The cAMP Pathway as Therapeutic Target in Autoimmune and Inflammatory Diseases

A new therapeutic for the treatment of moderate-to-severe plaque psoriasis: apremilast

(2016) Andrea Chiricozzi et al.   Expert Review of Clinical Immunology

Generation and functions of second messengers microdomains

(2015) Riccardo Filadi et al.   CELL CALCIUM

Phosphodiesterase 4 inhibitors for the treatment of chronic obstructive pulmonary disease: a review of current and developing drugs

(2015) Aaron M Mulhall et al.   EXPERT OPINION ON INVESTIGATIONAL DRUGS

MicroRNA-9 Regulates the Differentiation and Function of Myeloid-Derived Suppressor Cells via Targeting Runx1

(2015) Jie Tian et al.   JOURNAL OF IMMUNOLOGY

Longterm (52-week) Results of a Phase III Randomized, Controlled Trial of Apremilast in Patients with Psoriatic Arthritis

(2015) A. Kavanaugh et al.   JOURNAL OF RHEUMATOLOGY

Apremilast, an oral phosphodiesterase 4 (PDE4) inhibitor, in patients with moderate to severe plaque psoriasis: Results of a phase III, randomized, controlled trial (Efficacy and Safety Trial Evaluating the Effects of Apremilast in Psoriasis [ESTEEM] 1)

(2015) Kim Papp et al.   JOURNAL OF THE AMERICAN ACADEMY OF DERMATOLOGY

Cyclic AMP concentrations in dendritic cells induce and regulate Th2 immunity and allergic asthma

(2015) Jihyung Lee et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Treatment of psoriatic arthritis in a phase 3 randomised, placebo-controlled trial with apremilast, an oral phosphodiesterase 4 inhibitor

(2014) Arthur Kavanaugh et al.   ANNALS OF THE RHEUMATIC DISEASES

Phosphodiesterase: An Interface Connecting Cognitive Deficits to Neuropsychiatric and Neurodegenerative Diseases

(2014) Zhen-Zhen Wang et al.   CURRENT PHARMACEUTICAL DESIGN

Continuous T Cell Receptor Signals Maintain a Functional Regulatory T Cell Pool

(2014) J. Christoph Vahl et al.   IMMUNITY

Cyclic AMP-Mediated Suppression of Neutrophil Extracellular Trap Formation and Apoptosis by the Bordetella pertussis Adenylate Cyclase Toxin

(2014) Joshua C. Eby et al.   INFECTION AND IMMUNITY

Prostaglandin E2 Suppresses Lipopolysaccharide-Stimulated IFN-  Production

(2014) X. J. Xu et al.   JOURNAL OF IMMUNOLOGY

Human monocytes respond to extracellular cAMP through A2A and A2B adenosine receptors

(2014) Ester Sciaraffia et al.   JOURNAL OF LEUKOCYTE BIOLOGY

SAR156497, an Exquisitely Selective Inhibitor of Aurora Kinases

(2014) Jean-Christophe Carry et al.   JOURNAL OF MEDICINAL CHEMISTRY

Advances in targeting cyclic nucleotide phosphodiesterases

(2014) Donald H. Maurice et al.   NATURE REVIEWS DRUG DISCOVERY

Interferon α interferes with immunological tolerance

(2014) Christian Becker et al.   OncoImmunology

Phosphodiesterase-4 Inhibitor Therapy for Lung Diseases

(2013) Bianca Beghè et al.   AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE

Interferon-  Suppresses cAMP to Disarm Human Regulatory T Cells

(2013) N. Bacher et al.   CANCER RESEARCH

A Special Population of Regulatory T Cells Potentiates Muscle Repair

(2013) Dalia Burzyn et al.   CELL

Extracellular adenosine regulates naive T cell development and peripheral maintenance

(2013) Caglar Cekic et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Dopamine Receptors Modulate Cytotoxicity of Natural Killer Cells via cAMP-PKA-CREB Signaling Pathway

(2013) Wei Zhao et al.   PLoS One

The connection of β-catenin and phenobarbital in murine hepatocarcinogenesis: a critical discussion of Awuah et al., PLoS ONE 7(6):e39771, 2012

(2012) Albert Braeuning   ARCHIVES OF TOXICOLOGY

The Interferon Stimulated Gene 12 Inactivates Vasculoprotective Functions of NR4A Nuclear Receptors

(2012) Nikolina Papac-Milicevic et al.   CIRCULATION RESEARCH

Selective PDE inhibitors as novel treatments for respiratory diseases

(2012) Clive P Page et al.   CURRENT OPINION IN PHARMACOLOGY

cAMP response element modulator   controls IL2 and IL17A expression during CD4 lineage commitment and subset distribution in lupus

(2012) C. M. Hedrich et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Regulatory T cells control HIV replication in activated T cells through a cAMP-dependent mechanism

(2011) M. E. Moreno-Fernandez et al.   BLOOD

Role of PDE3A in regulation of cell cycle progression in mouse vascular smooth muscle cells and oocytes: implications in cardiovascular diseases and infertility

(2011) Najma Begum et al.   CURRENT OPINION IN PHARMACOLOGY

CD4-mediated regulatory T-cell activation inhibits the development of disease in a humanized mouse model of allergic airway disease

(2011) Helen Martin et al.   JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY

Repression of Cyclic Adenosine Monophosphate Upregulation Disarms and Expands Human Regulatory T Cells

(2011) M. Klein et al.   JOURNAL OF IMMUNOLOGY

Connexin 43 Signaling Enhances the Generation of Foxp3+ Regulatory T Cells

(2011) M. Kuczma et al.   JOURNAL OF IMMUNOLOGY

AKAPs: The architectural underpinnings of local cAMP signaling

(2011) Michael D. Kritzer et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

The transcription factor NR4A1 (Nur77) controls bone marrow differentiation and the survival of Ly6C− monocytes

(2011) Richard N Hanna et al.   NATURE IMMUNOLOGY

Regulatory T cells facilitate the nuclear accumulation of inducible cAMP early repressor (ICER) and suppress nuclear factor of activated T cell c1 (NFATc1)

(2011) M. Vaeth et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

PDE4-inhibitors: A novel, targeted therapy for obstructive airways disease

(2011) Zuzana Diamant et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Cyclic adenosine monophosphate and IL-10 coordinately contribute to nTreg cell-mediated suppression of dendritic cell activation

(2010) Melanie Fassbender et al.   CELLULAR IMMUNOLOGY

Cutting Edge: Mechanisms of IL-2-Dependent Maintenance of Functional Regulatory T Cells

(2010) L. Barron et al.   JOURNAL OF IMMUNOLOGY

Plectranthus barbatus: A Review of Phytochemistry, Ethnobotanical Uses and Pharmacology – Part 2

(2010) Rawiya Alasbahi et al.   PLANTA MEDICA

Mucosal adjuvant activity of cholera toxin requires Th17 cells and protects against inhalation anthrax

(2010) S. K. Datta et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

The preclinical pharmacology of roflumilast – A selective, oral phosphodiesterase 4 inhibitor in development for chronic obstructive pulmonary disease

(2010) Armin Hatzelmann et al.   PULMONARY PHARMACOLOGY & THERAPEUTICS

Apremilast: a novel PDE4 inhibitor in the treatment of autoimmune and inflammatory diseases

(2010) Georg Schett et al.   Therapeutic Advances in Musculoskeletal Disease

Synthesis and biological evaluation of novel phthalazinone derivatives as topically active phosphodiesterase 4 inhibitors

(2009) Kohei Kagayama et al.   BIOORGANIC & MEDICINAL CHEMISTRY

Discovery of selective PDE4B inhibitors

(2009) Kenji Naganuma et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Discovery and structure–activity study of a novel benzoxaborole anti-inflammatory agent (AN2728) for the potential topical treatment of psoriasis and atopic dermatitis

(2009) Tsutomu Akama et al.   BIOORGANIC & MEDICINAL CHEMISTRY LETTERS

Protection from graft-versus-host disease by HIV-1 envelope protein gp120-mediated activation of human CD4+CD25+ regulatory T cells

(2009) C. Becker et al.   BLOOD

Phosphodiesterase 7A inhibitor ASB16165 suppresses proliferation and cytokine production of NKT cells

(2009) Megumi Goto et al.   CELLULAR IMMUNOLOGY

Cyclic AMP-Specific Phosphodiesterase-4 as a Target for the Development of Antidepressant Drugs

(2009) Han-Ting Zhang   CURRENT PHARMACEUTICAL DESIGN

Adenylyl cyclases as innovative therapeutic goals

(2009) Barbara Pavan et al.   DRUG DISCOVERY TODAY

In vivo expansion of T reg cells with IL-2–mAb complexes: induction of resistance to EAE and long-term acceptance of islet allografts without immunosuppression

(2009) Kylie E. Webster et al.   JOURNAL OF EXPERIMENTAL MEDICINE

Inhibition of cAMP Degradation Improves Regulatory T Cell-Mediated Suppression

(2009) T. Bopp et al.   JOURNAL OF IMMUNOLOGY

Nonfunctional Regulatory T Cells and Defective Control of Th2 Cytokine Production in Natural Scurfy Mutant Mice

(2009) K. Lahl et al.   JOURNAL OF IMMUNOLOGY

Discovery of (S)-N-{2-[1-(3-Ethoxy-4-methoxyphenyl)-2-methanesulfonylethyl]-1,3-dioxo-2,3-dihydro-1H-isoindol-4-yl}acetamide (Apremilast), a Potent and Orally Active Phosphodiesterase 4 and Tumor Necrosis Factor-α Inhibitor

(2009) Hon-Wah Man et al.   JOURNAL OF MEDICINAL CHEMISTRY

Roflumilast in symptomatic chronic obstructive pulmonary disease: two randomised clinical trials

(2009) Peter MA Calverley et al.   LANCET

Distinct metabolism of cyclic adenosine monophosphate in regulatory and helper CD4+ T cells

(2009) Alexandr V. Bazhin et al.   MOLECULAR IMMUNOLOGY

Adenylyl Cyclase-A-kinase Anchoring Protein Complexes: The Next Dimension in cAMP Signaling

(2009) C. W. Dessauer   MOLECULAR PHARMACOLOGY

Cyclic AMP intoxication of macrophages by a Mycobacterium tuberculosis adenylate cyclase

(2009) Nisheeth Agarwal et al.   NATURE

Design of phosphodiesterase 4D (PDE4D) allosteric modulators for enhancing cognition with improved safety

(2009) Alex B Burgin et al.   NATURE BIOTECHNOLOGY

Capturing adenylyl cyclases as potential drug targets

(2009) Sandra Pierre et al.   NATURE REVIEWS DRUG DISCOVERY

Suppression of LPS-Induced TNF-  Production in Macrophages by cAMP Is Mediated by PKA-AKAP95-p105

(2009) E. A. Wall et al.   Science Signaling

Cyclic AMP

(2008) Carlos H. Serezani et al.   AMERICAN JOURNAL OF RESPIRATORY CELL AND MOLECULAR BIOLOGY

Resolution-phase macrophages possess a unique inflammatory phenotype that is controlled by cAMP

(2008) J. Bystrom et al.   BLOOD

cAMP: fuel for extracellular adenosine formation?

(2008) A Gödecke   BRITISH JOURNAL OF PHARMACOLOGY

The Role of Phosphodiesterases in Schizophrenia

(2008) Judith A Siuciak   CNS DRUGS

miR-142-3p restricts cAMP production in CD4+CD25− T cells and CD4+CD25+ TREG cells by targeting AC9 mRNA

(2008) Bo Huang et al.   EMBO REPORTS

Effect of phosphodiesterase 7 inhibitor ASB16165 on development and function of cytotoxic T lymphocyte

(2008) Kumiko Kadoshima-Yamaoka et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

cAMP regulates IL-10 production by normal human T lymphocytes at multiple levels: A potential role for MEF2

(2008) Kassiani Liopeta et al.   MOLECULAR IMMUNOLOGY