Advances in targeting cyclic nucleotide phosphodiesterases

PDE3, but not PDE4, reduces β1- and β2-adrenoceptor-mediated inotropic and lusitropic effects in failing ventricle from metoprolol-treated patients

(2013) Peter Molenaar et al.   BRITISH JOURNAL OF PHARMACOLOGY

NCS 613 exhibits anti-inflammatory effects on PBMCs from lupus patients by inhibiting p38 MAPK and NF-κB signalling pathways while reducing proinflammatory cytokine production

(2013) Issaka Yougbaré et al.   CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY

Novel Anti-Inflammatory Agents in COPD: Targeting Lung and Systemic Inflammation

(2013) Stelios Loukides et al.   CURRENT DRUG TARGETS

A Role for Phosphodiesterase 3B in Acquisition of Brown Fat Characteristics by White Adipose Tissue in Male Mice

(2013) Emilia Guirguis et al.   ENDOCRINOLOGY

Targeting protein–protein interactions within the cyclic AMP signaling system as a therapeutic strategy for cardiovascular disease

(2013) Louisa CY Lee et al.   Future Medicinal Chemistry

Corticosteroid resistance in patients with asthma and chronic obstructive pulmonary disease

(2013) Peter J. Barnes   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Cyclic nucleotide phosphodiesterase 3A1 protects the heart against ischemia-reperfusion injury

(2013) Masayoshi Oikawa et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Genomic and functional characterizations of phosphodiesterase subtype 4D in human cancers

(2013) D.-C. Lin et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Phosphodiesterase-8A binds to and regulates Raf-1 kinase

(2013) K. M. Brown et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Protein Kinase G Iα Inhibits Pressure Overload–Induced Cardiac Remodeling and Is Required for the Cardioprotective Effect of Sildenafil In Vivo

(2013) Robert M. Blanton et al.   Journal of the American Heart Association

Roflumilast: A Novel Treatment for Chronic Obstructive Pulmonary Disease

(2012) Debra J Reid et al.   ANNALS OF PHARMACOTHERAPY

Structure and Regulation of Soluble Guanylate Cyclase

(2012) Emily R. Derbyshire et al.   Annual Review of Biochemistry

Prolyl hydroxylase domain protein 2 regulates the intracellular cyclic AMP level in cardiomyocytes through its interaction with phosphodiesterase 4D

(2012) Zhaoxia Huo et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

cGMP–cAMP interplay in cardiac myocytes: a local affair with far-reaching consequences for heart function

(2012) Alessandra Stangherlin et al.   BIOCHEMICAL SOCIETY TRANSACTIONS

Novel 2-methoxyacylhydrazones as potent, selective PDE10A inhibitors with activity in animal models of schizophrenia

(2012) Neil S. Cutshall et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of oxazole-based PDE4 inhibitors with picomolar potency

(2012) Rongze Kuang et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of 4-hydroxy-1,6-naphthyridine-3-carbonitrile derivatives as novel PDE10A inhibitors

(2012) Udo Bauer et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery of selective biaryl ethers as PDE10A inhibitors: Improvement in potency and mitigation of Pgp-mediated efflux

(2012) Robert M. Rzasa et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

The SAR development of dihydroimidazoisoquinoline derivatives as phosphodiesterase 10A inhibitors for the treatment of schizophrenia

(2012) Ginny D. Ho et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Imidazopyridazinones as novel PDE7 inhibitors: SAR and in vivo studies in Parkinson’s disease model

(2012) Abhisek Banerjee et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Cilostazol-Based Triple Antiplatelet Therapy Compared to Dual Antiplatelet Therapy in Patients with Coronary Stent Implantation: A Meta-Analysis of 5,821 Patients

(2012) Deng-feng Geng et al.   CARDIOLOGY

Resveratrol Ameliorates Aging-Related Metabolic Phenotypes by Inhibiting cAMP Phosphodiesterases

(2012) Sung-Jun Park et al.   CELL

Inhibition of phosphodiestrase 9 induces cGMP accumulation and apoptosis in human breast cancer cell lines, MCF-7 and MDA-MB-468

(2012) R. Saravani et al.   CELL PROLIFERATION

The Future of Peptide-based Drugs

(2012) David J. Craik et al.   Chemical Biology & Drug Design

Pathological Cardiac Hypertrophy Alters Intracellular Targeting of Phosphodiesterase Type 5 From Nitric Oxide Synthase-3 to Natriuretic Peptide Signaling

(2012) Manling Zhang et al.   CIRCULATION

Phosphoinositide 3-Kinase γ Protects Against Catecholamine-Induced Ventricular Arrhythmia Through Protein Kinase A–Mediated Regulation of Distinct Phosphodiesterases

(2012) Alessandra Ghigo et al.   CIRCULATION

Phosphodiesterase Type 3A Regulates Basal Myocardial Contractility Through Interacting With Sarcoplasmic Reticulum Calcium ATPase Type 2a Signaling Complexes in Mouse Heart

(2012) Sanja Beca et al.   CIRCULATION RESEARCH

Nitrates as an Integral Part of Optimal Medical Therapy and Cardiac Rehabilitation for Stable Angina: Review of Current Concepts and Therapeutics

(2012) William E. Boden et al.   CLINICAL CARDIOLOGY

Identification of novel genetic variants in phosphodiesterase 8B (PDE8B), a cAMP-specific phosphodiesterase highly expressed in the adrenal cortex, in a cohort of patients with adrenal tumours

(2012) Anya Rothenbuhler et al.   CLINICAL ENDOCRINOLOGY

New bronchodilators

(2012) Garbo Mak et al.   CURRENT OPINION IN PHARMACOLOGY

Selective PDE inhibitors as novel treatments for respiratory diseases

(2012) Clive P Page et al.   CURRENT OPINION IN PHARMACOLOGY

Discovery and development of exenatide: the first antidiabetic agent to leverage the multiple benefits of the incretin hormone, GLP-1

(2012) David G Parkes et al.   Expert Opinion on Drug Discovery

Tetomilast: new promise for phosphodiesterase-4 inhibitors?

(2012) Stephen J Bickston et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

PDE Inhibition and cognition enhancement

(2012) Arjan Blokland et al.   EXPERT OPINION ON THERAPEUTIC PATENTS

Inactivation of Pde8b enhances memory, motor performance, and protects against age-induced motor coordination decay

(2012) L.-C. L. Tsai et al.   GENES BRAIN AND BEHAVIOR

PKA and PDE4D3 anchoring to AKAP9 provides distinct regulation of cAMP signals at the centrosome

(2012) Anna Terrin et al.   JOURNAL OF CELL BIOLOGY

Effect of the Phosphodiesterase 4 Inhibitor Roflumilast on Glucose Metabolism in Patients with Treatment-Naive, Newly Diagnosed Type 2 Diabetes Mellitus

(2012) E. F. M. Wouters et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Rapid Identification of a Novel Small Molecule Phosphodiesterase 10A (PDE10A) Tracer

(2012) Essa Hu et al.   JOURNAL OF MEDICINAL CHEMISTRY

Application of Structure-Based Drug Design and Parallel Chemistry to Identify Selective, Brain Penetrant, In Vivo Active Phosphodiesterase 9A Inhibitors

(2012) Michelle M. Claffey et al.   JOURNAL OF MEDICINAL CHEMISTRY

Structure-Based Discovery of Highly Selective Phosphodiesterase-9A Inhibitors and Implications for Inhibitor Design

(2012) Fei Meng et al.   JOURNAL OF MEDICINAL CHEMISTRY

The effect of phosphodiesterase inhibitors on the extinction of cocaine-induced conditioned place preference in mice

(2012) Shervin Liddie et al.   JOURNAL OF PSYCHOPHARMACOLOGY

The Usefulness of Brain Natriuretic Peptide in Complex Congenital Heart Disease

(2012) Jannet A. Eindhoven et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Cyclic Adenosine Monophosphate Phosphodiesterase Type 4 Protects Against Atrial Arrhythmias

(2012) Cristina E. Molina et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Avanafil, a Potent and Highly Selective Phosphodiesterase-5 Inhibitor for Erectile Dysfunction

(2012) Jun Kotera et al.   JOURNAL OF UROLOGY

Profiling of cAMP and cGMP phosphodiesterases in isolated ventricular cardiomyocytes from human hearts: Comparison with rat and guinea pig

(2012) W.B. Johnson et al.   LIFE SCIENCES

Phosphatidylinositol 3-Kinase-Binding Protein, PI3KAP/XB130, Is Required for cAMP-induced Amplification of IGF Mitogenic Activity in FRTL-5 Thyroid Cells

(2012) Daisuke Yamanaka et al.   MOLECULAR ENDOCRINOLOGY

Phosphodiesterase-4 promotes proliferation and angiogenesis of lung cancer by crosstalk with HIF

(2012) S S Pullamsetti et al.   ONCOGENE

Disease Progression in MRL/lpr Lupus-Prone Mice Is Reduced by NCS 613, a Specific Cyclic Nucleotide Phosphodiesterase Type 4 (PDE4) Inhibitor

(2012) Thérèse Keravis et al.   PLoS One

Inhaled corticosteroid and long-acting β2-agonist pharmacological profiles: effective asthma therapy in practice

(2012) Michael Tamm et al.   RESPIRATORY MEDICINE

Phosphodiesterase Inhibitors SuppressLactobacillus caseiCell-Wall-Induced NF-κB and MAPK Activations and Cell Proliferation through Protein Kinase A—or Exchange Protein Activated by cAMP-Dependent Signal Pathway

(2012) Takekatsu Saito et al.   TheScientificWorldJOURNAL

Resveratrol as a calorie restriction mimetic: therapeutic implications

(2012) Jay H. Chung et al.   TRENDS IN CELL BIOLOGY

Cilostazol Suppresses Angiotensin II–Induced Vasoconstriction via Protein Kinase A–Mediated Phosphorylation of the Transient Receptor Potential Canonical 6 Channel

(2011) Kinue Nishioka et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Effect of cilostazol on the progression of carotid intima-media thickness: A meta-analysis of randomized controlled trials

(2011) Deng-feng Geng et al.   ATHEROSCLEROSIS

Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart

(2011) Clint L. Miller et al.   BASIC RESEARCH IN CARDIOLOGY

Update on roflumilast, a phosphodiesterase 4 inhibitor for the treatment of chronic obstructive pulmonary disease

(2011) Klaus F. Rabe   BRITISH JOURNAL OF PHARMACOLOGY

Cyclic nucleotide phosphodiesterase (PDE) isozymes as targets of the intracellular signalling network: benefits of PDE inhibitors in various diseases and perspectives for future therapeutic developments

(2011) Thérèse Keravis et al.   BRITISH JOURNAL OF PHARMACOLOGY

Sildenafil Reverses ABCB1- and ABCG2-Mediated Chemotherapeutic Drug Resistance

(2011) Z. Shi et al.   CANCER RESEARCH

Roles of Sildenafil in Enhancing Drug Sensitivity in Cancer

(2011) Z. Shi et al.   CANCER RESEARCH

cGMP Signals Modulate cAMP Levels in a Compartment-Specific Manner to Regulate Catecholamine-Dependent Signaling in Cardiac Myocytes

(2011) Alessandra Stangherlin et al.   CIRCULATION RESEARCH

Phosphodiesterase 4D Regulates Baseline Sarcoplasmic Reticulum Ca 2+ Release and Cardiac Contractility, Independently of L-Type Ca 2+ Current

(2011) Sanja Beca et al.   CIRCULATION RESEARCH

PDE inhibitors: a new approach to treat metabolic syndrome?

(2011) Claire Lugnier   CURRENT OPINION IN PHARMACOLOGY

Subcellular signaling in the endothelium: cyclic nucleotides take their place

(2011) Donald H Maurice   CURRENT OPINION IN PHARMACOLOGY

The roles of cyclic nucleotide phosphodiesterases (PDEs) in steroidogenesis

(2011) Li-Chun Lisa Tsai et al.   CURRENT OPINION IN PHARMACOLOGY

PDE1 isozymes, key regulators of pathological vascular remodeling

(2011) Stefan Chan et al.   CURRENT OPINION IN PHARMACOLOGY

PDE5 inhibitors: targeting erectile dysfunction in diabetics

(2011) Sharron H Francis et al.   CURRENT OPINION IN PHARMACOLOGY

PDE3 inhibition in dilated cardiomyopathy

(2011) Matthew Movsesian et al.   CURRENT OPINION IN PHARMACOLOGY

Phosphodiesterases and regulation of female reproductive function

(2011) Marco Conti   CURRENT OPINION IN PHARMACOLOGY

Phosphodiesterase function and endocrine cells: links to human disease and roles in tumor development and treatment

(2011) Isaac Levy et al.   CURRENT OPINION IN PHARMACOLOGY

PDE10A Inhibitors: Novel Therapeutic Drugs for Schizophrenia

(2011) Jan Kehler et al.   CURRENT PHARMACEUTICAL DESIGN

Biochemical Basis of Asthma Therapy

(2011) Peter J. Barnes   JOURNAL OF BIOLOGICAL CHEMISTRY

Plasma Membrane Calcium Pump (PMCA4)-Neuronal Nitric-oxide Synthase Complex Regulates Cardiac Contractility through Modulation of a Compartmentalized Cyclic Nucleotide Microdomain

(2011) Tamer M. A. Mohamed et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Phosphodiesterase 2A Isoform Localized to Mitochondria Regulates Respiration

(2011) Rebeca Acin-Perez et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

A Phosphodiesterase 3B-based Signaling Complex Integrates Exchange Protein Activated by cAMP 1 and Phosphatidylinositol 3-Kinase Signals in Human Arterial Endothelial Cells

(2011) Lindsay S. Wilson et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Phosphodiesterase 3A (PDE3A) Deletion Suppresses Proliferation of Cultured Murine Vascular Smooth Muscle Cells (VSMCs) via Inhibition of Mitogen-activated Protein Kinase (MAPK) Signaling and Alterations in Critical Cell Cycle Regulatory Proteins

(2011) Najma Begum et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Effects of cilostazol in the heart

(2011) Natnicha Kanlop et al.   Journal of Cardiovascular Medicine

Phosphodiesterase 4B in the cardiac L-type Ca2+ channel complex regulates Ca2+ current and protects against ventricular arrhythmias in mice

(2011) Jérôme Leroy et al.   JOURNAL OF CLINICAL INVESTIGATION

Use of Structure-Based Design to Discover a Potent, Selective, In Vivo Active Phosphodiesterase 10A Inhibitor Lead Series for the Treatment of Schizophrenia

(2011) Christopher J. Helal et al.   JOURNAL OF MEDICINAL CHEMISTRY

Highly Potent, Selective, and Orally Active Phosphodiesterase 10A Inhibitors

(2011) Michael S. Malamas et al.   JOURNAL OF MEDICINAL CHEMISTRY

Disruption of the cyclic AMP phosphodiesterase-4 (PDE4)–HSP20 complex attenuates the β-agonist induced hypertrophic response in cardiac myocytes

(2011) Y.Y. Sin et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

AKAPs: The architectural underpinnings of local cAMP signaling

(2011) Michael D. Kritzer et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

GSK256066, an Exceptionally High-Affinity and Selective Inhibitor of Phosphodiesterase 4 Suitable for Administration by Inhalation: In Vitro, Kinetic, and In Vivo Characterization

(2011) C. J. Tralau-Stewart et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Are Phosphodiesterase Type 5 Inhibitors Associated with Vision‐Threatening Adverse Events? A Critical Analysis and Review of the Literature

(2011) Faris Azzouni et al.   Journal of Sexual Medicine

Phosphodiesterase Type 4D Gene Polymorphism: Association with the Response to Short-Acting Bronchodilators in Paediatric Asthma Patients

(2011) Malgorzata Labuda et al.   MEDIATORS OF INFLAMMATION

Integrating Cardiac PIP3 and cAMP Signaling through a PKA Anchoring Function of p110γ

(2011) Alessia Perino et al.   MOLECULAR CELL

Intra-Cellular Therapies and Takeda to develop PDE1 inhibitors for schizophrenia

(2011)   NATURE REVIEWS DRUG DISCOVERY

The selective phosphodiesterase 9 (PDE9) inhibitor PF-04447943 (6-[(3S,4S)-4-methyl-1-(pyrimidin-2-ylmethyl)pyrrolidin-3-yl]-1-(tetrahydro-2H-pyran-4-yl)-1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one) enhances synaptic plasticity and cognitive function in rodents

(2011) P.H. Hutson et al.   NEUROPHARMACOLOGY

Tadalafil for the treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia: Pathophysiology and mechanism(s) of action

(2011) Karl-Erik Andersson et al.   NEUROUROLOGY AND URODYNAMICS

Mammalian Cyclic Nucleotide Phosphodiesterases: Molecular Mechanisms and Physiological Functions

(2011) Sharron H. Francis et al.   PHYSIOLOGICAL REVIEWS

Phosphodiesterase 10A Upregulation Contributes to Pulmonary Vascular Remodeling

(2011) Xia Tian et al.   PLoS One

Polycystin-2 and phosphodiesterase 4C are components of a ciliary A-kinase anchoring protein complex that is disrupted in cystic kidney diseases

(2011) Y.-H. Choi et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Efficacy of Cilostazol in reducing restenosis in patients undergoing contemporary stent based PCI: a meta-analysis of randomised controlled trials

(2011) Umesh Tamhane et al.   EuroIntervention

Targeting Phosphoinositide-3-Kinase-δ with Theophylline Reverses Corticosteroid Insensitivity in Chronic Obstructive Pulmonary Disease

(2010) Yasuo To et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Cyclic Nucleotide Phosphodiesterase 1 Regulates Lysosome-Dependent Type I Collagen Protein Degradation in Vascular Smooth Muscle Cells

(2010) Yujun Cai et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

p62 (SQSTM1) and cyclic AMP phosphodiesterase-4A4 (PDE4A4) locate to a novel, reversible protein aggregate with links to autophagy and proteasome degradation pathways

(2010) Frank Christian et al.   CELLULAR SIGNALLING

The Phosphodiesterase Inhibitor Cilostazol Induces Regression of Carotid Atherosclerosis in Subjects With Type 2 Diabetes Mellitus

(2010) Naoto Katakami et al.   CIRCULATION

Feedback Control Through cGMP-Dependent Protein Kinase Contributes to Differential Regulation and Compartmentation of cGMP in Rat Cardiac Myocytes

(2010) Liliana R.V. Castro et al.   CIRCULATION RESEARCH

A Complex between FAK, RACK1, and PDE4D5 Controls Spreading Initiation and Cancer Cell Polarity

(2010) Bryan Serrels et al.   CURRENT BIOLOGY

Cyclic Nucleotide Phosphodiesterases (PDE) and Peptide Motifs

(2010) Therese Keravis et al.   CURRENT PHARMACEUTICAL DESIGN

Sub-picomolar relaxin signalling by a pre-assembled RXFP1, AKAP79, AC2, β-arrestin 2, PDE4D3 complex

(2010) Michelle L Halls et al.   EMBO JOURNAL

Cyclic nucleotide phosphodiesterase 7B mRNA: An unfavorable characteristic in chronic lymphocytic leukemia

(2010) Lingzhi Zhang et al.   INTERNATIONAL JOURNAL OF CANCER

Phosphodiesterase 4B is essential for TH2-cell function and development of airway hyperresponsiveness in allergic asthma

(2010) S.-L. Catherine Jin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Conformation Changes, N-terminal Involvement, and cGMP Signal Relay in the Phosphodiesterase-5 GAF Domain

(2010) Huanchen Wang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Small Molecule AKAP-Protein Kinase A (PKA) Interaction Disruptors That Activate PKA Interfere with Compartmentalized cAMP Signaling in Cardiac Myocytes

(2010) Frank Christian et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cyclic AMP Phosphodiesterase 4D (PDE4D) Tethers EPAC1 in a Vascular Endothelial Cadherin (VE-Cad)-based Signaling Complex and Controls cAMP-mediated Vascular Permeability

(2010) Sarah N. Rampersad et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

cAMP-stimulated Protein Phosphatase 2A Activity Associated with Muscle A Kinase-anchoring Protein (mAKAP) Signaling Complexes Inhibits the Phosphorylation and Activity of the cAMP-specific Phosphodiesterase PDE4D3

(2010) Kimberly L. Dodge-Kafka et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Frequent Phosphodiesterase 11A Gene (PDE11A) Defects in Patients with Carney Complex (CNC) Caused byPRKAR1AMutations:PDE11AMay Contribute to Adrenal and Testicular Tumors in CNC as a Modifier of the Phenotype

(2010) Rossella Libé et al.   JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM

Discovery of Imidazo[1,5-a]pyrido[3,2-e]pyrazines as a New Class of Phosphodiesterase 10A Inhibitiors

(2010) Norbert Höfgen et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phosphodiesterase 8A (PDE8A) regulates excitation–contraction coupling in ventricular myocytes

(2010) Enrico Patrucco et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Chronic Suppression of Phosphodiesterase 10A Alters Striatal Expression of Genes Responsible for Neurotransmitter Synthesis, Neurotransmission, and Signaling Pathways Implicated in Huntington's Disease

(2010) R. J. Kleiman et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Cyclic AMP Controls mTOR through Regulation of the Dynamic Interaction between Rheb and Phosphodiesterase 4D

(2010) H. W. Kim et al.   MOLECULAR AND CELLULAR BIOLOGY

How does cAMP/protein kinase A signaling lead to tumors in the adrenal cortex and other tissues?

(2010) Madson Q. Almeida et al.   MOLECULAR AND CELLULAR ENDOCRINOLOGY

Compartmentalized Cyclic Adenosine 3′,5′-Monophosphate at the Plasma Membrane Clusters PDE3A and Cystic Fibrosis Transmembrane Conductance Regulator into Microdomains

(2010) Himabindu Penmatsa et al.   MOLECULAR BIOLOGY OF THE CELL

Putting the lid on phosphodiesterase 4

(2010) Miles D Houslay et al.   NATURE BIOTECHNOLOGY

Signal integration through blending, bolstering and bifurcating of intracellular information

(2010) Catherine T Pawson et al.   NATURE STRUCTURAL & MOLECULAR BIOLOGY

Impaired appetitively as well as aversively motivated behaviors and learning in PDE10A-deficient mice suggest a role for striatal signaling in evaluative salience attribution

(2010) Elisabeth Piccart et al.   NEUROBIOLOGY OF LEARNING AND MEMORY

Regulation and therapeutic targeting of peptide-activated receptor guanylyl cyclases

(2010) Lincoln R. Potter   PHARMACOLOGY & THERAPEUTICS

Inhibition of the Striatal Specific Phosphodiesterase PDE10A Ameliorates Striatal and Cortical Pathology in R6/2 Mouse Model of Huntington's Disease

(2010) Carmela Giampà et al.   PLoS One

Phosphodiesterase 11A in brain is enriched in ventral hippocampus and deletion causes psychiatric disease-related phenotypes

(2010) M. P. Kelly et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Sildenafil reverses cardiac dysfunction in the mdx mouse model of Duchenne muscular dystrophy

(2010) C. M. Adamo et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Inhibition of phosphodiesterase-4 reverses memory deficits produced by Aβ25–35 or Aβ1–40 peptide in rats

(2010) Yu-Fang Cheng et al.   PSYCHOPHARMACOLOGY

Identification of PDE4B Over 4D subtype-selective inhibitors revealing an unprecedented binding mode

(2009) Michael Kranz et al.   BIOORGANIC & MEDICINAL CHEMISTRY

A new therapeutic approach in Parkinson’s disease: Some novel quinazoline derivatives as dual selective phosphodiesterase 1 inhibitors and anti-inflammatory agents

(2009) Sachin S. Laddha et al.   BIOORGANIC & MEDICINAL CHEMISTRY

The discovery of potent, selective, and orally bioavailable PDE9 inhibitors as potential hypoglycemic agents

(2009) Michael P. DeNinno et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Dual PDE3/4 inhibitors as therapeutic agents for chronic obstructive pulmonary disease

(2009) Katharine H Banner et al.   BRITISH JOURNAL OF PHARMACOLOGY

Role of Ca 2+ /Calmodulin-Stimulated Cyclic Nucleotide Phosphodiesterase 1 in Mediating Cardiomyocyte Hypertrophy

(2009) Clint L. Miller et al.   CIRCULATION RESEARCH

Reduced Adiposity and High-Fat Diet-Induced Adipose Inflammation in Mice Deficient for Phosphodiesterase 4B

(2009) Ren Zhang et al.   ENDOCRINOLOGY

Targeting cancer with phosphodiesterase inhibitors

(2009) Rajkumar Savai et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

ASB16165, a novel inhibitor for phosphodiesterase 7A (PDE7A), suppresses IL-12-induced IFN-γ production by mouse activated T lymphocytes

(2009) Kumiko Kadoshima-Yamaoka et al.   IMMUNOLOGY LETTERS

Dual Acylation of PDE2A Splice Variant 3

(2009) Corina Russwurm et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Differential Association of Phosphodiesterase 4D Isoforms with β2-Adrenoceptor in Cardiac Myocytes

(2009) Vania De Arcangelis et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

The Cardiac IKsPotassium Channel Macromolecular Complex Includes the Phosphodiesterase PDE4D3

(2009) Cecile Terrenoire et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Discovery of a Novel Class of Phosphodiesterase 10A Inhibitors and Identification of Clinical Candidate 2-[4-(1-Methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the Treatment of Schizophrenia†† Coordinates of the PDE10A crystal structures have been deposited in the Protein Data Bank for compound 1 (3HQW), 2 (3HQY), 3 (3HQW) and 9 (3HR1).

(2009) Patrick R. Verhoest et al.   JOURNAL OF MEDICINAL CHEMISTRY

Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor

(2009) Hon-Wah Man et al.   JOURNAL OF MEDICINAL CHEMISTRY

Phosphodiesterase 10A Inhibitor Activity in Preclinical Models of the Positive, Cognitive, and Negative Symptoms of Schizophrenia

(2009) S. M. Grauer et al.   JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS

Roflumilast in moderate-to-severe chronic obstructive pulmonary disease treated with longacting bronchodilators: two randomised clinical trials

(2009) Leonardo M Fabbri et al.   LANCET

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

(2009) Alex B Burgin et al.   NATURE BIOTECHNOLOGY

Phosphodiesterase 1C is dispensable for rapid response termination of olfactory sensory neurons

(2009) Katherine D Cygnar et al.   NATURE NEUROSCIENCE

Capturing adenylyl cyclases as potential drug targets

(2009) Sandra Pierre et al.   NATURE REVIEWS DRUG DISCOVERY

Phosphodiesterase Type 5 Inhibitors for Pulmonary Arterial Hypertension

(2009) Stephen L. Archer et al.   NEW ENGLAND JOURNAL OF MEDICINE

Interaction of phosphodiesterase 3A with brefeldin A-inhibited guanine nucleotide-exchange proteins BIG1 and BIG2 and effect on ARF1 activity

(2009) E. Puxeddu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Mechanism for the allosteric regulation of phosphodiesterase 2A deduced from the X-ray structure of a near full-length construct

(2009) J. Pandit et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Distinct phosphodiesterase-4D variants integrate into protein kinase A-based signaling complexes in cardiac and vascular myocytes

(2008) Daniel R. Raymond et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

DISC1, PDE4B, and NDE1 at the centrosome and synapse

(2008) Nicholas J. Bradshaw et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PDE5 inhibitors enhance tumor permeability and efficacy of chemotherapy in a rat brain tumor model

(2008) Keith L. Black et al.   BRAIN RESEARCH

Vardenafil, but not sildenafil or tadalafil, has calcium-channel blocking activity in rabbit isolated pulmonary artery and human washed platelets

(2008) H A Toque et al.   BRITISH JOURNAL OF PHARMACOLOGY

Signaling from β1- and β2-adrenergic receptors is defined by differential interactions with PDE4

(2008) Wito Richter et al.   EMBO JOURNAL

The Penile Erection Efficacy of a New Phosphodiesterase Type 5 Inhibitor, Mirodenafil (SK3530), in Rabbits with Acute Spinal Cord Injury

(2008) Ji-Youn JUNG et al.   JOURNAL OF VETERINARY MEDICAL SCIENCE

Beneficial effects of rolipram in the R6/2 mouse model of Huntington's disease

(2008) Zena DeMarch et al.   NEUROBIOLOGY OF DISEASE

Mutation inPDE8B,a Cyclic AMP–Specific Phosphodiesterase in Adrenal Hyperplasia

(2008) Anelia Horvath et al.   NEW ENGLAND JOURNAL OF MEDICINE

Compartmentation and compartment-specific regulation of PDE5 by protein kinase G allows selective cGMP-mediated regulation of platelet functions

(2008) L. S. Wilson et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Cyclic nucleotide phosphodiesterase profiling reveals increased expression of phosphodiesterase 7B in chronic lymphocytic leukemia

(2008) L. Zhang et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Selective phosphodiesterase inhibitors: a promising target for cognition enhancement

(2008) Olga A. H. Reneerkens et al.   PSYCHOPHARMACOLOGY

PDE9A-MEDIATED REGULATION OF CGMP: IMPACT ON SYNAPTIC PLASTICITY

(2008) Frank Menniti et al.   SCHIZOPHRENIA RESEARCH

PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia

(2008) S. Hossein Fatemi et al.   SCHIZOPHRENIA RESEARCH

Spectrin-anchored phosphodiesterase 4D4 restricts cAMP from disrupting microtubules and inducing endothelial cell gap formation

(2007) J. Creighton et al.   JOURNAL OF CELL SCIENCE