li et al.   MOLECULAR CANCER THERAPEUTICS

A Novel Sulindac Derivative that Potently Suppresses Colon Tumor Cell Growth by Inhibiting cGMP Phosphodiesterase and  -Catenin Transcriptional Activity

(2012) J. D. Whitt et al.   Cancer Prevention Research

Inhibition of phosphodiestrase 9 induces cGMP accumulation and apoptosis in human breast cancer cell lines, MCF-7 and MDA-MB-468

(2012) R. Saravani et al.   CELL PROLIFERATION

Sulindac inhibits tumor cell invasion by suppressing NF-κB-mediated transcription of microRNAs

(2012) X Li et al.   ONCOGENE

Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions

(2011) Sharron H. Francis et al.   PHYSIOLOGICAL REVIEWS

Phosphodiesterase 10A Upregulation Contributes to Pulmonary Vascular Remodeling

(2011) Xia Tian et al.   PLoS One

Colon Tumor Cell Growth-Inhibitory Activity of Sulindac Sulfide and Other Nonsteroidal Anti-Inflammatory Drugs Is Associated with Phosphodiesterase 5 Inhibition

(2010) H. N. Tinsley et al.   Cancer Prevention Research

PKG inhibits TCF signaling in colon cancer cells by blocking β-catenin expression and activating FOXO4

(2010) I-K Kwon et al.   ONCOGENE

Targeting cancer with phosphodiesterase inhibitors

(2009) Rajkumar Savai et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

Sulindac sulfide selectively inhibits growth and induces apoptosis of human breast tumor cells by phosphodiesterase 5 inhibition, elevation of cyclic GMP, and activation of protein kinase G

(2009) H. N. Tinsley et al.   MOLECULAR CANCER THERAPEUTICS

Expression of cyclic guanosine monophosphate-dependent protein kinase in metastatic colon carcinoma cells blocks tumor angiogenesis

(2008) In-Kiu Kwon et al.   CANCER

Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia

(2008) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA