Interplay between Cartilage and Subchondral Bone Contributing to Pathogenesis of Osteoarthritis

Deletion of beta catenin in hypertrophic growth plate chondrocytes impairs trabecular bone formation

(2013) Svitlana Golovchenko et al.   BONE

Early decrease of serum biomarkers of type II collagen degradation (Coll2-1) and joint inflammation (Coll2-1 NO2) by hyaluronic acid intra-articular injections in patients with knee osteoarthritis: A research study part of the Biovisco study

(2013) Y. Henrotin et al.   JOURNAL OF ORTHOPAEDIC RESEARCH

WNT signaling in bone homeostasis and disease: from human mutations to treatments

(2013) Roland Baron et al.   NATURE MEDICINE

Inhibition of TGF-β signaling in mesenchymal stem cells of subchondral bone attenuates osteoarthritis

(2013) Gehua Zhen et al.   NATURE MEDICINE

Gremlin 1, Frizzled-related protein, and Dkk-1 are key regulators of human articular cartilage homeostasis

(2012) J. C. H. Leijten et al.   ARTHRITIS AND RHEUMATISM

Biomechanical factors in osteoarthritis

(2012) Farshid Guilak   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Biological markers in osteoarthritis

(2012) J.Ch. Rousseau et al.   BONE

Sphingosine-1-phosphate inhibits interleukin-1β-induced inflammation in human articular chondrocytes

(2012) MYUNG-HEE MOON et al.   INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE

Sphingosine-1-phosphate modulates expression of vascular endothelial growth factor in human articular chondrocytes: a possible new role in arthritis

(2012) Kayo Masuko et al.   International Journal of Rheumatic Diseases

Aggravation of ADAMTS and Matrix Metalloproteinase Production and Role of ERK1/2 Pathway in the Interaction of Osteoarthritic Subchondral Bone Osteoblasts and Articular Cartilage Chondrocytes -- Possible Pathogenic Role in Osteoarthritis

(2012) I. PRASADAM et al.   JOURNAL OF RHEUMATOLOGY

Bone remodelling in osteoarthritis

(2012) David B. Burr et al.   Nature Reviews Rheumatology

Genetic deletion of low-density lipoprotein receptor-related protein 5 increases cartilage degradation in instability-induced osteoarthritis

(2012) L. Lodewyckx et al.   RHEUMATOLOGY

RANKL synthesized by articular chondrocytes contributes to juxta-articular bone loss in chronic arthritis

(2012) Maria J Martínez-Calatrava et al.   ARTHRITIS RESEARCH & THERAPY

Subchondral bone as a key target for osteoarthritis treatment

(2011) Santos Castañeda et al.   BIOCHEMICAL PHARMACOLOGY

WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways

(2011) Giovanna Nalesso et al.   JOURNAL OF CELL BIOLOGY

Increased chondrocyte sclerostin may protect against cartilage degradation in osteoarthritis

(2011) B.Y. Chan et al.   OSTEOARTHRITIS AND CARTILAGE

Application of biomarkers in the development of drugs intended for the treatment of osteoarthritis

(2011) V.B. Kraus et al.   OSTEOARTHRITIS AND CARTILAGE

The expression of RANKL and OPG in the various grades of osteoarthritic cartilage

(2011) Angus R. Upton et al.   RHEUMATOLOGY INTERNATIONAL

Articular cartilage and subchondral bone in the pathogenesis of osteoarthritis

(2010) Mary B. Goldring et al.   Annals of the New York Academy of Sciences

GDF5 deficiency in mice is associated with instability-driven joint damage, gait and subchondral bone changes

(2010) M. Daans et al.   ANNALS OF THE RHEUMATIC DISEASES

ERK-1/2 and p38 in the regulation of hypertrophic changes of normal articular cartilage chondrocytes induced by osteoarthritic subchondral osteoblasts

(2010) Indira Prasadam et al.   ARTHRITIS AND RHEUMATISM

Nonsteroidal antiinflammatory drugs and prostaglandin E2modulate the synthesis of osteoprotegerin and RANKL in the cartilage of patients with severe knee osteoarthritis

(2010) Juan Moreno-Rubio et al.   ARTHRITIS AND RHEUMATISM

Osteoarthritic changes in canine articular cartilage, subchondral bone, and synovium fifty-four months after transection of the anterior cruciate ligament

(2010) Kenneth D. Brandt et al.   ARTHRITIS AND RHEUMATISM

Control of Dkk-1 ameliorates chondrocyte apoptosis, cartilage destruction, and subchondral bone deterioration in osteoarthritic knees

(2010) Lin-Hsiu Weng et al.   ARTHRITIS AND RHEUMATISM

Targeting subchondral bone for treating osteoarthritis: what is the evidence?

(2010) Steeve Kwan Tat et al.   BEST PRACTICE & RESEARCH IN CLINICAL RHEUMATOLOGY

Subchondral bone loss following orthodontically induced cartilage degradation in the mandibular condyles of rats

(2010) Kai Jiao et al.   BONE

The bone–cartilage unit in osteoarthritis

(2010) Rik J. Lories et al.   Nature Reviews Rheumatology

Bone Morphogenetic Proteins and articular cartilage

(2010) P.M. van der Kraan et al.   OSTEOARTHRITIS AND CARTILAGE

Subchondral bone microstructural damage by increased remodelling aggravates experimental osteoarthritis preceded by osteoporosis

(2010) Miriam Bellido et al.   ARTHRITIS RESEARCH & THERAPY

Involvement of the Wnt signaling pathway in experimental and human osteoarthritis: Prominent role of Wnt-induced signaling protein 1

(2009) Arjen B. Blom et al.   ARTHRITIS AND RHEUMATISM

Proteinase-activated receptor (PAR)-2 activation impacts bone resorptive properties of human osteoarthritic subchondral bone osteoblasts

(2009) Nathalie Amiable et al.   BONE

Osteoarthritic cartilage chondrocytes alter subchondral bone osteoblast differentiation via MAPK signalling pathway involving ERK1/2

(2009) Indira Prasadam et al.   BONE

BMP canonical Smad signaling through Smad1 and Smad5 is required for endochondral bone formation

(2009) K. N. Retting et al.   DEVELOPMENT

Wnt/β-Catenin Signaling: Components, Mechanisms, and Diseases

(2009) Bryan T. MacDonald et al.   DEVELOPMENTAL CELL

From osteoarthritis treatments to future regenerative therapies for cartilage

(2009) Johann Clouet et al.   DRUG DISCOVERY TODAY

Chondrocyte survival in articular cartilage

(2009) A. K. Amin et al.   JOURNAL OF BONE AND JOINT SURGERY-BRITISH VOLUME

TGF-β1–induced migration of bone mesenchymal stem cells couples bone resorption with formation

(2009) Yi Tang et al.   NATURE MEDICINE

MAPKs are essential upstream signaling pathways in proteolytic cartilage degradation – divergence in pathways leading to aggrecanase and MMP-mediated articular cartilage degradation

(2009) B.-C. Sondergaard et al.   OSTEOARTHRITIS AND CARTILAGE

Cartilage homeostasis in health and rheumatic diseases

(2009) Mary B Goldring et al.   ARTHRITIS RESEARCH & THERAPY

WNT signaling in osteoarthritis and osteoporosis: What is the biological significance for the clinician?

(2009) Liesbet Lodewyckx et al.   Current Rheumatology Reports

Inhibition of β‐catenin signaling in articular chondrocytes results in articular cartilage destruction

(2008) Mei Zhu et al.   ARTHRITIS AND RHEUMATISM

Phenotypic characterization of osteoblasts from the sclerotic zones of osteoarthritic subchondral bone

(2008) Christelle Sanchez et al.   ARTHRITIS AND RHEUMATISM

Identification of the molecular response of articular cartilage to injury, by microarray screening: Wnt-16 expression and signaling after injury and in osteoarthritis

(2008) Francesco Dell'Accio et al.   ARTHRITIS AND RHEUMATISM

SOX9 Directly Binds CREB as a Novel Synergism With the PKA Pathway in BMP-2–Induced Osteochondrogenic Differentiation

(2008) Li Zhao et al.   JOURNAL OF BONE AND MINERAL RESEARCH

Activation of β-Catenin Signaling in Articular Chondrocytes Leads to Osteoarthritis-Like Phenotype in Adult β-Catenin Conditional Activation Mice

(2008) Mei Zhu et al.   JOURNAL OF BONE AND MINERAL RESEARCH

TGF-β1 and WISP-1/CCN-4 can regulate each other's activity to cooperatively control osteoblast function

(2008) Colette A. Inkson et al.   JOURNAL OF CELLULAR BIOCHEMISTRY

Germline mutations in WTX cause a sclerosing skeletal dysplasia but do not predispose to tumorigenesis

(2008) Zandra A Jenkins et al.   NATURE GENETICS

Discovery and development of the N-terminal procollagen type II (NPII) biomarker: a tool for measuring collagen type II synthesis

(2008) O.V. Nemirovskiy et al.   OSTEOARTHRITIS AND CARTILAGE

Should subchondral bone turnover be targeted when treating osteoarthritis?

(2008) M.A. Karsdal et al.   OSTEOARTHRITIS AND CARTILAGE

The BMP antagonists follistatin and gremlin in normal and early osteoarthritic cartilage: an immunohistochemical study

(2008) G. Tardif et al.   OSTEOARTHRITIS AND CARTILAGE

ADAMTS5−/− mice have less subchondral bone changes after induction of osteoarthritis through surgical instability: implications for a link between cartilage and subchondral bone changes

(2008) S.M. Botter et al.   OSTEOARTHRITIS AND CARTILAGE

On new bone formation in the pre-osteoarthritic joint

(2008) A. Thambyah et al.   OSTEOARTHRITIS AND CARTILAGE

Enhanced Expression of Osteocalcin mRNA in Human Osteoarthritic Trabecular Bone of the Proximal Femur Is Associated with Decreased Expression of Interleukin-6 and Interleukin-11 mRNA

(2006) Julia S. Kuliwaba et al.   JOURNAL OF BONE AND MINERAL RESEARCH