Biological aspects of early osteoarthritis

Management of Osteoarthritis of the Knee in the Active Patient

(2016) Brian T. Feeley et al.   JOURNAL OF THE AMERICAN ACADEMY OF ORTHOPAEDIC SURGEONS

Weight loss as treatment for knee osteoarthritis symptoms in obese patients: 1-year results from a randomised controlled trial

(2011) H. Bliddal et al.   ANNALS OF THE RHEUMATIC DISEASES

The infrapatellar fat pad of patients with osteoarthritis has an inflammatory phenotype

(2011) I. R. Klein-Wieringa et al.   ANNALS OF THE RHEUMATIC DISEASES

Onset of preclinical osteoarthritis: The angular spatial organization permits early diagnosis

(2011) Bernd Rolauffs et al.   ARTHRITIS AND RHEUMATISM

Closing ranks: The chondrocytes' move in bad times or biomechanical job sharing?

(2011) Juergen A. Mollenhauer   ARTHRITIS AND RHEUMATISM

Changes in subchondral bone early in the development of osteoarthritis

(2011) S. C. Mastbergen et al.   ARTHRITIS AND RHEUMATISM

Associations between proinflammatory cytokines in the synovial fluid and radiographic grading and pain-related scores in 47 consecutive patients with osteoarthritis of the knee

(2011) Sumihisa Orita et al.   BMC MUSCULOSKELETAL DISORDERS

Genetic indicators and susceptibility to osteoarthritis

(2011) J. Loughlin   BRITISH JOURNAL OF SPORTS MEDICINE

Recent advances in biomarkers in osteoarthritis

(2011) Debabrata Patra et al.   CURRENT OPINION IN RHEUMATOLOGY

Osteoarthritis prevention

(2011) Tuhina Neogi et al.   CURRENT OPINION IN RHEUMATOLOGY

Crosstalk between cartilage and bone: When bone cytokines matter

(2011) Thomas Funck-Brentano et al.   CYTOKINE & GROWTH FACTOR REVIEWS

Personalized medicine: new genomics, old lessons

(2011) Kenneth Offit   HUMAN GENETICS

What of guidelines for osteoarthritis?

(2011) Anita Y. N. LIM et al.   International Journal of Rheumatic Diseases

Microarray Analysis of the Infrapatellar Fat Pad in Knee Osteoarthritis: Relationship with Joint Inflammation

(2011) R. GANDHI et al.   JOURNAL OF RHEUMATOLOGY

Osteoarthritis: an update with relevance for clinical practice

(2011) Johannes WJ Bijlsma et al.   LANCET

Osteoarthritis year 2010 in review: genetics

(2011) J. Loughlin   OSTEOARTHRITIS AND CARTILAGE

Effects of an intensive weight loss program on knee joint loading in obese adults with knee osteoarthritis

(2011) J. Aaboe et al.   OSTEOARTHRITIS AND CARTILAGE

Improving subchondral bone integrity reduces progression of cartilage damage in experimental osteoarthritis preceded by osteoporosis

(2011) M. Bellido et al.   OSTEOARTHRITIS AND CARTILAGE

Osteoarthritis year 2010 in review: pathomechanisms

(2011) W.B. van den Berg   OSTEOARTHRITIS AND CARTILAGE

Gene Therapy for Cartilage Repair

(2011) Henning Madry et al.   Cartilage

Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis

(2010) Mary B. Goldring et al.   Annals of the New York Academy of Sciences

GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subchondral bone changes

(2010) M. Daans et al.   ANNALS OF THE RHEUMATIC DISEASES

Assessment of synovitis with contrast-enhanced MRI using a whole-joint semiquantitative scoring system in people with, or at high risk of, knee osteoarthritis: the MOST study

(2010) A. Guermazi et al.   ANNALS OF THE RHEUMATIC DISEASES

Tonic modulation of spinal hyperexcitability by the endocannabinoid receptor system in a rat model of osteoarthritis pain

(2010) Devi Rani Sagar et al.   ARTHRITIS AND RHEUMATISM

Attenuation of osteoarthritis progression by reduction of discoidin domain receptor 2 in mice

(2010) Lin Xu et al.   ARTHRITIS AND RHEUMATISM

Unfavorable Results of Partial Meniscectomy for Complete Posterior Medial Meniscus Root Tear With Early Osteoarthritis: A 5- to 8-Year Follow-Up Study

(2010) Seung Beom Han et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

Open-Wedge Osteotomy Using an Internal Plate Fixator in Patients With Medial-Compartment Gonarthritis and Varus Malalignment: 3-Year Results With Regard to Preoperative Arthroscopic and Radiographic Findings

(2010) Philipp Niemeyer et al.   ARTHROSCOPY-THE JOURNAL OF ARTHROSCOPIC AND RELATED SURGERY

Novel targets in bone and cartilage

(2010) Christian Beyer et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

The clinical relevance of genetic susceptibility to osteoarthritis

(2010) Ana M. Valdes et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Developing a minimum standard of care for treating people with osteoarthritis of the hip and knee

(2010) Lyn March et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Why is osteoarthritis an age-related disease?

(2010) A. Shane Anderson et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Epidemiology of Osteoarthritis

(2010) Yuqing Zhang et al.   CLINICS IN GERIATRIC MEDICINE

NF-κB Signaling: Multiple Angles to Target OA

(2010) Kenneth B. Marcu et al.   CURRENT DRUG TARGETS

The genetic epidemiology of osteoarthritis

(2010) Ana M Valdes et al.   CURRENT OPINION IN RHEUMATOLOGY

Molecular mechanisms of cartilage remodelling in osteoarthritis

(2010) Jessica Bertrand et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

The anatomical basis for a novel classification of osteoarthritis and allied disorders

(2010) Dennis McGonagle et al.   JOURNAL OF ANATOMY

Acetabular and proximal femoral alignment in patients with osteoarthritis of the dysplastic hip and its influence on the progression of disease

(2010) H. Aoki et al.   JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME

The subchondral bone: a new frontier in articular cartilage repair

(2010) Henning Madry   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

The basic science of the subchondral bone

(2010) Henning Madry et al.   KNEE SURGERY SPORTS TRAUMATOLOGY ARTHROSCOPY

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

HIF2α central player in osteoarthritis

(2010) Alexandra Flemming   NATURE REVIEWS DRUG DISCOVERY

Concentrated efforts to detect early OA

(2010) Rowan Higgs   Nature Reviews Rheumatology

The role of synovitis in pathophysiology and clinical symptoms of osteoarthritis

(2010) Jérémie Sellam et al.   Nature Reviews Rheumatology

Genetic epidemiology of hip and knee osteoarthritis

(2010) Ana M. Valdes et al.   Nature Reviews Rheumatology

The role of the cartilage matrix in osteoarthritis

(2010) Dick Heinegård et al.   Nature Reviews Rheumatology

Muscle weakness, afferent sensory dysfunction and exercise in knee osteoarthritis

(2010) Ewa M. Roos et al.   Nature Reviews Rheumatology

The bone–cartilage unit in osteoarthritis

(2010) Rik J. Lories et al.   Nature Reviews Rheumatology

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

The infrapatellar fat pad should be considered as an active osteoarthritic joint tissue: a narrative review

(2010) S. Clockaerts et al.   OSTEOARTHRITIS AND CARTILAGE

Histopathology atlas of animal model systems – overview of guiding principles

(2010) T. Aigner et al.   OSTEOARTHRITIS AND CARTILAGE

Inhibition of osteoclasts prevents cartilage loss and pain in a rat model of degenerative joint disease

(2010) B.W. Strassle et al.   OSTEOARTHRITIS AND CARTILAGE

In vivo structural analysis of subchondral trabecular bone in osteoarthritis of the hip using multi-detector row CT

(2010) K. Chiba et al.   OSTEOARTHRITIS AND CARTILAGE

Large-scale meta-analysis of interleukin-1 beta and interleukin-1 receptor antagonist polymorphisms on risk of radiographic hip and knee osteoarthritis and severity of knee osteoarthritis

(2010) H.J.M. Kerkhof et al.   OSTEOARTHRITIS AND CARTILAGE

Role of Diet in Rheumatic Disease

(2010) Sophia Li et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Articular Cartilage: Structure and Regeneration

(2010) José Becerra et al.   TISSUE ENGINEERING PART B-REVIEWS

Bone and cartilage in osteoarthritis: is what's best for one good or bad for the other?

(2010) Steven R Goldring et al.   ARTHRITIS RESEARCH & THERAPY

Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis

(2010) Miriam Bellido et al.   ARTHRITIS RESEARCH & THERAPY

Subchondral bone attrition may be a reflection of compartment-specific mechanical load: the MOST Study

(2009) T. Neogi et al.   ANNALS OF THE RHEUMATIC DISEASES

Cartilage loss occurs in the same subregions as subchondral bone attrition: A within-knee subregion-matched approach from the multicenter osteoarthritis study

(2009) T. Neogi et al.   ARTHRITIS AND RHEUMATISM

Does knee malalignment increase the risk of development and progression of knee osteoarthritis? A systematic review

(2009) Stephanie Tanamas et al.   ARTHRITIS AND RHEUMATISM

A functional polymorphism in the catechol-O-methyltransferase gene is associated with osteoarthritis-related pain

(2009) Joyce B. J. van Meurs et al.   ARTHRITIS AND RHEUMATISM

Meniscal tear in knees without surgery and the development of radiographic osteoarthritis among middle-aged and elderly persons: The multicenter osteoarthritis study

(2009) Martin Englund et al.   ARTHRITIS AND RHEUMATISM

The infrapatellar fat pad in knee osteoarthritis: An important source of interleukin-6 and its soluble receptor

(2009) Emilie Distel et al.   ARTHRITIS AND RHEUMATISM

Effect of thigh strength on incident radiographic and symptomatic knee osteoarthritis in a longitudinal cohort

(2009) Neil A. Segal et al.   ARTHRITIS AND RHEUMATISM

Cartilage repair in a rat model of osteoarthritis through intraarticular transplantation of muscle-derived stem cells expressing bone morphogenetic protein 4 and soluble flt-1

(2009) Tomoyuki Matsumoto et al.   ARTHRITIS AND RHEUMATISM

The treatment and prevention of knee osteoarthritis: a tool for clinical decision-making

(2009) Henning Bliddal et al.   EXPERT OPINION ON PHARMACOTHERAPY

Syndecan-4 regulates ADAMTS-5 activation and cartilage breakdown in osteoarthritis

(2009) Frank Echtermeyer et al.   NATURE MEDICINE

Osteotomien am Kniegelenk bei Monokompartmentarthrose

(2009) S. Hofmann et al.   ORTHOPADE

The association of prevalent medial meniscal pathology with cartilage loss in the medial tibiofemoral compartment over a 2-year period

(2009) M.D. Crema et al.   OSTEOARTHRITIS AND CARTILAGE

The Role of the Meniscus in Knee Osteoarthritis: a Cause or Consequence?

(2009) Martin Englund et al.   RADIOLOGIC CLINICS OF NORTH AMERICA

The Meniscus in Knee Osteoarthritis

(2009) Martin Englund et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Commentary: Is It Useful to Subset “Primary” Osteoarthritis? A Critique Based on Evidence Regarding the Etiopathogenesis of Osteoarthritis

(2009) Kenneth D. Brandt et al.   SEMINARS IN ARTHRITIS AND RHEUMATISM

Cartilage homeostasis in health and rheumatic diseases

(2009) Mary B Goldring et al.   ARTHRITIS RESEARCH & THERAPY

Evaluation of microfracture of traumatic chondral injuries to the knee in professional football and rugby players

(2009) Masoud Riyami et al.   Journal of Orthopaedic Surgery and Research

Modulation of xylosyltransferase I expression provides a mechanism regulating glycosaminoglycan chain synthesis during cartilage destruction and repair

(2008) Narayanan Venkatesan et al.   FASEB JOURNAL

Sustained NF-κB activation produces a short-term cell proliferation block in conjunction with repressing effectors of cell cycle progression controlled by E2F or FoxM1

(2008) Marianna Penzo et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The Contribution of Genes to Osteoarthritis

(2008) Ana M. Valdes et al.   MEDICAL CLINICS OF NORTH AMERICA

Deletion of frizzled-related protein reduces voluntary running exercise performance in mice

(2008) R.J.U. Lories et al.   OSTEOARTHRITIS AND CARTILAGE

On new bone formation in the pre-osteoarthritic joint

(2008) A. Thambyah et al.   OSTEOARTHRITIS AND CARTILAGE

Epidemiology of Osteoarthritis

(2008) Yuqing Zhang et al.   RHEUMATIC DISEASE CLINICS OF NORTH AMERICA

Bone marrow edema pattern in advanced hip osteoarthritis: quantitative assessment with magnetic resonance imaging and correlation with clinical examination, radiographic findings, and histopathology

(2008) Mihra S. Taljanovic et al.   SKELETAL RADIOLOGY

Reappraising metalloproteinases in rheumatoid arthritis and osteoarthritis: destruction or repair?

(2008) Gillian Murphy et al.   Nature clinical practice. Rheumatology

The additive effect of individual genes in predicting risk of knee osteoarthritis

(2007) A M Valdes et al.   ANNALS OF THE RHEUMATIC DISEASES