Human phosphodiesterase 4D7 (PDE4D7) expression is increased in TMPRSS2-ERG-positive primary prostate cancer and independently adds to a reduced risk of post-surgical disease progression

The activity of cAMP-phosphodiesterase 4D7 (PDE4D7) is regulated by protein kinase A-dependent phosphorylation within its unique N-terminus

(2015) Ashleigh M. Byrne et al.   FEBS LETTERS

Novel long non-coding RNAs are specific diagnostic and prognostic markers for prostate cancer

(2015) René Böttcher et al.   Oncotarget

The cAMP phosphodiesterase-4D7 (PDE4D7) is downregulated in androgen-independent prostate cancer cells and mediates proliferation by compartmentalising cAMP at the plasma membrane of VCaP prostate cancer cells

(2014) D J P Henderson et al.   BRITISH JOURNAL OF CANCER

Heterozygous mutations in cyclic AMP phosphodiesterase-4D (PDE4D) and protein kinase A (PKA) provide new insights into the molecular pathology of acrodysostosis

(2014) Tadashi Kaname et al.   CELLULAR SIGNALLING

Mitotic activation of the DISC1-inducible cyclic AMP phosphodiesterase-4D9 (PDE4D9), through multi-site phosphorylation, influences cell cycle progression

(2014) Catherine L. Sheppard et al.   CELLULAR SIGNALLING

Polymorphisms inPDE4Dare Associated with a Risk of COPD in Non-Emphysematous Koreans

(2014) Hyoung-Kyu Yoon et al.   COPD-Journal of Chronic Obstructive Pulmonary Disease

Cancer incidence and mortality worldwide: Sources, methods and major patterns in GLOBOCAN 2012

(2014) Jacques Ferlay et al.   INTERNATIONAL JOURNAL OF CANCER

Advances in targeting cyclic nucleotide phosphodiesterases

(2014) Donald H. Maurice et al.   NATURE REVIEWS DRUG DISCOVERY

Punctuated Evolution of Prostate Cancer Genomes

(2013) Sylvan C. Baca et al.   CELL

Identification ofTDRD1as a direct target gene ofERGin primary prostate cancer

(2013) Joost L. Boormans et al.   INTERNATIONAL JOURNAL OF CANCER

Pan-cancer patterns of somatic copy number alteration

(2013) Travis I Zack et al.   NATURE GENETICS

Discovery and Validation of a Prostate Cancer Genomic Classifier that Predicts Early Metastasis Following Radical Prostatectomy

(2013) Nicholas Erho et al.   PLoS One

Exome Sequencing Identifies PDE4D Mutations in Acrodysostosis

(2012) Hane Lee et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Exome Sequencing Identifies PDE4D Mutations as Another Cause of Acrodysostosis

(2012) Caroline Michot et al.   AMERICAN JOURNAL OF HUMAN GENETICS

Clonal Progression of Prostate Cancers from Gleason Grade 3 to Grade 4

(2012) A. G. Sowalsky et al.   CANCER RESEARCH

Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation

(2011) Kirsty F. MacKenzie et al.   BIOCHEMICAL JOURNAL

TMPRSS2-ERG -specific transcriptional modulation is associated with prostate cancer biomarkers and TGF-β signaling

(2011) Jan C Brase et al.   BMC CANCER

Defining and predicting indolent and low risk prostate cancer

(2011) Chris H. Bangma et al.   CRITICAL REVIEWS IN ONCOLOGY HEMATOLOGY

Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions

(2011) Sharron H. Francis et al.   PHYSIOLOGICAL REVIEWS

Integrative Genomic Profiling of Human Prostate Cancer

(2010) Barry S. Taylor et al.   CANCER CELL

Roles of cAMP and cAMP-dependent protein kinase in the progression of prostate cancer: Cross-talk with the androgen receptor

(2010) Dennis Merkle et al.   CELLULAR SIGNALLING

RNA-Seq gene expression estimation with read mapping uncertainty

(2009) Bo Li et al.   BIOINFORMATICS

Identification of PDE4D as a Proliferation Promoting Factor in Prostate Cancer Using a Sleeping Beauty Transposon-Based Somatic Mutagenesis Screen

(2009) E. P. Rahrmann et al.   CANCER RESEARCH

Overexpression of Prostate-Specific TMPRSS2(exon 0)-ERG Fusion Transcripts Corresponds with Favorable Prognosis of Prostate Cancer

(2009) K. G. Hermans et al.   CLINICAL CANCER RESEARCH

Mortality Results from a Randomized Prostate-Cancer Screening Trial

(2009) Gerald L. Andriole et al.   NEW ENGLAND JOURNAL OF MEDICINE

Screening and Prostate-Cancer Mortality in a Randomized European Study

(2009) Fritz H. Schröder et al.   NEW ENGLAND JOURNAL OF MEDICINE

Underpinning compartmentalised cAMP signalling through targeted cAMP breakdown

(2009) Miles D. Houslay   TRENDS IN BIOCHEMICAL SCIENCES

FIRMA: a method for detection of alternative splicing from exon array data

(2008) E. Purdom et al.   BIOINFORMATICS

TMPRSS2:ERG Fusion Identifies a Subgroup of Prostate Cancers with a Favorable Prognosis

(2008) O. R. Saramaki et al.   CLINICAL CANCER RESEARCH