Lysyl oxidases: from enzyme activity to extracellular matrix cross-links
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Title
Lysyl oxidases: from enzyme activity to extracellular matrix cross-links
Authors
Keywords
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Journal
Essays in Biochemistry
Volume 63, Issue 3, Pages 349-364
Publisher
Portland Press Ltd.
Online
2019-09-05
DOI
10.1042/ebc20180050
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Note: Only part of the references are listed.- ATP7A delivers copper to the lysyl oxidase family of enzymes and promotes tumorigenesis and metastasis
- (2019) Vinit Shanbhag et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Analyses of lysine aldehyde cross-linking in collagen reveal that the mature cross-link histidinohydroxylysinonorleucine is an artifact
- (2019) David R. Eyre et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lysyl oxidase–like 2 (LOXL2)–mediated cross-linking of tropoelastin
- (2019) Christian E. H. Schmelzer et al. FASEB JOURNAL
- A comprehensive map of human elastin cross‐linking during elastogenesis
- (2019) Tobias Hedtke et al. FEBS Journal
- LOXL2—A New Target in Antifibrogenic Therapy?
- (2019) Angela Puente et al. INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
- Anti-metastatic Inhibitors of Lysyl Oxidase (LOX): Design and Structure–Activity Relationships
- (2019) Leo Leung et al. JOURNAL OF MEDICINAL CHEMISTRY
- Interplay Between LOX Enzymes and Integrins in the Tumor Microenvironment
- (2019) Pier Giorgio Amendola et al. Cancers
- Differential cleavage of lysyl oxidase by the metalloproteinases BMP1 and ADAMTS2/14 regulates collagen binding through a tyrosine sulfate domain
- (2019) Tamara Rosell-García et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- A Three-Dimensional Model of Human Lysyl Oxidase, a Cross-Linking Enzyme
- (2019) Sylvain D. Vallet et al. ACS Omega
- The apparent competitive action of ECM proteases and cross-linking enzymes during fibrosis: Applications to drug discovery
- (2018) Nikolaos A. Afratis et al. ADVANCED DRUG DELIVERY REVIEWS
- Inhibitor of lysyl oxidase improves cardiac function and the collagen/MMP profile in response to volume overload
- (2018) Elia C El Hajj et al. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
- Inhibition of the lox enzyme family members with old and new ligands. selectivity analysis revisited
- (2018) István Hajdú et al. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
- Identification of pyridinoline, a collagen crosslink, as a novel intrinsic ligand for the receptor for advanced glycation end-products (RAGE)
- (2018) Yoto Murakami et al. BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY
- Lysyl oxidase in cancer inhibition and metastasis
- (2018) Kathryn A. Johnston et al. CANCER LETTERS
- Multiscale mechanical effects of native collagen cross-linking in tendon
- (2018) Jeremy D. Eekhoff et al. CONNECTIVE TISSUE RESEARCH
- Simtuzumab Is Ineffective for Patients with Bridging Fibrosis or Compensated Cirrhosis Caused by Nonalcoholic Steatohepatitis
- (2018) Stephen A. Harrison et al. GASTROENTEROLOGY
- Lysyl Oxidases
- (2018) Fernando Rodriguez-Pascual et al. JOURNAL OF GLAUCOMA
- Recombinant Human Lysyl Oxidase-like 2 Secreted from Human Embryonic Kidney Cells Displays Complex and Acidic Glycans at All Three N-Linked Glycosylation Sites
- (2018) Eden P. Go et al. JOURNAL OF PROTEOME RESEARCH
- Elastin in lung development and disease pathogenesis
- (2018) Robert P. Mecham MATRIX BIOLOGY
- Interactions between lysyl oxidases and ADAMTS proteins suggest a novel crosstalk between two extracellular matrix families
- (2018) Rohtem Aviram et al. MATRIX BIOLOGY
- Molecular and tissue alterations of collagens in fibrosis
- (2018) Sylvie Ricard-Blum et al. MATRIX BIOLOGY
- Crystal structure of human lysyl oxidase-like 2 (hLOXL2) in a precursor state
- (2018) Xi Zhang et al. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
- Thrombospondin-1 promotes matrix homeostasis by interacting with collagen and lysyl oxidase precursors and collagen cross-linking sites
- (2018) Silvia Rosini et al. Science Signaling
- Lysyl oxidase-like 2 inhibition ameliorates glomerulosclerosis and albuminuria in diabetic nephropathy
- (2018) Stefanie Stangenberg et al. Scientific Reports
- Thrombospondin-1 promotes matrix homeostasis by interacting with collagen and lysyl oxidase precursors and collagen cross-linking sites
- (2018) Silvia Rosini et al. Science Signaling
- Evaluation of Fluorine-18-Labeled α1(I)-N-Telopeptide Analogs as Substrate-Based Radiotracers for PET Imaging of Melanoma-Associated Lysyl Oxidase
- (2018) Manuela Kuchar et al. Frontiers in Chemistry
- Simtuzumab for Primary Sclerosing Cholangitis: Phase 2 Study Results With Insights on the Natural History of the Disease
- (2018) Andrew J. Muir et al. HEPATOLOGY
- Glycation of type I collagen selectively targets the same helical domain lysine sites as lysyl oxidase- mediated cross-linking
- (2018) David M Hudson et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Elastin is heterogeneously cross-linked
- (2018) Christoph U. Schräder et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Inhibition of angiogenesis in endothelial cells by Human Lysyl oxidase propeptide
- (2018) Ragavachetty Nagaraj Nareshkumar et al. Scientific Reports
- Insights into the structure and dynamics of lysyl oxidase propeptide, a flexible protein with numerous partners
- (2018) Sylvain D. Vallet et al. Scientific Reports
- Extracellular Processing of Lysyl Oxidase-like 2 and Its Effect on Amine Oxidase Activity
- (2018) Kazushi Okada et al. BIOCHEMISTRY
- Is This the Last Requiem for Simtuzumab?
- (2018) Peter Fickert HEPATOLOGY
- Therapeutic options to reduce advanced glycation end products in patients with diabetes mellitus: A review
- (2018) Philipp Jud et al. DIABETES RESEARCH AND CLINICAL PRACTICE
- Selective targeting of lysyl oxidase-like 2 (LOXL2) suppresses hepatic fibrosis progression and accelerates its reversal
- (2017) Naoki Ikenaga et al. GUT
- Proteolytic processing of lysyl oxidase–like-2 in the extracellular matrix is required for crosslinking of basement membrane collagen IV
- (2017) Alberto J. López-Jiménez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Infrared microspectroscopic determination of collagen cross-links in articular cartilage
- (2017) Lassi Rieppo et al. JOURNAL OF BIOMEDICAL OPTICS
- Identification of 4-(Aminomethyl)-6-(trifluoromethyl)-2-(phenoxy)pyridine Derivatives as Potent, Selective, and Orally Efficacious Inhibitors of the Copper-Dependent Amine Oxidase, Lysyl Oxidase-Like 2 (LOXL2)
- (2017) Martin W. Rowbottom et al. JOURNAL OF MEDICINAL CHEMISTRY
- Fragments generated upon extracellular matrix remodeling: Biological regulators and potential drugs
- (2017) Sylvie Ricard-Blum et al. MATRIX BIOLOGY
- A quick overview to the early phase clinical trials of Simtuzumab®: Are we loosing the most promising anti-fibrotic product?
- (2017) Akif Altinbas MEDICAL HYPOTHESES
- Lysyl Oxidase 3 Is a Dual-Specificity Enzyme Involved in STAT3 Deacetylation and Deacetylimination Modulation
- (2017) Li Ma et al. MOLECULAR CELL
- Identification of Histidine 303 as the Catalytic Base of Lysyl Oxidase via Site-Directed Mutagenesis
- (2017) Rachel N. Oldfield et al. PROTEIN JOURNAL
- The Role of the Lysyl Oxidases in Tissue Repair and Remodeling: A Concise Review
- (2017) Linyi Cai et al. Tissue Engineering and Regenerative Medicine
- Small Molecule Lysyl Oxidase-like 2 (LOXL2) Inhibitors: The Identification of an Inhibitor Selective for LOXL2 over LOX
- (2017) John H. Hutchinson et al. ACS Medicinal Chemistry Letters
- Pre-clinical evaluation of small molecule LOXL2 inhibitors in breast cancer
- (2017) Joan Chang et al. Oncotarget
- The Role of the Lysyl Oxidases in Tissue Repair and Remodeling: A Concise Review
- (2017) Linyi Cai et al. Tissue Engineering and Regenerative Medicine
- Functional importance of lysyl oxidase family propeptide regions
- (2017) Philip C. Trackman Journal of Cell Communication and Signaling
- Comparative analysis of lysyl oxidase (like) family members in pulmonary fibrosis
- (2017) Verena Aumiller et al. Scientific Reports
- Lysyl Oxidase, a Targetable Secreted Molecule Involved in Cancer Metastasis
- (2016) Thomas R. Cox et al. CANCER RESEARCH
- Molecular insights into prolyl and lysyl hydroxylation of fibrillar collagens in health and disease
- (2016) Rutger A. F. Gjaltema et al. CRITICAL REVIEWS IN BIOCHEMISTRY AND MOLECULAR BIOLOGY
- Lysyl Oxidase Isoforms and Potential Therapeutic Opportunities for Fibrosis and Cancer
- (2016) Philip C. Trackman EXPERT OPINION ON THERAPEUTIC TARGETS
- Lysyl oxidase-like 2 (LOXL2) oxidizes trimethylated lysine 4 in histone H3
- (2016) Nicolás Herranz et al. FEBS Journal
- Fibromodulin Interacts with Collagen Cross-linking Sites and Activates Lysyl Oxidase
- (2016) Sebastian Kalamajski et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lysyl Oxidase-like-2 Cross-links Collagen IV of Glomerular Basement Membrane
- (2016) Carolina Añazco et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Enzymatic and non-enzymatic functions of the lysyl oxidase family in bone
- (2016) Philip C. Trackman MATRIX BIOLOGY
- Loss of fibulin-4 results in abnormal collagen fibril assembly in bone, caused by impaired lysyl oxidase processing and collagen cross-linking
- (2016) Takako Sasaki et al. MATRIX BIOLOGY
- Lysyl oxidase propeptide promotes adipogenesis through inhibition of FGF-2 signaling
- (2016) John D. Griner et al. Adipocyte
- Collagen and elastin cross-linking is altered during aberrant late lung development associated with hyperoxia
- (2015) Ivana Mižíková et al. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY
- Syndecan-4 is a key determinant of collagen cross-linking and passive myocardial stiffness in the pressure-overloaded heart
- (2015) Kate M. Herum et al. CARDIOVASCULAR RESEARCH
- The lysyl oxidase inhibitor -aminopropionitrile reduces body weight gain and improves the metabolic profile in diet-induced obesity in rats
- (2015) M. Miana et al. Disease Models & Mechanisms
- The function and mechanisms of action of LOXL2 in cancer (Review)
- (2015) LINGHONG WU et al. INTERNATIONAL JOURNAL OF MOLECULAR MEDICINE
- Lysyl Oxidase Activity Is Required for Ordered Collagen Fibrillogenesis by Tendon Cells
- (2015) Andreas Herchenhan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lysyl hydroxylase 2 induces a collagen cross-link switch in tumor stroma
- (2015) Yulong Chen et al. JOURNAL OF CLINICAL INVESTIGATION
- Cancer-Associated Fibroblasts Induce a Collagen Cross-link Switch in Tumor Stroma
- (2015) D. Pankova et al. MOLECULAR CANCER RESEARCH
- LOXL2 Oxidizes Methylated TAF10 and Controls TFIID-Dependent Genes during Neural Progenitor Differentiation
- (2015) Ane Iturbide et al. MOLECULAR CELL
- Urinary pyridinoline cross-links as biomarkers of osteogenesis imperfecta
- (2015) Uschi Lindert et al. Orphanet Journal of Rare Diseases
- Origin and evolution of lysyl oxidases
- (2015) Xavier Grau-Bové et al. Scientific Reports
- Human copper-dependent amine oxidases
- (2014) Joel Finney et al. ARCHIVES OF BIOCHEMISTRY AND BIOPHYSICS
- Human lysyl oxidase-like 2
- (2014) Hee-Jung Moon et al. BIOORGANIC CHEMISTRY
- Fourier Transform Infrared Spectroscopic Characterization of Mineralizing Type I Collagen Enzymatic Trivalent Cross-Links
- (2014) E. P. Paschalis et al. CALCIFIED TISSUE INTERNATIONAL
- Insilico study of anti-carcinogenic lysyl oxidase-like 2 inhibitors
- (2014) Syed Aun Muhammad et al. COMPUTATIONAL BIOLOGY AND CHEMISTRY
- Lysine post-translational modifications of collagen
- (2014) Mitsuo Yamauchi et al. Essays in Biochemistry
- A new role for LOX and LOXL2 proteins in transcription regulation
- (2014) Ane Iturbide et al. FEBS Journal
- Lysyl oxidase in cancer research
- (2014) Lara Perryman et al. Future Oncology
- Glycosylation and Cross-linking in Bone Type I Collagen
- (2014) Masahiko Terajima et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Increased C-telopeptide Cross-linking of Tendon Type I Collagen in Fibromodulin-deficient Mice
- (2014) Sebastian Kalamajski et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- LOXL1-associated Candidate Epithelial Pathomechanisms in Exfoliation Glaucoma
- (2014) Rozalia Laczko et al. JOURNAL OF GLAUCOMA
- Lysyl Oxidases in the Trabecular Meshwork
- (2014) Robert J. Wordinger et al. JOURNAL OF GLAUCOMA
- Expression and Regulation of LOXL1 and Elastin-related Genes in Eyes With Exfoliation Syndrome
- (2014) Janey L. Wiggs et al. JOURNAL OF GLAUCOMA
- Expression and Regulation of LOXL1 and Elastin-related Genes in Eyes With Exfoliation Syndrome
- (2014) Matthias Zenkel et al. JOURNAL OF GLAUCOMA
- Lateral Growth Limitation of Corneal Fibrils and Their Lamellar Stacking Depend on Covalent Collagen Cross-linking by Transglutaminase-2 and Lysyl Oxidases, Respectively
- (2013) Lei Wang et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Post-translational Modifications of Recombinant Human Lysyl Oxidase-like 2 (rhLOXL2) Secreted fromDrosophilaS2 Cells
- (2013) Li Xu et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Time-resolved Analysis of the Matrix Metalloproteinase 10 Substrate Degradome
- (2013) Pascal Schlage et al. MOLECULAR & CELLULAR PROTEOMICS
- A Novel Proteolytic Processing of Prolysyl Oxidase
- (2011) Phimon Atsawasuwan et al. CONNECTIVE TISSUE RESEARCH
- The Enzymatic Activity of Lysyl Oxidas-like-2 (LOXL2) Is Not Required for LOXL2-induced Inhibition of Keratinocyte Differentiation
- (2011) Jennie Lugassy et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Control of Megakaryocyte Expansion and Bone Marrow Fibrosis by Lysyl Oxidase
- (2011) Alexia Eliades et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- The Conserved Scavenger Receptor Cysteine-Rich Superfamily in Therapy and Diagnosis
- (2011) V. G. Martinez et al. PHARMACOLOGICAL REVIEWS
- Modulation of Lysyl Oxidase-like 2 Enzymatic Activity by an Allosteric Antibody Inhibitor
- (2010) Hector M. Rodriguez et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Maturation of Collagen Ketoimine Cross-links by an Alternative Mechanism to Pyridinoline Formation in Cartilage
- (2010) David R. Eyre et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Interaction between Periostin and BMP-1 Promotes Proteolytic Activation of Lysyl Oxidase
- (2010) Takumi Maruhashi et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Role of Lysyl Oxidase Propeptide in Secretion and Enzyme Activity
- (2010) Jessica L. Grimsby et al. JOURNAL OF CELLULAR BIOCHEMISTRY
- Identification of the copper-binding ligands of lysyl oxidase
- (2010) Karlo M. Lopez et al. JOURNAL OF NEURAL TRANSMISSION
- Identification of the disulfide bonds of lysyl oxidase
- (2010) Xi Chen et al. JOURNAL OF NEURAL TRANSMISSION
- Chromatin supraorganization, mitotic abnormalities and proliferation in cells with increased or down-regulated lox expression: Indirect evidence of a LOX–histone H1 interaction in vivo
- (2010) Maria Luiza S. Mello et al. MICRON
- The human lysyl oxidase-like 2 protein functions as an amine oxidase toward collagen and elastin
- (2010) Young-Mi Kim et al. MOLECULAR BIOLOGY REPORTS
- Allosteric inhibition of lysyl oxidase–like-2 impedes the development of a pathologic microenvironment
- (2010) Vivian Barry-Hamilton et al. NATURE MEDICINE
- The Lysyl Oxidases LOX and LOXL2 Are Necessary and Sufficient to Repress E-cadherin in Hypoxia
- (2009) Ruth Schietke et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lysyl Oxidase Binds Transforming Growth Factor-β and Regulates Its Signaling via Amine Oxidase Activity
- (2008) Phimon Atsawasuwan et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Lysyl Oxidase Oxidizes Cell Membrane Proteins and Enhances the Chemotactic Response of Vascular Smooth Muscle Cells
- (2008) Héctor A. Lucero et al. JOURNAL OF BIOLOGICAL CHEMISTRY
- Advances in collagen cross-link analysis
- (2008) David R. Eyre et al. METHODS
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