Signaling Pathways in Cartilage Repair

Canonical Wnt signaling skews TGF-β signaling in chondrocytes towards signaling via ALK1 and Smad 1/5/8

(2014) Martijn H. van den Bosch et al.   CELLULAR SIGNALLING

Bone Morphogenetic Proteins

(2014) A.C. Carreira et al.   JOURNAL OF DENTAL RESEARCH

Sonic Hedgehog Improves Redifferentiation of Dedifferentiated Chondrocytes for Articular Cartilage Repair

(2014) Lin Lin et al.   PLoS One

CD44 and Hyaluronan Promote the Bone Morphogenetic Protein 7 Signaling Response in Murine Chondrocytes

(2014) Na Luo et al.   Arthritis & Rheumatology

Osteoprotegerin reduces the development of pain behaviour and joint pathology in a model of osteoarthritis

(2013) Devi Rani Sagar et al.   ANNALS OF THE RHEUMATIC DISEASES

Mitogen-Activated Protein Kinase Pathways in Osteoblasts

(2013) Matthew B. Greenblatt et al.   Annual Review of Cell and Developmental Biology

Hypoxia Promotes the Production and Inhibits the Destruction of Human Articular Cartilage

(2013) Brendan L. Thoms et al.   ARTHRITIS AND RHEUMATISM

Deletion of beta catenin in hypertrophic growth plate chondrocytes impairs trabecular bone formation

(2013) Svitlana Golovchenko et al.   BONE

The NF-κB signalling pathway in osteoarthritis

(2013) Stella Rigoglou et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Interplay between Cartilage and Subchondral Bone Contributing to Pathogenesis of Osteoarthritis

(2013) Ashish Sharma et al.   INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES

WNT signaling and chondrocytes: from cell fate determination to osteoarthritis physiopathology

(2013) Nadia Sassi et al.   JOURNAL OF RECEPTORS AND SIGNAL TRANSDUCTION

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

(2013) Gehua Zhen et al.   NATURE MEDICINE

Hypertrophic differentiation during chondrogenic differentiation of progenitor cells is stimulated by BMP-2 but suppressed by BMP-7

(2013) M.M.J. Caron et al.   OSTEOARTHRITIS AND CARTILAGE

CCN4 induces IL-6 production through αvβ5 receptor, PI3K, Akt, and NF-κB singling pathway in human synovial fibroblasts

(2013) Chun-Han Hou et al.   ARTHRITIS RESEARCH & THERAPY

Homeostatic Mechanisms in Articular Cartilage and Role of Inflammation in Osteoarthritis

(2013) Xavier Houard et al.   Current Rheumatology Reports

Gremlin 1, Frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis

(2012) J. C. H. Leijten et al.   ARTHRITIS AND RHEUMATISM

Emerging Frontiers in cartilage and chondrocyte biology

(2012) Amanda J. Fosang et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

The role of synovitis in osteoarthritis pathogenesis

(2012) Carla R. Scanzello et al.   BONE

WNT Signaling and Cartilage: Of Mice and Men

(2012) Bin Ma et al.   CALCIFIED TISSUE INTERNATIONAL

Cartilage development and degeneration: a Wnt Wnt situation

(2012) Katherine Ann Staines et al.   CELL BIOCHEMISTRY AND FUNCTION

Insights on Biology and Pathology of HIF-1α/-2α, TGFβ/BMP, Wnt/β-Catenin, and NF-κB Pathways in Osteoarthritis

(2012) Longhuo Wu et al.   CURRENT PHARMACEUTICAL DESIGN

Regulation of bone and cartilage development by network between BMP signalling and transcription factors

(2012) R. Nishimura et al.   JOURNAL OF BIOCHEMISTRY

Hypoxia-inducible Factor-1 (HIF-1) but Not HIF-2 Is Essential for Hypoxic Induction of Collagen Prolyl 4-Hydroxylases in Primary Newborn Mouse Epiphyseal Growth Plate Chondrocytes

(2012) Ellinoora Aro et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Cartilage-specific β-catenin signaling regulates chondrocyte maturation, generation of ossification centers, and perichondrial bone formation during skeletal development

(2012) Debbie Y Dao et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Activation of Indian hedgehog promotes chondrocyte hypertrophy and upregulation of MMP-13 in human osteoarthritic cartilage

(2012) F. Wei et al.   OSTEOARTHRITIS AND CARTILAGE

CTGF Increases IL-6 Expression in Human Synovial Fibroblasts through Integrin-Dependent Signaling Pathway

(2012) Shan-Chi Liu et al.   PLoS One

A role for age-related changes in TGFβ signaling in aberrant chondrocyte differentiation and osteoarthritis

(2012) Peter M van der Kraan et al.   ARTHRITIS RESEARCH & THERAPY

Bone morphogenetic protein-2-induced Wnt/beta-catenin signaling pathway activation through enhanced low-density-lipoprotein receptor-related protein 5 catabolic activity contributes to hypertrophy in osteoarthritic chondrocytes

(2012) Ioanna Papathanasiou et al.   ARTHRITIS RESEARCH & THERAPY

Indian hedgehog gene transfer is a chondrogenic inducer of human mesenchymal stem cells

(2012) Andre F Steinert et al.   ARTHRITIS RESEARCH & THERAPY

Tight regulation of wingless-type signaling in the articular cartilage - subchondral bone biomechanical unit: transcriptomics in Frzb-knockout mice

(2012) Liesbet Lodewyckx et al.   ARTHRITIS RESEARCH & THERAPY

Recent progress in understanding molecular mechanisms of cartilage degeneration during osteoarthritis

(2011) Meina Wang et al.   Annals of the New York Academy of Sciences

Subchondral bone as a key target for osteoarthritis treatment

(2011) Santos Castañeda et al.   BIOCHEMICAL PHARMACOLOGY

Mechanics of chondrocyte hypertrophy

(2011) C. C. van Donkelaar et al.   Biomechanics and Modeling in Mechanobiology

Activation of Akt leading to NF-κB up-regulation in chondrocytes stimulated with fibronectin fragment

(2011) Tadashi Yasuda   BIOMEDICAL RESEARCH-TOKYO

Wnt signaling in cartilage development and degeneration

(2011) Jang-Soo Chun et al.   BMB Reports

The Role of Growth Factors in Cartilage Repair

(2011) Lisa A. Fortier et al.   CLINICAL ORTHOPAEDICS AND RELATED RESEARCH

Update on Wnt signaling in bone cell biology and bone disease

(2011) David G. Monroe et al.   GENE

C/EBPβ and RUNX2 cooperate to degrade cartilage with MMP-13 as the target and HIF-2α as the inducer in chondrocytes

(2011) Makoto Hirata et al.   HUMAN MOLECULAR GENETICS

E74-like Factor 3 (ELF3) Impacts on Matrix Metalloproteinase 13 (MMP13) Transcriptional Control in Articular Chondrocytes under Proinflammatory Stress

(2011) Miguel Otero et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways

(2011) Giovanna Nalesso et al.   JOURNAL OF CELL BIOLOGY

Roles of β-catenin signaling in phenotypic expression and proliferation of articular cartilage superficial zone cells

(2011) Rika Yasuhara et al.   LABORATORY INVESTIGATION

The relationship between fibrogenic TGFβ1 signaling in the joint and cartilage degradation in post-injury osteoarthritis

(2011) A. Plaas et al.   OSTEOARTHRITIS AND CARTILAGE

Inhibition of Gsk3β in cartilage induces osteoarthritic features through activation of the canonical Wnt signaling pathway

(2011) R.L. Miclea et al.   OSTEOARTHRITIS AND CARTILAGE

Molecular differentiation between osteophytic and articular cartilage – clues for a transient and permanent chondrocyte phenotype

(2011) K. Gelse et al.   OSTEOARTHRITIS AND CARTILAGE

Chondrocyte hypertrophy and osteoarthritis: role in initiation and progression of cartilage degeneration?

(2011) P.M. van der Kraan et al.   OSTEOARTHRITIS AND CARTILAGE

ERK-1/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage chondrocytes induced by osteoarthritic subchondral osteoblasts

(2010) Indira Prasadam et al.   ARTHRITIS AND RHEUMATISM

Phase 1 safety and tolerability study of BMP-7 in symptomatic knee osteoarthritis

(2010) David J Hunter et al.   BMC MUSCULOSKELETAL DISORDERS

Dickkopf-1 (Dkk-1) in plasma and synovial fluid is inversely correlated with radiographic severity of knee osteoarthritis patients

(2010) Sittisak Honsawek et al.   BMC MUSCULOSKELETAL DISORDERS

NF-κB Signaling: Multiple Angles to Target OA

(2010) Kenneth B. Marcu et al.   CURRENT DRUG TARGETS

Mechanism and evolution of cytosolic Hedgehog signal transduction

(2010) C. W. Wilson et al.   DEVELOPMENT

Stimulation of chondrocyte hypertrophy by chemokine stromal cell-derived factor 1 in the chondro-osseous junction during endochondral bone formation

(2010) Lei Wei et al.   DEVELOPMENTAL BIOLOGY

Molecular mechanisms of cartilage remodelling in osteoarthritis

(2010) Jessica Bertrand et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

Effect of growth hormone, insulin-like growth factor I, basic fibroblast growth factor, and transforming growth factor β on cell proliferation and proteoglycan synthesis by avian postembryonic growth plate chondrocytes

(2010) Gaston Rosselot et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Shifting HIFs in osteoarthritis

(2010) Matthew Husa et al.   NATURE MEDICINE

Transcriptional regulation of endochondral ossification by HIF-2α during skeletal growth and osteoarthritis development

(2010) Taku Saito et al.   NATURE MEDICINE

Hypoxia-inducible factor-2α is a catabolic regulator of osteoarthritic cartilage destruction

(2010) Siyoung Yang et al.   NATURE MEDICINE

Role of proinflammatory cytokines in the pathophysiology of osteoarthritis

(2010) Mohit Kapoor et al.   Nature Reviews Rheumatology

Bone Morphogenetic Proteins and articular cartilage

(2010) P.M. van der Kraan et al.   OSTEOARTHRITIS AND CARTILAGE

The transcription factor AP-2ɛ regulates CXCL1 during cartilage development and in osteoarthritis

(2010) A.-K. Wenke et al.   OSTEOARTHRITIS AND CARTILAGE

Regulation of mechanical stress-induced MMP-13 and ADAMTS-5 expression by RUNX-2 transcriptional factor in SW1353 chondrocyte-like cells

(2010) T. Tetsunaga et al.   OSTEOARTHRITIS AND CARTILAGE

Requirement of the NF-κB pathway for induction of Wnt-5A by interleukin-1β in condylar chondrocytes of the temporomandibular joint: functional crosstalk between the Wnt-5A and NF-κB signaling pathways

(2010) Xian-Peng Ge et al.   OSTEOARTHRITIS AND CARTILAGE

Advanced glycation end products induce the expression of interleukin-6 and interleukin-8 by receptor for advanced glycation end product-mediated activation of mitogen-activated protein kinases and nuclear factor- B in human osteoarthritis chondrocytes

(2010) Z. Rasheed et al.   RHEUMATOLOGY

Smad Signaling Determines Chondrogenic Differentiation of Bone-Marrow-Derived Mesenchymal Stem Cells: Inhibition of Smad1/5/8P Prevents Terminal Differentiation and Calcification

(2010) Catharine A. Hellingman et al.   TISSUE ENGINEERING PART A

The Unfolded Protein Response in Health and Disease

(2009) Richard C. Austin   ANTIOXIDANTS & REDOX SIGNALING

Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis

(2009) Shi-Lu Chia et al.   ARTHRITIS AND RHEUMATISM

Regulation of autophagy in human and murine cartilage: Hypoxia-inducible factor 2 suppresses chondrocyte autophagy

(2009) Jolene Bohensky et al.   ARTHRITIS AND RHEUMATISM

Calcification of articular cartilage in human osteoarthritis

(2009) M. Fuerst et al.   ARTHRITIS AND RHEUMATISM

Matrix metalloproteinase 13–deficient mice are resistant to osteoarthritic cartilage erosion but not chondrocyte hypertrophy or osteophyte development

(2009) C. B. Little et al.   ARTHRITIS AND RHEUMATISM

Hypoxia-inducible factor 1α inhibits the fibroblast-like markers type I and type III collagen during hypoxia-induced chondrocyte redifferentiation: Hypoxia not only induces type II collagen and aggrecan, but it also inhibits type I and type III collagen in the hypoxia-inducible factor 1α-dependent redifferentiation of chondrocytes

(2009) Elise Duval et al.   ARTHRITIS AND RHEUMATISM

Osteoarthritic cartilage chondrocytes alter subchondral bone osteoblast differentiation via MAPK signalling pathway involving ERK1/2

(2009) Indira Prasadam et al.   BONE

BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation

(2009) K. N. Retting et al.   DEVELOPMENT

The extracellular regulation of bone morphogenetic protein signaling

(2009) D. Umulis et al.   DEVELOPMENT

Bone morphogenetic protein receptors and signal transduction

(2009) K. Miyazono et al.   JOURNAL OF BIOCHEMISTRY

Growth Factor Regulation of Growth Factors in Articular Chondrocytes

(2009) Shuiliang Shi et al.   JOURNAL OF BIOLOGICAL CHEMISTRY

Increase in ALK1/ALK5 Ratio as a Cause for Elevated MMP-13 Expression in Osteoarthritis in Humans and Mice

(2009) E. N. Blaney Davidson et al.   JOURNAL OF IMMUNOLOGY

ER stress in Alzheimer's disease: a novel neuronal trigger for inflammation and Alzheimer's pathology

(2009) Antero Salminen et al.   Journal of Neuroinflammation

Modulating hedgehog signaling can attenuate the severity of osteoarthritis

(2009) Alvin C Lin et al.   NATURE MEDICINE

MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation – divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation

(2009) B.-C. Sondergaard et al.   OSTEOARTHRITIS AND CARTILAGE

Transcriptional networks controlling chondrocyte proliferation and differentiation during endochondral ossification

(2009) Manuela Wuelling et al.   PEDIATRIC NEPHROLOGY

Modulation of OPG, RANK and RANKL by human chondrocytes and their implication during osteoarthritis

(2009) S. Kwan Tat et al.   RHEUMATOLOGY

ERK1/2 Activation Induced by Inflammatory Cytokines Compromises Effective Host Tissue Integration of Engineered Cartilage

(2009) Farida Djouad et al.   TISSUE ENGINEERING PART A

Cartilage homeostasis in health and rheumatic diseases

(2009) Mary B Goldring et al.   ARTHRITIS RESEARCH & THERAPY

The NF- B Family of Transcription Factors and Its Regulation

(2009) A. Oeckinghaus et al.   Cold Spring Harbor Perspectives in Biology

Defining the roles of inflammatory and anabolic cytokines in cartilage metabolism

(2008) M B Goldring et al.   ANNALS OF THE RHEUMATIC DISEASES

The dynamic interplay between osteoclasts and the immune system

(2008) Tomoki Nakashima et al.   ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS

Differential expression of GADD45β in normal and osteoarthritic cartilage: Potential role in homeostasis of articular chondrocytes

(2008) Kosei Ijiri et al.   ARTHRITIS AND RHEUMATISM

Regulation of articular chondrocyte proliferation and differentiation by indian hedgehog and parathyroid hormone-related protein in mice

(2008) Xuesong Chen et al.   ARTHRITIS AND RHEUMATISM

Functional characterization of hypertrophy in chondrogenesis of human mesenchymal stem cells

(2008) Michael B. Mueller et al.   ARTHRITIS AND RHEUMATISM

Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis

(2008) Francesco Dell'Accio et al.   ARTHRITIS AND RHEUMATISM

Regulation of cartilage formation and maturation by mitogen-activated protein kinase signaling

(2008) Brent E. Bobick et al.   BIRTH DEFECTS RESEARCH PART C-EMBRYO TODAY-REVIEWS

Shared Principles in NF-κB Signaling

(2008) Matthew S. Hayden et al.   CELL

Biology of hypoxia-inducible factor-2α in development and disease

(2008) S A Patel et al.   CELL DEATH AND DIFFERENTIATION

Signaling cross-talk between TGF-β/BMP and other pathways

(2008) Xing Guo et al.   CELL RESEARCH

Indian hedgehog signals independently of PTHrP to promote chondrocyte hypertrophy

(2008) K. K. Mak et al.   DEVELOPMENT

The IKK-NF-κB pathway: a source for novel molecular drug targets in pain therapy?

(2008) Ellen Niederberger et al.   FASEB JOURNAL

Analysis of the Runx2 promoter in osseous and non-osseous cells and identification of HIF2A as a potent transcription activator

(2008) Hiroyuki Tamiya et al.   GENE

Biological impact of the fibroblast growth factor family on articular cartilage and intervertebral disc homeostasis

(2008) Michael B. Ellman et al.   GENE

Effects induced by BMPS in cultures of human articular chondrocytes: Comparative studies

(2008) Susan Chubinskaya et al.   GROWTH FACTORS

Autophagy–physiology and pathophysiology

(2008) Yasuo Uchiyama et al.   HISTOCHEMISTRY AND CELL BIOLOGY

Application of BMP-7 to tibial non-unions: A 3-year multicenter experience

(2008) Nikolaos K. Kanakaris et al.   INJURY-INTERNATIONAL JOURNAL OF THE CARE OF THE INJURED

ALK1 Opposes ALK5/Smad3 Signaling and Expression of Extracellular Matrix Components in Human Chondrocytes

(2008) Kenneth W Finnson et al.   JOURNAL OF BONE AND MINERAL RESEARCH

SOX9 Directly Binds CREB as a Novel Synergism With the PKA Pathway in BMP-2–Induced Osteochondrogenic Differentiation

(2008) Li Zhao et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

(2008) Mei Zhu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

p38/NF‐kB‐dependent expression of COX‐2 during differentiation and inflammatory response of chondrocytes

(2008) Valentina Ulivi et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Sox9, a key transcription factor of bone morphogenetic protein-2-induced chondrogenesis, is activated through BMP pathway and a CCAAT box in the proximal promoter

(2008) Qiuhui Pan et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Bone morphogenetic proteins in tissue engineering: the road from laboratory to clinic, part II (BMP delivery)

(2008) P. C. Bessa et al.   Journal of Tissue Engineering and Regenerative Medicine

Current concepts in the pathogenesis of osteoarthritis

(2008) S. Krasnokutsky et al.   OSTEOARTHRITIS AND CARTILAGE

A novel in vivo murine model of cartilage regeneration. Age and strain-dependent outcome after joint surface injury

(2008) N.M. Eltawil et al.   OSTEOARTHRITIS AND CARTILAGE

Hyaluronan promotes the chondrocyte response to BMP-7

(2008) R.A. Andhare et al.   OSTEOARTHRITIS AND CARTILAGE

Endochondral ossification: How cartilage is converted into bone in the developing skeleton

(2007) E.J. Mackie et al.   INTERNATIONAL JOURNAL OF BIOCHEMISTRY & CELL BIOLOGY

ESE-1 is a potent repressor of type II collagen gene (COL2A1) transcription in human chondrocytes

(2007) Haibing Peng et al.   JOURNAL OF CELLULAR PHYSIOLOGY

Basic fibroblast growth factor accelerates matrix degradation via a neuro-endocrine pathway in human adult articular chondrocytes

(2007) Hee-Jeong Im et al.   JOURNAL OF CELLULAR PHYSIOLOGY

The quantitative and functional relation between insulin-like growth factor-I (IGF) and IGF-binding proteins during human osteoarthritis

(2007) Teresa I. Morales   JOURNAL OF ORTHOPAEDIC RESEARCH

The potential role of vascular endothelial growth factor (VEGF) in cartilage

(2007) M. Murata et al.   OSTEOARTHRITIS AND CARTILAGE