Regulatory Effects and Interactions of the Wnt and OPG-RANKL-RANK Signaling at the Bone-Cartilage Interface in Osteoarthritis

Clinical implications of macrophage dysfunction in the development of osteoarthritis of the knee

(2019) Jinwei Xie et al.   CYTOKINE & GROWTH FACTOR REVIEWS

microRNA‐138 Induces Cell Survival and Reduces WNT/β‐Catenin Signaling of Osteoarthritis Chondrocytes Through NEK2

(2019) Weiling Xu et al.   IUBMB LIFE

Osteoarthritis

(2019) David J Hunter et al.   LANCET

NF-B Signaling Pathways in Osteoarthritic Cartilage Destruction

(2019) Choi et al.   Cells

Cartilage regeneration and ageing: Targeting cellular plasticity in osteoarthritis

(2018) Marta Varela-Eirin et al.   AGEING RESEARCH REVIEWS

Synovial macrophage M1 polarisation exacerbates experimental osteoarthritis partially through R-spondin-2

(2018) Haiyan Zhang et al.   ANNALS OF THE RHEUMATIC DISEASES

Extracellular matrix content and WNT/β-catenin levels of cartilage determine the chondrocyte response to compressive load

(2018) Heiko Praxenthaler et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

Non-canonical Wnt induces chondrocyte de-differentiation through Frizzled 6 and DVL-2/B-raf/CaMKIIα/syndecan 4 axis

(2018) Zhe Xie et al.   CELL DEATH AND DIFFERENTIATION

Vital Roles of β-catenin in Trans-differentiation of Chondrocytes to Bone Cells

(2018) Yan Jing et al.   International Journal of Biological Sciences

PPARβ/δ: Linking Metabolism to Regeneration

(2018) Ajit Magadum et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Results from a 52-week randomized, double-blind, placebo-controlled, phase 2 study of a novel, intra-articular wnt pathway inhibitor (SM04690) for the treatment of knee osteoarthritis

(2018) Y. Yazici et al.   OSTEOARTHRITIS AND CARTILAGE

A small-molecule inhibitor of the Wnt pathway (SM04690) as a potential disease modifying agent for the treatment of osteoarthritis of the knee

(2018) V. Deshmukh et al.   OSTEOARTHRITIS AND CARTILAGE

PKR activation causes inflammation and MMP-13 secretion in human degenerated articular chondrocytes

(2018) Ching-Hou Ma et al.   Redox Biology

Protective effects of dioscin against cartilage destruction in a monosodium iodoacetate (MIA)-indcued osteoarthritis rat model

(2018) Jiawei Lu et al.   BIOMEDICINE & PHARMACOTHERAPY

Carbon monoxide ameliorates Staphylococcus aureus-elicited COX-2/IL-6/MMP-9-dependent human aortic endothelial cell migration and inflammatory responses

(2018) Ming-Horng Tsai et al.   IMMUNOLOGY LETTERS

Polygalacic acid inhibits MMPs expression and osteoarthritis via Wnt/β-catenin and MAPK signal pathways suppression

(2018) Kai Xu et al.   INTERNATIONAL IMMUNOPHARMACOLOGY

Regulatory role of IKKɑ in myocardial ischemia/reperfusion injury by the determination of M1 versus M2 polarization of macrophages

(2018) Yide Cao et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Ischemic damage and early inflammatory infiltration are different in the core and penumbra lesions of rat brain after transient focal cerebral ischemia

(2018) Emőke Horváth et al.   JOURNAL OF NEUROIMMUNOLOGY

Roles of Mitogen-Activated Protein Kinases in Osteoclast Biology

(2018) Kyunghee Lee et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The signaling protein Wnt5a promotes TGFβ1-mediated macrophage polarization and kidney fibrosis by inducing the transcriptional regulators Yap/Taz

(2018) Ye Feng et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

mTORC1 signaling suppresses Wnt/β-catenin signaling through DVL-dependent regulation of Wnt receptor FZD level

(2018) Hao Zeng et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Imbalance of M1/M2 macrophages is linked to severity level of knee osteoarthritis

(2018) Baolong Liu et al.   Experimental and Therapeutic Medicine

Energy Metabolism of the Osteoblast: Implications for Osteoporosis

(2017) Wen-Chih Lee et al.   ENDOCRINE REVIEWS

Osteoblast role in osteoarthritis pathogenesis

(2017) Nicola Maruotti et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Osteocyte-specific WNT1 regulates osteoblast function during bone homeostasis

(2017) Kyu Sang Joeng et al.   JOURNAL OF CLINICAL INVESTIGATION

Wnt-β-catenin signaling pathway inhibition by sclerostin may protect against degradation in healthy but not osteoarthritic cartilage

(2017) Jiang Wu et al.   Molecular Medicine Reports

Wnt5a induces catabolic signaling and matrix metalloproteinase production in human articular chondrocytes

(2017) G. Huang et al.   OSTEOARTHRITIS AND CARTILAGE

A novel Wnt pathway inhibitor, SM04690, for the treatment of moderate to severe osteoarthritis of the knee: results of a 24-week, randomized, controlled, phase 1 study

(2017) Y. Yazici et al.   OSTEOARTHRITIS AND CARTILAGE

Meloxicam ameliorates the cartilage and subchondral bone deterioration in monoiodoacetate-induced rat osteoarthritis

(2017) Előd Nagy et al.   PeerJ

Sclerostin antibodies in osteoporosis: latest evidence and therapeutic potential

(2017) Michael R. McClung   Therapeutic Advances in Musculoskeletal Disease

Alteration of Wnt5a expression and of the non-canonical Wnt/PCP and Wnt/PKC-Ca2+ pathways in human osteoarthritis osteoblasts

(2017) Xavier Martineau et al.   PLoS One

Obesity-associated metabolic syndrome spontaneously induces infiltration of pro-inflammatory macrophage in synovium and promotes osteoarthritis

(2017) Antonia RuJia Sun et al.   PLoS One

Wnt7a Inhibits IL-1β Induced Catabolic Gene Expression and Prevents Articular Cartilage Damage in Experimental Osteoarthritis

(2017) Averi L. Gibson et al.   Scientific Reports

Runx2 Controls Bone Resorption through the Down-Regulation of the Wnt Pathway in Osteoblasts

(2016) Coline Haxaire et al.   AMERICAN JOURNAL OF PATHOLOGY

WNT16 antagonises excessive canonical WNT activation and protects cartilage in osteoarthritis

(2016) Giovanna Nalesso et al.   ANNALS OF THE RHEUMATIC DISEASES

PPARβ/δ and lipid metabolism in the heart

(2016) Xavier Palomer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

High circulating osteoprotegerin levels are associated with non-zero blood groups

(2016) Elod Erno Nagy et al.   BMC Cardiovascular Disorders

Wnt signaling and cellular metabolism in osteoblasts

(2016) Courtney M. Karner et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Inhibitors of Growth 1b Suppresses Peroxisome Proliferator-Activated Receptor-β/δ Expression Through Downregulation of Hypoxia-Inducible Factor 1α in Osteoblast Differentiation

(2016) Bo Qu et al.   DNA AND CELL BIOLOGY

Overexpression of HMGB1 A-box reduced IL-1β-induced MMP expression and the production of inflammatory mediators in human chondrocytes

(2016) Yahui Fu et al.   EXPERIMENTAL CELL RESEARCH

Monoclonal antibodies for the treatment of osteoarthritis

(2016) Shuang Zheng et al.   EXPERT OPINION ON BIOLOGICAL THERAPY

Mangiferin Inhibits IL-1β-Induced Inflammatory Response by Activating PPAR-γ in Human Osteoarthritis Chondrocytes

(2016) Yanlong Qu et al.   INFLAMMATION

The role of the wnt/β-catenin signaling pathway in formation and maintenance of bone and teeth

(2016) Peipei Duan et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Sclerostin expression in the subchondral bone of patients with knee osteoarthritis

(2016) Long Wu et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Neutral solute transport across osteochondral interface: A finite element approach

(2016) Vahid Arbabi et al.   JOURNAL OF BIOMECHANICS

Emerging role of metabolic signaling in synovial joint remodeling and osteoarthritis

(2016) Ronald K. June et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Transplanted Senescent Cells Induce an Osteoarthritis-Like Condition in Mice

(2016) Ming Xu et al.   JOURNALS OF GERONTOLOGY SERIES A-BIOLOGICAL SCIENCES AND MEDICAL SCIENCES

Atorvastatin alleviates renal ischemia-reperfusion injury in rats by promoting M1-M2 transition

(2016) Qi Wang et al.   Molecular Medicine Reports

Ageing and the pathogenesis of osteoarthritis

(2016) Richard F. Loeser et al.   Nature Reviews Rheumatology

Subchondral plate porosity colocalizes with the point of mechanical load during ambulation in a rat knee model of post-traumatic osteoarthritis

(2016) H. Iijima et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoclasts are recruited to the subchondral bone in naturally occurring post-traumatic equine carpal osteoarthritis and may contribute to cartilage degradation

(2016) A. Bertuglia et al.   OSTEOARTHRITIS AND CARTILAGE

Regulation of Matrix Metalloproteinase-2 Activity by COX-2-PGE2-pAKT Axis Promotes Angiogenesis in Endometriosis

(2016) Sayantan Jana et al.   PLoS One

Interaction of HIF1α and β-catenin inhibits matrix metalloproteinase 13 expression and prevents cartilage damage in mice

(2016) Wafa Bouaziz et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

What drives osteoarthritis?—synovialversussubchondral bone pathology

(2016) Thomas Hügle et al.   RHEUMATOLOGY

Increased receptor activator of nuclear factor κβ ligand/osteoprotegerin ratio exacerbates cartilage destruction in osteoarthritis in vitro

(2016) Ji-Zhou Zeng et al.   Experimental and Therapeutic Medicine

Silencing of Wnt5a prevents interleukin-1β-induced collagen type II degradation in rat chondrocytes

(2016) Shiping Shi et al.   Experimental and Therapeutic Medicine

Crosstalk between Wnt/β-Catenin and NF-κB Signaling Pathway during Inflammation

(2016) Bin Ma et al.   Frontiers in Immunology

THU0473 Diacerein Reduces Antagonists of WNT Enabling this System's Activity in Human Osteoarthritic Subchondral Bone Osteoblasts

(2015) J. Martel-Pelletier et al.   ANNALS OF THE RHEUMATIC DISEASES

HIF-1α as a Regulator of BMP2-Induced Chondrogenic Differentiation, Osteogenic Differentiation, and Endochondral Ossification in Stem Cells

(2015) Nian Zhou et al.   CELLULAR PHYSIOLOGY AND BIOCHEMISTRY

The Regulatory Role of Signaling Crosstalk in Hypertrophy of MSCs and Human Articular Chondrocytes

(2015) Leilei Zhong et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Elevated marrow inflammatory cells and osteoclasts in subchondral osteosclerosis in human knee osteoarthritis

(2015) Jeroen Geurts et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Wnt signaling in cartilage development and diseases: lessons from animal studies

(2015) Yu Usami et al.   LABORATORY INVESTIGATION

Understanding the Mysterious M2 Macrophage through Activation Markers and Effector Mechanisms

(2015) Tamás Rőszer   MEDIATORS OF INFLAMMATION

Characterization of diabetic osteoarthritic cartilage and role of high glucose environment on chondrocyte activation: toward pathophysiological delineation of diabetes mellitus-related osteoarthritis

(2015) M.-C. Laiguillon et al.   OSTEOARTHRITIS AND CARTILAGE

Multicolor flow cytometry-based cellular phenotyping identifies osteoprogenitors and inflammatory cells in the osteoarthritic subchondral bone marrow compartment

(2015) B.E. Pippenger et al.   OSTEOARTHRITIS AND CARTILAGE

Using diet-induced obesity to understand a metabolic subtype of osteoarthritis in rats

(2015) K.H. Collins et al.   OSTEOARTHRITIS AND CARTILAGE

Osteocytes mediate the anabolic actions of canonical Wnt/β-catenin signaling in bone

(2015) Xiaolin Tu et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Wnts talking with the TGF-β superfamily: WISPers about modulation of osteoarthritis

(2015) Martijn H. van den Bosch et al.   RHEUMATOLOGY

Generalized Degenerative Joint Disease in Osteoprotegerin (Opg) Null Mutant Mice

(2015) B. Bolon et al.   VETERINARY PATHOLOGY

Biology of Bone Tissue: Structure, Function, and Factors That Influence Bone Cells

(2015) Rinaldo Florencio-Silva et al.   Biomed Research International

Altered Expression of Wnt Signaling Pathway Components in Osteogenesis of Mesenchymal Stem Cells in Osteoarthritis Patients

(2015) Pilar Tornero-Esteban et al.   PLoS One

A review of crosstalk between MAPK and Wnt signals and its impact on cartilage regeneration

(2014) Ying Zhang et al.   CELL AND TISSUE RESEARCH

Canonical Wnt signaling skews TGF-β signaling in chondrocytes towards signaling via ALK1 and Smad 1/5/8

(2014) Martijn H. van den Bosch et al.   CELLULAR SIGNALLING

Signaling Pathways in Cartilage Repair

(2014) Erminia Mariani et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Potential Role of Hyaluronic Acid on Bone in Osteoarthritis: Matrix Metalloproteinases, Aggrecanases, and RANKL Expression are Partially Prevented by Hyaluronic Acid in Interleukin 1-stimulated Osteoblasts

(2014) Z. Mladenovic et al.   JOURNAL OF RHEUMATOLOGY

Osteoblast-derived WNT16 represses osteoclastogenesis and prevents cortical bone fragility fractures

(2014) Sofia Movérare-Skrtic et al.   NATURE MEDICINE

Association between adiponectin and cartilage degradation in human osteoarthritis

(2014) P.-J. Francin et al.   OSTEOARTHRITIS AND CARTILAGE

Lack of sclerostin promotes osteoarthritis by activating canonical and non-canonical WNT pathways

(2014) W. Bouaziz et al.   OSTEOARTHRITIS AND CARTILAGE

OARSI guidelines for the non-surgical management of knee osteoarthritis

(2014) T.E. McAlindon et al.   OSTEOARTHRITIS AND CARTILAGE

Bone–cartilage interface crosstalk in osteoarthritis: potential pathways and future therapeutic strategies

(2014) X.L. Yuan et al.   OSTEOARTHRITIS AND CARTILAGE

Physiological Functions of Peroxisome Proliferator-Activated Receptor β

(2014) Jaap G. Neels et al.   PHYSIOLOGICAL REVIEWS

WNT7B Promotes Bone Formation in part through mTORC1

(2014) Jianquan Chen et al.   PLoS Genetics

Dkk-1-Mediated Inhibition of Wnt Signaling in Bone Ameliorates Osteoarthritis in Mice

(2014) Thomas Funck-Brentano et al.   Arthritis & Rheumatology

Low sirtuin 1 levels in human osteoarthritis subchondral osteoblasts lead to abnormal sclerostin expression which decreases Wnt/β-catenin activity

(2013) Élie Abed et al.   BONE

Interplay between Cartilage and Subchondral Bone Contributing to Pathogenesis of Osteoarthritis

(2013) Ashish Sharma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

T Cell Factor 4 Is a Pro-catabolic and Apoptotic Factor in Human Articular Chondrocytes by Potentiating Nuclear Factor κB Signaling

(2013) Bin Ma et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

RANKL/OPG Ratio and DKK-1 Expression in Primary Osteoblastic Cultures from Osteoarthritic and Osteoporotic Subjects

(2013) A. Corrado et al.   JOURNAL OF RHEUMATOLOGY

PPARβ/δ governs Wnt signaling and bone turnover

(2013) Carina Scholtysek et al.   NATURE MEDICINE

WNT1 Mutations in Early-Onset Osteoporosis and Osteogenesis Imperfecta

(2013) Christine M. Laine et al.   NEW ENGLAND JOURNAL OF MEDICINE

The WNT signaling pathway from ligand secretion to gene transcription: Molecular mechanisms and pharmacological targets

(2013) Hoeke A. Baarsma et al.   PHARMACOLOGY & THERAPEUTICS

HIF-1α Inhibits Wnt Signaling Pathway by Activating Sost Expression in Osteoblasts

(2013) Dafu Chen et al.   PLoS One

Lrp5 and Lrp6 Exert Overlapping Functions in Osteoblasts during Postnatal Bone Acquisition

(2013) Ryan C. Riddle et al.   PLoS One

Similar Properties of Chondrocytes from Osteoarthritis Joints and Mesenchymal Stem Cells from Healthy Donors for Tissue Engineering of Articular Cartilage

(2013) Amilton M. Fernandes et al.   PLoS One

Genome-wide expression profiles of subchondral bone in osteoarthritis

(2013) Ching-Heng Chou et al.   ARTHRITIS RESEARCH & THERAPY

Association of atherosclerosis with presence and progression of osteoarthritis: the Rotterdam Study

(2012) Theun Antonius Hoeven et al.   ANNALS OF THE RHEUMATIC DISEASES

WNT Signaling and Cartilage: Of Mice and Men

(2012) Bin Ma et al.   CALCIFIED TISSUE INTERNATIONAL

Genome-wide meta-analysis identifies 56 bone mineral density loci and reveals 14 loci associated with risk of fracture

(2012) Karol Estrada et al.   NATURE GENETICS

Mechanisms and targets of angiogenesis and nerve growth in osteoarthritis

(2012) Paul I. Mapp et al.   Nature Reviews Rheumatology

Subchondral bone and osteoarthritis: biological and cellular aspects

(2012) Y. Henrotin et al.   OSTEOPOROSIS INTERNATIONAL

R-spondins are newly recognized players in osteoarthritis that regulate Wnt signaling in osteoblasts

(2011) Élie Abed et al.   ARTHRITIS AND RHEUMATISM

Regulation of subchondral bone osteoblast metabolism by cyclic compression

(2011) Christelle Sanchez et al.   ARTHRITIS AND RHEUMATISM

Proteases involved in cartilage matrix degradation in osteoarthritis

(2011) Linda Troeberg et al.   BIOCHIMICA ET BIOPHYSICA ACTA-PROTEINS AND PROTEOMICS

Osteoprotegerin is associated with cardiovascular risk in hypertension and/or diabetes

(2011) Ana M. Blázquez-Medela et al.   EUROPEAN JOURNAL OF CLINICAL INVESTIGATION

WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways

(2011) Giovanna Nalesso et al.   JOURNAL OF CELL BIOLOGY

Biological aspects of early osteoarthritis

(2011) Henning Madry et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Roles of β-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells

(2011) Rika Yasuhara et al.   LABORATORY INVESTIGATION

Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis

(2011) B.Y. Chan et al.   OSTEOARTHRITIS AND CARTILAGE

The expression of RANKL and OPG in the various grades of osteoarthritic cartilage

(2011) Angus R. Upton et al.   RHEUMATOLOGY INTERNATIONAL

An Updated Overview on Wnt Signaling Pathways

(2010) Tata Purushothama Rao et al.   CIRCULATION RESEARCH

WISP-1/CCN4 regulates osteogenesis by enhancing BMP-2 activity

(2010) Mitsuaki Ono et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

Significance of the serum CTX-II level in an osteoarthritis animal model: a 5-month longitudinal study

(2010) M.E. Duclos et al.   OSTEOARTHRITIS AND CARTILAGE

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the rabbit

(2010) S. Laverty et al.   OSTEOARTHRITIS AND CARTILAGE

The OARSI histopathology initiative – recommendations for histological assessments of osteoarthritis in the rat

(2010) N. Gerwin et al.   OSTEOARTHRITIS AND CARTILAGE

Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis

(2010) Miriam Bellido et al.   ARTHRITIS RESEARCH & THERAPY

Wnt signal transduction pathways

(2010) Yuko Komiya et al.   Organogenesis

Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: Prominent role of Wnt-induced signaling protein 1

(2009) Arjen B. Blom et al.   ARTHRITIS AND RHEUMATISM

Regulation of bone development and extracellular matrix protein genes by RUNX2

(2009) Toshihisa Komori   CELL AND TISSUE RESEARCH

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

In situ measurement of transport between subchondral bone and articular cartilage

(2009) Jun Pan et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Twenty bone-mineral-density loci identified by large-scale meta-analysis of genome-wide association studies

(2009) Fernando Rivadeneira et al.   NATURE GENETICS

Subchondral bone marrow lesions are highly associated with, and predict subchondral bone attrition longitudinally: the MOST study

(2009) F.W. Roemer et al.   OSTEOARTHRITIS AND CARTILAGE

Increased Prevalence of Metabolic Syndrome in Individuals with Osteoarthritis: An Analysis of NHANES III Data

(2009) Rajitkanok Amy Puenpatom et al.   POSTGRADUATE MEDICINE

Inhibition of β‐catenin signaling in articular chondrocytes results in articular cartilage destruction

(2008) Mei Zhu et al.   ARTHRITIS AND RHEUMATISM

Cartilage in normal and osteoarthritis conditions

(2008) Johanne Martel-Pelletier et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Differential modulation of RANKL isoforms by human osteoarthritic subchondral bone osteoblasts: Influence of osteotropic factors

(2008) Steeve Kwan Tat et al.   BONE

Wnt signaling and osteoarthritis

(2008) Frank P. Luyten et al.   BONE

Interaction of FOXO with β-Catenin Inhibits β-Catenin/T Cell Factor Activity

(2008) Diana Hoogeboom et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Targeted Deletion of the Sclerostin Gene in Mice Results in Increased Bone Formation and Bone Strength

(2008) Xiaodong Li et al.   JOURNAL OF BONE AND MINERAL RESEARCH

TGF-β1 and WISP-1/CCN-4 can regulate each other's activity to cooperatively control osteoblast function

(2008) Colette A. Inkson et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Effects of hypoxia on glucose transport in primary equine chondrocytesin vitroand evidence of reduced GLUT1 gene expression in pathologic cartilagein vivo

(2008) Siriporn Peansukmanee et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

Enhanced expression of interleukin-6, matrix metalloproteinase-13, and receptor activator of NF-κB ligand in cells derived from osteoarthritic subchondral bone

(2008) Kei Sakao et al.   JOURNAL OF ORTHOPAEDIC SCIENCE

Circulating Osteoprotegerin Levels and Long-Term Prognosis in Patients With Acute Coronary Syndromes

(2008) Torbjørn Omland et al.   JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY

Wnt/β-catenin signaling stimulates matrix catabolic genes and activity in articular chondrocytes: its possible role in joint degeneration

(2008) Takahito Yuasa et al.   LABORATORY INVESTIGATION

From individual Wnt pathways towards a Wnt signalling network

(2008) H. A Kestler et al.   PHILOSOPHICAL TRANSACTIONS OF THE ROYAL SOCIETY B-BIOLOGICAL SCIENCES

Wnt–β-catenin signaling in the pathogenesis of osteoarthritis

(2008) Maripat Corr   Nature clinical practice. Rheumatology