PPARβ/δ: Linking Metabolism to Regeneration

TLR3 Mediates Repair and Regeneration of Damaged Neonatal Heart through Glycolysis Dependent YAP1 Regulated miR-152 Expression

(2018) Xiaohui Wang et al.   CELL DEATH AND DIFFERENTIATION

The Anticancer Potential of Peroxisome Proliferator-Activated Receptor Antagonists

(2018) Laura De Lellis et al.   ChemMedChem

Regulation and phylogeny of skeletal muscle regeneration

(2018) Meryem B. Baghdadi et al.   DEVELOPMENTAL BIOLOGY

Interrelationship between diabetes mellitus and heart failure: the role of peroxisome proliferator-activated receptors in left ventricle performance

(2018) Evangelos Oikonomou et al.   HEART FAILURE REVIEWS

PPARβ/δ: A Key Therapeutic Target in Metabolic Disorders

(2018) Xavier Palomer et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Immunology Guides Skeletal Muscle Regeneration

(2018) F. Sass et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Pivotal Roles of Peroxisome Proliferator-Activated Receptors (PPARs) and Their Signal Cascade for Cellular and Whole-Body Energy Homeostasis

(2018) Shreekrishna Lamichane et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

The balancing act of the liver: tissue regeneration versus fibrosis

(2018) Lucía Cordero-Espinoza et al.   JOURNAL OF CLINICAL INVESTIGATION

A TLR/AKT/FoxO3 immune tolerance–like pathway disrupts the repair capacity of oligodendrocyte progenitors

(2018) Taasin Srivastava et al.   JOURNAL OF CLINICAL INVESTIGATION

PTEN knockdown with the Y444F mutant AAV2 vector promotes axonal regeneration in the adult optic nerve

(2018) Qing-huai Liu et al.   Neural Regeneration Research

Role of the immune system in regeneration and its dynamic interplay with adult stem cells

(2018) Prasad Abnave et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

An unexpected friend − ROS in apoptosis-induced compensatory proliferation: Implications for regeneration and cancer

(2018) Neha Diwanji et al.   SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY

Injected Human Muscle Precursor Cells Overexpressing PGC-1α Enhance Functional Muscle Regeneration after Trauma

(2018) Deana Haralampieva et al.   Stem Cells International

Regulatory T-Cells: Potential Regulator of Tissue Repair and Regeneration

(2018) Jiatao Li et al.   Frontiers in Immunology

Cancer-associated cachexia

(2018) Vickie E. Baracos et al.   Nature Reviews Disease Primers

Advances in Skin Regeneration Using Tissue Engineering

(2017) Komal Vig et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

Peroxisome proliferator-activated receptor-β/δ inhibits human neuroblastoma cell tumorigenesis by inducing p53- and SOX2-mediated cell differentiation

(2017) Pei-Li Yao et al.   MOLECULAR CARCINOGENESIS

Inflammation and metabolism in tissue repair and regeneration

(2017) Sabine A. Eming et al.   SCIENCE

Oxygen, Metabolism, and Regeneration: Lessons from Mice

(2017) Ellen Heber-Katz   TRENDS IN MOLECULAR MEDICINE

Macrophages induce AKT/β-catenin-dependent Lgr5+ stem cell activation and hair follicle regeneration through TNF

(2017) Xusheng Wang et al.   Nature Communications

Surgical, ethical, and psychosocial considerations in human head transplantation

(2017) Allen Furr et al.   International Journal of Surgery

Quiescence Exit of Tert + Stem Cells by Wnt/β-Catenin Is Indispensable for Intestinal Regeneration

(2017) Han Na Suh et al.   Cell Reports

Loss of foxo rescues stem cell aging in Drosophila germ line

(2017) Filippo Artoni et al.   eLife

The Role of Inflammation in Age-Related Sarcopenia

(2017) Sebastiaan Dalle et al.   Frontiers in Physiology

Acceleration of bone regeneration by activating Wnt/β-catenin signalling pathway via lithium released from lithium chloride/calcium phosphate cement in osteoporosis

(2017) Li Li et al.   Scientific Reports

Early Postnatal Cardiomyocyte Proliferation Requires High Oxidative Energy Metabolism

(2017) Ana Elisa Teófilo Saturi de Carvalho et al.   Scientific Reports

Towards regenerating the mammalian heart: challenges in evaluating experimentally induced adult mammalian cardiomyocyte proliferation

(2016) David C. Zebrowski et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Activation of Peroxisome Proliferator–Activated Receptor-δ as Novel Therapeutic Strategy to Prevent In-Stent Restenosis and Stent ThrombosisHighlights

(2016) Jarkko Hytönen et al.   ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY

Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) activates promyogenic signaling pathways, thereby promoting myoblast differentiation

(2016) Sang-Jin Lee et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

PPARβ/δ and lipid metabolism in the heart

(2016) Xavier Palomer et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS

The Akt signaling pathway is required for tissue maintenance and regeneration in planarians

(2016) T. Harshani Peiris et al.   BMC DEVELOPMENTAL BIOLOGY

Succinate Dehydrogenase Supports Metabolic Repurposing of Mitochondria to Drive Inflammatory Macrophages

(2016) Evanna L. Mills et al.   CELL

Regenerated Endothelium and Its Senescent Response to Aggregating Platelets

(2016) Paul M. Vanhoutte   CIRCULATION JOURNAL

Proliferation, survival and metabolism: the role of PI3K/AKT/mTOR signalling in pluripotency and cell fate determination

(2016) Jason S. L. Yu et al.   DEVELOPMENT

Inhibitors of Growth 1b Suppresses Peroxisome Proliferator-Activated Receptor-β/δ Expression Through Downregulation of Hypoxia-Inducible Factor 1α in Osteoblast Differentiation

(2016) Bo Qu et al.   DNA AND CELL BIOLOGY

Increase of human prostate cancer cell (DU145) apoptosis by telmisartan through PPAR-delta pathway

(2016) Tony Tong-Lin Wu et al.   EUROPEAN JOURNAL OF PHARMACOLOGY

Epithelial NEMO/IKKγ limits fibrosis and promotes regeneration during pancreatitis

(2016) Lap Kwan Chan et al.   GUT

Macrophages in Tissue Repair, Regeneration, and Fibrosis

(2016) Thomas A. Wynn et al.   IMMUNITY

Interaction between platelets and endothelial progenitor cells via LPA-Edg-2 axis is augmented by PPAR-δ activation

(2016) Jung-Kyu Han et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Modifying the mechanics of healing infarcts: Is better the enemy of good?

(2016) Samantha A. Clarke et al.   JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY

Reparative inflammation takes charge of tissue regeneration

(2016) Michael Karin et al.   NATURE

FoxO1: a novel insight into its molecular mechanisms in the regulation of skeletal muscle differentiation and fiber type specification

(2016) Meng Xu et al.   Oncotarget

GSK3β regulates AKT-induced central nervous system axon regeneration via an eIF2Bε-dependent, mTORC1-independent pathway

(2016) Xinzheng Guo et al.   eLife

A Flavonoid Compound Promotes Neuronal Differentiation of Embryonic Stem Cells via PPAR-β Modulating Mitochondrial Energy Metabolism

(2016) Yu-qin Mei et al.   PLoS One

Extracellular signaling molecules to promote fracture healing and bone regeneration

(2015) K.D. Hankenson et al.   ADVANCED DRUG DELIVERY REVIEWS

Inactivation of PPARβ/δ adversely affects satellite cells and reduces postnatal myogenesis

(2015) Preeti Chandrashekar et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

Cardiomyocyte proliferation in cardiac development and regeneration: a guide to methodologies and interpretations

(2015) Marina Leone et al.   AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY

Peroxisome proliferator-activated receptors (PPARs) and PPAR agonists: the ‘future’ in dermatology therapeutics?

(2015) Mrinal Gupta et al.   ARCHIVES OF DERMATOLOGICAL RESEARCH

Cardiomyocyte lipotoxicity is mediated by Il-6 and causes down-regulation of PPARs

(2015) Taha Haffar et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Muscle-specific GSK-3β ablation accelerates regeneration of disuse-atrophied skeletal muscle

(2015) Nicholas A.M. Pansters et al.   BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE

PPARs and ERRs: molecular mediators of mitochondrial metabolism

(2015) Weiwei Fan et al.   CURRENT OPINION IN CELL BIOLOGY

Akt-mediated foxo1 inhibition is required for liver regeneration

(2015) Montse Pauta et al.   HEPATOLOGY

Peroxisome Proliferator-activated Receptor-D (PPARD) Coordinates Mouse Spermatogenesis by Modulating Extracellular Signal-regulated Kinase (ERK)-dependent Signaling

(2015) Pei-Li Yao et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

AMP-activated Protein Kinase Stimulates Warburg-like Glycolysis and Activation of Satellite Cells during Muscle Regeneration

(2015) Xing Fu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Autocrine VEGF maintains endothelial survival through regulation of metabolism and autophagy

(2015) C. K. Domigan et al.   JOURNAL OF CELL SCIENCE

Activation of PPARβ/δ protects cardiac myocytes from oxidative stress-induced apoptosis by suppressing generation of reactive oxygen/nitrogen species and expression of matrix metalloproteinases

(2015) Eleftheria Barlaka et al.   PHARMACOLOGICAL RESEARCH

Macrophages decide between regeneration and fibrosis in muscle

(2015) Pura Muñoz-Cánoves et al.   TRENDS IN ENDOCRINOLOGY AND METABOLISM

Wound Healing and Skin Regeneration

(2015) M. Takeo et al.   Cold Spring Harbor Perspectives in Medicine

Reduced FOXO1 Expression Accelerates Skin Wound Healing and Attenuates Scarring

(2014) Ryoichi Mori et al.   AMERICAN JOURNAL OF PATHOLOGY

Involvement of peroxisome proliferator-activated receptor β/δ (PPAR β/δ) in BDNF signaling during aging and in Alzheimer disease: Possible role of 4-hydroxynonenal (4-HNE)

(2014) Elisabetta Benedetti et al.   CELL CYCLE

Impaired Musculoskeletal Response to Age and Exercise in PPARβ−/−Diabetic Mice

(2014) He Fu et al.   ENDOCRINOLOGY

Biological perspectives of delayed fracture healing

(2014) K.D. Hankenson et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

Activation of Peroxisome Proliferator-Activated Receptor- /  (PPAR- / ) Inhibits Human Breast Cancer Cell Line Tumorigenicity

(2014) P.-L. Yao et al.   MOLECULAR CANCER THERAPEUTICS

Insulin/IGF1 Signaling Inhibits Age-Dependent Axon Regeneration

(2014) Alexandra B. Byrne et al.   NEURON

Physiological Functions of Peroxisome Proliferator-Activated Receptor β

(2014) Jaap G. Neels et al.   PHYSIOLOGICAL REVIEWS

TRPV1 Activation Attenuates High-Salt Diet-Induced Cardiac Hypertrophy and Fibrosis through PPAR-δUpregulation

(2014) Feng Gao et al.   PPAR Research

The Antifibrosis Effects of Peroxisome Proliferator-Activated Receptorδon Rat Corneal Wound Healing after Excimer Laser Keratectomy

(2014) Yun Gu et al.   PPAR Research

Cross-enhancement of ANGPTL4 transcription by HIF1 alpha and PPAR beta/delta is the result of the conformational proximity of two response elements

(2014) Tsuyoshi Inoue et al.   GENOME BIOLOGY

PPAR Agonists as Therapeutics for CNS Trauma and Neurological Diseases

(2013) Shweta Mandrekar-Colucci et al.   ASN Neuro

Nuclear receptor/microRNA circuitry links muscle fiber type to energy metabolism

(2013) Zhenji Gan et al.   JOURNAL OF CLINICAL INVESTIGATION

The Tangled Circuitry of Metabolism and Apoptosis

(2013) Joshua L. Andersen et al.   MOLECULAR CELL

Metabolism of inflammation limited by AMPK and pseudo-starvation

(2013) Luke A. J. O'Neill et al.   NATURE

PPARβ/δ governs Wnt signaling and bone turnover

(2013) Carina Scholtysek et al.   NATURE MEDICINE

Metabolism in physiological cell proliferation and differentiation

(2013) Michalis Agathocleous et al.   TRENDS IN CELL BIOLOGY

 -catenin is selectively required for the expansion and regeneration of mature pancreatic acinar cells in mice

(2012) M. D. Keefe et al.   Disease Models & Mechanisms

β-Catenin and Peroxisome Proliferator-activated Receptor-δ Coordinate Dynamic Chromatin Loops for the Transcription of Vascular Endothelial Growth Factor A Gene in Colon Cancer Cells

(2012) Injoo Hwang et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Sarcospan-dependent Akt activation is required for utrophin expression and muscle regeneration

(2012) Jamie L. Marshall et al.   JOURNAL OF CELL BIOLOGY

Functional Role of PPARδ in Corneal Epithelial Wound Healing

(2011) Yoshikuni Nakamura et al.   AMERICAN JOURNAL OF PATHOLOGY

Somatic Oxidative Bioenergetics Transitions into Pluripotency-Dependent Glycolysis to Facilitate Nuclear Reprogramming

(2011) Clifford D.L. Folmes et al.   Cell Metabolism

Peroxisome proliferator-activated receptor-δ activates endothelial progenitor cells to induce angio-myogenesis through matrix metallo-proteinase-9-mediated insulin-like growth factor-1 paracrine networks

(2011) Jung-Kyu Han et al.   EUROPEAN HEART JOURNAL

β-Catenin and p120 Mediate PPARδ-Dependent Proliferation Induced by Helicobacter pylori in Human and Rodent Epithelia

(2011) Toni A. Nagy et al.   GASTROENTEROLOGY

Myogenic Akt signaling attenuates muscular degeneration, promotes myofiber regeneration and improves muscle function in dystrophin-deficient mdx mice

(2011) M. H. Kim et al.   HUMAN MOLECULAR GENETICS

Activation of Peroxisome Proliferator-Activated Receptor–δ Enhances Regenerative Capacity of Human Endothelial Progenitor Cells by Stimulating Biosynthesis of Tetrahydrobiopterin

(2011) Tongrong He et al.   HYPERTENSION

Peroxisome proliferator-activated receptor β/δ (PPARβ/δ) is highly expressed in liposarcoma and promotes migration and proliferation

(2011) Kay-Dietrich Wagner et al.   JOURNAL OF PATHOLOGY

New insights into the role of PPARs

(2011) Alexandra Montagner et al.   PROSTAGLANDINS LEUKOTRIENES AND ESSENTIAL FATTY ACIDS

GW0742, a High-Affinity PPAR-δ Agonist, Mediates Protection in an Organotypic Model of Spinal Cord Damage

(2011) Emanuela Esposito et al.   SPINE

The contrasting roles of PPARδ and PPARγ in regulating the metabolic switch between oxidation and storage of fats in white adipose tissue

(2011) Lee D Roberts et al.   GENOME BIOLOGY

PPARδ regulates satellite cell proliferation and skeletal muscle regeneration

(2011) Alison R Angione et al.   Skeletal Muscle

PPARδ agonist-mediated ROS stimulates mouse embryonic stem cell proliferation through cooperation of p38 MAPK and Wnt/β-catenin

(2010) A Young Jeong et al.   CELL CYCLE

PPARδ inhibits IL-1β-stimulated proliferation and migration of vascular smooth muscle cells via up-regulation of IL-1Ra

(2010) H. J. Kim et al.   CELLULAR AND MOLECULAR LIFE SCIENCES

Direct activation of forkhead box O3 by tumor suppressors p53 and p73 is disrupted during liver regeneration in mice

(2010) Svitlana Kurinna et al.   HEPATOLOGY

Role of Peroxisome Proliferator-activated Receptor δ/β in Hepatic Metabolic Regulation

(2010) Sihao Liu et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Energy Metabolic Phenotype of the Cardiomyocyte During Development, Differentiation, and Postnatal Maturation

(2010) Gary D Lopaschuk et al.   JOURNAL OF CARDIOVASCULAR PHARMACOLOGY

The FoxO3/type 2 deiodinase pathway is required for normal mouse myogenesis and muscle regeneration

(2010) Monica Dentice et al.   JOURNAL OF CLINICAL INVESTIGATION

Circulating mitochondrial DAMPs cause inflammatory responses to injury

(2010) Qin Zhang et al.   NATURE

PTEN deletion enhances the regenerative ability of adult corticospinal neurons

(2010) Kai Liu et al.   NATURE NEUROSCIENCE

Spatiotemporal compartmentalization of key physiological processes during muscle precursor differentiation

(2010) E. M. Ozbudak et al.   PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA

Peroxisome Proliferator-Activated Receptors Protect against Apoptosis via 14-3-3

(2010) Kenneth K. Wu   PPAR Research

Peroxisome proliferator-activated receptor β stimulation induces rapid cardiac growth and angiogenesis via direct activation of calcineurin

(2009) Nicole Wagner et al.   CARDIOVASCULAR RESEARCH

Twist-1 Is a PPARδ-Inducible, Negative-Feedback Regulator of PGC-1α in Brown Fat Metabolism

(2009) Dongning Pan et al.   CELL

Pharmacological activation of PPAR /  stimulates utrophin A expression in skeletal muscle fibers and restores sarcolemmal integrity in mature mdx mice

(2009) P. Miura et al.   HUMAN MOLECULAR GENETICS

Regulation of epithelial–mesenchymal IL-1 signaling by PPARβ/δ is essential for skin homeostasis and wound healing

(2009) Han Chung Chong et al.   JOURNAL OF CELL BIOLOGY

Peroxisome proliferator-activated receptor β activation promotes myonuclear accretion in skeletal muscle of adult and aged mice

(2009) C. Giordano et al.   PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY

Pharmacological activation of PPARβ promotes rapid and calcineurin-dependent fiber remodeling and angiogenesis in mouse skeletal muscle

(2008) Céline Gaudel et al.   AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM

PPARδ agonist L-165041 inhibits rat vascular smooth muscle cell proliferation and migration via inhibition of cell cycle

(2008) Hyun-Joung Lim et al.   ATHEROSCLEROSIS

Quantitative expression patterns of peroxisome proliferator-activated receptor-β/δ (PPARβ/δ) protein in mice

(2008) Elizabeth E. Girroir et al.   BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS

Peroxisome Proliferator-Activated Receptor-  Induces Cell Proliferation by a Cyclin E1-Dependent Mechanism and Is Up-regulated in Thyroid Tumors

(2008) L. Zeng et al.   CANCER RESEARCH

Peroxisome Proliferator–Activated Receptor-δ Agonist Enhances Vasculogenesis by Regulating Endothelial Progenitor Cells Through Genomic and Nongenomic Activations of the Phosphatidylinositol 3-Kinase/Akt Pathway

(2008) Jung-Kyu Han et al.   CIRCULATION

Ligand Activation of Peroxisome Proliferator-Activated Receptor- /  Inhibits Cell Proliferation in Human HaCaT Keratinocytes

(2008) M. G. Borland et al.   MOLECULAR PHARMACOLOGY

NF-κB links innate immunity to the hypoxic response through transcriptional regulation of HIF-1α

(2008) Jordi Rius et al.   NATURE

Wound repair and regeneration

(2008) Geoffrey C. Gurtner et al.   NATURE

Review of the expression of peroxisome proliferator-activated receptors alpha (PPARα), beta (PPARβ), and gamma (PPARγ) in rodent and human development

(2008) Barbara D. Abbott   REPRODUCTIVE TOXICOLOGY

Promoting Axon Regeneration in the Adult CNS by Modulation of the PTEN/mTOR Pathway

(2008) K. K. Park et al.   SCIENCE

PPARδ Enhances Keratinocyte Proliferation in Psoriasis and Induces Heparin-Binding EGF-Like Growth Factor

(2007) Malgorzata Romanowska et al.   JOURNAL OF INVESTIGATIVE DERMATOLOGY

High-Glucose-Induced Prostaglandin E2and Peroxisome Proliferator-Activated Receptor δ Promote Mouse Embryonic Stem Cell Proliferation

(2007) Yun Hee Kim et al.   STEM CELLS