Hydroxyurea and a cGMP-amplifying agent have immediate benefits on acute vaso-occlusive events in sickle cell disease mice

Inhibition of acetylcholinesterase and phosphodiesterase-9A has differential effects on hippocampal early and late LTP

(2012) Katja S. Kroker et al.   NEUROPHARMACOLOGY

Hydroxyurea therapy of a murine model of sickle cell anemia inhibits the progression of pneumococcal disease by down-modulating E-selectin

(2011) J. D. Lebensburger et al.   BLOOD

Hospitalization for pain in patients with sickle cell disease treated with sildenafil for elevated TRV and low exercise capacity

(2011) R. F. Machado et al.   BLOOD

Hydroxyurea for sickle cell anemia: what have we learned and what questions still remain?

(2011) Patrick T McGann et al.   CURRENT OPINION IN HEMATOLOGY

Inhibition of phosphodiesterase 9A reduces cytokine-stimulated in vitro adhesion of neutrophils from sickle cell anemia individuals

(2011) Lediana Iagalo Miguel et al.   INFLAMMATION RESEARCH

CXCL1 and its receptor, CXCR2, mediate murine sickle cell vaso-occlusion during hemolytic transfusion reactions

(2011) Jung-Eun Jang et al.   JOURNAL OF CLINICAL INVESTIGATION

The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents

(2011) P.H. Hutson et al.   NEUROPHARMACOLOGY

Beneficial effects of nitric oxide breathing in adult patients with sickle cell crisis

(2010) C. Alvin Head et al.   AMERICAN JOURNAL OF HEMATOLOGY

GMI-1070, a novel pan-selectin antagonist, reverses acute vascular occlusions in sickle cell mice

(2010) J. Chang et al.   BLOOD

Aggregation of mononuclear and red blood cells through an  4 1-Lu/basal cell adhesion molecule interaction in sickle cell disease

(2010) V. Chaar et al.   HAEMATOLOGICA

Hydroxyurea therapy requires HbF induction for clinical benefit in a sickle cell mouse model

(2010) J. D. Lebensburger et al.   HAEMATOLOGICA

Hydroxyurea enhances SMN2 gene expression through nitric oxide release

(2010) Cheng Xu et al.   NEUROGENETICS

Vasculopathy in sickle cell disease: Biology, pathophysiology, genetics, translational medicine, and new research directions

(2009) Gregory J. Kato et al.   AMERICAN JOURNAL OF HEMATOLOGY

Heterotypic interactions enabled by polarized neutrophil microdomains mediate thromboinflammatory injury

(2009) Andrés Hidalgo et al.   NATURE MEDICINE

Arginine therapy of transgenic-knockout sickle mice improves microvascular function by reducing non-nitric oxide vasodilators, hemolysis, and oxidative stress

(2008) Dhananjay K. Kaul et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

High expression of the cGMP-specific phosphodiesterase, PDE9A, in sickle cell disease (SCD) and the effects of its inhibition in erythroid cells and SCD neutrophils

(2008) Camila Bononi Almeida et al.   BRITISH JOURNAL OF HAEMATOLOGY

Sodium nitrite promotes regional blood flow in patients with sickle cell disease: a phase I/II study

(2008) A. Kyle Mack et al.   BRITISH JOURNAL OF HAEMATOLOGY

Increased adhesive properties of neutrophils in sickle cell disease may be reversed by pharmacological nitric oxide donation

(2008) A. A. Canalli et al.   HAEMATOLOGICA

PSGL-1 engagement by E-selectin signals through Src kinase Fgr and ITAM adapters DAP12 and FcRγ to induce slow leukocyte rolling

(2008) Alexander Zarbock et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Altered levels of cytokines and inflammatory mediators in plasma and leukocytes of sickle cell anemia patients and effects of hydroxyurea therapy

(2008) C. Lanaro et al.   JOURNAL OF LEUKOCYTE BIOLOGY